地榆化学成分、炮制工艺及药理作用研究进展

doi:10.3969/j.issn.1001-8131.2026.02.038

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Abstract Sanguisorba officinalis L.tastes bitter,sour and astringent,and is slightly cold in nature.It enters the Liver and Large Intestine Meridians,and was first recorded in Shennong Ben Cao Jing(Shennong's Classic of Materia Medica).As a commonly used traditional Chinese medicine in clinical practice,it has the traditional efficacy of cooling blood to stop bleeding,detoxifying and promoting wound healing.This paper systematically reviews the relevant research literatures in recent years,and clarifies that the core chemical constituents of Sanguisorba officinalis L.include saponins(the total content of sanguisorbin Ⅰ/Ⅱ is 1.5 2.1 mg/g),tannins(the content of ellagic acid in carbonized Sanguisorba officinalis L.is up to 34.86 mg/g at maximum),flavonoids,etc.Among the processing technologies,carbonized Sanguisorba officinalis L.has the widest application.Orthogonal tests have confirmed that stir-frying at 250℃ for 14 minutes is the optimal process,which can significantly increase the content of hemostatic active ingredients.Modern pharmacological studies have verified that Sanguisorba officinalis L.and its active components possess various pharmacological effects such as hemostasis,wound repair,intestinal mucosal protection,anti-inflammation,antioxidation,antibacterial activity and immunoregulation.It is widely used in clinical fields including hemorrhagic diseases,skin injuries and inflammatory bowel diseases,and shows unique advantages in the protection against intestinal damage caused by tumor radiotherapy and chemotherapy,as well as the treatment of diabetic foot ulcers.Processing is an important link in the clinical application of Sanguisorba officinalis L.,and different processing methods significantly affect its chemical constituents and pharmacological activities.By comprehensively analyzing the characteristics of chemical constituents,the influence of processing technology,the mechanism of pharmacological effects and the expansion of clinical application of Sanguisorba officinalis L.,this paper points out the existing problems in current research,such as unclear synergistic mechanism of components and insufficient development of non-medicinal parts,so as to provide references for its further research,development and precise clinical application.

Key words： Sanguisorba officinalis L. Chemical constituents Pharmacological effects Processing technology Clinical application

Received: 10 February 2026

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R734.2

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	Articles by authors
	Wang Chaoqun
	Zhang Guiqun
	Huo Jinhai

Cite this article:

Wang Chaoqun,Zhang Guiqun,Huo Jinhai. Research Progress on Chemical Constituents,Processing Technology and Pharmacological Effects of Sanguisorba officinalis L[J]. journal1, 2026, 46(2): 129-133.

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http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2026.02.038 OR http://www.hrbyybjb.org.cn/EN/Y2026/V46/I2/129

