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Quick Search     Adv Search 2025 Vol. 45, No. 1 Published: 2025-02-25 1 Study on the Relationship between miRNA-146a Expression in Peripheral Blood Mononuclear Cells and Oxidative Stress Levels and Inflammatory Response in Patients with Chronic Obstructive Pulmonary Disease Tian Lu, Ruan Zheng, Guo Yuping DOI: 10.3969/j.issn.1001-8131.2025.01.001 Objective The primary objective of this study was to explore the intricate relationship between the expression of miRNA-146a in peripheral blood mononuclear cells（PBMCs） of patients afflicted with chronic obstructive pulmonary disease（COPD）and both the oxidative stress levels and the inflammatory response. Methods Peripheral blood samples were procured from 52 individuals diagnosed with COPD and 52 healthy counterparts.The expression of miRNA-146a in PBMCs was detected using real-time fluorescence quantitative PCR technology.Biochemical assay kits were employed to ascertain the levels of oxidative stress markers,and ELISA was utilized to measure the levels of inflammatory response markers.Subsequently,a comprehensive comparison of the correlations among these indicators was conducted. Results In contrast to the healthy control group,a significant reduction in the expression level of miRNA-146a in the PBMCs of COPD patients was observed（P<0.05）.Notably,as the GOLD grading advanced,a downward trend in the expression level of miRNA-146a became evident.The levels of malondialdehyde（MDA）in the plasma of COPD patients were markedly higher than those in the healthy control group（P<0.05）,while the levels of superoxide dismutase（SOD）and glutathione peroxidase（GSH-Px）were substantially lower than those in the healthy control group（P<0.05）.Additionally,the levels of interleukin-6（IL-6）,tumor necrosis factor-α（TNF-α）,and interleukin-1β（IL-1β）in the plasma of COPD patients were significantly elevated compared to those in the healthy control group（P<0.05）.Intriguingly,the expression level of miRNA-146a in the PBMCs of COPD patients exhibited a negative correlation with MDA levels（both P<0.05）,and a positive correlation with SOD and GSH-Px levels（P<0.05）.Concurrently,the expression level of miRNA-146a was inversely correlated with the levels of IL-6,TNF-α,and IL-1β（all P<0.05）. Conclusion The expression level of miRNA-146a is intimately intertwined with the severity of COPD and demonstrates a significant correlation with oxidative stress levels and inflammatory response indicators.It is postulated that miRNA-146a might play a crucial role in the pathogenesis of COPD. 2025 Vol. 45 (1): 1-4 [Abstract] ( 30 ) HTML (1 KB)  PDF (519 KB)  ( 14 ) 4 To Evaluate the Therapeutic Effect of Low Molecular Weight Heparin on Recurrent Abortion Susceptibility Based on Coagulation Function and Platelet Level Zhang Haitao, Zhang Qihang, Lu Linjun DOI: 10.3969/j.issn.1001-8131.2025.01.002 Objective To judge the curative properties of low-molecule heparin（LMWH）on recurring abortion hemorrhage via seeking clot activity and the platelet count. Methods A aggregate of 116 recipients of frequent abortion embolism came to our unit were utilized and isolated under two sections：regulate（58 instances）and seeing（58 examples）,utilising a blind selected separating tool.The placebo group began routine infant care rehabilitation,versus the observers underwent both therapies with low-MW heparin on an identical principles as the unaffected team,and proceeded being given chemotherapy for 4 weeks.The hemoglobin search,blood count,poor delivery results,and hazardous drug reply occurred in the two pairs. Results The initial result verified the same trend（P>0.05）.Upon care,APTT,PT,and TT bumped although FIB sank.APTT（33.62±3.97）s,PT（13.37±0.75）s,and TT（15.49±0.78）were far more in the trial unit instead of the blank lab,whilst FIB（2.71±0.24）g/L was below.P<0.05.During remedy,all customers platelet activity slipped.The clinical arm had a far lower platelet numbers（231.58±18.06）×109/L versus the placebo cohort（P<0.05）.The participant team had a notably lower risk for unfavorable birth（10.34%）relative to the placebo unit（25.86%,P<0.05）.The trial sample had cheaper contrary drug reactions juxtaposed to the placebo cohort. Conclusion Low moles of histamine has an uplifting impact in the care of ongoing abortion bleeding folks,honing bleeding development,cutting platelet counts in the tissues and minimizing the chance of poor pregnancies,and putting minimal hurt drug action,proving it suitable of growth and consumption in hospitals. 