Abstract：Objective To investigate the expression level of cell proliferation-associated antigen（ki-67）in non-small cell lung cancer（NSCLC）and the mutation of vascular endothelial growth factor receptor（EGFR）and its clinical correlation. Methods 56 patients with NSCLC were collected and divided into groups according to whether ki-67 was positive or not.Tissue samples were collected after surgical resection or biopsy.Immunohistochemistry and Super-ARMS were used to determine the expression of ki-67 and EGFR mutation,respectively.Spearman analyzed the correlation between ki-67 expression level and EGFR mutation and clinic. Results Except gender,age,histological type,lymph node metastasis and distant metastasis,the proportion of moderate/low differentiation and TNM stage Ⅲ+Ⅳ in ki-67 positive group was higher than that in ki-67 negative group,and the difference was statistically significant（P<0.05）.The ratio of wild type in ki-67 positive group was higher than that in ki-67 negative group,and the difference was statistically significant（P<0.05）.Spearman correlation showed that the expression level of ki-67 was negatively correlated with EGFR mutation（r=-0.382,P=0.004）,but positively correlated with differentiation degree and TNM stage（r=0.356,P=0.007;r=0.306,P=0.022）. Conclusion ki-67 expression and EGFR mutation can both participate in the occurrence and progress of NSCLC,and there is a correlation between ki-67 expression and EGFR mutation,which suggests that they can play a synergistic role.Therefore,the combination of clinical features,ki-67 expression and EGFR mutation can provide key guidance for clinical diagnosis and treatment.
2024, Vol. 44 
