Effect of Jiawei Zhenwu Decoction on renal fibrosis and renal function in patients with chronic kidney disease of spleen-kidney yang deficiency
Liu Lingyi1, Liu Hongwei2, Niu Xiping1
1. Dialysis room of Nephrology Department of Luohe Hospital of traditional Chinese medicine;Luohe 462000,Henan,China; 2. Wuyang County People's Hospital; Wuyang County 462400,Henan,China
Abstract：Objective To analyze the effect of Jiawei Zhenwu decoction on renal fibrosis and renal function in patients with chronic kidney disease（CKD） stage 2-3 of spleen-kidney yang deficiency type.Methods 76 patients with chronic kidney disease（CKD） stage 2-3 of spleen-kidney yang deficiency type were selected and randomly divided into a control group（n=38） and a test group（n=38）.The control group was treated with conventional western medicine,and the test group was treated with Jiawei Zhenwu Decoction on the basis of the control group.The curative effect,TCM syndrome score,renal fibrosis[hyaluronic acid（HA）,collagen Ⅳ（Col Ⅳ）] and renal function [blood urea nitrogen（BUN）,creatinine（SCR）] of the two groups were compared.Results The total effective rate of the test group94.74%（36/38） was higher than that of the control group（71.05%（27/38）（P<0.05）;Compared with the control group,the TCM syndrome score of the test group after treatmentwas lower（P<0.05）;Compared with the control group,the levels of HA and Col - Ⅳ in the test group after treatment were lower（P<0.05）;Compared with the control group,the levels of BUN and SCR in the test group after treatment were lower（P<0.05）.Conclusion The application of Jiawei Zhenwu decoction in the treatment of chronic kidney disease with spleen-kidney yang deficiency type can significantly improve the therapeutic effect,relieve clinical symptoms,inhibit renal fibrosis,improve renal function,and has outstanding clinical application value.
刘铃燚, 刘宏伟, 牛喜平. 加味真武汤对脾肾阳虚型慢性肾脏病患者肾纤维化及肾功能指标的影响[J]. 哈尔滨医药, 2023, 43(3): 132-134.
Liu Lingyi, Liu Hongwei, Niu Xiping. Effect of Jiawei Zhenwu Decoction on renal fibrosis and renal function in patients with chronic kidney disease of spleen-kidney yang deficiency. journal1, 2023, 43(3): 132-134.
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2023, Vol. 43 
