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2026 Vol. 46, No. 3 Published: 2026-06-25

	1	Comparison of the Application of 3.0T MR 3D T1-SPACE Enhancement and T1 TSE DIXON Enhancement Sequence in Nasopharyngeal Carcinoma Scanning
		Mei Guangxiong, Mei Hongde, Zhong Qingke
		DOI: 10.3969/j.issn.1001-8131.2026.03.001
		Objective Compare the application effects of 3.0T MR 3D T1-SPACE enhancement and T1 TSE DIXON enhancement sequences in nasopharyngeal carcinoma(NPC)scanning.Methods 105 patients diagnosed with nasopharyngeal carcinoma in our hospital between January 2022 and March 2025 were selected and underwent 3.0T MR 3D T1-SPACE enhancement and T1 TSE DIXON enhancement sequence examinations.The artifacts and tumor display effects,detection of primary lesion invasion range,and cervical lymph node metastasis examination were compared between the two examination methods.Results The artifact and tumor display effect scores of the 3D T1-SPACE enhancement sequence were points and points,respectively,which were higher than those of the T1 TSE DIXON enhancement sequence points and points(P<0.05).Compared with the T1 TSE DIXON enhancement sequence,the detection rates of NPC invasion into the cavernous sinus,intracranial,sinus,skull base bone,retropharyngeal lymph nodes,oropharynx,and parapharyngeal space in the 3D T1-SPACE enhancement sequence were,and,respectively,which were higher than those in the T1 TSE DIXON enhancement sequence respectively(P<0.05).The detection rates of cervical lymph node metastasis in Zone II and Zone III using 3D T1-SPACE enhancement sequence were respectively,which were higher than those ofusing T1 TSE DIXON enhancement sequence(P<0.05).Conclusion The application of T1 TSE DIXON enhancement sequence and 3D T1-SPACE enhancement sequence in NPC scanning can provide more satisfactory image quality,and the detection rate of primary lesion invasion range is higher,with a higher detection rate of cervical lymph node metastasis in Zone II and Zone III.
		2026 Vol. 46 (3): 1-4 [Abstract] ( 128 ) HTML (1 KB) PDF (607 KB) ( 6 )

	5	Construction of Early Warning Model for Infectious Diseases Based on Multidimensional Parameters Fusion of Blood Routine and Optimization of Decision Threshold
		Zhang Yu
		DOI: 10.3969/j.issn.1001-8131.2026.03.002
		Objective To construct an early warning machine learning model for infectious diseases based on multidimensional parameters of complete blood count(CBC),optimize decision thresholds,and improve the accuracy and clinical utility of infection diagnosis.Methods A multicenter retrospective cohort study was conducted,collecting data from 5,317 suspected infectious disease patients in the emergency departments of three research centers from January 2023 to December 2024,including 1,683 cases in the infection group and 3,634 cases in the non-infection control group.CBC results within 24 hours of hospital admission were collected,and routine,derived inflammatory,and cell population data parameters were extracted to construct three hierarchical feature sets.LASSO regression combined with random forest was used to screen features,and the predictive performance of six machine learning algorithms was compared.Six threshold determination methods were systematically evaluated,with the introduction of clinical utility weighting functions and adaptive threshold strategies.Model performance was assessed through internal and external validation.Results The extended fusion hierarchical XGBoost model achieved an AUC of 0.874 on the internal validation set,superior to the basic fusion hierarchical model;the dynamic fusion hierarchical AUC increased to 0.891.The XGBoost model outperformed other algorithms.The model demonstrated stable performance in external validation.Subgroup analysis of bacteremia showed better predictive performance for Gram-negative bacteremia.SHAP analysis indicated that the top five most contributing features were procalcitonin,etc.The adaptive threshold strategy significantly improved the net recclassification index,with a low threshold in the high-risk group achieving a sensitivity of 91.23%.Conclusion The XGBoost model based on multidimensional parameter fusion of CBC can effectively predict infectious diseases,and the introduction of cell population data enhances model performance.The adaptive threshold strategy enables individualized early warning,demonstrating clinical translational potential to provide decision support for early infection identification in emergency departments and primary healthcare institutions.
		2026 Vol. 46 (3): 5-13 [Abstract] ( 156 ) HTML (1 KB) PDF (1486 KB) ( 10 )

