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2026 Vol. 46, No. 2
Published: 2026-04-25
1
Bibliometric Analysis of GDM Management and Health Education (2014-2024)
Wei Xuan, Liu Ruiqian
DOI: 10.3969/j.issn.1001-8131.2026.02.001
Objective
This study employs bibliometric methods to conduct a knowledge mapping analysis of the current status,key issues,and development trends in the management and health education of Gestational Diabetes Mellitus(GDM) from 2014 to 2024,based on literature from Chinese and English databases.
Methods
Literature was retrieved from the China National Knowledge Infrastructure(CNKI) and Web of Science databases.Using a subject heading search strategy,Cite Space 6.4.R1 software was utilized to construct co-occurrence networks and burst detection maps,analyzing publication trends,core institutions,author collaboration,and the evolution of research hot spots.
Results
After screening,235 valid Chinese articles and 837 English articles were included.The data indicate sustained growth in research interest,with notable differences between Chinese and English literature.Domestic research is highly concentrated in journals such as Diabetes New World,led by institutions like Anhui Medical University.International research is supported by high-impact journals like BMC Pregnancy and Childbirth and led by top universities such as Harvard University and Monash University.Keyword analysis reveals that Chinese studies focus on "health education,""nursing intervention," and short-term pregnancy outcomes,while international research emphasizes "risk factors""pathological mechanisms" and long-term metabolic health of both mother and child.Emerging trends show that "personalized intervention,""digital management,""Internet+," and "multidisciplinary collaboration" have become common frontiers of global interest.
Conclusion
Global research interest in GDM management continues to rise,with the field gradually expanding.Research is transitioning from singular blood glucose control towards a whole-life-cycle,precision-based,and digitalized approach.Domestic research in China needs to further explore underlying mechanisms and actively integrate Internet technologies to enhance its international competitiveness.
2026 Vol. 46 (2): 1-6 [
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] (
122
)
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7
Study on the Correlation between Doxycycline Blood Concentration and Coagulation Function Indicators in Patients with Severe Pulmonary Infection
Zhang Pei, Li Nan, Han Jialin
DOI: 10.3969/j.issn.1001-8131.2026.02.002
Objective
To explore the correlation between doxycycline steady-state blood drug concentration and coagulation function indicators in patients with severe pulmonary infections,providing a basis for clinical individualized medication.
Method
A total of 110 patients with severe pulmonary infections admitted to our ICU from January 2023 to January 2025 were prospectively included and divided into an observation group(n=60)and a control group(n=50)based on whether doxycycline was used or not.On the third day of administration,the observation group measured the steady-state peak concentration(C
0
)and trough concentration(C
0
),and dynamically monitored the prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(FIB),international normalized ratio(INR),and platelet count(PLT)of both groups before treatment and on the third and seventh days of treatment.Pearson correlation and multiple linear regression were used to analyze the relationship between blood drug concentration and coagulation indicators.
Result
On the third day of treatment,PT,APTT,and INR in the observation group significantly increased compared to baseline(
P<
0.05),while FIB and PLT significantly decreased(
P<
0.05).On the seventh day,they returned to baseline levels;There was no significant difference in the indicators of the control group before and after treatment(
P>
0.05).The observation group's doxycycline C
2
was(3.28±1.15)μg/mL,and C
0
was(1.46±0.62)μg/mL.C
2
is significantly positively correlated withΔPT,ΔAPTT,and ΔINR(r=0.582,0.517,0.603,
P<
0.001),and significantly negatively correlated with ΔFIB and ΔPLT(r=-0.493,-0.446,
P<
0.01);There is no significant correlation between C
0
and various indicators.Multiple regression analysis showed that doxycycline C
0
(β=0.412),combined use of cefoperazone sulbactam(β=0.306),and baseline APTT prolongation(β=0.251)were independent risk factors for PT elevation(
P<
0.05).
Conclusion
Doxycycline can cause transient coagulation dysfunction in patients with severe pulmonary infections,with the degree of impact significantly correlated with the steady-state peak concentration.When C
0
>3.95 μg/mL,the risk of coagulation dysfunction increases significantly.It is recommended to monitor blood drug concentrations clinically and avoid concomitant use with cefoperazone-sulbactam.
2026 Vol. 46 (2): 7-10 [
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135
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11
Application Value Analysis of Somatostatin Combined with Esomeprazole in the Treatment of Liver Cirrhosis Complicated with Upper Gastrointestinal Bleeding
Gou Xi, Yang Jing, Liu Min
DOI: 10.3969/j.issn.1001-8131.2026.02.003
Objective
This study aims to observe the clinical efficacy of the combined therapy with the two drugs.
