预防性注射尼可地尔是否可以减少急性 STEMI 患者PCI 期间无复流现象

doi:10.3969/j.issn.1001-8131.2022.05.003

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Abstract Objective To investigate whether prophylactic intracoronary administration of nicodil can reduce the incidence of NRP in STEMI patients undergoing PCI. Methods A total of 280 patients with persistent acute STEMI and suitable for inpatient PCI who received treatment were selected and divided into observation group（140 cases）and control group（140 cases）according to the double-blind method.The incidence of NRP,interleukin 6 and the levels of hs-CRP,cTnT and CK-MB were observed every 4 hours before and after PCI.And major adverse cardiovascular events at day 30. Results The incidence of NRP in the observation group was 24%,which was significantly lower than that in the control group（P&LT;0.05）.Seven days after surgery,The observation group NT-proBNP（607.31±82.20）ng·L^-1,CK-MB（328.00±77.95）U·L^-1,cTnI（3.14±0.55）μg·L^-1 were significantly less than the control group NT-proBNP（734.47±82.60）ng·L^-1,CK-1MB（440.89±88.94）U·L^-1,cTnI（4.48±1.00）μg·L^-1（P<0.05）.Before surgery,there were no significant differences in NT-proBNP,CK-MB and cTnI between the two groups（P&GT;0.05）.At 7 days after operation,LVEF in the observation group was significantly higher than that in the control group（P&LT;0.05）.At 7 days postoperatively,WMSI in the observation group was significantly lower than that in the control group（P&LT;0.05）.Before surgery,there was no significant difference in LVEF and WMSI between the two groups（P&GT;0.05）.The observation group（0 cases of hypotension and 6 cases of major cardiac adverse events）were significantly lower than the control group（14 cases of hypotension and 28 cases of major cardiac adverse events）（P<0.05）. Conclusion The results of this study will determine the effectiveness of prophylactic intracoronary administration of nicodil to reduce the incidence of NRP during PCI in patients with acute STEMI.

Key words： Nicodil No reflow phenomenon Percutaneous coronary intervention ST-segment elevation myocardial infarction

Received: 03 August 2021

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R543.3+1

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	Zhou Can

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Zhou Can. Can Preventive Injection of Nicorandil Reduce No Reflow During PCI in Patients With Acute STEMI[J]. journal1, 2022, 42(5): 6-8.

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http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2022.05.003 OR http://www.hrbyybjb.org.cn/EN/Y2022/V42/I5/6

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