Abstract：Objective To investigate the diagnostic value of combined serum N-terminal pro-B-type natriuretic peptide(pro-BNP),homocysteine(HCY),and high-sensitivity C-reactive protein(hs-CRP)testing for acute myocardial infarction(AMI).Methods Eighty-six patients with acute coronary syndrome(ACS)admitted to our hospital between January 2021 and January 2025 were enrolled.They were divided into a study group(AMI patients,n=43)and a control group(non-AMI patients,n=43)based on AMI occurrence.Morning fasting venous blood samples were collected from both groups.Serum levels of pro-BNP,HCY,and hs-CRP were measured using corresponding assays.Serum marker levels were compared between groups,and the sensitivity,specificity,accuracy,positive predictive value,negative predictive value,true positive rate,and false positive rate of both individual markers and combined testing for AMI diagnosis were analysed.Results Serum pro-BNP,HCY,and hs-CRP levels were significantly higher in the study group than in the control group(P<0.05).Diagnostic performance analysis revealed that the combined detection of pro-BNP,HCY,and hs-CRP combined detection exhibited a sensitivity of 97.67%,specificity of 95.35%,accuracy of 96.51%,positive predictive value of 95.45%,negative predictive value of 97.62%,true positive rate of 97.67%,and false positive rate of 4.65%,all superior to individual marker testing.Conclusion The combined serum testing of pro-BNP,HCY,and hs-CRP demonstrates high clinical utility in diagnosing AMI.It effectively enhances diagnostic accuracy,providing crucial guidance for the early clinical diagnosis and treatment of AMI,and warrants wider implementation.
刘立雪, 李娜, 贺玉丹. 血清pro-BNP、HCY、hs-CRP联合检测诊断急性心肌梗死的价值[J]. 哈尔滨医药, 2026, 46(3): 18-20.
Liu Lixue, Li Na, He Yudan. The value of combined detection of serum pro-BNP,HCY and hs-CRP in the diagnosis of acute myocardial infarction. journal1, 2026, 46(3): 18-20.
2026, Vol. 46 