Methods
All patients were randomLy divided into two groups:52 patients were treated with esomeprazole alone(control group),and 53 patients were treated with somatostatin combined with esomeprazole(observation group).The clinical efficacy,coagulation function and liver function levels were compared between the two groups.
Results
The overall clinical efficacy and clinical effective rate were both superior in the observation group(
Z
=-5.057,
P
=0.000;χ
2
=7.244,
P
=0.008).After treatment,the fibrinogen(Fib)level was elevated,while prothrombin time(PT)and activated partial thromboplastin time(APTT)were significantly decreased in both groups compared with those before treatment(
P<
0.05),and the improvements in the observation group were more significant(
t
=5.847,
P
=0.000;
t
=-8.337,
P
=0.000;
t
=-8.235,
P
=0.000).The liver function indexes were reduced in both groups after treatment(
P<
0.05),with more prominent improvements in the observation group(
t
=-13.564,
P
=0.000;
t
=-8.228,
P
=0.000;
t
=-12.841,
P
=0.000).
Conclusion
Somatostatin combined with esomeprazole can achieve satisfactory hemostatic effect,improve the coagulation function and liver function of patients,with favorable clinical efficacy,which is worthy of clinical promotion and application.
2026 Vol. 46 (2): 11-13 [
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] (
125
)
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14
Clinical Curative Effect of Camrelizumab Combined with SP Chemotherapy in Advanced Esophageal Cancer and Its Influences on Cellular Immunity and Prognosis
Fu Peibiao, Chen Yanmin, Wang Zhenzhen, Zhang Yanyan, Zheng Huihui
DOI: 10.3969/j.issn.1001-8131.2026.02.004
Objective
To explore clinical curative effect of camrelizumab combined with S-1 plus cisplatin(SP)chemotherapy in advanced esophageal cancer and its influences on cellular immune function and prognosis.
Methods
A total of 202 patients with advanced esophageal cancer treated in The Second People's Hospital of Jiaozuo were enrolled between March 2021 and June 2024.According to random number table method,they were divided into control group(101 cases,SP chemotherapy regimen)and observation group(101 cases,camrelizumab combined with SP chemotherapy regimen).The clinical curative effect,serum tumor markers(CEA,CA19-9,CYFRA21-1,SCC),T lymphocyte subsets(CD3
+
,CD4
+
,CD8
+
)and the occurrence of adverse reactions were compared between the two groups.
Results
After treatment,objective response rate(ORR)and disease control rate(DCR)in observation group were and（
P<
0.05）,higher than those in control group.The levels of CEA,CA19-9,CYFRA21-1 and SCC in observation group were（
P<
0.05）,lower than those in control group The levels of peripheral blood CD3
+
,CD4
+
and CD4
+
/CD8
+
in observation group were higher than those in control group（
P<
0.05）,while CD8
+
was lower than that in control group.The differences in all the above indexes between the two groups were statistically significant(
P<
0.05).In terms of safety,there was no significant difference in the incidence of adverse reactions between the two groups(
P>
0.05).After 1 year of follow-up,cumulative survival rate in observation group was higher than that in control group(Log-rank χ
2
=9.221,
P
=0.002).
Conclusion
The combination therapy of camrelizumab and SP regimen can significantly improve curative effect and survival status in patients with advanced esophageal cancer by significantly down-regulating tumor indexes and activating immune function.
2026 Vol. 46 (2): 14-18 [
Abstract
] (
117
)
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19
Comparison of Biomarkers in Asthma COPD and Asthma-COPD Overlap
Yao Zhihui, Liu Xingdong, Xie Junying
DOI: 10.3969/j.issn.1001-8131.2026.02.005
Objective
To compare biomarkers in asthma,COPD,and asthma-COPD overlap(ACO).
Methods
50 patients per group(asthma,COPD,ACO,and healthy controls)were included.Inflammatory,protease-related,and fibrotic biomarkers were analyzed.Correlation analysis assessed biomarker-disease associations.
Results
Eosinophilic markers(FeNO, IL-5)were highest in asthma,neutrophil/protease markers(MMP-9, NE)in COPD,and TGF-β in ACO.FeNO correlated strongly with asthma,MMP-9 with COPD,and TGF-β most strongly with ACO.
Conclusion
Asthma shows eosinophilic inflammation,COPD exhibits neutrophilic inflammation and oxidative stress,while ACO combines features of both with a distinct pro-fibrotic profile.
