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2025 Vol. 45, No. 3 Published: 2025-06-25

	1	ALDH1A1 and miR-140: Potential Therapeutic Targets and Strategies for Cervical Cancer
		Zinati Nuertai, Rou Qian, Zhang Meng, Ming Jie, Liu Ying
		DOI: 10.3969/j.issn.1001-8131.2025.03.001
		Objective This study aimed to explore the expression levels of ALDH1A1 and miR-140 in cervical cancer cell lines and study their interactions.Through in-depth understanding of the mechanism of action of ALDH1A1 and miR-140 in the occurrence and development of cervical cancer,it provides new potential targets and treatment strategies for the diagnosis and treatment of cervical cancer. Methods Cervical cancer dataset was obtained from the NCBI GEO database,and R（3.5.0）software package Limma was used to screen Differentially Expressed Genes（DEGs）on the chip data.The selected differentially expressed genes were analyzed by Gene Ontology Biological Process（GO BP）function and Kyoto Encyclopedia of Genes and Genomes（KEGG）pathway,to construct the competing endogenous RNA network（ceRNA）of differential mRNA,microRNA and lncRNA;the protein-protein interaction network（PPI）of differential mRNA was constructed to select Hub genes.The Kaplan-Meier survival curve was drawn to understand its risk of disease,and cell experiments and qRT-PCR were performed to detect the expression levels of differential mRNA and target miRNA in each group of cells,and double luciferase experiments were performed to verify the interaction between the two. Results By analyzing the cervical cancer dataset in NCBI GEO database,the Hub gene ALDH1A1 was screened out and its miRNA was found.From the Kaplan-Meier curve,it was concluded that ALDH1A1 was a risk factor for the occurrence and development of cervical cancer,and the prognosis of the high expression group was significantly worse than that of the low expression group.The results of cell experiments showed that in cervical cancer cell lines,the expression level of ALDH1A1 was higher,while the expression level of miR-140 was lower.Further experiments showed that miR-140 could significantly inhibit the expression of ALDH1A1 in cervical cancer cell lines. Conclusion The high expression of ALDH1A1 and the low expression of miR-140 may be closely related to the occurrence and development of cervical cancer.miR-140 targets ALDH1A1 and inhibits its expression.This reveals the important role of ALDH1A1 and miR-140 in the occurrence and development of cervical cancer.
		2025 Vol. 45 (3): 1-6 [Abstract] ( 14 ) HTML (1 KB) PDF (2232 KB) ( 16 )

	7	Based on the Efficacy of Stellate Ganglion Block Combined with CBT-I in Intractable Insomnia
		Li Yi, Gao Pengtao
		DOI: 10.3969/j.issn.1001-8131.2025.03.002
		Objective To investigate the efficacy of stellate ganglion block(Stellate Ganglion Block,SGB)combined with cognitive behavioral therapy for insomnia(Cognitive Behavioral Therapy for Insomnia,CBT-I)in the treatment of intractable insomnia. Methods 80 patients were selected as the study subjects.These patients were randomly assigned to two groups,each containing 40 patients.Patients in the control group received SGB therapy,whereas those in the observation group received a combination of SGB therapy with CBT-I therapy.Treatment response rate,Pittsburgh Sleep Quality Scale(pittsburgh sleep quality index,PSQI)scores,and psychological status were compared. Results The total effective rate of treatment in the observation group was 92.50%,which was higher than that of the control group at 72.50%(χ²=5.541,P=0.019).Before treatment,there was no significant difference in PSQI scores between the two groups(P>0.05).At 2,4,and 8 weeks after treatment,PSQI scores in both groups decreased,and those in the observation group were significantly lower than those in the control group(P<0.05).After treatment,SAS and SDS scores in both groups showed a downward trend,and those in the observation group were lower than those in the control group(P<0.05).The dropout rate in the observation group was 2.50%,which was lower than that of the control group at 17.50%(χ²=5.000,P=0.025). Conclusion SGB combined with CBT-I has significant clinical effects in the treatment of intractable insomnia,which can effectively improve the sleep quality,reduce anxiety and depression,and have mild adverse reactions and good patient compliance.It is a comprehensive treatment method worthy of promotion.
		2025 Vol. 45 (3): 7-10 [Abstract] ( 15 ) HTML (1 KB) PDF (582 KB) ( 5 )

