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Quick Search     Adv Search 2026 Vol. 46, No. 5 Published: 2026-10-25 1 Predictive Value of Serum BDNF,Ghrelin and MPO Levels in Patients with Coronary Heart Disease after PCI Li Hongjie, Li Peng, Ma Yulian, Xie Zhijiang, Li Qin, Guo Junhua, Li Zhimei, Song Wei DOI: 10.3969/j.issn.1001-8131.2026.05.001 Objective To investigate the predictive value of serum levels of brain-derived neurotrophic factor(BDNF),ghrelin,and myeloperoxidase(MPO)for postoperative depressive episodes in patients with coronary heart disease undergoing percutaneous coronary intervention(PCI). Methods A total of 200 patients with coronary heart disease who underwent PCI in our hospital from July 2020 to September 2022 were prospectively enrolled.Based on the occurrence of depressive episodes within three months after surgery,patients were divided into a depression group(n=117)and a non-depression group(n=83).Relevant clinical data were collected.Univariate analysis and multivariate logistic regression analysis were used to assess the correlations between BDNF,ghrelin,and MPO levels and postoperative depressive episodes.Receiver operating characteristic(ROC)curves were used to evaluate the individual and combined predictive values of BDNF,ghrelin,and MPO for depressive episodes. Results Univariate and multivariate logistic regression analyses showed that BDNF(OR=0.486,95%CI=0.377-0.701,P<0.001),ghrelin(OR=0.529,95%CI=0.324-0.863,P=0.011),and MPO(OR=1.235,95%CI=1.033-1.352,P<0.001)were independent risk factors for depressive episodes.ROC curve analysis showed that the areas under the curve for BDNF,ghrelin,and MPO alone in predicting depressive episodes were 0.729(95%CI=0.661-0.798),0.729(95%CI=0.659-0.800),and 0.775(95%CI=0.708-0.842),respectively,while the area under the curve for the combined prediction was 0.879(95%CI=0.829-0.928). Conclusion Serum BDNF,Ghrelin and MPO are closely related to postoperative depressive episodes in patients with coronary heart disease before PCI,and single or combined detection has a good predictive effect,which can provide a basis for clinical prevention of depressive episodes. 2026 Vol. 46 (5): 1-5 [Abstract] ( 16 ) HTML (1 KB)  PDF (615 KB)  ( 2 ) 6 Study on the Correlation between Fatty Acid Binding Protein 4 and Cognitive Dysfunction after Ischemic Stroke Wang Feihong, Zhou Yi, Wang Xianhui, Lü Yaxing DOI: 10.3969/j.issn.1001-8131.2026.05.002 Objective To explore the association between the level of fatty acid binding protein 4(FABP4)in circulating blood and post-stroke cognitive impairment(PSCI)after acute ischemic stroke. Methods A total of 114 patients with acute ischemic stroke treated in the neurology department of our hospital were included.According to the Mini-Mental State Examination(MMSE)score,the participants were divided into the cognitive impairment group(32 cases)and the non-cognitive impairment group(82 cases).Demographic characteristics,past medical history,lifestyle information,fasting blood glucose,lipid profile,homocysteine,and serum FABP4 concentration of all study subjects were collected.Additionally,visceral fat area was evaluated by abdominal CT.Univariate analysis was first conducted to compare the differences in various indicators between different groups,and then the items with significant differences were further analyzed by multivariate Logistic regression to obtain the related risk factors for PSCI after acute ischemic stroke.Moreover,Pearson correlation analysis was used to assess the linear relationship between visceral fat,FABP4,and PSCI. Results Multivariate analysis indicated that advanced age(OR=2.223),high homocysteine(OR=1.895),high serum FABP4(OR=3.104),and high visceral fat content(OR=2.625)were all influencing factors for the occurrence of PSCI.The Results of correlation analysis showed that visceral fat area(r=0.645)and serum FABP4 level(r=0.588)were significantly positively correlated with PSCI(P<0.001 for both). Conclusion In patients with acute ischemic stroke,elevated serum FABP4 concentration,visceral fat accumulation,advanced age,and hyperhomocysteinemia are independent predictors of PSCI,and FABP4 and visceral fat content have a clear positive association with the occurrence of cognitive impairment. 