血清miR-210、IL-17水平与急性脑梗死患者脑侧支循环不良的相关性分析

doi:10.3969/j.issn.1001-8131.2024.02.003

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摘要目的分析血清微小RNA-210（miR-210）、白细胞介素17（IL-17）水平与急性脑梗死（ACI）患者脑侧支循环不良的相关性。方法纳入68例ACI患者作为研究对象,主要检查项目为血清miR-210、IL-17水平,根据脑血管造影检查结果评估脑侧支循环情况,分为脑侧支循环不良和脑侧支循环良好组。分析血清miR-210、IL-17与ACI患者脑侧支循环不良的相关性,评估血清miR-210、IL-17对ACI患者脑侧支循环不良的预测价值。结果纳入的68例ACI患者,发生脑侧支循环不良18例,脑侧支循环良好50例;脑侧支循环不良组血清miR-210表达低于良好组,IL-17表达高于良好组（P<0.05）。经Logistic回归分析显示,血清miR-210水平低,IL-17水平高与ACI患者脑侧支循环不良的发生有关（P<0.05）。绘制受试者工作特征（ROC）曲线结果显示,血清miR-210、IL-17联合预测ACI患者脑侧支循环不良的曲线下面积（AUC）为0.864。结论血清miR-210水平低、IL-17水平高与ACI患者脑侧支循环不良有关,联合检测血清miR-210、IL-17对ACI患者脑侧支循环不良有较高预测价值。

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	王婷

关键词 ：急性脑梗死, 脑侧支循环, 微小RNA-210, 白细胞介素17

Abstract：Objective To analyze the correlation between serum micrornA-210（miR-210）and interleukin-17（IL-17）levels and poor collateral circulation in patients with acute cerebral infarction（ACI）. Methods A total of 68 patients with ACI were prospectively included as research objects.The main examination items were serum miR-210 and IL-17 levels,and the collateral circulation was evaluated according to the results of cerebrovascular angiography.The patients were divided into poor and good group.The correlation between serum miR-210 and IL-17 and poor collateral circulation in ACI patients was analyzed,and the predictive value of serum miR-210 and IL-17 for poor collateral circulation in ACI patients was evaluated. Results Among the 68 ACI patients included,there were 18 cases of poor collateral circulation and 50 cases of good collateral circulation.The expression of miR-210 and IL-17 in poor collateral circulation group was lower than that in good group（P<0.05）.Logistic regression analysis showed that low level of serum miR-210 and high level of IL-17 were associated with the occurrence of poor collateral circulation in ACI patients（P<0.05）.Receiver operating characteristic（ROC）curve showed that the area under the curve（AUC）of the combined prediction of serum miR-210 and IL-17 for poor collateral circulation in ACI patients was 0.864. Conclusion Low level of serum miR-210 and high level of IL-17 are associated with poor collateral circulation in ACI patients.Combined detection of serum miR-210 and IL-17 has a high predictive value for poor collateral circulation in ACI patients.

Key words： acute cerebral infarction Collateral circulation Microrna-210 Interleukin 17

收稿日期: 2023-03-30

PACS:

R743.33

引用本文:

王婷. 血清miR-210、IL-17水平与急性脑梗死患者脑侧支循环不良的相关性分析[J]. 哈尔滨医药, 2024, 44(2): 8-10.
Wang Ting. Correlation Analysis of Serum miR-210 and IL-17 Levels with Poor Collateral Circulation in Patients with Acute Cerebral Infarction. journal1, 2024, 44(2): 8-10.

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