2026 Vol. 46 (2): 19-22 [
Abstract
] (
147
)
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22
Effect of General Anesthesia Combined with Epidural Anesthesia on Hemodynamic Indexes and Recovery Quality in Patients Undergoing Laparoscopic Radical Resection of Colorectal Cancer
Liu Wei, Chen Weifei, Chen Jia
DOI: 10.3969/j.issn.1001-8131.2026.02.006
Objective
To investigate the anesthetic effect of general anesthesia combined with epidural block(EB)anesthesia in patients undergoing laparoscopic radical resection of colorectal cancer(lrrcc),focusing on the impact of the combined anesthesia scheme on hemodynamic indexes and recovery quality.
Methods
88 patients with lrrcc in our hospital were randomly divided into two groups,with 44 cases in each group from.The control group was given general anesthesia.On the basis of general anesthesia,the observation group was given EB anesthesia.Hemodynamic parameters [mean arterial pressure(map)and heart rate(HR)],recovery quality and adverse reactions were compared between the two groups.
Results
compared with the control group,the map and HR of the observation group with general anesthesia combined with EB anesthesia at T1 and T2 were lower,the recovery time and extubation time were shorter,and the total incidence of adverse reactions was lower,with statistical difference(
P<
0.05).
Conclusion
the use of general anesthesia combined with EB anesthesia during lrrcc operation is conducive to stabilizing the hemodynamics of patients,improving the quality of recovery,shortening the time of recovery and extubation,and has less adverse reactions.
2026 Vol. 46 (2): 22-24 [
Abstract
] (
122
)
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25
Comparison of Clinical Characteristics of Patients with Different Therapeutic Effects after Root Canal Treatment for Periapical Periodontitis
Cheng Hong, Wang Guanghua, Guo Kaijie
DOI: 10.3969/j.issn.1001-8131.2026.02.007
Objective
To explore the clinical characteristics of patients with different therapeutic outcomes after root canal treatment for periapical periodontitis,in order to provide a reference for clinical evaluation of therapeutic efficacy.
Methods
A retrospective analysis was conducted on 282 patients with periapical periodontitis admitted to our hospital from December 2019 to December 2022.All patients underwent root canal treatment and were followed up for 3 years.According to the therapeutic effect,they were divided into the poor therapeutic effect group(70 cases)and the good therapeutic effect group(212 cases).The clinical data of the two groups of patients were compared [age,gender,tooth position(anterior teeth,posterior teeth),number of root fillings(single root canal,double root canal,multiple root canals),quality of root fillings(complete,incomplete),whether there was fistula before surgery,whether there was gingival swelling before surgery,whether there was secondary caries,whether there was crown leakage,whether there was re-treatment,whether there was instrument fracture,and the range of low-density shadow(<5mm,>5mm)];The risk factors for poor therapeutic effect after root canal treatment in patients with apical periodontitis were analyzed through multivariate Logistic regression.
Results
The age,gender,number of root fillings,preoperative fistula,preoperative gingival swelling,and the range of low-density shadow were comparable between the two groups(
P>
0.05);The proportions of posterior tooth position,incomplete root filling quality,secondary caries,crown leakage,re-treatment and instrument fracture in the poor therapeutic effect group were all higher than those in the good therapeutic effect group(
P<
0.05).Multivariate Logistic regression analysis showed that posterior tooth position,incomplete root filling quality,secondary caries,crown leakage,re-treatment,and instrument fracture were independent risk factors for poor therapeutic effect after root canal treatment in patients with periapical periodontitis(
P<
0.05).A risk prediction model was established.
Conclusion
The therapeutic effect of root canal treatment in patients with periapical periodontitis is affected by the position of posterior teeth,incomplete root filling quality,secondary caries,crown leakage,re-treatment,and instrument breakage.Close clinical monitoring should be carried out.
2026 Vol. 46 (2): 25-28 [
Abstract
] (
110
)
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29
Analysis of the Correlation Between the Degree of Neurological Deficit and Negative Emotions in Patients with Acute Cerebral Infarction
Wang Ge, Zhao Lulu, Wang Shitan
DOI: 10.3969/j.issn.1001-8131.2026.02.008
Objective
To investigate the correlation between the degree of neurological deficit and negative emotions in patients with acute cerebral infarction.