2026 Vol. 46 (5): 6-8 [Abstract] ( 11 ) HTML (1 KB)  PDF (439 KB)  ( 2 ) 9 Effects of High Sensitivity C-reactive Protein and Homocysteine on Neurological Deficit and Prognosis in Patients with Acute Cerebral Infarction Ju Xinjie, Guo Gang, Zhang Weihua DOI: 10.3969/j.issn.1001-8131.2026.05.003 Objective Analysis of Variation Patterns of Homocysteine(Hcy)and High-Sensitivity Markers in Peripheral Blood During the Onset Stage of Acute Ischemic Stroke(ACI). Methods A total of 70 patients with ACI admitted to the Department of Neurology,The Zhumadian first people's Hospital from May 2022 to May 2024 were retrospectively selected as the study group,and 65 healthy subjects who underwent physical examination in the Health Management Center of our hospital during the same period were selected as the control group.Serum Hcy and hs-CRP levels were detected and compared between the two groups.According to the National Institutes of Health Stroke Scale(NIHSS)score,ACI patients were divided into mild group(n=25),moderate group(n=28)and severe group(n=17);Using the modified Rankin Scale(mRS)score at 3 months after onset as the criterion,70 patients were divided into a favorable prognosis group(n=45)and an unfavorable prognosis group(n=25).Spearman correlation analysis was performed to evaluate the relationship between inflammatory protein markers and NIHSS scores;multivariate Logistic regression was used to identify risk factors affecting the short-term recovery of acute ischemic stroke(ACI).ROC curve was drawn to evaluate the predictive value of serum Hcy and hs-CRP for poor short-term prognosis of ACI. Results The levels of serum Hcy and hs-CRP in the study group were significantly higher than those in the control group(P<0.05).There were significant differences in serum Hcy and hs-CRP levels among different neurological deficit groups(P<0.05),and the levels increased with the aggravation of the disease(severe group>moderate group>mild group).Spearman correlation analysis showed that serum Hcy(r=0.665)and hs-CRP(r=0.601)levels in ACI patients were significantly positively correlated with NIHSS scores(P<0.001).Multivariate logistic regression analysis confirmed that high NIHSS score on admission,elevated serum homocysteine,and high expression of high-sensitivity C-reactive protein were independent risk factors for poor short-term outcome in acute cerebral infarction(P<0.05).ROC curve analysis showed that the AUC of Hcy combined with hs-CRP in predicting poor short-term prognosis of ACI was which was better than that of single indicator. Conclusion Serum Hcy and hs-CRP levels are closely related to the degree of neurological deficit in ACI patients,and the combined detection of the two has high clinical value in assessing disease severity and predicting short-term prognosis. 2026 Vol. 46 (5): 9-12 [Abstract] ( 8 ) HTML (1 KB)  PDF (581 KB)  ( 2 ) 13 Analysis of the Characteristics of Pathogenic Bacteria and Their Drug Resistance in Adult Patients with Severe Community-acquired Pneumonia in the Emergency Department Lü Chengtian, Yan Yongxin, Liu Shizhuan, Guan Yuanzhi Zhou Ming DOI: 10.3969/j.issn.1001-8131.2026.05.004 Objective Investigating the pathogenic characteristics and antibiotic resistance analysis of severe community-acquired pneumonia(SCAP)in emergency adults,providing a basis for early empirical selection of antibiotics. Methods We collected 202 cases of SCAP patients in our hospital from July 2024 to October 2025,conducted sputum bacterial cultures for them,and performed drug sensitivity tests to understand the pathogenic bacteria in the patients and analyze their drug resistance situation. Results A total of 224 pathogens were detected in 202 patients,including 118 Gram-negative bacteria(52.68%),59 Gram-positive bacteria(26.34%),and 47 fungi(20.98%).Among the patients,Pseudomonas aeruginosa,Acinetobacter baumannii,and Klebsiella pneumoniae had a resistance