Research Status and Prospects of the Association Between Systemic Autoimmune Diseases and Cervical Lesions
Subinuer·Abulimiti1, Han Lili2, *
1. Graduate School of Xinjiang Medical University,Urumqi,Xinjiang, 830054,China; 2. Department of Obstetrics and Gynecology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi,Xinjiang, 830001,China
Abstract：Systemic Autoimmune Diseases(SADs)are a group of disorders caused by abnormal autoimmune responses.In recent years,research on their intersection with gynecological diseases has become increasingly active.It has been observed that patients with SADs exhibit a higher incidence of cervical lesions,suggesting a potentially complex pathophysiological link between the two.Current studies in this field focus on epidemiological characteristics,immunological mechanisms,and clinical manifestations,though disagreements and knowledge gaps remain.This article reviews recent advances,explores how immune dysregulation affects the cervical epithelial microenvironment and immune surveillance mechanisms potentially promoting the development of cervical lesions and summarizes existing diagnostic and therapeutic approaches.It aims to provide a theoretical foundation for clinical research and offers perspectives on future directions to facilitate early detection and precision treatment of cervical lesions in patients with SADs.
苏比努尔·阿不力米提, 韩莉莉. 系统性免疫性疾病与宫颈病变关联的研究现状与展望[J]. 哈尔滨医药, 2026, 46(1): 139-141.
Subinuer·Abulimiti, Han Lili. Research Status and Prospects of the Association Between Systemic Autoimmune Diseases and Cervical Lesions. journal1, 2026, 46(1): 139-141.
[1] David E,Belot A,Lega JC,et al.Human papillomavirus and systemic lupus erythematosus[J].Rev Med Interne,2021,42(7):498-504. [2] 洪丹丹,商婷婷,郭红玉,等.基于“伏邪理论”探讨Toll样受体在宫颈高危型人乳头瘤病毒持续感染中的作用[J].中国中药杂志,2025,50(7):1974-1979. [3] Dominoni M,Barcellini A,Pasquali MF,et al.The Role of Neutrophil-Lymphocytes Ratio in the Prognosis of CIN2+ Recurrence after Excisional Treatment[J].Gynecol Obstet Invest,2024,89(4):295-303. [4] He Z,Du C.Vitamin D,immune microenvironment,and cer-vical lesions:mechanisms and therapeutic strategies from polyps to carcinoma[J].Front Nutr,2025,12:1688910. [5] Moscicki AB,Flowers L,Huchko MJ,et al.Updated Review for Guidelines for Cervical Cancer Screening in Immuno-suppressed Women Without HIV Infection[J].Journal of Lower Genital Tract Disease,2025,29(2):168-179. [6] Dellino M,Cerbone M,Fortunato F,et al.Incidence of pre-neoplastic and neoplastic lesions of the cervix before and after the COVID-19 pandemic[J].Int J Gynecol Cancer,2024,4(2):224-228. [7] Mochizuki T,Otani N,Ando M,,et al.Imaging using di-ffusion-weighted whole-body imaging with background signal suppression for methotrexate-associated lymphopro-liferative disorder:A case report[J].Mod Rheumatol Case Rep.Imaging using di-ffusion-weighted whole-body imaging with background signal suppression for methotrexate-associated lymphopro-liferative disorder:A case report[J].Mod Rheumatol Case Rep,2025,9(2):rxae078. [8] Dujardin C,Balcaen T,Vanoost A,et al.Risk factors for high-grade squamous intraepithelial lesions or cervical cancer in chronic inflammatory bowel disease[J].Gynecol Obstet Fertil Senol,2024,52(7-8):460-465. [9] Vaheb S,Rajaei Z,Shaygannejad V,et al.The association between information processing speed and clinical features in people with multiple sclerosis and neuromyelitis optica:a comparative study[J].Neurol Sci,2025,46(8):3783-3795. [10] Ghosh Md R,Roy D,León-Ruiz M,et al.Seropositive Neuromyelitis Optica in a Case of Undiagnosed Anky-losing Spondylitis:A Neuro-Rheumatological Conun-drum[J].Qatar Med J,2022,2022(3):29. [11] Chen S,Liang XL,He S,et al.Encephalitis in Kikuchi-Fujimoto disease being immune-mediated[J].Neurol Sci,2022,43(6):3983-3987. [12] Boudes M,Venard V,Routiot T,et al.Prevalence and Dis-tribution of HPV Genotypes in Immunosuppressed Patients in Lorraine Region[J].Viruses,2021,13(12). [13] Chen M,Cui Q,Chen M,et al.Risk of human papill-omavirus infection and cervical intraepithelial lesions in Chinese renal transplant recipients[J].Front Oncol,2022,12:905548. [14] Swase TD,Fasogbon IV,Eseoghene IJ,et al.The impact of HPV/HIV co-infection on immunosuppression,HPV genotype,and cervical cancer biomarkers[J].BMC Cancer,2025,25(1):202. [15] Li J,Xu X,Liu X,Zeng T,Zhang L,Zheng Q.Anti-inflammatory effects and related mechanisms of narin-genin in human periodontal ligament stem cells under lipopolysaccharide stimulation based on RNA sequen-cing[J].华西口腔医学杂志,2024,42(4):512-520. [16] Yu L,Chen X,Liu X,et al.Significance of Triple Detection of p16/ki-67 Dual-Staining,Liquid-Based Cytolo-gy and HR HPV Testing in Screening of Cervical Cancer:A Retrospective Study[J].Front Oncol,2022,12:915418. [17] Fei M,Yu Y,Hu X,Xu H,Liu F.The Value of Immunocytochemical Staining for the HPV E7 Protein in the Diagnosis of Cervical Lesions[J].Int J Gen Med,2023,16:1081-1089. [18] 李翔,贺斯黎,赵行平,等.高危型人乳头瘤病毒感染患者宫颈脱落细胞JAM3/PAX1高甲基化诊断宫颈高级别病变[J].中南大学学报(医学版),2023,48(12):1820-1829. [19] Peng G,Dong H,Liang T,Li L,Liu J.Diagnosis of cervical precancerous lesions based on multimodal feature changes[J].Comput Biol Med,2021,130:104209. [20] Ivanova Y,Kornovski Y,Kostov S,et al.Prognostic factors for low-and high grade squamous intraepithelial lesions in histological preparations following LLETZ procedure[J].Wiad Lek,2024,77(8):1562-1568. [21] Tsai YH,Lu JW,Tu JI,et al.Molecular Hydrogen as an Adjuvant Therapy in Comorbid Sj?gren's Syndrome,SLE,and ILD:A Case Report on Immune Modulation and Fatigue Reduction[J].In Vivo,2025,39(4):2228-2235. [22] Graüa J,Preti M,Pollano B,et al.Performance of Different Follow-Up Strategies and Genotype-Based Recurrence Risk After Treatment of Cervical High-Grade Squamous Intraepithelial Lesion[J].J Low Genit Tract Dis,2024,28(2):131-136.
2026, Vol. 46 
