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Quick Search     Adv Search 2026 Vol. 46, No. 1 Published: 2026-02-25 1 Study on Tanshinone ⅡA Inducing Differentiation of CD44+CD24-/low Breast Cancer Stem Cells Sun Hongguang, Wang Yanming, Jia Zhongming DOI: 10.3969/j.issn.1001-8131.2026.01.001 Objective To isolate the CD44+CD24-/low subpopuLation from breast cancer cells using MACS immunomagnetic bead sorting,and to investigate the differentiation-inducing effect of tanshinoneⅡA on this cell subpopuLation. Methods The CD44+CD24-/low cell subpopuLation was sorted by MACS immunomagnetic bead sorting,and the proportion of this subpopuLation before and after sorting was determined by flow cytometry.After co-cuLturing the CD44+CD24-/low cell subpopuLation with different concentrations of tanshinoneⅡA,the cell cycle distribution was detected by flow cytometry to clarify the role of tanshinoneⅡA in the differentiation of breast cancer stem cells. Results Approximately 6% of CD44+CD24-/low cells were successfuLly obtained via MACS immunomagnetic bead sorting,and flow cytometric identification showed that the purity of this cell subpopuLation reached 93.85%.After intervention with different concentrations of tanshinone ⅡA,the distribution ratios of CD44+CD24-/low cells in G0/G1 phase,S phase and G2/M phase exhibited significant differences.As the concentration of tanshinone ⅡA increased from 0 μg/mL to 10 μg/mL,the proportion of cells in G0/G1 phase decreased continuously from 92.83±0.25% to 84.07±0.15%,indicating that tanshinoneⅡA exerted a remarkable concentration-dependent reguLatory effect on cell cycle progression. Conclusion The CD44+CD24-/low cell subpopuLation can be successfuLly isolated using MACS immunomagnetic bead sorting.TanshinoneⅡA can promote more cells of this subpopuLation to exit the quiescent G0/G1 phase and enter the active proliferation cycle,accelerate the processes of DNA replication(S phase)and cell division(G2/M phase),thereby enhancing cell proliferative activity. 2026 Vol. 46 (1): 1-4 [Abstract] ( 15 ) HTML (1 KB)  PDF (589 KB)  ( 7 ) 4 Study on the Value of Multi-b-value DWI and T2 Mapping Quantitative Techniques in the Diagnosis of Prostate Cancer and Benign Prostatic Hyperplasia Nodules Wang Xu, Chen Ting, Wang Shan, Xie Xiaoping DOI: 10.3969/j.issn.1001-8131.2026.01.002 Objective To investigate the diagnostic value of multi-b-value diffusion-weighted imaging(DWI)and T2 mapping quantitative parameters in differentiating prostate cancer(PCa)from benign prostatic hyperplasia(BPH). Materials and Methods A retrospective analysis was conducted on imaging data from 67 pathologically confirmed PCa patients and 66 BPH patients who underwent MR examination in our hospital.ADC values from DWI at b=1000 and 2000 s/mm2 and T2 mapping values were measured in both groups.Differences in ADC values at different b-values and T2 values between the two groups were compared. Results Operating characteristic(ROC)curve analysis was used to evaluate the diagnostic performance of each parameter and the combined ADC2000-T2 model. Results The ADC1000,ADC2000,and T2 values in the PCa group were significantly lower than those in the BPH group,with statistically significant differences(P<0.01).The AUC values for differentiating PCa from BPH were 0.80 for ADC1000,0.83 for ADC2000,0.89 for T2 value,and 0.92 for the combined ADC2000-T2 model.The diagnostic performance of the combined ADC2000-T2 mapping model was superior to that of ADC1000 or ADC2000 alone,and the difference was statistically significant. Conclusion Quantitative parameters from DWI and T2 mapping sequences demonstrate good diagnostic value in differentiating PCa from BPH.Moreover,the combined model incorporating high b-value DWI and T2 mapping further improves diagnostic performance,providing a reliable basis for the clinical diagnosis of PCa. 2026 Vol. 46 (1): 4-7 [Abstract] ( 17 ) HTML (1 KB)  PDF (569 KB)  ( 4 ) 8 Analysis of Risk Factors for Lung Cancer in Chronic Obstructive Pulmonary Disease with Emphysema Type Yang Zhilu, Sha ZhengKai, Zhang Xiangjie, Zhang Pan, Liu Xiaoxiao DOI: 10.3969/j.issn.1001-8131.2026.01.003 Objective To examine the risk factors associated with lung cancer in individuals with chronic obstructive pulmonary disease(COPD)who also have emphysema. Methods A total of 318 patients with emphysema type COPD admitted to our hospital from June.According