rate of 0.00% to meropenem and imipenem,and showed relatively low resistance(<30.00%)to amikacin and cefoperazone-sulbactam.Among the patients,Streptococcus pneumoniae and Staphylococcus aureus had a resistance rate of 0.00% to vancomycin and teicoplanin,and showed relatively low resistance(<30.00%)to tetracycline,gentamicin,and levofloxacin. Conclusion In clinical practice,it is important to improve pathogen detection and drug sensitivity testing as early as possible,and to select antibiotics reasonably based on the Results of drug sensitivity testing.This is of great significance for reducing the mortality rate and improving the prognosis of emergency SCAP patients.However,this study has the limitation of limited sample size,and in the future,the sample size needs to be expanded to obtain data with higher levels of evidence. 2026 Vol. 46 (5): 13-15 [Abstract] ( 13 ) HTML (1 KB)  PDF (449 KB)  ( 2 ) 16 Expression and Correlation of Ki-67 and p53 in High-Grade Intraepithelial Neoplasia and Adenocarcinoma of the Colorectum Qu Chengyuan, Ye Qinglong, Chen Jing DOI: 10.3969/j.issn.1001-8131.2026.05.005 Objective To investigate the expression differences and correlations of Ki-67 and p53 in colorectal high-grade intraepithelial neoplasia(HGIN)and adenocarcinoma tissues,thereby providing a reference for clinical risk assessment of malignant transformation. Methods A total of 72 patients with colorectal lesions admitted to our hospital from January 2018 to December 2025 were retrospectively enrolled,including 27 cases of high-grade intraepithelial neoplasia and 45 cases of adenocarcinoma.The protein expressions of Ki-67 and p53 in lesion tissues were detected using the immunohistochemical SP method.Fisher’s exact test was used to correct statistical Results in small-sample subgroups,and Spearman’s rank correlation analysis was applied to assess correlations between indicators. Results The positive expression rate of Ki-67 in the adenocarcinoma group was significantly higher than that in the HGIN group(P<0.05).In the HGIN subgroup with malignant tendency,the positive rates of both Ki-67 and p53 were higher than those in the subgroup without malignant tendency(P<0.05).The nature of the lesion was significantly positively correlated with Ki-67 expression,and Ki-67 expression was also significantly positively correlated with p53 expression(P<0.001). Conclusion Combined detection of Ki-67 and p53 can accurately assess the risk of malignant transformation in colorectal high-grade intraepithelial neoplasia,assist in clinical pathological differential diagnosis and individualized treatment,and has high clinical application value. 2026 Vol. 46 (5): 16-18 [Abstract] ( 8 ) HTML (1 KB)  PDF (542 KB)  ( 2 ) 19 Correlation Analysis Between Triglyceride-Glucose Index and Sarcopenia in Patients with Chronic Heart Failure Hao Yuanbin, Yang Zhenyuan, Zhou Ye DOI: 10.3969/j.issn.1001-8131.2026.05.006 Objective To investigate the association between the triglyceride-glucose index and sarcopenia in patients with chronic heart failure,and to evaluate its screening value for sarcopenia risk. Methods A total of 150 patients with chronic heart failure who were treated at our hospital between December 2021 and December 2025 were enrolled.Based on diagnostic criteria for sarcopenia,they were divided into a sarcopenia group(38 cases)and a non-sarcopenia group(112 cases).Baseline data,laboratory parameters,and echocardiographic measurements were collected,and the TyG index was calculated.Multivariate logistic regression was used to identify independent risk factors for sarcopenia,Pearson correlation analysis was employed to assess the relationship between the TyG index and other indicators,and the trends in sarcopenia detection rates were analyzed by stratifying patients into four quartiles based on the TyG index. Results In the sarcopenia group,fasting blood glucose,triglycerides,and the TyG index were all higher than in the non-sarcopenia group(P<0.05).Multivariate logistic regression analysis revealed that the TyG index(OR=4.159,95% CI:3.636~4.682,P=0.003),NYHA