Effects of Different Anesthesia Methods on Perioperative Neurocognitive Disorders and Inflammatory Factor IL-6 in Elderly Patients Undergoing Total Hip Replacement
Wu Xianping, Yang Yanping, Chen Xian, Wu Yanfang, Jiang Ying
Shunde Hospital of Guangzhou University of Chinese medicine, Foshan 528300, China
Abstract：Objective To study the effects of different anesthesia methods on perioperative neurocognitive disorders（PND）and inflammatory factors in elderly patients undergoing total hip replacement. Methods 72 patients with total hip replacement were randomly divided into general anesthesia group and peripheral nerve block group according to different anesthesia methods.The cognitive function of patients was measured by MMSE score 24 hours before operation（T0）,24 hours after operation（T1）,1 week after operation（T2）,1 month after operation（T3）,3 months after operation（T4）and half a year after operation（T5）.The expression level of serum IL-6 factor was measured by venous blood from patients at T0,T1 and T2.Adverse reactions such as agitation,nausea,vomiting and vertigo were recorded. Results Compared with the general anesthesia group,IL-6 in the peripheral nerve block group decreased significantly at 24 hours（T1）and 1 week（T2）after operation,and MMSE score increased significantly at the same time（P<0.05）;Among them,4 patients in the general anesthesia group developed PND at 24 hours（T1）and 1 week（T2）after operation,and 2 patients still had PND at 1 month（T3）and 3 months（T4）,while there was no PND in the peripheral nerve block group.The incidence of nausea and vomiting after general anesthesia was significantly lower than that after general anesthesia（P<0.05）. Conclusion Different anesthesia methods have different effects on postoperative cognitive function and inflammatory factors in elderly patients undergoing total hip replacement.Peripheral nerve block can reduce the occurrence of perioperative neurocognitive disorder.
2022, Vol. 42 