	11	Investigate the Efficacy and Mechanism of Xiaoaiping Combined with FOLFOX6 Regimen in the Treatment of Advanced Rectal Cancer Based on IL-6/STAT3 Signaling Pathway in Peripheral Blood
		Li Jing, Hu Yuyue, Ma Huili
		DOI: 10.3969/j.issn.1001-8131.2025.03.003
		Objective To investigate the efficacy and mechanism of Xiaoaiping combined with FOLFOX6 regimen in the treatment of advanced rectal cancer based on peripheral blood interleukin-6(IL-6)/signal transduction factor and transcriptional activation factor(STAT3)signaling pathway. Methods 102 patients with advanced rectal cancer were divided into control group and experimental group by random number table method,with 51 cases in each group.The control group received FOLFOX6 chemotherapy,and the experimental group received Xiaocarpine on the basis of the control group.Clinical efficacy,conventional tumor markers [carcinoembryonic antigen(CEA),glycoprotein antigen 199(CA199)],cellular immune function,and peripheral blood IL-6/STAT3 signaling pathway related indexes[IL-6,STAT3] were observed and compared between the two groups. Results The Objective response rate(ORR)and disease control rate(DCR)of the experimental group were higher than those of the control group(P<0.05).After treatment,CEA and CA199 in experimental group were lower than those in control group(P<0.05).After treatment,CD8⁺ in the experimental group was lower than that in the control group,and CD3⁺,CD4⁺,CD4⁺/ CD8⁺ were higher than that in the control group(P<0.05).IL-6 and STAT3 in the experimental group were lower than those in the control group after treatment(P<0.05). Conclusion Xiaoaiping combined with FOLFOX6 regimen in the treatment of advanced rectal cancer is helpful to improve clinical efficacy and reduce the level of serum tumor markers,which may be related to the regulation of immunity and IL-6STAT3 signaling pathway in peripheral blood.
		2025 Vol. 45 (3): 11-14 [Abstract] ( 29 ) HTML (1 KB) PDF (572 KB) ( 15 )

	14	Effect of Laparoscopic Ovarian Cyst Removal on Ovarian Reserve Function,Fertility and Complications in Patients with Ovarian Cysts of Childbearing Age
		Wang Xiaofeng, Sang Huige, Zhao Song
		DOI: 10.3969/j.issn.1001-8131.2025.03.004
		Objective To investigate the effect of laparoscopic ovarian cyst removal(LOCR)on ovarian reserve function,fertility and complications in childbearing age ovarian cysts(OC). Methods 112 OC patients of childbearing age diagnosed were selected.Using simple random allocation,the patients were divided into groups A and B,with 56 patients in each group.Patients in group A were treated with LOCR and group B with conventional laparotomy.Observe the general situation of patients during the operation(operation time,intraoperative bleeding,intestinal exhaust time,etc.),after different time pain,compare the two groups of ovarian reserve function [serum follicle-stimulating hormone(FSH),estradiol(E2),luteinizing hormone(LH)],quality of sexual life and postoperative fever and wound bleeding complications. Results Group A took time(61.48±4.99)min,intraoperative bleeding(77.18±6.97)mL,first discharge time(12.55±2.14)h and postoperative time to ambulation(3.94±1.37)d.Compared with Group B,each group was significantly decreased(P<0.05).At 6h,12h,24h and 72h after surgery,the postoperative pain level in patients in Group A was significantly lower than that in patients in Group B(P<0.05).E2,LH and FSH decreased in both months compared with preoperative,and the change in group A compared with group B(P<0.05).After 3 months postoperative follow-up,29(51.79%)were pregnant in group A;28(50.00%),with no significant difference between the two groups(P>0.05).Group A(5.36%)had a lower complication rate than Group B(19.64%)(P<0.05). Conclusion LOCR has less damage,shorter recovery period,lower complication rate,less damage to ovarian reserve function,and less impact on patient fertility.
		2025 Vol. 45 (3): 14-17 [Abstract] ( 17 ) HTML (1 KB) PDF (576 KB) ( 7 )