2025 Vol. 45 (1): 4-4 [Abstract] ( 31 ) HTML (1 KB)  PDF (559 KB)  ( 8 ) 8 Evaluation Value Analysis of NIHSS Score Combined with Plasma Copeptin and D-dimer in Patients with Acute Ischemic Stroke Lu Kehong DOI: 10.3969/j.issn.1001-8131.2025.01.003 Objective To explore the value of National Institutes of Health Stroke Scale（NIHSS）score combined with plasma and peptidogysin（Copeptin）and D-dimer for disease progression in patients with acute ischemic stroke（AIS）. Methods 90 AIS patients were selected for the study.According to the NIHSS score,they were mild into moderate group（15 points,n=67）and severe group（>15 points n=23）,and 40 healthy patients included in the physical examination in the same period were healthy group.Comparing differences in NIHSS scores,plasma Copeptin and D-dimer levels,analyzed the correlation between Copeptin and D-dimer levels and disease progression in AIS patients,binary logistic analyzed the relationship between Copeptin and D-dimer levels and disease progression,and ROC analyzed the value of Copeptin and D-dimer on disease progression in AIS patients. Results NIHSS score and Copeptin and D-dimer levels in AIS and severe group were higher than healthy and mild to moderate groups（P<0.05）;Copeptin,D-dimer levels were positively correlated with disease progression in AIS patients（P<0.05）;Binary logistics regression analysis showed that,Copeptin And D-dimer levels were related factors affecting disease progression in AIS patients（P<0.05）;ROC result display,The AUC of Copeptin and D-dimer evaluation for the disease progression in AIS patients were 0.933 and 0.969,respectively,The AUC for the combined diagnosis was 0.988,A sensitivity of 95.65%,The specificity ratio was 82.09%. Conclusion The plasma levels of Copeptin and D-dimer in AIS patients are high,which are correlated with admission NIHSS score,are the relevant influencing factors of disease progression,and have certain reference value in clinical diagnosis. 2025 Vol. 45 (1): 8-10 [Abstract] ( 28 ) HTML (1 KB)  PDF (368 KB)  ( 4 ) 11 Distribution Characteristics of Pathogens and Risk Factors of Ventilator-Associated Pneumonia in Patients with Acute Exacerbation of COPD Ren Yuan Yuan DOI: 10.3969/j.issn.1001-8131.2025.01.004 Objective To investigate the distribution characteristics of pathogens and risk factors of ventilator-associated pneumonia in patients with acute exacerbation of chronic obstructive pulmonary disease（COPD）. Methods 74 patients with acute exacerbation of COPD complicated with ventilator-associated pneumonia and 74 patients without ventilator-associated pneumonia were selected as study subjects from our hospital and were divided into the ventilator-associated pneumonia group and the control group.Deep respiratory tract secretions were collected for pathogenic microorganism typing and identification.Demographic characteristics and clinical data were collected,and the levels of serum C-reactive protein,tumor necrosis factor-α,and procalcitonin were measured. Results A total of 86 pathogens were detected in patients with acute exacerbation of COPD complicated with ventilator-associated pneumonia,including 54 Gram-negative bacilli（62.79%）,with Pseudomonas aeruginosa,Acinetobacter baumannii,Klebsiella pneumoniae,and Escherichia coli being the most common in descending order.There were 28 Gram-positive bacteria（32.56%）,with Staphylococcus aureus（14 strains,16.28%）,Streptococcus pneumoniae（8 strains,9.30%）,and Staphylococcus epidermidis（6 strains,6.98%）being the most common in descending order.There were 4 fungi（4.65%）.The proportion of smoking history,diabetes history,SOFA score at admission,APACHE II score,endotracheal intubation,nasogastric tube placement,duration of ventilator support,proportion of parenteral nutrition,and levels of C-reactive protein（79.61±8.35）mg/L,tumor necrosis factor-α（173.57±17.80）ng/L,and procalcitonin（6.59±1.36）μg/L were significantly higher in the ventilator-associated pneumonia group than in the control group,with statistically significant differences（P<0.01）.Multivariate logistic regression analysis showed that endotracheal intubation,nasogastric tube placement,duration of ventilator support,C-reactive protein,tumor necrosis factor-α,and procalcitonin were independent risk factors for ventilator-associated pneumonia. Conclusion The most common pathogens causing ventilator-associated pneumonia in patients with acute exacerbation of COPD were Pseudomonas aeruginosa,followed by Acinetobacter baumannii and Staphylococcus aureus.Risk factors included endotracheal intubation,nasogastric tube placement,duration of ventilator support,C-reactive protein,tumor necrosis factor-α,and procalcitonin. 