Abstract：Objective This study was aimed to investigate the clinical effects of esomeprazole in the treatment of peptic ulcer and influence on serum levels of inflammatory factors and gastrointestinal hormones.Methods 80 patients with peptic ulcer were enrolled in this study and randomly assigned to receive omegaprazole quadruple therapy（control group,40 cases）or esomeprazole quadruple therapy（observation group,40 cases）.Clinical effects of the two groups were compared.Meanwhile,serum inflammatory factors [interleukin-8（IL-8）,tumor necrosis factor-α（TNF-α）],gastrointestinal hormones [gastrin（GAS）,plasma motilin（MOT）,somatostatin（SS）],Hp clearance rate and drug safety were observed.Results After treatment,the total response rate in the observation group was 95.00%,higher than 87.50% in the control group（P>0.05）.After treatment,IL-8,TNF-α,GAS and MOT significantly decreased,while SS significantly increased in the 2 groups.Besides,IL-8,TNF-α,GAS and MOT were lower,and SS was significantly higher in the observation group than in the control group（P<0.05）.The Hp clearance rate was significantly higher in the observation group than in the control group after treatment（P<0.05）.No significant difference was found between the 2 groups in the total incidence of adverse drug reactions（P>0.05）.Conclusion The clinical effect of esomeprazole in the treatment of patients with peptic ulcer is definite.It has significant advantages in lower inflammatory factor levels and regulating serum gastrointestinal hormones.Besides,it can effectively improve the Hp clearance rate,with certain safety.
王东芳. 埃索美拉唑治疗消化性溃疡患者的临床效果观察[J]. 哈尔滨医药, 2022, 42(2): 11-13.
Wang Dongfang. Clinical Effect Observation of Esomeprazole in the Treatment of Peptic Ulcer. journal1, 2022, 42(2): 11-13.
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2022, Vol. 42 