	18	The Association of Sufentanil and Remifentanil/Sufentanil on Postoperative Analgesia and Complications in Patients with Minimally Invasive Cardiac Surgery:A Propensity Score-matching Study
		Pan Lin, Wei Hanwei
		DOI: 10.3969/j.issn.1001-8131.2025.03.005
		Objective To retrospectively analyze the impact of using sufentanil alone versus sufentanil in combination with remifentanil on postoperative analgesia and complications in patients undergoing minimally invasive cardiac surgery. Methods Select right axillary small incision minimally invasive heart valve surgery patients,according to the intraoperative anesthesia analgesia scheme into sufentanil group and sufentanil combined remifentanil group,using the nearest matching method,and 1:1 matching,set the caliper value of 0.02,to compare the two groups of postoperative extubation time,ICU stay time,remedial analgesia,NRS score and postoperative complications. Results A total of 354 patients were screened and 82 patients(41 pairs)were successfully matched.The difference of ICU stay,CPOT score,and postoperative complications between the two groups(P>0.05);the dose(morphine equivalent)of sufentanil and remifentanil was significantly higher than that of sufentanil group(P<0.05),and the ICU NRS score of sufentanil group,ICU salvage analgesia,ward NRS score,and ward remedial analgesia were significantly lower than those of sufentanil group,respectively(P<0.05). Conclusion In right axillary small incision cardiac surgery,compared with the use of low-dose sufentanil combined with remifentanil,the use of high-dose sufentanil alone can provide better perioperative analgesia.However,there was no significant difference between the two analgesia regimens in terms of post-extubation time and postoperative atelectasis and other complications.
		2025 Vol. 45 (3): 18-21 [Abstract] ( 24 ) HTML (1 KB) PDF (513 KB) ( 4 )

	22	Study on the Improvement of Uterine Artery Hemodynamics and Bone Metabolism Indicators in Patients with Endometriosis Treated with Dienogest Postoperatively
		Zhang Zigui, Zhang Xungong, Feng Linna, Yu Tiantian
		DOI: 10.3969/j.issn.1001-8131.2025.03.006
		Objective To investigate the effects of dienogest on uterine artery hemodynamics and bone metabolism indicators in patients with endometriosis after surgery. Methods 115 patients with endometriosis treated in our hospital were selected as the study subjects.They were randomly divided into two groups using a blind selection method.The control group received a leuprorelin acetate treatment regimen,while the observation group was treated with dienogest in addition to leuprorelin acetate.The clinical efficacy,bone mineral density(BMD)and bone metabolism indicators,hemodynamic parameters,Visual Analogue Scale(VAS)scores,pain-related stress factor levels,and adverse reactions were compared between the two groups. Results In the observation group,2 cases did not complete the full course of medication,and 1 case had missing data.In the control group,1 case had incomplete data,and 1 case withdrew midway.Therefor,55 cases in each group were finally included in the study.The total clinical effective rate in the observation group was 94.55%,significantly higher than that in the control group(P<0.05).After treatment,the observation group showed higher lumbar spine BMD(1.15±0.05 g/cm³),femoral trochanter BMD(1.11±0.05 g/cm³),DGP(29.44±3.69 ng/mL),and BALP(10.65±1.03 μg/L)levels compared to the control group,while the β-CTX level(0.44±0.11 ng/mL)was significantly lower(P<0.05).Post-treatment,the maximum blood flow velocity of the left uterine artery in the observation group(37.45±3.32 cm/s)was higher than that in the control group,and the pulsatility and resistance indices were lower.Similarly,the maximum blood flow velocity of the right uterine artery in the observation group(41.45±3.58 cm/s)was significantly higher than that in the control group,with lower pulsatility and resistance indices(P<0.05).After treatment,the observation group had significantly lower non-menstrual lower abdominal pain scores(1.67±0.47)and dysmenorrhea scores(2.09±0.29)compared to the control group.Additionally,the levels of PGF(246.26±22.19 pg/mL)and NGF(133.94±13.18 pg/mL)in the observation group were significantly lower than those in the control group(P<0.05).The total incidence of adverse reactions in the observation group was 7.27%,significantly lower than that in the control group(P<0.05). Conclusion The combination of dienogest and leuprorelin acetate significantly improves uterine artery hemodynamics and bone metabolism indicators in patients with endometriosis,reduces pain levels,and lowers the incidence of adverse reactions.However,due to the short observation period in this study,future research should extend the observation time to more comprehensively evaluate the long-term efficacy and safety of dienogest in the treatment of endometriosis.
		2025 Vol. 45 (3): 22-26 [Abstract] ( 24 ) HTML (1 KB) PDF (654 KB) ( 8 )