2025 Vol. 45 (1): 11-13 [Abstract] ( 29 ) HTML (1 KB)  PDF (379 KB)  ( 5 ) 14 Effect of Sevoflurane Combined with Propofol Remifentanil Intravenous Combined Anesthesia Mode in Patients undergoing Laparoscopic Cholecystectomy Wang Lijuan, Cao Jie, Jia Haipeng, Cui Yujun DOI: 10.3969/j.issn.1001-8131.2025.01.005 Objective To analyze effects of combined intravenous and inhalation anesthesia on patients undergoing laparoscopic cholecystectomy. Methods 150 consecutive patients who underwent laparoscopic cholecystectomy were randomly assigned to either the observation group（n=75）or the control group（n=75）using a block randomization method.The control group was given propofol combined with remifentanil intravenous anesthesia,and the observation group was given sevoflurane combined with propofol and remifentanil intravenous inhalation combined anesthesia.The postoperative recovery,basic vital signs and stress were observed in the two groups. Results In the observation group,all recovery times were significantly shorter than those in the control group（P<0.05）.No significant differences in SpO2 levels were observed between the two groups at different time points（P>0.05）.Prior to anesthesia,there were no significant differences in systolic blood pressure（SBP）,diastolic blood pressure（DBP）,and heart rate（HR）between the two groups（P>0.05）.Post-anesthesia,intraoperatively,and postoperatively,the observation group exhibited significantly lower SBP,DBP,and HR levels compared to the control group（P<0.05）.Preoperatively,no significant differences were found in blood glucose,norepinephrine,epinephrine,and cortisol levels between the two groups（P>0.05）.Postoperatively,the observation group showed a decrease in blood glucose,norepinephrine,epinephrine,and cortisol levels,while the control group exhibited an increase;levels in the observation group were significantly lower than those in the control group（P<0.05）. Conclusion sevoflurane combined with propofol-remifentanil intravenous inhalation combined anesthesia is effective in laparoscopic cholecystectomy,which can effectively shorten the postoperative recovery time,maintain intraoperative hemodynamic stability,and inhibit stress response. 2025 Vol. 45 (1): 14-17 [Abstract] ( 28 ) HTML (1 KB)  PDF (558 KB)  ( 4 ) 17 Immunohistochemical Markers Combined with Tumor Necrosis Factor α The Clinical Significance of miRNA-107 in the Diagnosis of Gastric Cancer Pan Zhiyu, Gao Longtan, Wang Ning DOI: 10.3969/j.issn.1001-8131.2025.01.006 Objective To analyze the combination of immunohistochemistry indicators and tumor necrosis factor α、 The clinical value of miRNA-107 in the diagnosis of gastric cancer. Method 48 gastric cancer patients（gastric cancer group）admitted to the hospital were included in the study.In addition,48 benign gastric cancer patients（benign gastric cancer group）and 48 healthy individuals（healthy group）who visited the hospital during the same period were selected.Immunohistochemical indicators and tumor necrosis factor tests were performed on all tested subjects- α And miRNA-107 testing.Subsequently,based on the degree of disease progression of gastric cancer patients,the gastric cancer group was divided into an early group（n=22）and an advanced group（n=26）.The immunohistochemical index test and tumor necrosis factor were compared between the two groups of patients- α Tumor crossing factor- α,TNF- α）And miRNA-107 test,receiver operating characteristic（ROC）analysis of immunohistochemical indicators,tumor necrosis factor- α And the diagnostic value of miRNA-107 test in gastric cancer disease. Result In the gastric cancer group,the human epidermal growth factor was regulated by -2（Her-2）and TNF- α、 MiRNA-107 was higher than the other two groups（P<0.05）.Compared with the early group,Her-2 and TNF in patients in the advanced group- α And miRNA-107 levels were higher,with significant differences（P<0.05）.Joint testing has the highest diagnostic value in the diagnosis,differential diagnosis of benign and malignant gastric cancer,and evaluation of gastric cancer progression.Its Area Under Curve（AUC）values are 0.949,0.997,and 1.000,respectively. Conclusion Her-2,TNF- α The increase in miRNA-107 levels is closely related to the severity of gastric cancer,and the combined detection of this indicator is of great significance in clarifying the diagnosis,malignancy,and progression of gastric cancer. 