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| Effect of Intraperitoneal Hyperthermic Perfusion Chemotherapy Combined With DP Regimen in the Treatment of Advanced Ovarian Cancer |
| Zhu Chun, Sun Liangqi, Qu Jia |
| Henan Shenhuo Group Staff General Hospital,Henan,China |
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Abstract Objective To investigate the clinical effect of intraperitoneal hyperthermic chemotherapy（IHPC）combined with docetaxel and cisplatin（DP）in the treatment of advanced ovarian cancer.Methods According to the treatment method,80 patients with advanced ovarian cancer were divided into control group and observation group,40 cases in each group.The control group was treated with DP regimen,and the observation group was treated with IHPC.The clinical efficacy was compared between the two groups,and the serum tumor markers [carcinoembryonic antigen（CEA）,carbohydrate antigen 125（CA125）] were compared between the two groups before and after treatment.Results After 12 weeks of treatment,the clinical total effective rate of the observation group was higher than that of the control group（P<0.05）;after 12 weeks of treatment,the levels of CEA and CA125 in the two groups were lower than those before treatment,and the observation group was lower（P<0.05）.Conclusion IHPC combined with DP regimen can effectively improve the clinical efficacy and reduce serum tumor markers in patients with advanced ovarian cancer.
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Received: 27 January 2021
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2022, Vol. 42 