to the results of histopathological examination,they were divided into lung cancer group(33 cases)and non-lung cancer group(285 cases).The clinical data of the two groups were compared,and binary logistic regression analysis was used to screen the independent risk factors of emphysematous COPD complicated with lung cancer. Results The comparison of basic clinical data between two groups of COPD patients with emphysema showed that there were statistically significant differences in gender,age,smoking index,COPD duration,persistent chest pain,and hemoptysis between patients with concurrent lung cancer and those without concurrent lung cancer(P<0.05).The binary logistic regression analysis showed that age,smoking index,COPD duration,persistent chest pain,and hemoptysis are independent risk factors for pulmonary emphysema COPD complicated with lung cancer,which can increase the risk of concurrent lung cancer by 3.30 times,5.30 times,3.20 times,4.12 times,and 3.64 times,respectively(P<0.05). Conclusion Age,smoking index,COPD duration,persistent chest pain,and hemoptysis are independent risk factors for lung cancer in COPD with emphysema,which can increase the risk of lung cancer by 3.30 times,5.30 times,3.20 times,4.12 times,and 3.64 times,respectively.Therefore,comprehensive preventive measures should be taken,including quitting smoking,actively treating COPD,and regularly undergoing chest X-rays or CT scans,in order to reduce the risk of developing lung cancer and improve the quality of life of patients. 2026 Vol. 46 (1): 8-12 [Abstract] ( 20 ) HTML (1 KB)  PDF (741 KB)  ( 6 ) 12 Clinical Effect Evaluation of Prone Position Mechanical Ventilation in the Treatment of Severe Aspiration Pneumonia Complicated with Acute Respiratory Distress Syndrome Zheng Yongjian, Zhuang Feicui, Huang Zhaoxin, Xiao Huiliang DOI: 10.3969/j.issn.1001-8131.2026.01.004 Objective To analyze the clinical effective mechanism of prone position mechanical ventilation for patients with severe aspiration pneumonia complicated with acute respiratory distress syndrome. Methods 60 patients with severe aspiration pneumonia complicated with acute respiratory distress syndrome were selected from.The simple randomization method was divided into two groups,the control group(conventional mechanical ventilation treatment,n=30)and the study group(prone position mechanical ventilation treatment,n=30).Summarize the feedback data. Results after the intervention,the overall improvement of arterial blood gas analysis indexes in the study group was better than that in the control group,and the difference was statistically significant(P<0.05).After the intervention,the heart rate level of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).The clinical efficacy of the study group was better than that of the control group after the intervention,and the difference was statistically significant(P<0.05).After the intervention,the sputum drainage volume of the control group wa which was lower than that of the study group,and the difference was statistically significant(P<0.05). Conclusion for patients with severe aspiration pneumonia,the application of prone position mechanical ventilation treatment intervention is conducive to the improvement of arterial blood gas indicators,the increase of drainage volume,and the prognosis of heart rate and respiratory rate,which has a significant increase in clinical efficacy. 2026 Vol. 46 (1): 12-14 [Abstract] ( 15 ) HTML (1 KB)  PDF (443 KB)  ( 4 ) 15 The Relationship between Serum FGF-23Levels, the Progression of Chronic Kidney Disease to End-stage Renal Disease in Patients Wang Yonglei, Fan Jiajia, He Yanyan DOI: 10.3969/j.issn.1001-8131.2026.01.005 Objective Exploring the relationship between serum FGF-23 levels and the progression of end-stage renal disease in patients with chronic kidney disease. Methods Select 97 end-stage renal disease(ESRD)patients undergoing hemodialysis at the Seventh Affiliated Hospital of Xinjiang Medical University between July,along with 30 healthy individuals receiving routine health examinations during the same period as the control group.Compare baseline characteristics,blood biochemical markers,and renal function parameters between the two groups.Evaluate clinical indicators and cardiorenal parameters across different CKD stages,and analyze the correlation between FGF-23 and renal function. Results The observation group