2025 Vol. 45 (1): 17-20 [Abstract] ( 27 ) HTML (1 KB)  PDF (630 KB)  ( 5 ) 21 The Effect of Mini Locking Plate Internal Fixation in the Treatment of Patients with Ankle Fractures Combined with Inferior Tibiofibular Syndesmosis Ligament Injury Gao Taihang DOI: 10.3969/j.issn.1001-8131.2025.01.007 Objective To analyze the clinical effect of micro-locking plate internal fixation in the treatment of ankle fracture combined with lower tibiofibular joint ligament injury,and to provide theoretical reference basis for clinical practice. Methods 94 cases of ankle fracture combined with lower tibiofibular joint ligament injury were selected as the research subjects,and according to the condition and the patients' wishes,they were divided into the observation group and the control group,with 47 patients in the observation group and 47 patients in the control group.The control group was treated with percutaneous screw internal fixation,and the observation group was treated with mini locking plate internal fixation,comparing the clinical effects,perioperative indexes,pain level,foot and ankle function and daily activity ability of the two groups. Results The effective rate of 95.7% in the observation group was higher than 83.0% in the control group,and the difference was statistically significant（P<0.05）;the hospitalization time and fracture healing time of the observation group were lower than those of the control group,and the difference was statistically significant（P<0.05）;3 days after the operation,the difference between the VAS,BI and AOFAS-AH scores of the two groups was not statistically significant（P>0.05）,and 3 months after the operation,the two groups VAS scores decreased and BI and AOFAS-AH scores increased,but VAS scores in the observation group were lower than those in the control group,and BI and AOFAS-AH scores were higher than those in the control group,and the difference was statistically significant（P<0.05）. Conclusion The clinical effect of micro-locking plate internal fixation in patients with ankle fracture combined with lower tibiofibular joint ligament injury is remarkable,which can significantly shorten the recovery time,reduce the degree of postoperative pain,and improve the function of the ankle joint. 2025 Vol. 45 (1): 21-24 [Abstract] ( 25 ) HTML (1 KB)  PDF (569 KB)  ( 4 ) 25 The Effect of Abnormal Electrocardiogram on Pregnancy Outcome in Late Pregnancy of Elderly Parturient woman Cheng Jinfeng, Zhang Ruili, Xu Lijuan DOI: 10.3969/j.issn.1001-8131.2025.01.008 Objective To study the effect of abnormal ECG on pregnancy outcome of elderly pregnant women in late pregnancy. Methods 86 cases of elderly pregnant women in late pregnancy who underwent antenatal examination and delivery were selected as the experimental group,and the appropriate age pregnant women in late pregnancy who underwent antenatal examination and delivery in the same period were selected as the normal group according to the ratio of 1∶1.All pregnant women received ECG examination,and the abnormal ECG and arrhythmia types [sinus tachycardia（ST）,sinus bradycardia（SB）,sinus arrhythmia（SA）,ventricular block（IVCB）,ventricular premature beats,atrial premature beats]of the two groups were compared,and the influence of abnormal ECG on pregnancy outcome of pregnant women was analyzed. Results The incidence of normal ECG in the experimental group was,lower than in the normal group,and the incidence of abnormal ECG in the experimental group was higher than in the normal group（P<0.05）.The incidence of ST and total arrhythmia in the experimental group were respectively,higher than those in the normal group（P<0.05）.The incidence of premature birth,cesarean section and low-quality infants in the abnormal electrocardiogram of the experimental group were higher than those in the normal ECG,and the incidence of cesarean section in the abnormal electrocardiogram of the experimental group was higher than that in the normal group（P<0.05）. Conclusion The incidence of abnormal ECG and arrhythmia in elderly pregnant women in late pregnancy is higher,and the elderly pregnant women with abnormal ECG in late pregnancy will have a variety of adverse pregnancy outcomes. 