Abstract：Objective To compare the application of 3D-ICBT and IC-ISBT in the treatment of locally advanced cervical cancer. Methods 60 patients with locally advanced cervical cancer were divided into the IC-ISBT group(34 cases)and the 3D-ICBT group(26 cases)based on the treatment regimen. Results The short-term efficacy,irradiation dose of clinical target volume and organs at risk,adverse reactions were compared between the two groups(P<0.05).The D90%(EQD2)of high-risk clinical target volume in the IC-ISBT group was significantly higher than that in the 3D-ICBT group(P<0.05).There was no difference in the D90%(EQD2)of intermediate-risk clinical target volume between the two groups(P>0.05).The D1cm3(EQD2)and D2cm3(EQD2)of rectum and bladder in the IC-ISBT group were significantly lower than those in the 3D-ICBT group(P<0.05).There was no difference in the D1cm3(EQD2)and D2cm3(EQD2)of sigmoid colon and small intestine between the two groups(P>0.05).Compared with the 3D-ICBT group,the incidence of radiation cystitis and radiation enteritis in the IC-ISBT group were significantly reduced(P<0.05). Conclusion Compared with 3D-ICBT,IC-ISBT can more significantly increase the radiation dose to high-risk clinical target volume in patients with locally advanced cervical cancer,reduce the irradiation dose to organs at risk,and thereby improve the short-term ORR while reducing the risk of local adverse reactions caused by radiotherapy.
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2026, Vol. 46 
