多囊卵巢综合征PI3K/AKT通路分子表达与胰岛素敏感性研究

doi:10.3969/j.issn.1001-8131.2026.04.004

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Abstract Objective To investigate the correlation between the molecular expression of the PI3K/AKT signaling pathway and insulin sensitivity in patients with polycystic ovary syndrome(PCOS). Methods Sixty PCOS patients who visited our hospital from January 2024 to January 2025 were selected as the PCOS group,and 30 healthy women who underwent physical examinations during the same period were selected as the control group.The differences in the protein and mRNA expression levels of key molecules in the PI3K/AKT pathway(PI3K,AKT,insulin receptor substrate-1(IRS-1),and GLUT4) in peripheral blood mononuclear cells were detected and compared between the two groups.Pearson correlation analysis was used to analyze the correlation between the molecular expression level of the PI3K/AKT pathway and insulin sensitivity indicators. Results Patients in the PCOS group had higher FBG,2hPG,FINS,and HOMA-IR than the control group,while their ISI and glucose uptake were lower(P<0.05).The protein and mRNA expression levels of PI3K,AKT,IRS-1,and GLUT4 in the PCOS group were lower than those in the control group(P<0.05).The protein and mRNA expression levels of PI3K,AKT,IRS-1,and GLUT4 were positively correlated with glucose uptake and ISI(P<0.05),and negatively correlated with HOMA-IR(P<0.05). Conclusion Downregulation of PI3K/AKT pathway molecules in ovarian granulosa cells of PCOS patients is closely related to insulin resistance.

Key words： Polycystic ovary syndrome PI3K/AKT signaling pathway Insulin sensitivity Islet resistance

Received: 01 April 2026

PACS:

R711.75

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	Articles by authors
	Dong Lei
	Xu Quanxiao
	Wang Bo
	Xu Fangfang

Cite this article:

Dong Lei,Xu Quanxiao,Wang Bo, et al. Study on the Molecular Expression of PI3K/AKT Pathway and Insulin Sensitivity in Polycystic Ovary Syndrome[J]. journal1, 2026, 46(4): 11-13.

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http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2026.04.004 OR http://www.hrbyybjb.org.cn/EN/Y2026/V46/I4/11

[1] 席瑞,郭东霞,冯凯,等.1990-2021年全球和中国女性多囊卵巢综合征的疾病负担及10年趋势预测[J].天津医药,2026,54(2):211-215.
[2] 多囊卵巢综合征诊治路径专家共识编写组.多囊卵巢综合征诊治路径专家共识[J].中华生殖与避孕杂志,2023,43(4):337-345.
[3] 张馨牙,杜洁,李红艳,等.多囊卵巢综合征慢病管理的智能模式探讨[J].中华健康管理学杂志,2026,20(2):161-166.
[4] 中华医学会内分泌学分会.二甲双胍在多囊卵巢综合征中的临床应用专家共识[J].中华内分泌代谢杂志,2025,41(12):979-991.
[5] 徐海燕,杜青,陈娟,等.苍附导痰汤对肥胖型PCOS-IR模型大鼠卵巢TLR4/NF-κB p65信号通路的影响[J].中国药理学通报,2023,39(4):787-793.
[6] 卢清,曾莉,丁易钤,等.PCOS患者肠道菌群水平与糖代谢的关系及对PCOS伴胰岛素抵抗的预测价值[J].生殖医学杂志,2025,34(10):1359-1365.
[7] 闫朋宣,刘奕清,咸楠星,等.中药调控PI3K/Akt信号通路干预多囊卵巢综合征大鼠实验研究的现状、问题及对策[J].中国实验方剂学杂志,2025,31(1):259-266.
[8] 乔炳翔. 基于PI3K/AKT通路探讨助阳化湿法对PCOS合并胰岛素抵抗的作用机制[D].辽宁:辽宁中医药大学,2024.
[9] 中华医学会妇产科学分会内分泌学组及指南专家组.多囊卵巢综合征中国诊疗指南[J].中华妇产科杂志,2018,53(1):2-6.
[10] 陈一畅,张明,匡洪影.中药调控PI3K/Akt信号通路改善多囊卵巢综合征的研究进展[J].中国医药导报,2025,22(27):152-156.
[11] 康宝文,陈萍,徐广立,等.中药调控PI3K/Akt信号通路治疗多囊卵巢综合征研究进展[J].辽宁中医药大学学报,2025,27(11):120-126.
[12] 林玉玲,李玉杰,李增一,等.柴胡皂苷A调控PI3K/Akt通路对2型糖尿病小鼠胰岛素抵抗的影响[J].中国老年学杂志,2024,44(4):928-931.
[13] 蔺文娟,李鹤,芮守月,等.基于IL-6/PI3K/AKT信号通路探讨补肾助排汤对多囊卵巢综合征伴胰岛素抵抗大鼠的干预机制[J].中国中医药信息杂志,2025,32(6):121-127.
[14] 金君健,斯日古楞,李子怡,等.环氧二十碳三烯酸通过调节PI3K/AKT信号通路改善HepG2细胞胰岛素抵抗[J].动物医学进展,2025,46(8):71-75.
[15] Senn JJ,Klover PJ,Nowak IA,et al.Suppressor of cytokine signaling-3(SOCS-3),a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes[J].J Biol Chem,2003,278(16):13740-13746.