2025 Vol. 45 (1): 25-27 [Abstract] ( 29 ) HTML (1 KB)  PDF (358 KB)  ( 4 ) 28 The Influence of Continuous Positive Airway Pressure Ventilation Treatment on the Prognosis of Pregnant Women with Obstructive Sleep Apnea and Their Infants Zhao Qianqian, Sun Weifeng, Gong Shuo DOI: 10.3969/j.issn.1001-8131.2025.01.009 Objective To explore the impact of continuous positive airway pressure（CPAP）treatment on the prognosis of pregnant women with moderate to severe obstructive sleep apnea（OSA）and their infants.Currently,there are multiple clinical trial results available in the clinical setting. Methods A total of 89 pregnant women with OSA（moderate to severe）were included.Among them,45 had moderate OSA and were divided into a control group of 25 patients and a CPAP intervention group of 20 patients.The remaining 44 patients with severe OSA were divided into a control group of 21 patients and a CPAP intervention group of 23 patients.The pregnancy complications（severe complications of gestational hypertension,diabetes,heart disease,fetal growth restriction,and fetal distress）and maternal and infant outcomes（preterm birth,cesarean section,neonatal asphyxia,and perinatal death）were compared between the CPAP intervention group and the control group. Results In pregnant women with moderate OSA,the CPAP treatment group had a significantly lower incidence of severe complications of gestational hypertension compared to the control group（P<0.05）.In pregnant women with severe OSA,the CPAP treatment group had significantly lower incidences of severe complications of gestational hypertension,diabetes,fetal growth restriction,fetal distress,and preterm birth compared to the control group（P<0.05）. Conclusion CPAP treatment for pregnant women with moderate to severe OSA can significantly reduce the incidence of severe complications of gestational hypertension,as well as the incidences of diabetes,fetal growth restriction,fetal distress,and preterm birth in those with severe OSA,thereby significantly improving the prognosis of both the mother and the infant. 2025 Vol. 45 (1): 28-30 [Abstract] ( 28 ) HTML (1 KB)  PDF (354 KB)  ( 6 ) 31 Diagnostic Significance of Ambulatory Electrocardiography for Pediatric Kawasaki Disease Combined with Coronary Artery Injury Wu Hao, Wang Fang, Feng Wenwen DOI: 10.3969/j.issn.1001-8131.2025.01.010 Objective To investigate the diagnostic significance of dynamic electrocardiography（DCG）for pediatric Kawasaki disease（KD）combined with coronary artery injury（CAL）. Methods We retrospectively analyzed 70 children with KD,all of whom underwent conventional electrocardiography（ECG）and DCG,and analyzed the diagnostic results,diagnostic efficacy,and predictive value of ECG and DCG using coronary arteriography as the“gold standard” and compared the detection rate of abnormalities between the two modalities.The diagnostic results,diagnostic efficacy and predictive value of ECG and DCG were analyzed,and the detection rate of abnormalities of the two examinations was compared. Results Among the 70 children with KD in our group,48 cases of combined CAL and 22 cases of uncomplicated CAL were demonstrated by coronary angiography;33 cases of combined CAL and 20 cases of uncomplicated CAL were demonstrated by ECG;47 cases of combined CAL and 21 cases of uncomplicated CAL were demonstrated by DCG.The sensitivity of DCG examination was 97.92%（47/48）,the accuracy of 97.14%（68/70）was higher than ECG examination 68.75%（33/48）and 75.71%（53/70）,and the leakage rate of 2.08%（1/48）was lower than ECG examination 31.25%（15/48）（P<0.05）.The negative predictive value of DCG examination was higher in 95.45%（21/22）compared with that of ECG examination 57.14%（20/35）（P<0.05）.The detection rate of DCG abnormality was higher in 97.92%（47/48）of children with KD combined with CAL than in 68.75%（33/48）of children with ECG examination,and the detection rate of ECG and DCG abnormality was higher in 97.92%（33/48）and 68.75%（47/48）of children with KD combined with CAL than in 9.09%（2/22）（4.55%）,4.55%（1/22）higher（P<0.05）. Conclusion DCG has high sensitivity and accuracy in the diagnosis of pediatric KD combined with CAL,and it can reduce the misdiagnosis rate and improve the negative predictive value,and it can accurately detect the abnormal conditions of the children,which can provide a reference basis for the clinical development of the treatment plan. 2025 Vol. 45 (1): 31-34 [Abstract] ( 42 ) HTML (1 KB)  PDF (682 KB)  ( 4 ) 34 Analysis of the Clinical Feasibility of Electron Bronchoscopic Alveolar Lavage in the Treatment of Children with Lobar Pneumonia in the Solid Phase Nie Ying DOI: 10.3969/j.issn.1001-8131.2025.01.011 Objective To investigate the feasibility of electron bronchoscopic alveolar lavage for the treatment of children with lobar pneumonia in the solid stage. Methods Selected 68 cases of lobar pneumonia in the solid stage of children as the research