functional class(OR=3.323,95% CI:3.067~3.579,P=0.025),left ventricular end-diastolic diameter(OR=3.387,95% CI:3.151~3.623,P=0.014)were all independent risk factors for sarcopenia.Pearson correlation analysis showed that the TyG index was positively correlated with left atrial diameter,left ventricular end-diastolic diameter,interventricular septal thickness,and left ventricular end-systolic diameter(r=0.159~0.231,P<0.05),and negatively correlated with left ventricular ejection fraction(r=-0.187,P=0.022).After stratification by TyG index quartiles,the prevalence of sarcopenia gradually increased from 20.00% in the Q1 group to 51.35% in the Q4 group(χ2=85.486,P<0.001). Conclusion The TyG index is an independent risk factor for sarcopenia in patients with chronic heart failure.It is significantly associated with cardiac chamber enlargement and impaired cardiac function,and the risk of sarcopenia increases progressively with rising TyG index values.Given its simplicity and low cost,the TyG index may serve as a potential biomarker for screening the risk of sarcopenia in patients with chronic heart failure. 2026 Vol. 46 (5): 19-23 [Abstract] ( 12 ) HTML (1 KB)  PDF (624 KB)  ( 0 ) 24 Evaluation of the Regulatory Effect and Safety of Immune Checkpoint Inhibitors Combined with Interventional Therapy on Tumor Metabolic Activity in Elderly Patients with Advanced Non-small Cell Lung Cancer Liu Liang, Yang Qin, Lai Yong DOI: 10.3969/j.issn.1001-8131.2026.05.007 Objective To investigate the regulatory effect of immune checkpoint inhibitors combined with interventional therapy on tumor metabolic activity in elderly patients with advanced non-small cell lung cancer and to evaluate its safety. Methods A total of 100 elderly patients diagnosed with advanced non-small cell lung cancer and admitted to the Second Department of Oncology of Meishan Second People's Hospital from January 2023 to April 2025 were enrolled as research subjects.Among them,80 cases underwent bronchial artery embolization and 20 cases received ablation therapy.All patients were treated with interventional therapy combined with immune checkpoint inhibitors.Clinical efficacy,quality of life,survival rates,and adverse reactions were compared between the two groups. Results The 6-month and 1-year survival rates in the bronchial artery embolization group were 90.00% and 80.00%,respectively,while those in the ablation group were both 100.00%.Tumor metabolic activity-related parameters in both groups decreased significantly after treatment compared with baseline(P<0.05).Adverse reactions in the entire cohort were predominantly mild(grade 1~2).Hematological toxicity occurred in 21 cases(21.00%),including 4 cases of grade 3 severe hematological toxicity;gastrointestinal reactions in 23 cases(23.00%);thyroid dysfunction in 20 cases(20.00%);liver dysfunction in 17 cases(17.00%);fatigue in 12 cases(12.00%);and rash in 8 cases(8.00%).No grade 4~5 severe or fatal adverse reactions were observed throughout the study. Conclusion The combination of interventional therapy and immune checkpoint inhibitors can significantly improve clinical efficacy,prolong survival,effectively suppress tumor metabolic activity,and exhibit manageable adverse reactions in elderly patients with advanced non-small cell lung cancer,demonstrating high clinical promotion value. 2026 Vol. 46 (5): 24-26 [Abstract] ( 9 ) HTML (1 KB)  PDF (634 KB)  ( 0 ) 27 Analysis of Traumatic Stress Response,Stone Clearance Effect and Safety of Percutaneous Nephrolithotomy in the Treatment of Upper Urinary Tract Calculi Complicated with Hypertension Xiao Haiting, Du Wei, Tao Jiao, Cheng Shuanglei DOI: 10.3969/j.issn.1001-8131.2026.05.008 Objective To analyze the application value of percutaneous nephrolithotomy(PCNL)in the treatment of upper urinary tract calculi complicated with hypertension,and to explore its influence on perioperative indicators,stone clearance effect,inflammatory factor levels,traumatic stress response and safety. Methods 86 patients with upper urinary tract calculi from June 2024 to January 2026 were selected and