	14	Fluid Resuscitation and Its Impact on Cognitive Prognosis in Patients with Septic Encephalopathy:A Prospective Cohort Study
		Yu Qing, Lai Wen, Xu Zuqing, Fan Lumei
		DOI: 10.3969/j.issn.1001-8131.2026.03.003
		Objective Septic-associated encephalopathy(SAE)is a common cerebral dysfunction associated with septic shock,which can lead to neurological and cognitive impairments.Early and adequate fluid resuscitation during septic shock not only reduces the risk of mortality but also significantly improves medium-to-long-term neurological outcomes for patients with SAE.This study investigated the relationship between fluid resuscitation and cognitive prognosis in SAE patients via TCD（Transcranial Doppler ultrasonography）,with implications for early intervention.Methods In this prospective cohort study,150 patients with septic shock were enrolled and categorised into SAE and non-SAE groups on the basis of clinical diagnostic criteria.SAE patients received standardised fluid resuscitation and were stratified into successful resuscitation and unsuccessful resuscitation subgroups.TCD was performed 24 hours,48 hours,1 week,and 2 weeks after admission to evaluate cerebral perfusion.Cognitive function was assessed on day 30 using the Mini-Mental State Examination(MMSE).Results TCD effectively identified SAE in septic shock patients.Significant differences in TCD-negative detection rates were observed between the successful and unsuccessful resuscitation subgroups at 48 hours,1 week,and 2 weeks(P<0.05).Statistically distinct MMSE scores were also noted at the 30-day follow-up.Conclusion Effective fluid resuscitation in septic shock patients has positive implications for neurological recovery and medium-to-long-term cognitive improvement.TCD exhibits favourable efficacy and operational feasibility in the evaluation of neurological outcomes for prognostic purposes,thus supporting its integration into clinical decision-making protocols.
		2026 Vol. 46 (3): 14-17 [Abstract] ( 137 ) HTML (1 KB) PDF (591 KB) ( 8 )

	18	The value of combined detection of serum pro-BNP,HCY and hs-CRP in the diagnosis of acute myocardial infarction
		Liu Lixue, Li Na, He Yudan
		DOI: 10.3969/j.issn.1001-8131.2026.03.004
		Objective To investigate the diagnostic value of combined serum N-terminal pro-B-type natriuretic peptide(pro-BNP),homocysteine(HCY),and high-sensitivity C-reactive protein(hs-CRP)testing for acute myocardial infarction(AMI).Methods Eighty-six patients with acute coronary syndrome(ACS)admitted to our hospital between January 2021 and January 2025 were enrolled.They were divided into a study group(AMI patients,n=43)and a control group(non-AMI patients,n=43)based on AMI occurrence.Morning fasting venous blood samples were collected from both groups.Serum levels of pro-BNP,HCY,and hs-CRP were measured using corresponding assays.Serum marker levels were compared between groups,and the sensitivity,specificity,accuracy,positive predictive value,negative predictive value,true positive rate,and false positive rate of both individual markers and combined testing for AMI diagnosis were analysed.Results Serum pro-BNP,HCY,and hs-CRP levels were significantly higher in the study group than in the control group(P<0.05).Diagnostic performance analysis revealed that the combined detection of pro-BNP,HCY,and hs-CRP combined detection exhibited a sensitivity of 97.67%,specificity of 95.35%,accuracy of 96.51%,positive predictive value of 95.45%,negative predictive value of 97.62%,true positive rate of 97.67%,and false positive rate of 4.65%,all superior to individual marker testing.Conclusion The combined serum testing of pro-BNP,HCY,and hs-CRP demonstrates high clinical utility in diagnosing AMI.It effectively enhances diagnostic accuracy,providing crucial guidance for the early clinical diagnosis and treatment of AMI,and warrants wider implementation.
		2026 Vol. 46 (3): 18-20 [Abstract] ( 121 ) HTML (1 KB) PDF (421 KB) ( 6 )