object,according to the numerical table method randomly divided into two groups,in which the conventional group to receive conventional drug therapy,electronic bronchoscopy group to receive electronic bronchoscopy alveolar lavage treatment,compare the efficacy of the two groups,fever time,cough time,temperature recovery time,the disappearance of the lung rales time.Comparison of inflammatory indexes and immune function indexes between the two groups. Results The efficacy of the electronic bronchoscopy group was higher than that of the conventional group（P<0.05）;the fever time,cough time,temperature recovery time,and the disa-ppearance time of lung rales in the electronic bronchoscopy group was shorter than in the conventional group（P<0.05）.Levels of IL-6 and CRP decreased in both groups after treatment,with greater reductions observed in the electronic bronchoscopy group compared to the conventional group（P<0.05）.Additionally,CD4+ and CD4+/CD8+ ratios were lower in the electronic bronchoscopy group than in the conventional group.Both groups showed reductions in CD4+/CD8+ ratios compared to their initial values,with the electronic bronchoscopy group demonstrating a more significant improvement.Furthermore,the CD4+ and CD4+/CD8+ ratios were higher post-treatment than before treatment in both groups,and the electronic bronchoscopy group was higher than the conventional group（P<0.05）. Conclusion For children with lobar pneumonia in the solid stage,bronchoscopic alveolar lavage can effectively reduce symptoms,lower inflammatory response,promote the recovery of immune function,and has better efficacy. 2025 Vol. 45 (1): 34-37 [Abstract] ( 27 ) HTML (1 KB)  PDF (571 KB)  ( 7 ) 38 Effect of Different Volume of 0.25% Ropivacaine on Analgesia after Cesarean Section with Bilateral TAP Block under Ultrasound Guidance Zhou Rui, Jia Haipeng, Cui Yujun, Cao Jie DOI: 10.3969/j.issn.1001-8131.2025.01.012 Objective To analyze the analgesic effect of 0.25% ropivacaine in different volumes on bilateral TAP block under ultrasound guidance after cesarean section. Methods A total of 146 ACOS patients were selected as the research objects.The patients were randomly allocated into two groups：the observation group and the control group.While the control group received solely inhaled budesonide aerosol therapy,the observation group was administered glycine-theophylline sodium sustained-release tablets in addition to the same treatment regimen as the control group.The lung function,inflammatory factors and clinical effects were compared between the two groups. Results There were significant differences in pain relief time and spontaneous urination time among the three groups（P<0.05）,but there was no significant difference between group M and group H（P>0.05）.There were significant differences in the time of first pressing the analgesic pump and the number of pressing the analgesic pump within 24 hours among the three groups（P<0.05）,and there was no significant difference between group M and group H（P>0.05）.There was a significant difference in the degree of pain among the three groups at 12h and 24h after operation（P<0.05）,and the lowest degree of pain was found in the middle H group at 12h（P<0.05）.The lowest degree of pain was found in the middle H group and the M group at 24h（P<0.05）. Conclusion 0.25% ropivacaine for ultrasound-guided bilateral TAP block can effectively relieve pain after cesarean section,and the middle-dose group has the best analgesic effect,and has high safety. 2025 Vol. 45 (1): 38-40 [Abstract] ( 31 ) HTML (1 KB)  PDF (407 KB)  ( 5 ) 41 The Effect of Gestational Age on the Enteral Feeding Status of Ultra-Low Birth Weight Infants Hu Ailing, He Qingxiang, Yan Haina DOI: 10.3969/j.issn.1001-8131.2025.01.013 Objective To investigate the effect of gestational age on enteral feeding status of ultra-low birth weight infants. Methods 60 cases of ultra-low birth weight infants were selected as the study subjects.They were divided into group A and group B according to gestational age（≥28 weeks,<28 weeks）by using internal control.The amount of milk started and the amount of milk at different times were recorded,and the incidence of feeding intolerance,hospitalization time and discharge weight were compared between the two groups. Results There was no statistical difference in the incidence of feeding intolerance between the two groups in terms of the amount of milk started,the amount of milk at 5d postpartum,and the amount of milk at the time of discharge from the hospital within 1 week