randomly divided into two groups.The control group(n=43)received transurethral ureteroscopic holmium laser lithotripsy,and the observation group(n=43)received percutaneous nephrolithotomy.The perioperative indicators,stone removal effect,inflammatory factor levels,trauma stress response indicators and safety of the two groups were compared. Results There were significant differences in operative time and intraoperative blood loss between the two groups(P<0.05).Compared with the control group,the observation group exhibited higher stone clearance rates on days 3 postoperatively and at 1 month postoperatively(P<0.05).No significant differences were observed in preoperative levels of inflammatory factors or trauma stress markers between the two groups(P>0.05).On day 1 postoperatively,levels of C-reactive protein,tumor necrosis factor-α,interleukin-6,cortisol,adrenaline,and noradrenaline increased in both groups,with significantly higher values in the observation group(P<0.05).No statistically significant differences were found in hospitalization duration or complications between the groups(P>0.05). Conclusion Percutaneous nephrolithotomy for upper urinary tract calculi complicated by hypertension demonstrates superior efficacy compared to transurethral holmium laser lithotripsy;however,the latter Results in less bleeding and more effective reduction of inflammatory effects and traumatic stress responses,Clinical analysis should be conducted rationally,and selection should be made judiciously. 2026 Vol. 46 (5): 27-30 [Abstract] ( 9 ) HTML (1 KB)  PDF (571 KB)  ( 0 ) 31 Predictive Value of Systemic Immune-Inflammation Index Combined with BMI for Early Metabolic Dysfunction-Associated Steatotic Liver Disease in Adolescents Tan Kaiqin, Huang Chaodi DOI: 10.3969/j.issn.1001-8131.2026.05.009 Objective To evaluate the predictive value of the systemic immune-inflammation index(SII)combined with body mass index(BMI)for early metabolic dysfunction-associated steatotic liver disease(MASLD)in adolescents. Methods A cross-sectional study was conducted using data from 1,227 adolescents in the 2017~2020 National Health and Nutrition Examination Survey(NHANES).Early MASLD was defined by a controlled attenuation parameter(CAP)248 dB/m.Multivariable logistic regression was used to identify risk factors for MASLD and construct a combined predictive model.The predictive performance was evaluated using the receiver operating characteristic(ROC)curve. Results Among the 1,227 participants,the prevalence of early MASLD was 26.8%(329/1,227).Multivariable regression analysis showed that BMI category was an independent risk factor for early MASLD,with obese adolescents having a 4.730-fold higher risk compared to those with normal weight(95% CI: 3.947-5.668,P<0.001).ROC analysis revealed that the area under the curve(AUC)for SII and BMI category alone was 0.610 and 0.819,respectively.The combined predictive model significantly improved the AUC to 0.827(95% CI: 0.800-0.855,P<0.001).Furthermore,a synergistic effect between SII and obesity was observed,with high SII status increasing the prevalence of MASLD by 14.0% in the overweight/obese group. Conclusion The combination of SII and BMI provides a robust and non-invasive tool for predicting early MASLD in adolescents.Given its cost-effectiveness and accessibility,this model can assist clinicians in identifying high-risk individuals for early intervention. 2026 Vol. 46 (5): 31-34 [Abstract] ( 9 ) HTML (1 KB)  PDF (608 KB)  ( 0 ) 35 The Predictive Value of Immature Platelet Fraction for the Bleeding Risk during the 6-month Dual Antiplatelet Therapy for Coronary Artery Disease Wu Xiaoying, Nie Ruqiong DOI: 10.3969/j.issn.1001-8131.2026.05.010 Objective To explore the predictive value of immature platelet fraction(IPF)for bleeding risk in patients with coronary artery disease(CAD)receiving 6-month dual antiplatelet therapy(DAPT). Methods A prospective study was conducted.A total of 213 patients with acute coronary syndrome or stable CAD after percutaneous coronary intervention were consecutively enrolled.All patients