exhibited significantly higher systolic blood pressure,diastolic blood pressure,mean arterial pressure,serum uric acid,and FGF-23 levels compared to the control group,while estimated glomerular filtration rate was lower(P<0.05).After treatment,the observation group showed significant reductions in BUN,SCr,FGF-2,FGF-23,Cyc-C,eGFR,left ventricular mass index,and ejection fractioncompared to pretreatment levels,whereas creatinine clearance rateincreased(P<0.05).Across the five CKD stages,eGFR progressively declined with disease progression,while parathyroid hormone(PTH)levels gradually increased.Significant intergroup differences were observed in uric acid,FGF-23,BUN,SCr,Ccr,FGF-2,Cyc-C,eGFR,PTH,LVMI,and LVEF(P<0.05).FGF-23 correlated negatively with BUN,SCr,Cyc-C,PTH,LVMI,and LVEF.BUN and SCr showed significant negative correlations with LVMI,LVEF,and eGFR but positive correlations with Cyc-C,FGF-2,and PTH.eGFR positively correlated with LVMI and LVEF but negatively with PTH.Cyc-C demonstrated a strong negative correlation with LVEF,while LVMI and LVEF were inversely related(all P<0.05). Conclusion FGF-23 can serve as an early and sensitive biomarker for the progression of chronic kidney disease to CKD,helping to identify high-risk patients at risk of early or rapid disease progression.High levels of FGF-23 are important factors in predicting the progression of end-stage renal disease(ESRD)in CKD patients.In the future,treatment strategies targeting FGF-23 can be developed and standardized testing can be promoted to break the vicious cycle of promoting CKD progression and cardiovascular damage. 2026 Vol. 46 (1): 15-19 [Abstract] ( 18 ) HTML (1 KB)  PDF (676 KB)  ( 5 ) 20 The Efficacy of Sintilimab Combined with Platinum-based Chemotherapy in the Treatment of Advanced NSCLC Patients and Its Influence on Serum Notch1 and Dickkopf-1 Levels Kang Lihua, Zhai Fengyu, Liu Yuefen DOI: 10.3969/j.issn.1001-8131.2026.01.006 Objective To observe the efficacy of sintilimab combined with platinum-based chemotherapy in the treatment of advanced non-small cell lung cancer(NSCLC)patients and its impact on serum Notch1 and Dickkopf-1 levels. Methods A total of 106 patients with advanced NSCLC admitted from selected and randomly divided into two groups using a random number table.The single group was treated with platinum-based chemotherapy,while the combination group was treated with sintilimab combined with platinum-based chemotherapy.The objective response rate,disease control rate,Notch1 mRNA,Dickkopf-1,T lymphocyte subsets,tumor markers,and adverse reaction rates were compared between the two groups. Results The disease control rate was higher in the combination therapy group than in the single-agent group(P<0.05).There was no significant difference in objective response rates between the two groups(P>0.05).Pre-treatment study-related indicators showed no significant differences between the two groups(P>0.05).After three treatment cycles,both groups showed decreased Notch1 mRNA and Dickkopf-1 levels compared to baseline.The combined therapy group exhibited lower levels than the single-agent group after three cycles(P<0.05).After three treatment cycles,the combined therapy group exhibited higher CD3+,CD4+,and CD4+/CD8+ ratios compared to pre-treatment levels and the monotherapy group after three cycles.Conversely,CD8+ levels were lower than pre-treatment and monotherapy group levels after three cycles(P<0.05).No significant differences were observed in T lymphocyte subsets between monotherapy groups before and after treatment(P>0.05).After three treatment cycles,both groups showed decreased levels of carbohydrate antigen 125(CA125),squamous cell carcinoma antigen(SCCA),and carcinoembryonic antigen(CEA)compared to baseline.The combined therapy group exhibited lower levels than the single-therapy group after three cycles(P<0.05).The incidence of adverse reactions was comparable between groups(3.77% in the single-agent group vs.7.55%in the combination group;P>0.05). Conclusion Sintilimab combined with platinum-based chemotherapy in the treatment of advanced NSCLC can improve immune function,inhibit the expression of Notch1,Dickkopf-1,and tumor markers,and increase the objective response rate. 2026 Vol. 46 (1): 20-24 [Abstract] ( 15 ) HTML (1 KB)  PDF (611 KB)  ( 4 ) 24 Comparative Value of Multislice Spiral Computed Tomography and Magnetic Resonance Imaging