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| The Correlation between Serum Levels of PCT, Acidic Glyceprotein and Heptoglobin and the Severity of Acute COPD |
| Wang Yu |
| Department of Respiratory Medicine, Xiangcheng First People's Hospital, Xiangcheng, Henan 466200 |
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Abstract Objective To study PCT α 1 The correlation between the levels of acid glycoprotein and haptoglobin and the severity of acute COPD. Methods 70 patients with acute COPD were selected as the study subjects.According to the severity of the disease, they were divided into stable COPD group of 34 patients and acute exacerbation（AECOPD）group of 36 patients, and 40 volunteers who came to our hospital for health examination at the same time were selected as the control group.Detection of serum by enzyme-linked immunosorbent assay α 1 Acid glycoprotein（α 1-AG）level, the level of procalcitonin（PCT）was detected by immunofluorescence double antibody sandwich method, the level of serum haptoglobin（HPT）was measured by immune scattering rate turbidimetry, and the level of forced vital capacity（FVC）and forced expiratory volume in one second（FEV1）were measured by pulmonary function meter; Pearson was used to analyze pulmonary function indicators and serum PCT α 1-Correlation of AG and HPT. Results Serum PCT α 1-AG and HPT levels were higher than those in the control group, and serum PCT α 1-AG, HPT levels and pulmonary function indicators FEV1, FEV1/FVC increased with the severity of the disease; Serum PCT and HPT were negatively correlated with FEV1 and FEV1/FVC in patients with COPD The level of α 1-AG was positively correlated with FEV1% and FEV1/FVC, and the difference was statistically significant（P< 0.05）. Conclusion Serum PCT The levels of α 1-AG and HPT are closely related to the severity of COPD patients, which is of great significance in evaluating the patients' condition.
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Received: 12 December 2022
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2023, Vol. 43 
