摘要目的 分析标准外伤大骨瓣开颅术联合亚低温在重型颅脑外伤的效果。方法 选取76例重型颅脑外伤患者,按随机数字表法分为实验组（n=38）和对照组（n=38）,对照组采用标准外伤大骨瓣开颅术治疗,实验组采取标准外伤大骨瓣开颅术联合亚低温治疗。对比两组临床疗效、颅内压水平、美国国立卫生研究院卒中量表（national institute of health stroke scale,NIHSS）评分、免疫功能（CD8+、CD4+）水平及并发症发生率。结果 实验组总有效率94.74%（36/38）较对照组73.68%（28/38）高（P<0.05）;治疗1、2、3d后,实验组颅内压水平较对照组低（P<0.05）;治疗后,实验组NIHSS评分较对照组低（P<0.05）;治疗后,实验组CD8+水平较对照组低,CD4+水平较对照组高（P<0.05）;实验组并发症发生率5.26%（2/38）较对照组26.32%（10/38）低（P<0.05）。结论 标准外伤大骨瓣开颅术结合亚低温治疗重型颅脑外伤病人,可提高临床疗效,降低颅内压水平,改善神经功能损伤状态,改善免疫功能,减少术后并发症发生。
Abstract：Objective To analyze the effect of standard large trauma craniotomy combined with mild-hypothermia in severe craniocerebral trauma. Methods 76 cases of patients with severe craniocerebral trauma were selected,and they all were divided into an experimental group（n=38）and a control group（n=38）according to the method of random number table.The control group was treated with standard large trauma craniotomy,while the experimental group was treated with standard large trauma craniotomy combined with mild-hypothermia.The clinical efficacy,intracranial pressure level,national institute of health stroke scale（NIHSS）score,immune function（CD8+、CD4+）level and complicationsoccurrence rate of the two groups were compared. Results The total effective rate 94.74%（36/38）of the experimental groupwas higher than73.68%（28/38）of the control group（P<0.05）;After 1d,2d and 3d of treatment,the levels of intracranial pressure in the experimental group was lower than that in the control group（P<0.05）;After treatment,the NIHSS score of the experimental group was lower than that of the control group（P<0.05）;After treatment,the level of CD8+ in the experimental group was lower than that in the control group,while the level of CD4+ was higher than that in the control group（P<0.05）;The occurrence rate of complications 5.26%（2/38）in the experimental group waslower than 26.32%（10/38）in the control group（P<0.05）. Conclusion The standard large traumacraniotomy combined with mild-hypothermia in the treatment of severe craniocerebral trauma can improve the clinical efficacy,decrease the level of intracranial pressure,improve the state of neurological injury,improve the immune function and reduce the occurrence ofpostoperative complications.
沈江宜, 杨荣刚, 刘旭. 标准外伤大骨瓣开颅术联合亚低温在重型颅脑外伤的应用效果[J]. 哈尔滨医药, 2024, 44(2): 11-13.
Shen Jiangyi, Yang Ronggang, Liu Xu. Application Effect of Standard Large Trauma Craniotomy Combined with Sub-low Temperature in Severe Craniocerebral Trauma. journal1, 2024, 44(2): 11-13.
2024, Vol. 44 