in T Staging of Oesophageal Cancer Jing Yingxuan, Wang Yuan DOI: 10.3969/j.issn.1001-8131.2026.01.007 Objective Contrast analysis of multislice CT(MSCT)and magnetic resonance imaging(MRI)for esophageal cancer in T staging diagnosis value. Methods 87 patients with pathologically confirmed oesophageal carcinoma at our institution were selected according to inclusion and exclusion criteria.All patients underwent MSCT and MRI examinations,with pathological T staging serving as the gold standard.The T staging results from MSCT and MRI were statistically analysed to compare diagnostic accuracy and assess concordance rates and consistency with pathological findings. Results MSCT diagnosed 7 cases,21 cases,40 cases and 19 cases of T1,T2,T3 and T4 respectively.The MRI examination identified 10 cases,18 cases,38 cases and 21 cases for T1,T2,T3 and T4 respectively.The diagnostic accuracies of MRI for T1,T2,T3,and T4 stages were,respectively,all exceeding MSCT diagnosis rates of(P<0.05).The consistency between MRI diagnosis of oesophageal cancer T staging and pathological findings was higher than that of MSCT diagnosis.The diagnostic concordance rate for MRI was,surpassing that of MSCT(P<0.05). Conclusion Compared with MSCT,MRI demonstrated higher accuracy and concordance rates in diagnosing T staging for oesophageal cancer,alongside greater consistency with pathological findings. 2026 Vol. 46 (1): 24-26 [Abstract] ( 15 ) HTML (1 KB)  PDF (399 KB)  ( 4 ) 27 Value Analysis of MSCT Reconstruction Combined with CT Angiography in the Diagnosis of Thoracoabdominal Aortic Dissection Li Shiyi, Chen Chunbing, Wang Rentang, Wu Yu, Wang Ying DOI: 10.3969/j.issn.1001-8131.2026.01.008 Objective To analyze the value of multi-slice spiral CT(MSCT)reconstruction combined with CT angiography(CTA)in the diagnosis of thoracoabdominal aortic dissection. Methods A total of 117 patients with suspected thoracoabdominal aortic dissection admitted to the hospital from.All patients underwent MSCT plain scan and CTA enhanced scan after admission.The original data of MSCT plain scan were post-processed and reconstructed by multi-planar reconstruction(MPR),maximum intensity projection(MIP),volume rendering(VR),etc.Then,taking digital subtraction angiography(DSA)or surgical pathological results as the gold standard,the diagnostic efficacy of MSCT plain scan,MSCT reconstruction,CTA alone and in combination for thoracoabdominal aortic dissection was compared and analyzed.At the same time,the evaluation results of the four diagnostic methods for the typing of thoracoabdominal aortic dissection,the intimal tear and the involvement of branch vessels were evaluated. Results ①When MSCT plain scan,MSCT reconstruction and CTA were used in combination for the diagnosis of thoracoabdominal aortic dissection,the diagnostic efficacy was higher than that of single diagnosis.The diagnostic efficacy of MSCT reconstruction was better than that of MSCT plain scan,and the difference was statistically significant(P<0.05).There was no significant difference in the diagnostic efficacy between CTA and MSCT reconstruction(P>0.05).The consistency between the combined diagnosis and the gold standard was good(Kappa=0.928),the consistency between CTA,MSCT reconstruction and the gold standard was moderate(Kappa=0.706,0.689),and the consistency between MSCT plain scan and the gold standard was poor(Kappa=0.453).②When MSCT plain scan,MSCT reconstruction and CTA were used in combination,the evaluation coincidence rates for Stanford type A and Stanford type B of thoracoabdominal aortic dissection were respectively,which were higher than those of MSCT plain scan,MSCT reconstruction and CTA in single diagnosis,and the differences were statistically significant(P<0.05).③The results of the gold standard showed that there were a total of 108 intimal tears.When MSCT plain scan,MSCT reconstruction and CTA were used in combination for evaluation,the detection rate of intimal tears in thoracoabdominal aortic dissection was 95.37%,which was higher than that of MSCT plain scan(62.96%),MSCT reconstruction(77.78%)and CTA(82.41%)in single evaluation,and the differences were statistically significant(P<0.05).