|
|
|
| Effects of Different Anesthesia Methods on Perioperative Neurocognitive Disorders and Inflammatory Factor IL-6 in Elderly Patients Undergoing Total Hip Replacement |
| Wu Xianping, Yang Yanping, Chen Xian, Wu Yanfang, Jiang Ying |
| Shunde Hospital of Guangzhou University of Chinese medicine, Foshan 528300, China |
|
|
|
|
Abstract Objective To study the effects of different anesthesia methods on perioperative neurocognitive disorders（PND）and inflammatory factors in elderly patients undergoing total hip replacement. Methods 72 patients with total hip replacement were randomly divided into general anesthesia group and peripheral nerve block group according to different anesthesia methods.The cognitive function of patients was measured by MMSE score 24 hours before operation（T0）,24 hours after operation（T1）,1 week after operation（T2）,1 month after operation（T3）,3 months after operation（T4）and half a year after operation（T5）.The expression level of serum IL-6 factor was measured by venous blood from patients at T0,T1 and T2.Adverse reactions such as agitation,nausea,vomiting and vertigo were recorded. Results Compared with the general anesthesia group,IL-6 in the peripheral nerve block group decreased significantly at 24 hours（T1）and 1 week（T2）after operation,and MMSE score increased significantly at the same time（P<0.05）;Among them,4 patients in the general anesthesia group developed PND at 24 hours（T1）and 1 week（T2）after operation,and 2 patients still had PND at 1 month（T3）and 3 months（T4）,while there was no PND in the peripheral nerve block group.The incidence of nausea and vomiting after general anesthesia was significantly lower than that after general anesthesia（P<0.05）. Conclusion Different anesthesia methods have different effects on postoperative cognitive function and inflammatory factors in elderly patients undergoing total hip replacement.Peripheral nerve block can reduce the occurrence of perioperative neurocognitive disorder.
|
|
Received: 02 August 2022
|
|
|
|
|
|
[1] 翟菲菲,黄宇光.围术期神经认知障碍:从术后到术前,从临床指标到生物学指标[J].临床麻醉学杂志,2019,35(4):317-318.
[2] 瞿巍巍,王志云,黄培.硬膜外麻醉与静脉全身麻醉对老年骨科手术术后精神状态及认知功能的影响[J].中国医师杂志,2016,18(3):453-455.
[3] 夏炳春,陈赐波,赵春燕,等.不同麻醉深度与老年骨科手术患者术后认知功能障碍的相关性研究[J].医学临床研究,2018,35(8):1524-1526.
[4] 钟雅,黄程,颜小华等.老年患者髋关节置换手术的麻醉护理研究[J].重庆医学,2017,46(17):2444-2446.
[5] 肖水亮,周红社.神经刺激仪引导定位坐骨神经-股神经阻滞对老年全髋置换术患者术后认知功能障碍的影响[J].中国医学物理学杂志,2018,35(9):8-10.
[6] 杨露,李艳华.老年人术后谵妄和认知功能障碍的研究进展.中国老年学志,2019,39(6):1508-1513.
[7] 段崇珍,崔卓,张夏青等.穴位电刺激对老年全麻患者术后认知功能障碍的干预效果[J].海南医学,2019,30(16):2071-2074.
[8] 高建华,魏智慧.股神经阻滞复合全身麻醉对老年膝关节置换患者术后认知功能及炎性因子水平的影响.临床误诊误治,2018,31(5):278-283.
[9] 李思盈,陈小云.超声下前路腰、骶丛阻滞在老年全髋置换中的应用研究重庆医学,2021,50(3):56-61. |
| [1] |
Guo Yuchang. The Effect of Atorvastatin Calcium Tablet on Neurologic Function and Serum Inflammatory Factors in Patients with Acute Ischemic Stroke[J]. journal1, 2022, 42(5): 9-11. |
| [2] |
. [J]. journal1, 2022, 42(4): 114-115. |
| [3] |
. [J]. journal1, 2022, 42(1): 134-136. |
| [4] |
Li Huan, Meng Gang. Effects of Sequential Therapy of Budesonide Combined With Azithromycin on Levels of Serum IFN-γ and MCP-4 in Children Patients With MPP[J]. journal1, 2021, 41(6): 25-27. |
| [5] |
. [J]. journal1, 2021, 41(6): 78-79. |
| [6] |
Cai Lixia. A Comparative Study of Effects of Standard Triple Therapy and Sequential Triple Therapy on the Levels of Serum Inflammatory Factors in Children Patients With Hp Infection[J]. journal1, 2021, 41(4): 19-20. |
|
|
|
|
2022, Vol. 42 