	27	Correlation between SFRP4 Levels in Peripheral Blood and Insulin Resistance and Obesity in Patients with Newly Diagnosed Type 2 Diabetes
		Wang Junyao, Luo Changxia, Sun Qunzhi, Tang Zhixiang, Huang Xiaoshan, Zhou Xingchen, Qiu Yuting, Guo Yiding
		DOI: 10.3969/j.issn.1001-8131.2025.03.007
		Objective To investigate the correlation between the expression level of secreted crimp-associated protein 4(SFRP4)in peripheral blood and insulin resistance(IR)and obesity in newly diagnosed type 2 diabetes mellitus(T2DM)patients. Methods Research methods: Fifty newly diagnosed T2DM patients were selected.According to body mass index(BMI), they were divided into non-obese subgroup(n=25, BMI<25kg/m²)and obese subgroup(n=25, BMI≥25kg/m²).At the same time, 40 healthy volunteers who underwent physical examination in the hospital during the same period were selected as the control group, including normal weight group(n=20, BMI<25kg/m²)and obese group(n=20,BMI≥25kg/m²).The concentration of SFRP4 in each group was determined by enzyme-linked immunosorbent assay(ELISA).Fasting blood glucose(FPG), glycated hemoglobin(HbA1c), triglyceride(TG), total cholesterol(TC), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), fasting insulin(Fins)and other metabolic indexes were detected.BMI, waist-hip ratio(WHR), insulin resistance index(HOMA-IR)and islet β cell function index(HOMA-β)were calculated to investigate the correlation between SFRP4 and IR and obesity degree. Results The plasma concentration of SFRP4 in T2DM was increased.SFRP4 was positively correlated with weight、BMI、FPG、HbA1c、TG、HDL-C、HOMA-IR（P<0.05）,and negatively correlated with HOMA-β（P<0.HbA1c、05).Multiple stepwise regression analysis showed that HbA1c and BMI were independently associated with SFRP4,HbA1c and BMI were independently associated with PGRN. Conclusions It was found that the concentration of secreted curl associated protein 4(SFRP4)was significantly increased in newly diagnosed type 2 diabetes mellitus(T2DM)patients.Correlation analysis showed that SFRP4 was significantly positively correlated with body mass index(BMI), fasting blood glucose(FPG), glycosylated hemoglobin(HbA1c), triglyceride(TG), high-density lipoprotein cholesterol(HDL-C)and insulin resistance index(HOMA-IR)(P<0.05).There was a negative correlation with islet β cell function index(HOMA-β)(P<0.05).Further multivariate regression analysis confirmed that HbA1c and BMI were independent predictors of SFRP4 concentration.The study concluded that the abnormal increase of SFRP4 in plasma of T2DM patients was particularly prominent in the obese subgroup.In addition, the change of SFRP4 level is closely related to T2DM, insulin resistance and obesity status.This finding suggests that early intervention of SFRP4 expression levels may open up new research directions for the prevention and treatment of T2DM.
		2025 Vol. 45 (3): 27-30 [Abstract] ( 14 ) HTML (1 KB) PDF (538 KB) ( 6 )