④The results of the gold standard showed that a total of 60 patients had involvement of branch vessels.When MSCT plain scan,MSCT reconstruction and CTA were used in combination for evaluation,the detection rate of involvement of branch vessels in patients with thoracoabdominal aortic dissection was 95.37%,which was higher than that of MSCT plain scan(62.96%),MSCT reconstruction(77.78%)and CTA(82.41%)in single evaluation,and the differences were statistically significant(P<0.50). Conclusion MSCT reconstruction combined with CTA has high diagnostic efficacy for thoracoabdominal aortic dissection,which can provide reliable imaging support for clinical diagnosis and treatment and is worthy of popularization. 2026 Vol. 46 (1): 27-30 [Abstract] ( 16 ) HTML (1 KB)  PDF (494 KB)  ( 4 ) 31 Diagnostic Significance of Multi-slice Spiral CT Angiography Combined with Serum Lipoprotein-a Testing for Preoperative Classification of Acute Aortic Dissection Wang Gaojun, Yang Hongwei, Wang Dateng, Yang Ming DOI: 10.3969/j.issn.1001-8131.2026.01.009 Objective To analyse the diagnostic significance of multi-slice spiral computed tomography angiography(CTA)combined with serum lipoprotein-a testing for preoperative classification of acute aortic dissection(AAD). Methods A retrosp-ective analysis was conducted on the clinical data of 92 AAD patients admitted to the Department of Cardiovascular Surgery,First Affiliated Hospital of Nanyang Medical College between January 2022 and December 2024.All patients underwent preoperative CTA and serum lipoprotein-a testing.Serum lipoprotein-a levels were compared across different Stanford classi-fications.Diagnostic outcomes and efficacy(sensitivity,specificity,accuracy)were evaluated for CTA,serum lipoprotein-a alone,and their combined use in classifying AAD. Results Surgical confirmation revealed 32(34.78%)Stanford Type A and 60(65.22%)Stanford Type B cases among the 92 patients.Serum lipoprotein-a levels were significantly higher in Stanford type A patients than in Stanford type B patients(P<0.05).No significant differences were observed in specificity or accuracy between CTA,combined CTA-lipoprotein-a diagnosis,and either modality alone(P>0.05).The diagnostic sensitivity of combined CTA and serum lipopro-tein-a was 96.88%(31/32),surpassing that of CTA alone(75.00%,24/32)and serum lipoprotein-a alone(59.38%,19/32)(P<0.05). Conclusion Combined CTA and serum lipoprotein-a testing effectively enhances the sensitivity of preoperative Stanford classification for AAD,providing reliable reference for early accurate classification and treatment planning in clinical practice. 2026 Vol. 46 (1): 31-33 [Abstract] ( 19 ) HTML (1 KB)  PDF (429 KB)  ( 1 ) 34 The Efficacy of Cetirizine Hydrochloride Combined with Ultraviolet Therapy in Treating Uremic Pruritus and Its Impact on IL-31 Levels He Yanyan, Liu Shuzhen, Wang Yongli DOI: 10.3969/j.issn.1001-8131.2026.01.010 Objective Investigating the efficacy of cetirizine hydrochloride combined with ultraviolet therapy in treating uremic pruritus and its impact on IL-31 levels. Methods A total of 100 patients with uremic pruritus treated at our hospital from August were enrolled and randomly divided into two groups(50 cases each)based on admission number parity.The control group received cetirizine hydrochloride monotherapy combined with phototherapy,while the treatment group underwent additional narrowband UVB therapy.The study compared clinical efficacy,laboratory parameters,pruritus severity,sleep quality,and adverse reactions between the two groups. Results The treatment group demonstrated significantly higher overall efficacyvs control,（P<0.05).Post-treatment laboratory results revealed markedly lower levels in the treatment group for serum calcium(Ca),phosphorus(P),5-HT,PTH,β2-MG,CRP,TNF-α,and IL-3 compared to controls(all P<0.05).Significant improvements were observed in pruritus and sleep parameters,with the treatment group showing lower scores than controls in VAS,FIIQand PSQI(all P<0.05).No statistically significant difference in adverse reactions was noted between groups(P>0.05). Conclusion The combination of cetirizine hydrochloride and narrowband UVB phototherapy demonstrates significant clinical benefits for uremic pruritus patients,effectively alleviating symptoms,reducing inflammatory markers,relieving itching,and improving sleep quality with favorable safety,indicating substantial clinical application value. 