	21	Basal Anchoring with Cavity Compression Closure Technique for Preventing Dead Space Formation After Resection of Subcutaneous Benign Cystic-Solid Masses
		Chen Zhuoqi, Chen Yongguo, Liu Jiawei, Lei Hua
		DOI: 10.3969/j.issn.1001-8131.2026.03.005
		Objective To evaluate the clinical efficacy of the basal anchoring with cavity compression closure technique in preventing postoperative dead space formation after resection of subcutaneous benign cystic-solid masses.Methods This study was a retrospective case series.A total of 42 consecutive patients with clinically and ultrasonographically diagnosed subcutaneous benign cystic-solid masses who met the inclusion criteria were treated with this technique between June 2024 and August 2025(all cases were postoperatively confirmed as benign).After complete mass excision and intradermal tension-reducing suture,a “U”-shaped non-absorbable anchoring suture was placed deep in the subcutaneous layer.A molded saline-moistened gauze bolster was placed over the incision,and the suture was tightened to generate vertical,uniform pressure,which was maintained for 2~3 days.The primary outcome measure was the success rate of dead space closure.Results Postoperative dead space closure was achieved in all 42 patients,with a success rate of 100%.No patient developed persistent seroma.The overall postoperative complication rate was 4.8%(2/42).Compared with conventional methods reported in the literature,this technique achieved superior outcomes in terms of seroma and overall complication rates.At the time of suture removal,the mean Vancouver Scar Scale(VSS)score was 2.8±1.5,and the mean Patient Scar Assessment Scale(PSAS)score was 18.5±7.2,indicating favorable early healing outcomes.Conclusion The basal anchoring with cavity compression closure technique is feasible,effectively ensures definitive dead space closure,and achieves reliable primary healing.Various strategies for seroma prevention described in the literature have inherent limitations,whereas this technique eliminates dead space at the source through active mechanical compression,demonstrating clear clinical advantages.Preliminary application suggests that it is both safe and effective.
		2026 Vol. 46 (3): 21-25 [Abstract] ( 133 ) HTML (1 KB) PDF (870 KB) ( 3 )

	26	PAX1/JAM3 Methylation and HPV E6/E7 mRNA Testing for the Detection of Cervical High-Grade Lesions(CIN2+):Diagnostic Performance and Combined Application
		Cao Jianing, Liu Jing, Han Lili
		DOI: 10.3969/j.issn.1001-8131.2026.03.006
		Objective To evaluate the diagnostic value of human papilloma virus(HPV)E6/E7 mRNA testing and PAX1/JAM3 gene promoter methylation analysis for high-grade cervical intraepithelial neoplasia(CIN2+),and to assess strategies for their combined use.Methods A total of 196 women with abnormal cervical screening results were enrolled.All participants underwent testing for HPV E6/E7 mRNA and PAX1/JAM3 promoter methylation.Using cervical biopsy histopathology as the gold standard,the positive rates of both markers were analyzed across different cervical lesion grades(including viralinfection,CIN I,CIN II,CIN III,and cervical cancer).The diagnostic performance of each marker alone and in combination was evaluated.Results The positive rates of both HPV E6/E7 mRNA and PAX1/JAM3 methylation increased significantly with the severity of cervical lesions(P<0.01).Multivariate logistic regression analysis identified both as independent risk factors for high-grade cervical lesions(CIN2+),with odds ratios(ORs)of 5.90 and 5.77,respectively.PAX1/JAM3 methylation had a greater specificity for diagnosing CIN2+(82.30%)and AUC(0.671).In the combination test,a serial(sequential)test approach greatly improved the specificity,up to 92.92%(AUC=0.687),while an approach in parallel significantly increased sensitivity up to 87.95%(AUC=0.674).Conclusion The HPV E6/E7 mRNA test has a high sensitivity and can be used as the primary method of cervical cancer screening;the PAX1/JAM3 methylation test has a high specificity,suggests considerable utility in triaging primary screen positive women.Combined usage of these two markers has complementary benefits,improving detection and accurate characterization of cervix pathology.
		2026 Vol. 46 (3): 26-31 [Abstract] ( 138 ) HTML (1 KB) PDF (740 KB) ( 9 )

