Abstract：Objective To investigate the effect and safety of low-dose valproate on cognitive function in patients with bipolar disorder（BPD）.Methods A retrospective study was conducted on 115 patients with BPD.Groups A,B,and C were set up according to different treatment doses of sodium valproate,with 40,40,and 35 patients in each group.Group A received 10mg/kg valproate,Group B 15mg/kg valproate and Group C 20mg/kg valproate.Comparing three groups of general data and clinical efficacy,test the plasma concentration related indicators（mean plasma concentration,steady state plasma concentration trough time）,and evaluate the three groups of young manic rating scale（YMRS）,the Montreal cognitive assessment scale（MoCA）score and liver function indicators[alanine aminotransferase（ALT）,glutamase aminotransferase（AST）,total bilirubin（TBIL）]level,and finally compare the adverse reactions.Results The total effective rates of the three groups were comparable（P>0.05）;The average blood drug concentrations of the three groups were comparable（P>0.05）;Compared with group A,groups B and C had shorter time to reach the steady-state blood drug concentration trough（P<0.05）;Multiple linear regression was used to correct the baseline data of three groups.Before treatment and 2 months after treatment,the MoCA and YMRS scores of the three groups were comparable（P>0.05）;Two months after treatment,YMRS scores decreased and MoCA scores increased in all three groups compared to before treatment（P<0.05）;Before treatment,the liver function levels of the three groups were comparable（P>0.05）;Two months after treatment,the liver function levels of all three groups increased compared to before treatment,and group A had a lower level（P<0.05）;Compared with groups B and C（17.50%,31.43%）,group A had a lower overall incidence of adverse reactions at 7.50%（P<0.05）.Conclusion 10mg/kg,15mg/kg,20mg/kg and 20 mg/kg of BPD can improve manic and depressive symptoms and cognitive function.However,10mg/kg of valproate had the least effect on liver function and had high safety.
李昱, 张应, 付艳梅. 小剂量丙戊酸钠对双相情感障碍患者认知功能的影响及安全性研究[J]. 哈尔滨医药, 2025, 45(2): 33-36.
Li Yu, Zhang Ying, Fu YanMei. The Effect and Safety of Low-dose Sodium Valproate on Cognitive Function in Patients with Bipolar Disorder. journal1, 2025, 45(2): 33-36.
2025, Vol. 45 