Methods
A total of 93 patients with acute cerebral infarction(onset time<24 h)treated in our hospital from divided into three groups according to the degree of neurological deficit:mild deficit group(n=32),moderate deficit group(n=35),and severe deficit group(n=26).General patient information was collected,along with scores from the Self-Rating Anxiety Scale(SAS)and the Self-Rating Depression Scale(SDS).
Results
The more severe the neurological deficit in patients with acute cerebral infarction,the higher the SAS and SDS scores,with significant differences(
P<
0.05).There were differences in SAS and SDS scores among patients of different ages and nutritional statuses(
P<
0.05),while no significant differences were found in SDS scores among patients of different genders,smoking history,drinking history,or education levels(
P>
0.05).Correlation analysis indicated that SAS and SDS scores were positively correlated with the degree of neurological impairment in acute cerebral infarction patients,while age was negatively correlated and nutritional status was positively correlated(
P<
0.05).Multivariate logistic regression analysis showed that lower SAS and SDS scores were negatively associated with the degree of neurological deficit,while female gender,older age,and the presence of nutritional risk were risk factors(
P<
0.05).
Conclusion
Negative emotions in patients with acute cerebral infarction are associated with the degree of neurological deficit.SAS and SDS scores show a positive correlation with the degree of neurological impairment,while older age and nutritional risk are identified as risk factors.
2026 Vol. 46 (2): 29-32 [
Abstract
] (
97
)
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33
Analysis of Monitoring Results of Common Pathogenic Bacteria and Drug Resistance Data in Longyan Traditional Chinese Medicine Hospital from 2022 to 2024
Jiang Weiwei, Lan Lijia
DOI: 10.3969/j.issn.1001-8131.2026.02.009
Objective
To analyze the distribution,drug resistance characteristics,and departmental clustering of common clinical pathogens in Longyan Traditional Chinese Medicine Hospital from 2022 to 2024,providing a basis for precision medication and infection prevention and control.
Method
From January 2022 to December 2024,2072 clinical microbiological specimens were collected from Longyan Traditional Chinese Medicine Hospital.The strains were identified by standardized isolation and culture,DL-96A system,and drug sensitivity tests were conducted according to CLSI standards.SPSS 26.0 was used for statistical analysis of the data.
Result
Among the 2072 isolated pathogenic bacteria,Gram negative bacteria accounted for 87.98%,with Pseudomonas aeruginosa,Escherichia coli,and Klebsiella pneumoniae being the dominant bacteria;Gram positive bacteria account for 12.02%,mainly Staphylococcus aureus.The detection rate of Acinetobacter baumannii has increased year by year to 8.62%,while that of Klebsiella pneumoniae has decreased to 2.44%.In terms of drug resistance,Pseudomonas aeruginosa has the lowest resistance rate to amikacin and the highest resistance rate to levofloxacin;Acinetobacter baumannii is highly resistant to all tested drugs;Staphylococcus aureus has the lowest resistance rate to amikacin and the highest resistance rate to amoxicillin/clavulanic acid.In the distribution of departments,Pseudomonas aeruginosa and Klebsiella pneumoniae are concentrated in the Rehabilitation Department and Intensive Care Medicine Department,while Acinetobacter baumannii is concentrated in the Intensive Care Medicine Department.
Conclusion
Clinical infections in hospitals are mainly caused by gram-negative bacteria,with an increasing proportion of Acinetobacter baumannii and prominent issues of multidrug resistance.It is necessary to optimize the use of antibiotics based on the characteristics of pathogenic bacteria and strengthen infection prevention and control in key departments.
2026 Vol. 46 (2): 33-36 [
Abstract
] (
113
)
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37
Analysis of Multi-pathogen Detection Results and Epidemiological Characteristics of Acute Respiratory Infection Cases in Jiaozuo City in 2024
Li Jie
DOI: 10.3969/j.issn.1001-8131.2026.02.010
Objective
To determine the pathogen spectrum composition,epidemiological characteristics,and population distribution patterns of acute respiratory infections(ARI)cases in Jiaozuo City,Henan Province in 2024,and to provide scientific basis for precise prevention and control of local respiratory infectious diseases and standardized clinical diagnosis and treatment.
Methods
A total of 766 specimens from ILI and SARI cases were collected from national influenza surveillance sentinel hospitals in Jiaozuo City from January to December 2024.Multiplex real-time fluorescent quantitative PCR technology was used to detect 16 common respiratory pathogens,and statistical analysis was performed on the test results and epidemiological characteristics.