[1] 袁振海,孙立立.地榆现代研究进展[J].中国中医药信息杂志,2007,(03):90-92.
[2] 包代琴,刘奕言,张紫森,等.地榆皂苷Ⅰ对脓毒症大鼠急性肺损伤的保护作用及机制研究[J].中国药房,2023,34(05):537-543.
[3] Wang Z,Yang C,Wu L,et al.Variation of Saponins in Sanguisorba officinalis L.before and after Processing(Paozhi)and Its Effects on Colon Cancer Cells In Vitro[J].Molecules,2022,27(24):9046.
[4] 吴龙龙,徐昊阳,张刘强,等.地榆化学成分及药理作用研究进展[J].世界科学技术-中医药现代化,2022,24(01):360-378.
[5] 于蓓蓓,钟方晓,董学.地榆化学成分研究进展[J].中国中医药信息杂志,2009,16(S1):103-105.
[6] 顾薇,姚俊宏,陆梦梦,等.基于“炒炭存性”理论研究炮制工艺对地榆抑菌功效的影响[J].中草药,2022,53(04):1042-1050.
[7] 程旭希,周子云,胡庆莲,等.基于止血药效的地榆炒炭工艺及质量标志物研究[J].中国中药杂志,2024,49(10):2710-2721.
[8] Zhou P,Li J,Chen Q,et al.A comprehensive review of genus Sanguisorba:traditional uses,chemical constituents and medical applications[J].Frontiers in pharmacology,2021,12:750165.
[9] 王越,王慧颖,姜岩,等.不同浓度细叶地榆乙醇提取物抗氧化活性分析[J].安徽农业科学,2025,53(14):163-166.
[10] Liang Y C,Huang Y T,Tsai S H,et al.Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages[J].Carcinogenesis,1999,20(10):1945-1952.
[11] 王英英,朱洁,鲁兰,等.中药地榆的成分以及其药理作用研究进展[J].四川中医,2022,40(08):216-223.
[12] 余南才,叶明波.地榆炮制前后鞣质及微量元素含量的变化[J].中国中药杂志,1994,(03):153-154.
[13] 张心一,黄振阳,何嘉伟,等.基于指纹图谱和多指标成分定量结合化学模式识别法评价不同产地地榆质量[J].中草药,2024,55(16):5649-5655.
[14] 孙立立,杨书斌,袁振海,等.地榆炮制现代研究综述[C]//中华中医药学会中药炮制分会.中华中医药学会第五届中药炮制分会学术会议论文集.山东省中医药研究院;山东省中医药研究院;山东省中医药研究院;山东省中医药研究院;山东省中医药研究院;2005:77-80.
[15] 张联. 中国药典“炮制通则”中药炮制方法分类探讨[J].中国现代应用药学,2020,37(18):2287-2290.
[16] 丁安伟,向谊,李军,等.地榆炭炮制工艺及质量标准研究[J].中国中药杂志,1995,(12):725-728+762.
[17] 顾薇,姚俊宏,陆梦梦,等.基于“炒炭存性”理论研究炮制工艺对地榆抑菌功效的影响[J].中草药,2022,53(04):1042-1050.
[18] 刘畅,周熙,刘倩宝,等.基于UPLC-Q-Orbitrap-HRMS的地榆炒炭前后化学成分差异分析[J].分析测试学报,2025,44(11):2362-2368.
[19] 王相,范帅帅,高乐,等.地榆及其炮制品地榆炭配方颗粒红外快速鉴别[J].药物评价研究,2018,41(11):2000-2004.
[20] 惠振焘,王雪娇.地榆炮制前后水提物抗炎效果研究[J].临床医药文献电子杂志,2018,5(21):169-172.
[21] 魏余灼,刘丽,卜树,等.地榆-槐花通过调节PI3K/Akt信号通路抑制溃疡性结肠炎小鼠血管生成[J].中国实验方剂学杂志,2025,31(11):40-50.
[22] 俞浩,毛斌斌,刘汉珍.炒炭对地榆中鞣质量及止血效果的影响[J].中成药,2014,36(06):1317-1320.
[23] 周本宏,松长青,姜姗,等.地榆鞣质提取物的抗菌活性及对金黄色葡萄球菌的抑菌机制研究[J].中国药师,2016,19(03):464-469.
[24] 于泽洋,李天博,王江宁.复方芪参提取物对糖尿病足溃疡模型大鼠创面愈合及HIF-1α/VEGF/VEGFR2通路的影响[J].河北医学,2021,27(03):374-379.
[25] 郇晓宇,孙庆.地榆在创面修复中的作用机制研究进展[J].中国中西医结合外科杂志,2020,26(06):1197-1199.
[26] 郭仕琪,李宇飞,李华山.从“消滞健脾”理论探讨溃疡性结肠炎的诊治[J].中国医药导报,2020,17(04):131-134.
[27] 孙佳婷,吴庆林,佟苗苗,等.地榆HPLC指纹图谱的构建及其COX-2抑制作用谱效关系研究[J].中国医院药学杂志,2025,45(18):2057-2063.
[28] 钟颖. 地榆皂苷Ⅱ抗肝癌作用机制研究[D].山东大学,2022.
[29] 毛迪锐,姜贵全,张诗朦,等.地榆多酚分离纯化及其抗氧化性研究[J].食品工业科技,2015,36(21):68-72.
[30] 张斌,鲁兰,王英英,等.地榆水提液对临床耐药菌MRSA的抗菌活性及机理研究[J].中药药理与临床,2020,36(04):120-124.
[31] 张凯睿,刘增援,王利利,等.地榆提取物对多重耐药大肠埃希氏菌的抑菌活性及机制研究[J].动物医学进展,2021,42(10):61-65.
[32] 张蕾,满莉,宛春雷,等.地榆提取物的体外抑菌活性及机制[J].吉林大学学报(理学版),2019,57(03):701-707.
[33] 马杨. 外用中药治疗糖尿病足的临床观察[J].世界最新医学信息文摘,2016,16(36):186-188.
[34] 裴智梅. 中药泡脚治疗糖尿病足的临床观察[C]//中国中西医结合学会虚证与老年病专业委员会.第九次全国中西医结合虚证与老年病学术会议论文集.长春市中心医院;2007:185-186.
[35] 高新英,聂晶.白头翁汤加味治疗溃疡性结肠炎的临床观察[J].世界最新医学信息文摘,2015,15(02):12-13.
[36] 韩军. 止血汤治疗内痔出血210例[J].陕西中医,2007,(04):456.
[37] 曲文超,董德.地榆止血汤治疗内痔便血[J].吉林中医药,1987,(03):16.
[38] 田静. 辨证治疗内痔出血28例[J].实用中医药杂志,2005,(12):724-725.
[39] 朱安龙. 仙芪地榆汤治疗放环后阴道出血30例[J].陕西中医,1995,(06):243.