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哈尔滨医药  2023, Vol. 43 Issue (2): 8-10    DOI: 10.3969/j.issn.1001-8131.2023.02.003
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两种血液净化方式对尿毒症合并MODS患者CRP、IL-6、TNF-α及血流动力学的影响
霍爱景
河南省濮阳市安阳地区医院,河南 濮阳 455000
Effect of Two Blood Purification Methods on CRP,IL-6,TNF-and Hemodynamics in Uremic Patients With MODS
Huo Aijing
Henan Puyang City,Anyang District Hospital,Henan Puyang 455000
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摘要 目的 探讨两种血液净化模式用于尿毒症合并MODS患者中对炎性因子、血流动力学的影响。方法 选取尿毒症合并MODS患者82例,按照随机数字表法分为两组,观察组41例,采用血液透析联合血液灌流(HD+HP)治疗,对照组41例,采用血液透析(HD)治疗。对两组患者治疗前后的毒素清除率和肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1(IL-1)及C反应蛋白(CRP)以及颈动脉血流速度,血流量及外周阻力进行检测,并比较分析。结果 对比两组治疗后的血清血肌酐、血尿素氮、甲状旁腺素、β2-微球蛋白含量均明显低于治疗前(P<0.05),并且观察组较之对照组,以上指标含量下降更显著(P<0.05),毒素清除率更高;两组患者治疗前的血清TNF-α、IL-6、IL-1、CRP和血流动力学指标水平比较均无统计学意义(P>0.05),治疗后,两组患者TNF-α、IL-6、IL-1、CRP均明显下降(P<0.05),而观察组较对照组来说以上指标下降更明显(P<0.05),并且通过治疗,观察组的血流速度,血流量均明显大于对照组,外周阻力明显小于对照组(P<0.05)。结论 HD+HP治疗用于尿毒症合并MODS的血液净化效果优于HD治疗,能够有效地减缓患者的炎症反应,并且对患者的血流动力学有一定的积极意义。
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霍爱景
关键词 尿毒症合并MODS血液透析血液灌流炎性因子血流动力学    
AbstractObjective To investigate the effects of different blood purification methods on inflammatory factors and hemodynamics in patients with MODS. Methods 82 patients with MODS were divided into two groups according to the random number table method.41 patients in the observation group were treated with hemodialysis combined with hemoperfusion(HD + HP),and 41 patients in the control group were treated with hemodialysis(HD).Toxin clearance,tumor necrosis factor-(TNF-),interleukin-6(IL-6),interleukin-1(IL-1)and C reactive protein(CRP),carotid blood flow and peripheral resistance,and were analyzed. Results After the treatment of the patients in both groups,The serum contents of creatinine,blood urea nitrogen,parTH and 2-microglobin were significantly lower than before treatment(P<0.05),And the observation group was compared with the control group,The content of the above index decreased more significantly(P<0.05),Higher clearance rate of toxins;No comparison of serum TNF-,IL-6,IL-1,CRP and hemodynamic index levels(P>0.05),post-treatment,TNF-,IL-6,IL-1,and CRP were significantly decreased in both groups(P<0.05),However,the observation group decreased more significantly than the control group(P<0.05),And through the treatment,The blood flow velocity in the observation group,The blood flow was all significantly greater than that of the control group,Peripheral resistance was significantly smaller than that in the control group(P<0.05). Conclusion HD + HP treatment for uremia with MODS is better than HD treatment,which can effectively slow down the inflammatory response and has some positive significance for the patient hemodynamics.
Key wordsuremia combined with MODS    hemodialysis    hemoperfusion    inflammatory factors    hemodynamics
收稿日期: 2022-05-07     
PACS:  R322.6+1  
引用本文:   
霍爱景. 两种血液净化方式对尿毒症合并MODS患者CRP、IL-6、TNF-α及血流动力学的影响[J]. 哈尔滨医药, 2023, 43(2): 8-10.
Huo Aijing. Effect of Two Blood Purification Methods on CRP,IL-6,TNF-and Hemodynamics in Uremic Patients With MODS. journal1, 2023, 43(2): 8-10.
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