2025年07月28日 星期一 首页   |   期刊介绍   |   编 委 会   |   投稿指南   |   期刊订阅   |   广告合作   |   联系我们   |   ENGLISH
哈尔滨医药  2023, Vol. 43 Issue (3): 24-26    DOI: 10.3969/j.issn.1001-8131.2023.03.009
  论著 本期目录 | 过刊浏览 | 高级检索 |
生长抑制因子4、缺氧诱导因子-1α在宫颈病变组织中的表达及与HR-HPV感染的关系研究
胡立娟
郑州市第一人民医院,河南 郑州 450001
The Expression of ING4 and Hypoxia-inducibleFactor-1 α in Cervical Lesions and Its Relationship with HR-HPV Infection
Hu Lijuan
Laboratory Department,Zhengzhou First People's Hospital,Zhengzhou 450001,China
全文: PDF (562 KB)   HTML (1 KB) 
输出: BibTeX | EndNote (RIS)      
摘要 目的 分析生长抑制因子4(ING4)、缺氧诱导因子-1α(HIF-1α)在宫颈病变组织中的表达及与高危型HPV(HR-HPV)感染的关系。方法 选取宫颈癌组织25份(宫颈癌组)、宫颈上皮内瘤变组织标本50份(CIN1组、CIN2-3组)、正常宫颈组织标本20份(正常组),术前检测HR-HPV,分析各组ING4、HIF-1α蛋白表达水平及其相关性、与病理参数关系。结果 宫颈癌组、CIN1组、CIN2-3组HR-HPV感染率高于正常组(P<0.05);正常组ING4阳性率最高,而HIF-1α阳性率最低,宫颈癌组HIF-1α阳性率最高(P<0.05);感染HR-HPV的组织中,宫颈癌组ING4阳性率最低(P<0.05),而HIF-1α阳性率最高(P<0.05);在感染HR-HPV的宫颈癌及CIN2-3组织中,ING4与HIF-1α水平呈负相关(P<0.05);年龄、淋巴结转移、脉管浸润、肌层浸润深度为感染HR-HPV的宫颈癌患者ING4阴性且HIF-1α阳性的独立危险因素(P<0.05)。结论 HR-HPV感染宫颈病变组织中ING4呈低表达,而HIF-1α呈高表达,从而抑制血管内皮细胞增殖、迁移,延缓宫颈病变进展。
服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
胡立娟
关键词 ING4HIF-1α宫颈病变高危型HPV感染    
AbstractObjective To analyze the expression of growth family member 4 (ING4) and hypoxia-inducible factor-1α (HIF-1α) in cervical lesions, and its relationship with high-risk HPV (HR-HPV) infection.Methods 25 cervical cancer tissuesamples(cervical cancer group),50 cervical intraepithelial neoplasia(CIN)tissue samples(CIN1 group,CIN2-3 group)and 20 normal cervical tissue samples(normal group)were collected.HR-HPV was detected before surgery.The protein expression levels and correlation of ING4 and HIF-1α in each group,and their relationship with pathological parameters were analyzed.Results The HR-HPV infection rate was higher incervical cancer group,CIN1 group and CIN2-3 group than in the normal group(P<0.05).The ING4 positive rate was the highest,and the HIF-1α positive rate was the lowest in the normal group.The HIF-1α positive rate was the highest in the cervical cancer group(P<0.05).In HR-HPV infected tissues,the ING4 positive rate was the lowest,and the HIF-1α positive rate was the highest in the cervical cancer group(P<0.05).There was a negative correlation between ING4 and HIF-1α levels in HR-HPV infected cervical cancer and CIN2-3 tissues(P<0.05).Age,lymph node metastasis,vascular invasion,and the depth of myometrial invasion were independent risk factors for ING4 negative and HIF-1α positive inpatients infected with HR-HPV(P<0.05).Conclusion The low expression of ING4 and high expression of HIF-1a in HR-HPV infected cervical lesions inhibit the proliferation and migration of vascular endothelial cells,thereby delaying the progression of cervical lesions.
Key wordsING4    HIF-1α    Cervical lesion    High-risk HPV infection
收稿日期: 2022-07-08     
PACS:  R711.74  
基金资助:河南省医学科技攻关计划项目(LHGJ20210743)
引用本文:   
胡立娟. 生长抑制因子4、缺氧诱导因子-1α在宫颈病变组织中的表达及与HR-HPV感染的关系研究[J]. 哈尔滨医药, 2023, 43(3): 24-26.
Hu Lijuan. The Expression of ING4 and Hypoxia-inducibleFactor-1 α in Cervical Lesions and Its Relationship with HR-HPV Infection. journal1, 2023, 43(3): 24-26.
链接本文:  
http://www.hrbyybjb.org.cn/CN/10.3969/j.issn.1001-8131.2023.03.009     或     http://www.hrbyybjb.org.cn/CN/Y2023/V43/I3/24
版权所有 © 《哈尔滨医药》编辑部  备案号: 黑ICP备19005758号-1
本系统由北京玛格泰克科技发展有限公司设计开发 技术支持:support@magtech.com.cn