Abstract：Objective To explore the association between the level of fatty acid binding protein 4(FABP4)in circulating blood and post-stroke cognitive impairment(PSCI)after acute ischemic stroke. Methods A total of 114 patients with acute ischemic stroke treated in the neurology department of our hospital were included.According to the Mini-Mental State Examination(MMSE)score,the participants were divided into the cognitive impairment group(32 cases)and the non-cognitive impairment group(82 cases).Demographic characteristics,past medical history,lifestyle information,fasting blood glucose,lipid profile,homocysteine,and serum FABP4 concentration of all study subjects were collected.Additionally,visceral fat area was evaluated by abdominal CT.Univariate analysis was first conducted to compare the differences in various indicators between different groups,and then the items with significant differences were further analyzed by multivariate Logistic regression to obtain the related risk factors for PSCI after acute ischemic stroke.Moreover,Pearson correlation analysis was used to assess the linear relationship between visceral fat,FABP4,and PSCI. Results Multivariate analysis indicated that advanced age(OR=2.223),high homocysteine(OR=1.895),high serum FABP4(OR=3.104),and high visceral fat content(OR=2.625)were all influencing factors for the occurrence of PSCI.The Results of correlation analysis showed that visceral fat area(r=0.645)and serum FABP4 level(r=0.588)were significantly positively correlated with PSCI(P<0.001 for both). Conclusion In patients with acute ischemic stroke,elevated serum FABP4 concentration,visceral fat accumulation,advanced age,and hyperhomocysteinemia are independent predictors of PSCI,and FABP4 and visceral fat content have a clear positive association with the occurrence of cognitive impairment.
王飞鸿, 周亦, 王贤慧, 吕亚星. 脂肪酸结合蛋白4与缺血性卒中后认知功能障碍的相关性研究[J]. 哈尔滨医药, 2026, 46(5): 6-8.
Wang Feihong, Zhou Yi, Wang Xianhui, Lü Yaxing. Study on the Correlation between Fatty Acid Binding Protein 4 and Cognitive Dysfunction after Ischemic Stroke. journal1, 2026, 46(5): 6-8.
2026, Vol. 46 
