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哈尔滨医药  2022, Vol. 42 Issue (6): 46-47    DOI: 10.3969/j.issn.1001-8131.2022.06.017
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TRAP1、EGF在食管癌中的表达水平及其与临床病理的关系研究
张翠芬, 王永峰, 张红鸽
河南省安阳市人民医院病理科,河南 安阳 455000
Expression of Trap 1 and EGF in Esophageal Carcinoma and Their Relationship With Clinicopathology
Zhang Cuifen, Wang Yongfeng, Zhang Hongge
Department of Pathology, Anyang People's Hospital, Anyang 455000, China
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摘要 目的 研究食管癌TRAP1、EGF的表达水平,同时也分析这两项指标和临床病理之间的相关性。方法 选择48例食管癌患者,纳入观察组;同时纳入48例健康人群作为对照组。通过免疫组化方法对受检者患者组织的TRAP1、EGF水平进行检测,并且分析这两项指标和临床病例之间的相关性。结果 观察组患者的TRAP1、EGF阳性率均高于对照组,观察组患者的这两项指标与TNM分期、发病位置、淋巴转移以及分化程度之间都存在着正相关性,差异有统计学意义(P<0.05)。结论 食管癌患者的TRAP1、EGF水平与正常人群差异较大,可以作为诊断食管癌的重要指标。同时这两项指标与临床病理之间存在的密切相关性,也为临床上采取更科学合理的治疗食管癌方法提供新依据。
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张翠芬
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关键词 食管癌TRAP1EGF表达水平临床病理    
AbstractObjective To study the expression levels of TRAP1 and EGF in esophageal cancer,and to analyze the correlation between these two indexes and Clinicopathology. Methods 48 patients with esophageal cancer treated were included in the observation group;At the same time,48 healthy people were included as the control group.The levels of TRAP1 and EGF in the tissues of patients were detected by immunohistochemical method,and the correlation between these two indexes and clinical cases was analyzed. Results The positive rates of TRAP1 and EGF in the observation group were higher than those in the control group.There was a positive correlation between these two indexes and TNM stage,location,lymphatic metastasis and degree of differentiation in the observation group(P<0.05). Conclusion The levels of TRAP1 and EGF in patients with esophageal cancer are significantly different from those in normal population,which can be used as an important index for the diagnosis of esophageal cancer.At the same time,the close correlation between these two indexes and Clinicopathology also provides a new basis for more scientific and reasonable treatment of esophageal cancer.
Key wordsEsophageal cancer    TRAP1    EGF    Expression level    Clinical pathology
收稿日期: 2021-08-27     
PACS:  R735.1  
引用本文:   
张翠芬, 王永峰, 张红鸽. TRAP1、EGF在食管癌中的表达水平及其与临床病理的关系研究[J]. 哈尔滨医药, 2022, 42(6): 46-47.
Zhang Cuifen, Wang Yongfeng, Zhang Hongge. Expression of Trap 1 and EGF in Esophageal Carcinoma and Their Relationship With Clinicopathology. journal1, 2022, 42(6): 46-47.
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http://www.hrbyybjb.org.cn/CN/10.3969/j.issn.1001-8131.2022.06.017     或     http://www.hrbyybjb.org.cn/CN/Y2022/V42/I6/46
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