	32	Based on Perineal Ultrasound Combined with Serum Fibulin-3,A Prediction Model for Postpartum Pelvic Floor Dysfunction of Parturients Undergoing Analgesia in Water Delivery was Established
		Qin Zhenzhen, Zhang Lulu, Zhang Xueqin
		DOI: 10.3969/j.issn.1001-8131.2026.03.007
		Objective The aim of this study was to investigate the value of transperineal ultrasound（TPUS） parameters combined with serum Fibulin-3 in predicting postpartum pelvic floor dysfunction（PFD） in women who experienced pain relief during water birth,and to construct a combined predictive model.Methods A total of 150 women who underwent water birth analgesia and were admitted to our hospital from January 2023 to June 2024 were selected as study subjects.Based on the pelvic floor function assessment results at 6~8 weeks postpartum,they were divided into an impaired group （n=45） and a normal group（n=105）.Serum Fibulin-3 levels were collected postpartum,and parameters such as the angle of progression（AOP） and fetal head direction angle（HD） were measured via perineal ultrasound.Multivariate logistic regression analysis was performed,and the predictive efficacy of each indicator and the combined model was evaluated using the receiver operating characteristic（ROC）curve.Results The obstructed group exhibited significantly higher rates of PFD family history（12,26.67%）,parity≥2（19,42.22%）,perineal laceration（12,26.67%）,prolonged active phase of the first stage of labor（10,22.22%）,prolonged second stage of labor（17,37.78%）,and neonatal body weight（3437.86±414.05）g compared to the normal group（all P<0.05）.The TIMP-1 level in the obstructed group were significantly lower than those in the normal group （all P<0.05）.The AOP in the obstructed group was significantly smaller than that in the normal group,while the HD,HPD,and mLA in the obstructed group were significantly larger than those in the normal group（all P<0.05）.Multivariate logistic regression analysis revealed that TIMP-1,Fibulin-3,and AOP were protective factors for postpartum PFD,whereas HD,HPD,and mLA enlargement were independent risk factors.The ROC curve showed that the AUC of the combined index reached 0.862,with sensitivity and specificity of 75.56% and 85.71%,respectively（all P<0.05）.Conclusion The combined perineal ultrasound parameters and serum Fibulin-3 model demonstrated significant predictive value for postpartum pain distress（PFD） in women undergoing water birth analgesia,providing a theoretical basis for early clinical prevention.
		2026 Vol. 46 (3): 32-35 [Abstract] ( 116 ) HTML (1 KB) PDF (547 KB) ( 6 )