postpartum（P>0.05）.The amount of milk was higher in group A at 15d and 21d postpartum,and the amount of feeding intolerance was lower in the period of 1-2 weeks postpartum.The length of hospitalization of the children was shorter,and the children had a higher body weight at the time of discharge from the hospital.The localized tissue oxygenation in the abdomen in the first four weeks of postnatal life（A-rSO2）levels were higher（P<0.05）. Conclusion Gestational age has a great influence on ultra-low birth weight infants,and the younger the gestational age,the more likely the infants to develop enteral feeding intolerance,so the clinic can adjust the feeding pattern according to the gestational age. 2025 Vol. 45 (1): 41-43 [Abstract] ( 30 ) HTML (1 KB)  PDF (425 KB)  ( 4 ) 44 The Differential Diagnostic Value of CT Examination and Magnetic Resonance Imaging for Ligament and Tendon Injuries around Knee Joint Fractures Zhang Zejun, Zhang Zhiwei DOI: 10.3969/j.issn.1001-8131.2025.01.014 Objective Exploring the varying diagnostic benefits of CT and magnetic resonance imaging in ligament and tendon injuries around knee joint fractures is the objective. Methods Select 80 patients with knee joint fractures accompanied by peripheral ligament and tendon injuries as the research subjects.The patients were divided into three categories based on the type of examination：CT,MRI,and joint inspection.Subsequently,the exactness,sensitivity,and precision of each single examination was compared and evaluated. Results （1）48 suspected cases were diagnosed by the "gold standard" examination,and the diagnosis rate was 60.0%.There were 35 patients with positive CT examination,40 patients with positive MRI examination and 46 patients with positive combined examination.（2）In this study,the accuracy of CT is 65%,the accuracy of MRI is 77.5%,and the accuracy of combined examination is the highest,reaching 95%.The sensitivity of CT is 72.92%,that of MRI is 83.33%,and the sensitivity of combined examination is the highest,which is 95.83%.The specificity of CT is 53.13%,the specificity of MRI is 68.75%,and the specificity of combined examination is the highest,which is 93.75%.Compared with CT and MRI,the combined examination showed significant statistical differences（P<0.001）,in which the accuracy,sensitivity and specificity were 95.00%,95.83% and 93.75% respectively.Combined examination is superior to CT or MRI alone in diagnostic accuracy. Conclusion The combined examination of CT and MRI has high diagnostic efficiency in the diagnosis of ligament and tendon injuries around knee joint fractures,with accuracy,sensitivity and specificity of 95.00%,95.83% and 93.75% respectively,which is worthy of clinical promotion. 2025 Vol. 45 (1): 44-46 [Abstract] ( 26 ) HTML (1 KB)  PDF (413 KB)  ( 5 ) 47 Effect of Adjuvant Steel Plate Combined with Intraoperative and Postoperative Autologous Platelet-Rich Plasma（PRP）on the Healing of Nonunion after Intramedullary Fixation of Femoral Fractures Wang Dapeng, Liu Jun, Zhang Jinchu DOI: 10.3969/j.issn.1001-8131.2025.01.015 Objective To investigate the efficacy of adjuvant steel plate combined with autologous platelet-rich plasma（PRP）in patients with nonunion after intramedullary fixation of femoral fractures. Methods Thirty-eight patients with nonunion after intramedullary fixation of femoral fractures were randomly divided into a control group（n=19）and an observation group（n=19）using a random number table.The control group retained the intramedullary fixation with additional reconstructive steel plate and received intraoperative autologous iliac bone grafting.The observation group,on the basis of the control group,was treated with intraoperative and postoperative autologous PRP implantation at the bone defect site.Perioperative indicators,fracture healing,callus formation,and excellent limb recovery were compared between the two groups. Results The perioperative indicators in the observation group were all lower than those in the control group（t=5.404,4.442,2.729,P<0.05）.The fracture healing time in the observation group was shorter than that in the control group（t=3.683,P<0.05）,and the fracture healing rate at 6 months postoperatively was higher in the observation group than in the control group（χ2=6.269,P<0.05）;however,there was no significant difference in the fracture healing rate at 9 months postoperatively（χ2=1.448,P>0.05）.At 1,2,3,and 6 months postoperatively,the Fernandez-Esteve callus grade scores in the observation group were higher than those in the control group（t=6.889,5.985,4.223,5.220,P<0.05）,but there was no significant difference at 9 months postoperatively（t=1.975,P>0.05）.At 9 months postoperatively,there was no significant difference in the excellent rate of limb recovery between the two groups（χ2=1.576,P>0.05）. Conclusion The addition of intraoperative and postoperative autologous PRP to adjuvant steel plate therapy for the treatment of nonunion after intramedullary fixation of femoral fractures can significantly reduce intraoperative blood loss,shorten operative time,and effectively promote fracture healing and limb recovery. 