	30	The Application Effect of Precise Hepatic Pedicle Anatomy in Laparoscopic Hepatectomy for Liver Cancer and Its Impact on Stress Response
		Yao Xuming, Ren Zhenhua, Cao Yingwei
		DOI: 10.3969/j.issn.1001-8131.2025.03.008
		Objective To investigate the effects of precise hepatic pedicle anatomy applied in laparoscopic hepatectomy for liver cancer and its impact on the inflammatory and immune stress response in patients. Methods 88 liver cancer patients were divided into two groups randomly.The control group(44 cases)underwent conventional liver resection.The observation group(44 cases)underwent liver resection using precise hepatic pedicle anatomy.The changes in liver function indices,inflammatory-immune indices,tumor marker levels,incidence of related complications,and recurrence rates were observed. Results On postoperative day 3,the serum levels of AST,ALT,TBIL,and γ-GT were significantly lower in the observation group compared to the control group(P<0.05).Additionally,on postoperative day 3,the levels of TNF-α,CRP,and IL-6 were significantly lower,and the levels of IgA,IgM,and IgG were significantly higher in the observation group compared to the control group(P<0.05).At three months postoperative,the levels of CA19-9,AFP,and TK1 were significantly lower in the observation group compared to the control group(P<0.05).The incidence of postoperative complications(5.55%)and recurrence rate(6.82%)in the observation group were significantly lower than those in the control group(18.18% and 22.73%,respectively)(P<0.05). Conclusion The application of precise hepatic pedicle anatomy in laparoscopic hepatectomy for liver cancer can better protect liver function,reduce inflammatory and immune stress responses,improve overall patient management outcomes,effectively reduce postoperative complications,lower recurrence risk,and help improve the patient's quality of life.
		2025 Vol. 45 (3): 30-33 [Abstract] ( 20 ) HTML (1 KB) PDF (534 KB) ( 7 )

	34	Research on the Diagnostic Value of Combined Serum Markers NT-proCNP,Interleukin-8 and Tumor Necrosis Factor-α in Sepsis-Associated Encephalopathy
		Guo Shuping, Liao Chunyan, Liu Qinghong, Huang Qingfei
		DOI: 10.3969/j.issn.1001-8131.2025.03.009
		Objective To study the combined diagnostic value of N-terminal pro-C-type natriuretic peptide（NT-proCNP）,interleukin-8（IL-8）and tumor necrosis factor-α（TNF-α）in sepsis-associated encephalopathy（SAE）. Methods A total of 80 patients with sepsis and septic shock were prospectively selected as the research objects.Taking the results of imaging-assisted examinations such as MRI and EEG as the clinical results of whether the patients had SAE,the patients were divided into the SAE group and the non-SAE group.The levels of NT-proCNP,IL-8 and TNF-α in the patients were detected,and the values of individual diagnosis and combined diagnosis were analyzed. Results The area under the curve（AUC）of NT-proCNP in diagnosing SAE was 0.844,the specificity was 0.846,and the sensitivity was 0.722;the AUC of IL-8 in diagnosing SAE was 0.869,the specificity was 0.962,and the sensitivity was 0.685;the AUC of TNF-α in diagnosing SAE was 0.886,the specificity was 0.885,and the sensitivity was 0.796;the AUC of the three combined in diagnosing SAE was 0.991,the specificity was 0.962,and the sensitivity was 0.981;the Delong test results showed that the efficiency of combined diagnosis of SAE was higher than that of individual diagnosis of SAE by NT-proCNP,IL-8 and TNF-α levels（Z=3.221,3.241,3.144,all P<0.05）. Conclusion The levels of NT-proCNP,IL-8 and TNF-α can be used as potential biological indicators for diagnosing SAE.The combined diagnosis of the three has excellent diagnostic efficiency,can help clinically and accurately diagnose whether patients have SAE,provide help for clinical treatment decisions,and can be popularized in clinical practice.
		2025 Vol. 45 (3): 34-36 [Abstract] ( 21 ) HTML (1 KB) PDF (421 KB) ( 3 )

