富血小板血浆（PRP）治疗下肢动脉硬化闭塞症Ⅲ期临床研究
陈文阁
黑龙江中医药大学附属第一医院周围血管病二科,黑龙江 哈尔滨 150000
Clinical Study of Platelet-rich Plasma（PRP）for Lower Extremity Atherosclerotic Occlusive Disease in Stage Ⅱ
Chen Wenge
Department of Peripheral Vascular Disease,The First Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150000,China
摘要 目的 观察富血小板血浆（PRP）治疗下肢动脉硬化闭塞症Ⅲ期的临床研究。方法 选取符合纳入标准的54例下肢动脉硬化闭塞症患者,随机分成两组,每组各27例。对照组给予静点银杏叶提取物注射液、注射用盐酸罂粟碱治疗,试验组在对照组的基础上加PRP治疗,两组均治疗14d,观察治疗前后创面愈合率、血清C反应蛋白（CRP）、纤维蛋白原（FIB）变化情况,评估临床疗效。结果 试验组治疗后创面愈合率、CRP下降幅度高于对照组（P <0.05）,治疗后FIB水平两组组间比较无明显差异（P >0.05）。结论 与单纯的清创换药相比,富血小板血浆（PRP）用于治疗下肢动脉硬化闭塞症Ⅲ期可以提高创面愈合率、减轻炎症反应,在临床上具有良好的疗效。
关键词 ：
富血小板血浆 ,
下肢动脉硬化闭塞症 ,
创面愈合 ,
C反应蛋白 ,
纤维蛋白原
Abstract ：Objective To observe the clinical study of platelet-rich plasma（PRP）for the treatment of lower extremity atherosclerotic occlusive disease stage Ⅲ.Methods 44 patients with lower extremity atherosclerotic occlusive disease who met the inclusion criteria were selected and randomly divided into two groups of 27 cases each.The control group was treated with intravenous Extract of Ginkgo Biloba Leaves injection and Papaverine hydrochloride for injection,and the treatment group was treated with PRP based on the control group.Both groups were treated for 2 weeks,and the clinical efficacy was evaluated by observing the wound healing rate,serum C-reactive protein（CRP）and fibrinogen（FIB）changes before and after treatment.Results The wound healing rate was higher in the treatment group than in the control group（P< 0.05）.The reduction of CRP level and FIB level before and after treatment was significantly higher in the treatment group than in the control group（P< 0.05）.Conclusion Compared with simple debridement,platelet-rich plasma（PRP）used for the treatment of lower limb atherosclerotic occlusive disease stage Ⅲ can improve the wound healing rate,reduce the inflammatory response,and lower fibrinogen,which has good efficacy in clinical practice.
Key words ：
platelet-rich plasma
lower extremity atherosclerotic occlusive disease
wound healing
C-reactive protein
fibrinogen
收稿日期: 2024-03-14
基金资助: 黑龙江省卫生健康委科研课题（20210404130252）
[1] 黄浪浪,徐驲,王建安,等.益气活血通脉颗粒治疗下肢动脉硬化闭塞症的临床研究[J].中药药理与临床,2022,38(01):184-187.et al .Expression and clinical significance of HSP27 and its phosphorylation in lower extremity arteriosclerosis obliterans[J].PeerJ,2020,8:e9305.et al .Platelet-rich plasma:Growth factor enhancement for bone grafts[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod,1998,85(6):638-646.et al .Topical Application of Keratinocyte Growth Factor Conjugated Gold Nanoparticles Accelerate Wound Healing[J].Nanomedicine,2018,14(5):1619-1628.et al .Platelet-Rich Plasma:New Performance Understandings and Therapeutic Considerations in 2020[J].Int J Mol Sci,2020,21(20).
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2024, Vol. 44 