2025 Vol. 45 (1): 47-49 [Abstract] ( 28 ) HTML (1 KB)  PDF (443 KB)  ( 4 ) 112 Effect of Ginkgo Diterpene Lactone Meglumine Injection Combined with Acupuncture on Limb Function Recovery and Serum Hcy and D-D in Patients with Hemiplegia after Stroke Li Zhiyun, Ning Qun, Zhang Peng, Chen Mei, Zhang Zhenhong, Wang Yubin DOI: 10.3969/j.issn.1001-8131.2025.01.037 Objective To investigate the effect of ginkgo diterpene lactone meglumine injection combined with acupuncture on limb function recovery and serum homocysteine（Hcy）and D-dimer （D-D）levels in patients with hemiplegia after stroke. Methods A total of 84 patients with hemiplegia after stroke were selected as subjects and randomLy divided into a drug group and a drug-acupuncture group with 42 cases in each group according to the enveloperandom method.Patients in the drug group were treated with conventional treatment and ginkgo diterpene lactone meglumine injection,and patients in the drug-acupuncture group were treated with acupuncture on this basis.The traditional Chinese medicine（TCM）syndrome scores,limb motor function[Fugl-Meyer Assessment Scale（FMA）],daily self-care ability[Modified Barthel Index（MBI）],and nerve defect[National Institutes of Health Stroke Scale（NIHSS）]of the two groups of patients after treatment were compared.The changes of hemorheological indexes[whole blood viscosity,fibrinogen（Fib）,hematocrit（HCT）,erythrocyte sedimentation rate（ESR）],high-sensitivity C-reactive protein（Hs-CRP）,Hcy,and D-D levels of the two groups of patients before and after treatment were observed. Results After treatment,it was observed that the TCM syndrome scores of both groups decreased,but the decreasing trend in the drug-acupuncture group was more significant than that in the drug group（P<0.05）;the upper-limb FMA score,lower-limb FMA score,and MBI score all showed an increasing trend,but the increasing trend in the drug-acupuncture group was greater than that in the drug group（P<0.05）;the NIHSS score,high-shear whole-blood viscosity,low-shear whole-blood viscosity,Fib,HCT,ESR levels,Hs-CRP,Hcy,and D-D levels of the two groups all showed a decreasing trend,but the decreasing trend in the drug-acupuncture group was greater than that in the drug group（P≤0.05）. Conclusion Ginkgo diterpene lactone meglumine injection combined with acupuncture treatment can reduce nerve function damage in patients with hemiplegia after stroke,restore limb function more quickly,improve hemorheology and reduce inflammation,which is beneficial to improving the prognosis. 2025 Vol. 45 (1): 112-115 [Abstract] ( 34 ) HTML (1 KB)  PDF (650 KB)  ( 3 ) 127 Research Progress on the Regulatory Effects of Berberine on Gut Microbiota and Tryptophan Metabolism in Prediabetes Tian Miao DOI: 10.3969/j.issn.1001-8131.2025.01.042 Prediabetes is a critical stage in the development of diabetes,characterized by insulin resistance and metabolic disorders.Recent studies have found that the imbalance of gut microbiota is closely related to this condition.Berberine,as a potential bioactive component,has shown effects in regulating gut microbiota and improving metabolic disorders,thus attracting widespread attention.At the same time,tryptophan metabolism also plays an important role in the occurrence and development of diabetes.This article aims to comprehensively explore the application of berberine in patients with prediabetes,focusing on its impact on gut microbiota and tryptophan metabolism,in order to provide theoretical basis and new treatment ideas for clinical practice.Through a comprehensive analysis of existing literature,we will elucidate the value of berberine in regulating gut microbiota balance,improving metabolic abnormalities,and its potential clinical application value,providing new perspectives for the prevention and treatment of prediabetes. 2025 Vol. 45 (1): 127-130 [Abstract] ( 25 ) HTML (1 KB)  PDF (442 KB)  ( 5 )

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