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| Application of Ambroxol Combined with Moxifloxacin In The Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease in Acute Exacerbation |
| Li Shujun |
| Henan Zhumadian Central Hospital,Henan 463000,China |
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Abstract Objective To investigate the efficacy of ambroxol combined with moxifloxacin in the treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）.Methods A total of 80 patients with AECOPD were included in the study.According to the treatment method,moxifloxacin+conventional treatment were included in the control group（40 cases）,and moxifloxacin+ambroxol+conventional treatment were included in the observation group（40 cases）.Both groups were treated for 12 days.The levels of serum inflammatory factors [C-reactive protein（CRP）and procalcitonin（PCT）] before and after 12 days of treatment were compared between the two groups;The disappearance time of cough,sputum and lung moist rales and the incidence of adverse reactions during treatment were compared between the two groups.Results The levels of CRP and PCT in the two groups decreased after 12 days of treatment compared with those before treatment,and the decrease in the observation group was greater（P<0.05）;The disappearance time of cough,expectoration and lung moist rales in the observation group was shorter than that in the control group（P;The incidence of adverse reactions was compared between the two groups（P>0.05）.Conclusion Ambroxol combined with moxifloxacin can effectively alleviate the inflammatory reaction and clinical symptoms of AECOPD patients,without increasing adverse reactions.
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Received: 28 September 2022
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2023, Vol. 43 