2026 Vol. 46 (1): 34-37 [Abstract] ( 20 ) HTML (1 KB)  PDF (616 KB)  ( 1 ) 38 Research on the Prediction of Preeclampsia Risk Using Ultrasound Multimodal Model Based on Fetal Hemodynamic Parameters Gao Ruolan, Cheng Yuanping, Guo Xiaorong DOI: 10.3969/j.issn.1001-8131.2026.01.011 Objective Construct and analyze the application value of the ultrasound multimodal model based on fetal hemodynamic parameters in predicting the risk of severe preeclampsia. Method The cross-sectional data of 74 pregnant women with severe preeclampsia who had regular prenatal examinations and delivered in our hospital from January were selected as the observation group,and another 50 pregnant women with normal prenatal examinations during the same period were selected as the control group.The general data of the two groups and the fluid dynamics parameters of the fetus were analyzed.Multiple regression analysis was used to analyze the factors influencing the occurrence of preeclampsia in pregnant women;Build a prediction model based on influencing factors and analyze its prediction efficacy. Result The levels of BMI,SBP and DBP in the preeclampsia group were significantly higher than those in the control group,while the gestational age at delivery was lower(P<0.05).The PI(1.37±0.13),RI(0.81±0.19)and S/D(3.67±0.43)of the umbilical artery in the preeclampsia group were all higher than those in the control group.However,the PI(1.08±0.16),RI(0.54±0.19),and S/D(2.42±0.31)of the fetal middle cerebral artery were lower than those of the control group(P<0.05);The results of multiple regression analysis showed that a high level of umbilical artery PI,RI,and S/D ratio in the fetus was a risk factor affecting the occurrence of preeclampsia in pregnant women.The high levels of PI,RI and S/D ratio of the fetal middle cerebral artery are its protective factors;Based on the influencing factors,a prediction model equation was constructed,Y=3.063× PI of the umbilical artery+1.051× S/D ratio of the umbilical artery +2.061× RI of the umbilical artery+2.610× PI of the fetal middle cerebral artery +3.762× RI of the fetal middle cerebral artery+2.783× S/D ratio of the fetal middle cerebral artery -2.618;The ROC curve indicated that the predictive model had a good predictive efficacy for preeclampsia in pregnant women(AUC=0.856),P<0.05. Conclusion Fetal hemodynamic parameters can be used as important indicators for the early identification of high risk.The high levels of umbilical artery PI,RI,and S/D ratios in the fetus are risk factors affecting the occurrence of preeclampsia in pregnant women.The high levels of PI,RI and S/D ratio of the fetal middle cerebral artery are its protective factors.Based on the influencing factors,The constructed prediction model has high prediction efficiency,which can improve early warning ability and provide basis for clinical intervention. 2026 Vol. 46 (1): 38-41 [Abstract] ( 13 ) HTML (1 KB)  PDF (546 KB)  ( 1 ) 42 Clinical Comparison of 3D-ICBT and IC-ISBT for Locally Advanced Cervical Cancer Zhang Rui, Jiang Qingfang, Feng Gaoqing, Zhang Minjie, Zhang Yuanhang DOI: 10.3969/j.issn.1001-8131.2026.01.012 Objective To compare the application of 3D-ICBT and IC-ISBT in the treatment of locally advanced cervical cancer. Methods 60 patients with locally advanced cervical cancer were divided into the IC-ISBT group(34 cases)and the 3D-ICBT group(26 cases)based on the treatment regimen. Results The short-term efficacy,irradiation dose of clinical target volume and organs at risk,adverse reactions were compared between the two groups(P<0.05).The D90%(EQD2)of high-risk clinical target volume in the IC-ISBT group was significantly higher than that in the 3D-ICBT group(P<0.05).There was no difference in the D90%(EQD2)of intermediate-risk clinical target volume between the two groups(P>0.05).The D1cm3(EQD2)and D2cm3(EQD2)of rectum and bladder in the IC-ISBT group were significantly lower than those in the 3D-ICBT group(P<0.05).There was no difference in the D1cm3(EQD2)and D2cm3(EQD2)of sigmoid colon and small intestine between the two groups(P>0.05).Compared with the 3D-ICBT group,the incidence of radiation cystitis and radiation enteritis in the IC-ISBT group were significantly reduced(P<0.05). Conclusion Compared with 3D-ICBT,IC-ISBT can more significantly increase the radiation dose to high-risk clinical target volume in patients with locally advanced cervical cancer,reduce the irradiation dose to organs at risk,and thereby improve the short-term ORR while reducing the risk of local adverse reactions caused by radiotherapy. 