卡瑞利珠单抗联合SP化疗方案治疗局部晚期食管癌临床疗效及对细胞免疫、预后的影响

doi:10.3969/j.issn.1001-8131.2026.02.004

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摘要目的探讨卡瑞利珠单抗联合替吉奥+顺铂（SP）化疗方案治疗局部晚期食管癌临床疗效及对细胞免疫功能、预后的影响。方法选取2021年3月至2024年6月于焦作市第二人民医院就诊的202例局部晚期食管癌患者,按随机数字表法分为对照组（101例,实施SP化疗方案）与观察组（101例,实施卡瑞利珠单抗联合SP化疗方案）。比较两组临床疗效、血清肿瘤标志物（CEA、CA19-9、CYFRA21-1及SCC）、T淋巴细胞亚群水平和不良反应发生率。结果观察组客观缓解率（ORR）与疾病控制率（DCR）均高于对照组（P<0.05）;观察组的CEA、CA19-9、CYFRA21-1、SCC水平均低于对照组（P<0.05）;观察组外周血CD3⁺、CD4⁺、CD4⁺/CD8⁺均高于对照组（P<0.05）,而观察组外周血CD8⁺低于对照组（P<0.05）。两组不良反应发生率差异无统计学意义（P>0.05）。随访1年,观察组患者累积生存率高于对照组（Log-rank χ²=9.221,P=0.002）。结论卡瑞利珠单抗与SP方案的联合疗法通过下调肿瘤指标并激活机体免疫能力,可改善晚期食管癌患者治疗效果和患者生存状况。

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	付培彪
	陈彦民
	王珍珍
	张彦彦
	郑辉辉

关键词 ：晚期食管癌, SP化疗, 卡瑞利珠单抗, 细胞免疫, 预后

Abstract：Objective To explore clinical curative effect of camrelizumab combined with S-1 plus cisplatin(SP)chemotherapy in advanced esophageal cancer and its influences on cellular immune function and prognosis. Methods A total of 202 patients with advanced esophageal cancer treated in The Second People's Hospital of Jiaozuo were enrolled between March 2021 and June 2024.According to random number table method,they were divided into control group(101 cases,SP chemotherapy regimen)and observation group(101 cases,camrelizumab combined with SP chemotherapy regimen).The clinical curative effect,serum tumor markers(CEA,CA19-9,CYFRA21-1,SCC),T lymphocyte subsets(CD3⁺,CD4⁺,CD8⁺)and the occurrence of adverse reactions were compared between the two groups. Results After treatment,objective response rate(ORR)and disease control rate(DCR)in observation group were and（P<0.05）,higher than those in control group.The levels of CEA,CA19-9,CYFRA21-1 and SCC in observation group were（P<0.05）,lower than those in control group The levels of peripheral blood CD3⁺,CD4⁺ and CD4⁺/CD8⁺ in observation group were higher than those in control group（P<0.05）,while CD8⁺ was lower than that in control group.The differences in all the above indexes between the two groups were statistically significant(P<0.05).In terms of safety,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After 1 year of follow-up,cumulative survival rate in observation group was higher than that in control group(Log-rank χ²=9.221,P=0.002). Conclusion The combination therapy of camrelizumab and SP regimen can significantly improve curative effect and survival status in patients with advanced esophageal cancer by significantly down-regulating tumor indexes and activating immune function.

Key words： Advanced esophageal cancer SP chemotherapy Camrelizumab Cellular immunity Prognosis

收稿日期: 2026-02-15

PACS:

R735.1

基金资助:河南省医学科技攻关计划项目（LHGJ20221012）

引用本文:

付培彪, 陈彦民, 王珍珍, 张彦彦, 郑辉辉. 卡瑞利珠单抗联合SP化疗方案治疗局部晚期食管癌临床疗效及对细胞免疫、预后的影响[J]. 哈尔滨医药, 2026, 46(2): 14-18.
Fu Peibiao, Chen Yanmin, Wang Zhenzhen, Zhang Yanyan, Zheng Huihui. Clinical Curative Effect of Camrelizumab Combined with SP Chemotherapy in Advanced Esophageal Cancer and Its Influences on Cellular Immunity and Prognosis. journal1, 2026, 46(2): 14-18.

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