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| Analysis of Advantages of Antibody Detection and Nucleic Acid Detection in the Clinical Diagnosis of AIDS |
| Shi Lingling, Dong Lin |
| Medical Laboratory Department,Sanmenxia Central Hospital,Sanmenxia 472000,China |
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Abstract Objective To analyze the advantages of antibody detection and nucleic acid detection in the diagnosis of AIDS patients. Methods A total of 100 AIDS patients diagnosed from January 2017 to February 2020 were used as observation subjects,including 72 early-infected patients and 28 middle-to-advanced patients.The clinical data were retrospectively analyzed,and the diagnosis accuracies of two detection methods on human immunodeficiency virus infectionin different periods were compared,and the diagnostic efficacy wascalculated. Results The accuracy of nucleic acid detectionand the accuracy of antibody detectionforvirus infection in patients with early AIDS were97.22% and 86.11% respectively,and the accuracy of nucleic acid detection was significantly higher than that of antibody detection（P<0.05）.The diagnostic accuracy of nucleic acid detectionand the diagnostic accuracy of antibody detectionforvirus infection in patients with middle-to-advanced AIDS were 82.14% and 92.86% respectively,and there was no statistically significant difference between the two detection methods（P>0.05）.The area under the curve of nucleic acid detection was higher than that of antibody detection（P<0.05）. Conclusion Nucleic acid detection and antibody detection are both effective methods for laboratory diagnosis of HIV infection.Relatively speaking,the accuracy of nucleic acid detectionis higher in early AIDS,and the accuracy of antibody detection is higher in middle-to-advanced AIDS.The diagnostic accuracy of the two detection methods varies at different periods,and overall nucleic acid detectionhas slightly better efficacy.
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Received: 17 November 2020
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2021, Vol. 41 