2026 Vol. 46 (1): 42-44 [Abstract] ( 16 ) HTML (1 KB)  PDF (412 KB)  ( 2 ) 45 Effects of LNG-IUS and Dydrogesterone on Clinical Symptoms,Sex Hormones and Recurrence Rate in Patients with Endometrial Polyps after Transcervical Resection of Endometrial Polyps Chen Rong DOI: 10.3969/j.issn.1001-8131.2026.01.013 Objective To observe the effects of levonorgestrel-releasing intrauterine system(LNG-IUS)and dydrogesterone on clinical symptoms,sex hormone levels and recurrence rate in patients with endometrial polyps(EP)after transcervical resection of endometrial polyps(TCRP). Methods A total of 90 EP patients admitted to our hospital from August,all of whom underwent TCRP.They were divided into the control group(treated with oral dydrogesterone after surgery)and the observation group(treated with postoperative LNG-IUS placement)by random number table method,with 45 cases in each group.The clinical symptoms,endometrial thickness,sex hormone levels,systemic adverse reactions and recurrence rate were observed and compared between the two groups. Results After treatment,the menstrual volume and menstrual days in the observation group were less than those in the control group,and the endometrial thickness was lower than that in the control group(P<0.05).The serum levels of luteinizing hormone(LH),estradiol(E2),progesterone(P)and follicle-stimulating hormone(FSH)in the observation group were all lower than those in the control group(P<0.05). Conclusion There was no significant difference in the incidence of systemic adverse reactions between the two groups(P>0.05).The recurrence rate of the observation group was lower than that of the control group(P<0.05). 2026 Vol. 46 (1): 45-47 [Abstract] ( 15 ) HTML (1 KB)  PDF (451 KB)  ( 3 ) 111 Clinical Study on the Treatment of Liver and Kidney Deficiency Type Knee Osteoarthritis with Liver and Kidney Strengthening Chinese Medicine Heat Therapy Combined with Small Needle Knife Acupuncture of Muscle and Fascia Trigger Points Deng Wei, Liu Gang DOI: 10.3969/j.issn.1001-8131.2026.01.033 Objective To analyze the effect of liver and kidney strengthening Chinese medicine heat therapy combined with small needle knife acupuncture of muscle and fascia trigger points in the treatment of patients with liver and kidney deficiency type knee osteoarthritis. Methods Eighty patients with knee osteoarthritis of liver-kidney deficiency type were enrolled from our hospital between January and December.The 40 patients in group A were administered celecoxib capsules and glucosamine hydrochloride tablets,while the 40 patients in group B received herbal hot compress for nourishing the liver and kidney and strengthening tendons and bones,combined with small needle-knife acupuncture at myofascial trigger points.The efficacy and safety were compared between the two groups. Results The total effective rate of group B was higher than that of group A(P<0.05);After treatment,the scores of knee joint pain or dull pain,waist and knee soreness,limb weakness,joint movement difficulty,insomnia and frequent dreams,dizziness and tinnitus,and frequent nocturnal urination in group B were all lower than those in group A(P<0.05);After treatment,the pain,stiffness,and daily activity function scores of group B were lower than those of group A(P<0.05);The incidence of adverse reactions between the two groups was compared(5.00%VS0.00%)(P>0.05). Conclusion Liver and kidney strengthening Chinese medicine heat therapy combined with small needle knife acupuncture of muscle and fascia trigger points can alleviate the symptoms of patients with liver and kidney deficiency type knee osteoarthritis,improve knee joint function,enhance therapeutic efficacy,and have high safety. 2026 Vol. 46 (1): 111-114 [Abstract] ( 12 ) HTML (1 KB)  PDF (619 KB)  ( 1 ) 125 Research Progress on Chemical Composition,Pharmacological Effects of Perilla frutescens and Its Product Development Analysis Chen Zhongxin, Zhai Chunmei DOI: 10.3969/j.issn.1001-8131.2026.01.037 This article reviews the relevant literature and data of the medicinal and edible plant Perilla frutescens both domestically and internationally,sorts out ancient book records and modern scientific research achievements,summarizes the chemical composition and pharmacological mechanism of Perilla frutescens,and deeply explores its application value and product research progress in the fields of medicine and diet.It elaborates on its effects in relieving surface cold,promoting qi and stomach,antioxidation,anti-inflammatory and other aspects,revealing its important value and development potential as a medicinal and edible plant.Perilla frutescens has various chemical components,such as volatile oils,flavonoids,phenolic acids,triterpenes and sterols,fatty acids,etc.These components endow Perilla frutescens with a wide range of pharmacological effects,including anti-inflammatory,antibacterial,antioxidant,anti-tumor,etc.This article will provide a theoretical basis for expanding the medicinal and dietary value of Perilla frutescens in the later stage. 