	37	Clinical Effect of Emergency Laparoscopic Cholecystectomy Combined with Common Bile Duct Exploration and Lithotomy T-tube Drainage in the Treatment of Acute Calculous Cholangitis
		Cai xin, Zhuo Gaji
		DOI: 10.3969/j.issn.1001-8131.2025.03.010
		Objective To investigate the clinical effect of emergency laparoscopic cholecystectomy combined with common bile duct exploration and T-tube drainage in the treatment of acute calculous cholangitis. Methods 48 patients with acute calculous cholangitis were selected as the study objects,and were randomly divided into control group and observation group according to random number table method,with 24 cases in each group.The control group was treated with common bile duct exploration and lithotomy and traditional open surgery,while the observation group was treated with laparoscopic cholecystectomy combined with common bile duct exploration and lithotomy.The operation status and recovery status(intraoperative blood loss,operation time,hospital stay,hospital cost,abdominal drainage time,intestinal function recovery time),incidence of complications(incision infection,postoperative bleeding,stone residue,bile leakage),serum inflammatory factors(TNF-α,IL-6),renin-angiotensin system(RAS)activity index levels(A ngⅠ and AngⅡ). Results There was no significant difference in operation time between the two groups(P>0.05).The amount of blood loss,hospitalization cost,hospitalization time,abdominal drainage time and intestinal function recovery time in observation group were significantly lower than those in control group(P<0.05).The complication rate of observation group was significantly lower than that of control group(P<0.05).After treatment,the levels of TNF-α and IL-6 in two groups were higher than before treatment,but the levels of TNF-α and IL-6 in observation group were lower than those in control group(P<0.05).After treatment,AngⅠ and AngⅡ levels in two groups were higher than before treatment,but AngⅠ and AngⅡ levels in observation group were lower than control group(P<0.05). Conclusion For patients with acute calculous cholangitis,emergency laparoscopic cholecystectomy combined with common bile duct exploration and lithotomy T-tube drainage can effectively improve surgical indicators and promote physical recovery of patients,which is worthy of clinical reference.
		2025 Vol. 45 (3): 37-39 [Abstract] ( 24 ) HTML (1 KB) PDF (407 KB) ( 3 )

	40	The Predictive Value of Serum ALT,AST,and Immunoglobulin Levels for the Severity of Hepatitis B in Patients
		Huang Chenlu, Huang Xinyi
		DOI: 10.3969/j.issn.1001-8131.2025.03.011
		Objective To explore the predictive value of serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),and immunoglobulin levels on the severity of hepatitis B(HB)in patients. Method 127 patients with HB were selected.The severity of the patients' condition was evaluated according to relevant standards,and serum ALT,AST,and immunoglobulin levels were detected and compared among patients with different severity levels.ALT,AST,and immunoglobulin levels were analyzed AST,The relationship and predictive value between immunoglobulin levels and the severity of HB patients. Result Among the 127 patients with HB,38 cases(29.92%)were mild,59 cases(46.46%)were moderate,and 30 cases(23.62%)were severe;Severe HB patients with ALT AST,The levels of immunoglobulin A(IgA),immunoglobulin M(IgM),and immunoglobulin G(IgG)were higher in moderate and mild patients,respectively(P<0.05);Kendall's tau-b correlation coefficient test showed that the levels of ALT,AST,IgA,IgM,and IgG were positively correlated with the severity of HB patients(r>0,P<0.05);Plotting ROC curves shows that the AUC of predicting moderate to severe illness in HB patients by detecting ALT,AST,IgA,IgM,and IgG separately or by combining various indicators is all greater than 0.70,indicating diagnostic value,with the highest value observed in combined detection. Conclusion Serum ALT AST、 The level of immunoglobulin is related to the severity of HB patients' condition and has high predictive value for the severity of HB patients' condition.It is considered to be one of the auxiliary indicators for judging the severity of patients' condition in the future.
		2025 Vol. 45 (3): 40-42 [Abstract] ( 22 ) HTML (1 KB) PDF (486 KB) ( 5 )