received dual antiplatelet therapy,and IPF was measured.Telephone follow-up was performed 6 months after discharge to collect data on bleeding events.The correlations between various factors and bleeding events were examined and a multivariate Logistic regression analysis was used to construct a predictive model for bleeding events. Results A total of 84 patients(39.4%)experienced bleeding events during the 6-month DAPT period,primarily manifesting as mucocutaneous bleeding.IPF was negatively correlated with bleeding risk at 6 months of DAPT(OR=0.703).Bleeding risk were also correlated with renal function,inflammation,left main coronary artery disease and ticagrelor use. Conclusion IPF can predict bleeding risk at 6 months in patients with CAD receiving DAPT. 2026 Vol. 46 (5): 35-37 [Abstract] ( 13 ) HTML (1 KB)  PDF (440 KB)  ( 0 ) 38 Comparative study of Transabdominal and Laparoscopic Total Hysterectomy for Patients with Benign Uterine Lesions Ding Xinyue, Lei Wen DOI: 10.3969/j.issn.1001-8131.2026.05.011 Objective To compare the Results of transabdominal and laparoscopic total hysterectomy(TLH)in the treatment of patients with benign uterine lesions. Methods Sixty-two patients with benign uterine lesions from our hospital were enrolled between.Using a randomised number table,they were divided into an observation group(n=31,undergoing total laparoscopic hysterectomy)and a control group(n=31,undergoing transabdominal hysterectomy).The perioperative indexes,inflammatory indexes [interleukin-6(IL-6),C-reactive protein(CRP)],postoperative recovery,and complication rates were compared between the 2 groups. Results Compared with the control group,the observation group had less intraoperative bleeding,longer operation time,and shorter days of antibiotic use(P<0.05);the levels of IL-6 and CRP were lower in the observation group compared with the control group at 1 d postoperatively(P<0.05);the time of defecation,time of getting out of bed,and the number of days of hospitalization in the observation group were shorter than that in the control group(P<0.05);and the complication rate in the observation group was 3.23%(1/31)was lower than 25.81%(8/31)in the control group(P<0.05). Conclusion Compared with TAH,TLH treatment of patients with benign uterine lesions can reduce bleeding,shorten the duration of antibiotic use and hospitalization days,promote postoperative exhaustion,improve body inflammation,and reduce the risk of complications,although it takes longer. 2026 Vol. 46 (5): 38-40 [Abstract] ( 6 ) HTML (1 KB)  PDF (446 KB)  ( 1 ) 41 SA/CUR-GO Composite Scaffold Induces Osteogenic Differentiation of Cells Liu Feng, Xie Qi, Li Hui, Zhou Hui, Fan Majuan, Zhang Rui DOI: 10.3969/j.issn.1001-8131.2026.05.012 Objective This study aimed to fabricate a composite hydrogel designated as SA/CUR-GO,composed of sodium alginate(SA),curcumin(CUR),and graphene oxide(GO),followed by comprehensive characterization of its morphological architecture,physicochemical properties,cytocompatibility,and osteogenic differentiation effects. Methods SA/CUR-GO composite hydrogels were prepared using a freeze-ionotropic gelation method.The experimental groups comprised SA,SA/GO,and SA/CUR-GO.Microstructural morphology was characterized using scanning electron microscopy(SEM).Chemical structural analysis was performed employing Fourier Transform Infrared Spectroscopy(FT-IR).Mechanical properties were assessed via compression testing using a universal testing machine.For in vitro biological evaluation,mouse bone marrow mesenchymal stem cells(mBMSCs)were cultured on the surfaces of the three hydrogel groups.The detection indicators included the effects on cell viability,proliferation ability,and osteogenic differentiation potential. Results Micro-morphological analysis revealed that all hydrogels exhibited an interconnected porous network.Notably,the SA/CUR-GO hydrogel displayed increased surface roughness and significantly enhanced mechanical strength.In vitro cellular experiments demonstrated that the SA/CUR-GO composite hydrogel possessed favorable cytocompatibility and significantly promoted the osteogenic differentiation of mBMSCs. Conclusion The SA/CUR-GO composite hydrogel demonstrates outstanding cytocompatibility and remarkable ability to promote the osteogenic differentiation of mBMSCs.These characteristics make it a highly promising biomaterial,especially with broad application prospects in the fields of periodontal tissue regeneration and orthodontic treatment. 