Analysis of the Test Results and Clinical Significance of Four Indicators of D-dimer and Blood Coagulation in Early,Middle and Late Pregnancy of Pregnant Women
Abstract：Objective To analyze the test results and clinical significance of D-dimer and blood coagulation in early,middle and late pregnancy. Methods 247 pregnant women were selected as the research subjects.The selected women were counted and divided into early pregnancy group（67 cases）,mid pregnancy group（81 cases）,and late pregnancy group（99 cases）based on their pregnancy period.50 healthy non pregnant women who underwent physical examination in the hospital during the same period were included as the control group.Compare the test results of four indexes of D-dimer and coagulation（fibrinogen,thromboplastin time（TT）,activated partial thrombin time（APTT）and Prothrombin time）in four groups,and analyze the test results and clinical significance of four indexes of D-dimer and coagulation in early,middle and late pregnancy of pregnant women. Results D-dimer and fibrinogen in the third trimester group were higher than those in the first trimester group and the second trimester group,and D-dimer and fibrinogen in the second trimester group were higher than those in the first trimester group;The TT,APTT,and PT levels in the late pregnancy group were lower than those in the early and mid pregnancy groups.The TT,APTT,and PT levels in the mid pregnancy group were lower than those in the early pregnancy group,and all three groups were lower than the control group,with statistically significant differences（F=539.341,90.144,73.226,32.676,93.263,P<0.05）.Pearson correlation analysis showed that D-dimer and fibrinogen were positively correlated with pregnancy progress（r=0.898,0.679,P<0.05）;TT,APTT,PT were negatively correlated with pregnancy progression（r=0.649,0.497,0.693,all P<0.05）. Conclusion The results of D-dimer and blood coagulation of pregnant women in early,middle and late pregnancy are quite different.Regular detection of pregnant women can effectively monitor the status of blood coagulation function in different pregnancy periods,and comprehensively warn of blood coagulation dysfunction and the risk of Deep vein thrombosis in middle and late pregnancy women.
张莹云. 孕产妇孕早、中、晚期D-二聚体、凝血四项指标检验结果及临床意义分析[J]. 哈尔滨医药, 2024, 44(3): 17-19.
Zhang Yingyun. Analysis of the Test Results and Clinical Significance of Four Indicators of D-dimer and Blood Coagulation in Early,Middle and Late Pregnancy of Pregnant Women. journal1, 2024, 44(3): 17-19.
2024, Vol. 44 