	43	Effect of Early Initiation of CRRT on Renal Function,Systemic Inflammatory Response and Short-term Prognosis in Elderly Patients with Septic Acute Kidney Injury
		Liu Yanqun, Sun Lidong, Yu Jifen
		DOI: 10.3969/j.issn.1001-8131.2025.03.012
		Objective To explore the effect of early initiation of continuous renal replacement therapy(CRRT)on renal function,systemic inflammatory response and short-term prognosis in elderly patients with acute kidney injury with sepsis. Methods Retrospectively selected 67 elderly patients with sepsis and acute kidney injury admitted to the Emergency intensive care department,early group(n=35)and late group(n=32)in the early group initiated CRRT within 12 hours after confirmed patients with AKI,and CRRT treatment was delayed to 48 hours in the late group.After propensity matching scores for all patient data,using propensity scoring to balance baseline characteristics between groups and adjusting for potential confounding factors,a total of 29 patients with no statistically significant difference in baseline.The treatment effect,renal function,systemic inflammatory response,short-term prognosis,and adverse reactions were compared between the two groups. Results After treatment,the sequential organ failure(SOFA)score,acute physiology and chronic health(APACHE Ⅱ)scores were lower than those in the advanced group(P<0.05).After treatment,the blood creatinine(SCr),urea nitrogen(BUN),hypersensitive C-responsive protein(hs-CRP)(TNF-α)were lower than in the advanced group(P<0.05),while the levels of urinary protein,interleukin-6(IL-6)were similar(P>0.05).The 28 d mortality and ICU stay in the early group were lower than the late group(P<0.05),while the 90 d mortality in the two groups was similar(P>0.05).The adverse reaction rate was similar in the two groups(χ²=0.744,P>0.05). Conclusion Compared with late CRRT,early initiation can improve the condition and renal function of elderly patients with acute kidney injury,relieve systemic inflammatory response,improve short-term prognosis,and have safety.
		2025 Vol. 45 (3): 43-46 [Abstract] ( 17 ) HTML (1 KB) PDF (534 KB) ( 5 )

	47	Application Effect of Laparoscopic Repair in Upper Gastrointestinal Perforation
		Geng Yantao, Liu Wanli, Liu Zhipeng, Zhang Shuaina
		DOI: 10.3969/j.issn.1001-8131.2025.03.013
		Objective To explore the effect of laparoscopic repair in upper gastrointestinal perforation. Methods 121 eligible patients with coronary heart disease and hyperlipidemia were selected,all from the Kaifeng 155 hospital,with different surgical methods for grouping principle is divided into two groups,including group A(traditional repair,60 cases),group B(laparoscopic repair,61 cases).Both groups were observed until discharge and followed-up for 1 month.Compared the two groups of perioperative indicators,VAS scores at different time points,inflammatory factors before and 3 d after surgery,quality of life before and 1 month after surgery,and the occurrence of complications during the observation period. Results Comparing Group A and B,Group B,group A and B decreased at 24 h and 48 h after surgery,and group B,3 d serum inflammation(CRP,PCT,IL-6,TNF-α),and group B(all P<0.05).During the observation period,the overall incidence of complications was different between groups A and B(P>0.05). Conclusion For patients with upper gastrointestinal perforation,laparoscopic repair can effectively improve operation-related parameters,reduce pain,control inflammation,improve the quality of life,and have high safety.
		2025 Vol. 45 (3): 47-49 [Abstract] ( 19 ) HTML (1 KB) PDF (421 KB) ( 5 )

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