急性脑梗死偏瘫患者干预后脑血流量和血清NT-3、BDNF水平与功能恢复的关系

doi:10.3969/j.issn.1001-8131.2024.01.002

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摘要目的探讨急性脑梗死偏瘫患者干预后脑血流量和血清神经营养因子-3（NT-3）、脑源性神经营养因子（BDNF）水平与功能恢复的关系。方法选取ACI患者60例,入院后均行常规治疗（抗凝、抗血小板、调脂、清除氧自由基和活血化瘀）和综合康复治疗,持续干预4周。比较患者治疗前、后脑血流量[大脑前动脉（ACA）、大脑中动脉（MCA）]、血清NT-3、BDNF水平和功能恢复[神经功能评价量表（NIHSS）、Fugl-Meyer运动功能量表（FMA）]水平。结果治疗后急性脑梗死偏瘫患者ACA水平和MCA水平均高于治疗前（P<0.05）。治疗后急性脑梗死偏瘫患者血清NT-3水平低于治疗前,BDNF水平高于治疗前（P<0.05）。治疗后急性脑梗死偏瘫患者NIHSS评分低于治疗前,FMA评分高于治疗前（P<0.05）。ACA、MCA、BDNF与NIHSS评分呈负相关,与FMA评分呈正相关（P<0.05）。NT-3与NIHSS评分呈正相关,与FMA评分呈负相关（P<0.05）。结论急性脑梗死偏瘫患者干预后脑血流量和血清NT-3、BDNF水平有明显改善,可以较好反映患者肢体功能与运动功能的恢复水平。

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关键词 ：急性脑梗死偏瘫, 脑血流量, 血清脑源性神经营养因子, 血清神经营养因子-3, 肢体运动功能, 认知功能

Abstract：Objective To explore the relationship between cerebral blood flow,serum neurotrophic factor-3（NT-3）,brain-derived neurotrophic factor（BDNF）and functional recovery in patients with acute cerebral infarction（ACI）and hemiplegia after intervention. Methods A total of 60 patients with ACI admitted to the hospital.After admission,all underwent routine treatments（anti-coagulation,anti-platelet,lipid regulation,removal of oxygen free radicals,promoting circulation and removing stasis）and comprehensive rehabilitation therapy.After 4 weeks of continuous intervention,cerebral blood flow [anterior cerebral artery（ACA）,middle cerebral artery（MCA）],levels of serum NT-3 and BDNF,and functional recovery [National Institutes of Health Stroke Scale（NIHSS）,Fugl-Meyer Assessment Scale（FMA）] were compared before and after treatment. Results After treatment,cerebral blood flow of ACA and MCA was increased（P<0.05）.After treatment,level of serum NT-3 was decreased,while BDNF level was increased（P<0.05）.After treatment,NIHSS score was decreased,while FMA score was increased（P<0.05）.ACA,MCA and BDNF were negatively correlated with NIHSS score,while positively correlated with FMA score（P<0.05）.NT-3 was positively correlated with NIHSS score,while negatively correlated with FMA score（P<0.05）. Conclusion The cerebral blood flow,levels of serum NT-3 and BDNF significantly improve in patients with acute cerebral infarction and hemiplegia after intervention,which can better reflect the recovery level of limb function and motor function.

Key words： Acute cerebral infarction and hemiplegia Cerebral blood flow Serum brain-derived neurotrophic factor Serum neurotrophic factor-3 Limb motor function Cognitive function

收稿日期: 2022-12-23

PACS:

R722.15

引用本文:

邓星明. 急性脑梗死偏瘫患者干预后脑血流量和血清NT-3、BDNF水平与功能恢复的关系[J]. 哈尔滨医药, 2024, 44(1): 8-10.
Deng Xingming. Relationship Between Cerebral Blood Flow,Serum NT-3,BDNF and Functional Recovery in Patients with Acute Cerebral Infarction and Hemiplegia after Intervention. journal1, 2024, 44(1): 8-10.

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http://www.hrbyybjb.org.cn/CN/10.3969/j.issn.1001-8131.2024.01.002 或 http://www.hrbyybjb.org.cn/CN/Y2024/V44/I1/8

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