2026 Vol. 46 (5): 41-45 [Abstract] ( 10 ) HTML (1 KB)  PDF (1165 KB)  ( 1 ) 46 Effect of Non-invasive Ventilator Combined with Progressive Respiratory Rehabilitation Training in the Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease He Lishen DOI: 10.3969/j.issn.1001-8131.2026.05.013 Objective To analyze the efficacy of non-invasive ventilator combined with progressive respiratory rehabilitation training in elderly patients with chronic obstructive pulmonary disease(COPD). Methods A total of 80 elderly COPD patients admitted to our hospital from June 2024 to December 2025 were enrolled in the study.They were randomly divided into a control group(non-invasive ventilator therapy,40 cases)and an observation group(progressive respiratory rehabilitation training+non-invasive ventilator therapy,40 cases)using a random number table.The clinical total effective rate,pulmonary function,blood gas levels,quality of life,and adverse reactions were compared between the two groups. Results The clinical total effective rate in the observation group was significantly higher than that in the control group(P<0.05).After 2 weeks of treatment,all pulmonary function indicators in the observation group were higher than those in the control group(P<0.05).The partial pressure of carbon dioxide(PaCO2)in the observation group was lower,while the partial pressure of oxygen(PaO2)was higher after 2 weeks of treatment(P<0.05).All quality of life scores in the observation group were lower than those in the control group after 2 weeks of treatment(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05). Conclusion Non-invasive ventilator combined with progressive respiratory rehabilitation training can effectively improve the clinical total effective rate,enhance pulmonary function and blood gas levels,and achieve higher quality of life with a lower incidence of adverse reactions. 2026 Vol. 46 (5): 46-48 [Abstract] ( 11 ) HTML (1 KB)  PDF (552 KB)  ( 0 ) 49 Surveillance of Bacterial Resistance in a Hospital in Quanzhou from 2023 to 2025 Chen Xiaoting, Zhou Jingqi, Hu Liping, Zhu Yan DOI: 10.3969/j.issn.1001-8131.2026.05.014 Objective To understand the sensitivity and resistance of clinical isolates to common antibiotics in Quanzhou Municipal First Hospital from 2023 to 2025. Methods From January 2023 to December 2025,non-repetitive pathogenic bacteria isolated from various clinical departments of Quanzhou First Hospital were collected.These bacteria were identified and subjected to drug susceptibility analysis using automated instrument methods,mass spectrometry,microbroth dilution,disk diffusion,and E-test methods. Results A total of 18707 nonduplicate isolates were collected for 3 years,including gram-negative bacteria(12478,66.7%)and gram-positive microorganisms(6229,33.3%).The detection rates of S.aureus(MRSA)were 22.4%,teicoplanin(TEC)、Vancomycin(VA)and linezolid(LZD)resistant staphylococci were not isolated.A few vancomycin and LZD resistant strains were identified in Enterococcus.Most of the Enterobacter in our hospital are still highly sensitive to carbapenems.The resistance rate of Acinetobacter baumannii to antibiotics other than polymyxin B(PMB)and tigecycline(TGC)is close to or higher than 30%.Carbapenem-resistant H.influenzae strains were not isolated. Conclusion Surveillance of bacterial resistance for 3 years in our hospital suggests that carbapenem-resistant Enterobacterales and baumanii are still on the rise.It is necessary to stewardship of antimicrobial agents and strengthen hospital infection control. 2026 Vol. 46 (5): 49-53 [Abstract] ( 4 ) HTML (1 KB)  PDF (659 KB)  ( 0 )

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