2026 Vol. 46 (1): 125-130 [Abstract] ( 13 ) HTML (1 KB)  PDF (779 KB)  ( 5 ) 131 Research Progress and Application Prospects of Digitalization in Traditional Chinese Medicine Ancient Texts Zhang Jingyi, Li Xiao, Huang Xiaoying, Zhu Qi, Lu Tianqian DOI: 10.3969/j.issn.1001-8131.2026.01.038 Ancient Chinese medical texts serve as the core carriers for the inheritance and innovation of traditional Chinese medicine(TCM)scholarship.The digitalization of these texts offers a novel pathway for their utilization,preservation,and dissemination.Given the challenges TCM ancient texts face—such as obscure knowledge,disconnection between ancient and modern contexts,and incomplete mechanisms for application and transformation—there is an urgent need to leverage artificial intelligence and big data technologies to overcome technical and practical hurdles.This paper systematically reviews research advancements in the digitalization of TCM ancient texts across data organization,technological applications,platform development,and clinical empowerment.It also outlines future directions,including precise clinical decision-making support,the intelligent inheritance of renowned physicians' expertise,auxiliary drug development,and multidisciplinary integration.The goal is to elevate TCM ancient texts from "support tools"to"decision-making partners," providing theoretical foundations and practical references for the intelligent inheritance and innovative development of TCM. 2026 Vol. 46 (1): 131-135 [Abstract] ( 14 ) HTML (1 KB)  PDF (823 KB)  ( 5 ) 135 Research Progress in the Diagnosis and Treatment of Chronic Endometritis Wang Kexin, Jiao Yonghui DOI: 10.3969/j.issn.1001-8131.2026.01.039 Chronic endometritis(CE)is a chronic inflammatory condition of the endometrium that may alter both its structure and physiological function,thereby affecting embryo implantation and the maintenance of pregnancy.Due to its frequent lack of specific clinical manifestations,CE is often underdiagnosed.Recent studies have shown a gradual increase in its prevalence,with its adverse impact on reproductive outcomes becoming increasingly significant.This review aims to summarize recent innovations in the diagnosis and treatment of CE through a comprehensive analysis of relevant literature,with the goal of providing a reference for standardized clinical management and future research directions. 2026 Vol. 46 (1): 135-138 [Abstract] ( 14 ) HTML (1 KB)  PDF (558 KB)  ( 6 ) 139 Research Status and Prospects of the Association Between Systemic Autoimmune Diseases and Cervical Lesions Subinuer·Abulimiti, Han Lili DOI: 10.3969/j.issn.1001-8131.2026.01.040 Systemic Autoimmune Diseases(SADs)are a group of disorders caused by abnormal autoimmune responses.In recent years,research on their intersection with gynecological diseases has become increasingly active.It has been observed that patients with SADs exhibit a higher incidence of cervical lesions,suggesting a potentially complex pathophysiological link between the two.Current studies in this field focus on epidemiological characteristics,immunological mechanisms,and clinical manifestations,though disagreements and knowledge gaps remain.This article reviews recent advances,explores how immune dysregulation affects the cervical epithelial microenvironment and immune surveillance mechanisms potentially promoting the development of cervical lesions and summarizes existing diagnostic and therapeutic approaches.It aims to provide a theoretical foundation for clinical research and offers perspectives on future directions to facilitate early detection and precision treatment of cervical lesions in patients with SADs. 2026 Vol. 46 (1): 139-141 [Abstract] ( 16 ) HTML (1 KB)  PDF (375 KB)  ( 8 )

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