	36	Correlation Analysis of Serum 25-Hydroxyvitamin D Levels and Antibody Titers in Autoimmune Thyroid Diseases
		Sun Fei, Wang Zhuan
		DOI: 10.3969/j.issn.1001-8131.2026.03.008
		Objective To investigate the correlation between serum 25-hydroxyvitamin D [25-（OH）D]levels and the titers of The presence of thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TgAb)in individuals with autoimmune thyroid disease（AITD）,and to explore its clinical significance.Methods A total of 102 patients with AITD admitted to the Department of internal medicine of Wolong District Hospital of traditional Chinese medicine in Nanyang from June 2024 to December 2025 were selected retrospectively as the research group,the Control Group consisted of 102 healthy individuals who underwent physical examination in the same period.Serum levels of 25-（OH）D,TPOAb,and TgAb were detected and compared between the two groups.The Study Group was further divided into deficiency,insufficiency,and sufficiency subgroups based on 25-（OH）D levels.The differences in antibody titers among subgroups were compared,and the correlation between serum 25-（OH）D and TPOAb/TgAb was analyzed using Spearman correlation coefficient.Results A significantly reduced level of serum 25-(OH)D was observed in the study group relative to the healthy controls,while the levels of TPOAb and TgAb were higher than those in the control group,with statistically significant differences(P<0.05).Subgroup analysis showed that the levels of TPOAb and TgAb in the deficiency subgroup were significantly higher than those in the insufficiency subgroup and the sufficiency subgroup,and the insufficiency subgroup was also significantly higher than the sufficiency subgroup(P<0.05).Spearman correlation analysis indicated that the serum 25-(OH)D level in AITD patients was significantly negatively correlated with the titers of TPOAb and TgAb(P<0.001).Conclusions Vitamin D deficiency is prevalent in AITD patients.Low levels of 25-（OH）D are closely associated with high titers of thyroid autoantibodies,suggesting that Vitamin D may participate in the pathological process of AITD as an immunomodulator.Monitoring its level has important reference value for assessing disease condition and guiding treatment.
		2026 Vol. 46 (3): 36-38 [Abstract] ( 131 ) HTML (1 KB) PDF (447 KB) ( 8 )

	39	Detection of HIF-1 in Fetal Umbilical Artery Blood and Ultrasound Parameters such as RI,PI,and S/D The Diagnostic Value for Fetal Intrauterine Distress
		Mo Yiyan, Chen Hongwang, Liu Xi
		DOI: 10.3969/j.issn.1001-8131.2026.03.009
		Objective To explore the application value of combined detection of umbilical cord blood hypoxia-inducible factor-1α(HIF-1α)and ultrasound umbilical blood flow parameters in the diagnosis of fetal distress.Methods Fifty pregnant women with confirmed fetal intrauterine distress who delivered at our hospital from May 2024 to February 2025 were selected as the experimental group,and 50 healthy pregnant women who delivered in our hospital during the same period were selected as the control group.Umbilical cord blood HIF-1α and fetal umbilical artery blood flow parameters(resistance index RI,pulsatility index PI,systolic peak velocity and diastolic end velocity ratio S/D,fetal heart rate)were jointly detected to evaluate the specificity of these indicators in diagnosing fetal intrauterine distress.Results The umbilical artery blood HIF-1α in the experimental group was significantly higher than that in the control group(P<0.05).The area under the curve(AUC)of serum HIF-1 for diagnosing fetal intrauterine distress was 0.632.The AUC of umbilical artery blood flow parameters in the experimental group:mid-term RI,PI,S/D,fetal heart rate were 0.614,0.618,0.609,0.548 respectively;late-term RI,PI,S/D,fetal heart rate:AUC were 0.576,0.503,0.536,0.548 respectively.Conclusion Umbilical artery blood HIF-1α is related to the occurrence of fetal distress,and it has certain application value for the early diagnosis of fetal distress and reducing the neonatal mortality rate.
		2026 Vol. 46 (3): 39-41 [Abstract] ( 132 ) HTML (1 KB) PDF (460 KB) ( 4 )

