Abstract：Objective Analysis of Variation Patterns of Homocysteine(Hcy)and High-Sensitivity Markers in Peripheral Blood During the Onset Stage of Acute Ischemic Stroke(ACI). Methods A total of 70 patients with ACI admitted to the Department of Neurology,The Zhumadian first people's Hospital from May 2022 to May 2024 were retrospectively selected as the study group,and 65 healthy subjects who underwent physical examination in the Health Management Center of our hospital during the same period were selected as the control group.Serum Hcy and hs-CRP levels were detected and compared between the two groups.According to the National Institutes of Health Stroke Scale(NIHSS)score,ACI patients were divided into mild group(n=25),moderate group(n=28)and severe group(n=17);Using the modified Rankin Scale(mRS)score at 3 months after onset as the criterion,70 patients were divided into a favorable prognosis group(n=45)and an unfavorable prognosis group(n=25).Spearman correlation analysis was performed to evaluate the relationship between inflammatory protein markers and NIHSS scores;multivariate Logistic regression was used to identify risk factors affecting the short-term recovery of acute ischemic stroke(ACI).ROC curve was drawn to evaluate the predictive value of serum Hcy and hs-CRP for poor short-term prognosis of ACI. Results The levels of serum Hcy and hs-CRP in the study group were significantly higher than those in the control group(P<0.05).There were significant differences in serum Hcy and hs-CRP levels among different neurological deficit groups(P<0.05),and the levels increased with the aggravation of the disease(severe group>moderate group>mild group).Spearman correlation analysis showed that serum Hcy(r=0.665)and hs-CRP(r=0.601)levels in ACI patients were significantly positively correlated with NIHSS scores(P<0.001).Multivariate logistic regression analysis confirmed that high NIHSS score on admission,elevated serum homocysteine,and high expression of high-sensitivity C-reactive protein were independent risk factors for poor short-term outcome in acute cerebral infarction(P<0.05).ROC curve analysis showed that the AUC of Hcy combined with hs-CRP in predicting poor short-term prognosis of ACI was which was better than that of single indicator. Conclusion Serum Hcy and hs-CRP levels are closely related to the degree of neurological deficit in ACI patients,and the combined detection of the two has high clinical value in assessing disease severity and predicting short-term prognosis.
剧新杰, 郭刚, 张卫华. 急性脑梗死患者血清同型半胱氨酸、超敏C反应蛋白水平与神经功能缺损程度及短期预后的相关性研究[J]. 哈尔滨医药, 2026, 46(5): 9-12.
Ju Xinjie, Guo Gang, Zhang Weihua. Effects of High Sensitivity C-reactive Protein and Homocysteine on Neurological Deficit and Prognosis in Patients with Acute Cerebral Infarction. journal1, 2026, 46(5): 9-12.
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2026, Vol. 46 