	42	Analysis of the Effect of Dual-wavelength Laser Combined with Periodontal Therapy on Diabetes Mellitus Complicated with Chronic Periodontitis
		Hong Feifei, Zhu Jianyu, Yuan Haibo, Lin Liangqin, Zhao Liang
		DOI: 10.3969/j.issn.1001-8131.2026.03.010
		Objective To analyze the therapeutic effect of dual-wavelength laser combined with periodontal basic therapy on diabetic patients with chronic periodontitis.Methods 60 cases of DM complicated with CP in our department from December randomly divided into two groups.The control group(30 cases)was given periodontal basic treatment,and the observation group(30 cases)was given dual-wavelength laser treatment.The clinical efficacy,periodontal parameters and inflammatory reaction in gingival sulcus were compared.Results The clinical efficacy of the observation group was higher(93.33%vs76.67%).After treatment,the levels of PD,BI and PLI in the two groups were all decreased,and the levels of IL-16,IL-8 and IL-10 in the observation group were lower(P<0.05).IL-4 all increased,especially in the observation group(P<0.05).Conclusion The application of dual-wavelength laser combined with periodontal basic therapy in patients with diabetes mellitus complicated with chronic periodontitis can effectively improve the clinical efficacy,periodontal parameters and inflammation level.
		2026 Vol. 46 (3): 42-44 [Abstract] ( 137 ) HTML (1 KB) PDF (446 KB) ( 3 )

	45	Observation on the Efficacy of Goal-oriented Rehabilitation Training in the Reconstruction of Walking Function in Patients with Incomplete Spinal Cord Injury
		Zhang Qiuying, Wang Liuyun, Wang Dongmei, Jia Daoyuan
		DOI: 10.3969/j.issn.1001-8131.2026.03.011
		Objective To investigate the efficacy of goal-directed rehabilitation training in the functional reconstruction of walking in patients with incomplete spinal cord injury(SCI).Methods A total of 86 patients diagnosed with incomplete SCI admitted to Shanghai Hudong Hospital from January 2021 to January 2026 were selected as the study subjects.They were randomly divided into groups using a random number table.The control group(n=43)received conventional rehabilitation training,while the observation group(n=43)received goal-directed rehabilitation training in addition to conventional rehabilitation training.Clinical outcomes,including motor function,balance function,and activities of daily living(ADL),were compared.Results The total effective rate in the observation group was 95.35%,significantly higher than that in the control group(69.77%)(P<0.05).After intervention,the scores of the 6-minute walk test(6MWT),10-meter walk test(10MWT),WISCI scale,Fugl-Meyer score,Berg score,and Barthel Index in the observation group were all higher than those in the control group(P<0.05).Conclusion Goal-directed rehabilitation training can effectively improve the walking function of patients with incomplete SCI,enhance their motor and balance functions,and demonstrate good therapeutic effects and high clinical value.
		2026 Vol. 46 (3): 45-48 [Abstract] ( 141 ) HTML (1 KB) PDF (557 KB) ( 3 )

	127	Research Progress on the Changes in Chemical Constituents and Pharmacological Effects of Yuanhu Zhitong Formula Induced by Vinegar Processing
		Shan Guoqing, Xue Lichao, Ju Haolin, Li Lehan, Wei Ning, Chen Da, Jiang Hai
		DOI: 10.3969/j.issn.1001-8131.2026.03.036
		Yuanhu Zhitong Formula is composed of two traditional Chinese medicines,Corydalis Rhizoma and Angelicae Dahuricae Radix,with the effects of regulating qi flow,promoting blood circulation,and relieving pain.This paper systematically reviews the relevant literatures on Yuanhu Zhitong Formula,and summarizes the core pharmacodynamic material basis for its main pharmacological activities such as analgesia,anti-inflammation and anti-tumor.On the basis of summarizing its chemical constituents and pharmacological effects,we further analyze the efficacy-enhancing effect of vinegar processing on Yuanhu Zhitong Formula,aiming to clarify the regulatory law of vinegar processing of single medicinal herbs on the formula.This review provides systematic theoretical reference and research ideas for the elucidation of the scientific connotation of processing,optimization of quality standards,rational clinical application and modern secondary development of Yuanhu Zhitong Formula.
		2026 Vol. 46 (3): 127-134 [Abstract] ( 122 ) HTML (1 KB) PDF (1051 KB) ( 15 )

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