Results
Among the 766 specimens,526 tested positive for at least one pathogen,with an overall positivity rate of 68.7%.There were 257 cases(33.6%)of single infection and 269 cases(35.1%)of mixed infections,including 176 cases(23.0%)of double infections,75 cases(9.8%)of triple infections,and 18 cases(2.3%)of quadruple or higher infections.The top five detected pathogens were Streptococcus pneumoniae(Sp,16.6%),Influenza A virus(Flu A,13.7%,with H1 subtype accounting for 12.4%),Haemophilus influenzae(HIb,11.5%),Mycoplasma pneumoniae(Mp,10.7%),and Human metapneumovirus(HMPV,9.4%).The 4-<18 age group had the highest overall positivity rate(78.9%),with particularly high detection rates of Sp(21.1%),HIb(17.9%),and Mp(13.7%)in this age group.The 0-<4 age group had a higher Sp infection rate(23.2%),while the ≥60 age group had the highest detection rate of SARS-CoV-2(15.3%).There was no significant difference in overall positivity rates between males and females(
P>
0.05),except for HIb detection rates,which were higher in females than males(
P=
0.035).The Mp detection rate in SARI cases(25.59%)was significantly higher than in ILI cases(4.55%).Temporally,Influenza A virus peaked in December(55.4%),while SARS-CoV-2 showed peaks in March(32.2%)and August(31.8%).
Conclusion
In 2024,the respiratory tract infections in Jiaozuo were mainly caused by SP,Flu A,HIb,Mp,and HMPV,with children and adolescents being high-risk groups,winter and spring being high-incidence periods,and mixed infections predominantly involving bacterial and viral co-infections.Therefore,respiratory infectious disease prevention and control in Jiaozuo should develop differentiated strategies targeting key populations,dominant pathogens,and epidemic periods,while strengthening pathogen surveillance and precise intervention for severe cases.
Conclusion
In 2024,Jiaozuo City's ARI epidemic is mainly caused by SP,Flu A,HIb,Mp,and HMPV,with children and adolescents as high-risk groups,winter and spring as peak seasons,and mixed infections primarily characterized by bacterial-viral co-infections.Therefore,respiratory infectious disease prevention and control in Jiaozuo City needs to develop differentiated strategies targeting key populations,dominant pathogens,and epidemic periods,while strengthening pathogen surveillance and precise intervention for severe cases.
2026 Vol. 46 (2): 37-40 [
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] (
109
)
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41
A Study on the Safety of Allylestrenol Combined with Dydrogesterone in the Treatment of Threatened Miscarriage Patients
Li Zhigang, Yan Shufen, Qi Ruihe, Liu Luyan
DOI: 10.3969/j.issn.1001-8131.2026.02.011
Objective
To study the safety of allylestrenol combined with dydrogesterone in the treatment of threatened miscarriage(TM)patients.
Methods
A total of 62 TM patients in our hospital from were randomly divided into a single group(n=31)and a combined group(n=31).The single group was treated with dydrogesterone,and the combined group was treated with allylestrenol combined with dydrogesterone.The curative effect,improvement time of symptoms,endocrine hormone [progesterone(P),estradiol(E2),β-human chorionic gonadotropin(β-hCG)],uterine blood flow parameters [pulsatility index(PI),resistance index(RI)],adverse reactions and pregnancy outcomes were compared between the two groups.
Results
The total effective rate of the combined group was,which was higher than that of the single group(
P<
0.05);compared with the single group,the improvement time of vaginal bleeding and low back and abdominal pain in the combined group was shorter(
P<
0.05);after treatment,compared with the single group,the levels of P,E2,and β-hCG in the combined group were higher(
P<
0.05);after treatment,compared with the single group,the levels of PI and RI in the combined group were lower(
P<
0.05);the incidence of adverse reactions in the combined group was,which was not significantly different from that of the single group(
P>
0.05);the success rate of miscarriage prevention in the combined group was,and the full-term delivery rate was,which were higher than those of the single group and,and the miscarriage rate was,which was lower than that of the single group(
P<
0.05).
Conclusion
The application of allylestrenol combined with dydrogesterone in TM can improve the curative effect,improve the levels of endocrine hormones and uterine blood flow,effectively relieve clinical symptoms,improve pregnancy outcomes,and have good safety.
2026 Vol. 46 (2): 41-44 [
Abstract
] (
120
)
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44
Evaluation of the Effect of the Integration of Physical Therapy and Medicine Model based on Patient-reported Outcomes in the Rehabilitation of Patients with Degenerative Meniscus Tear
Wang Yuchao, Li Ye, Huang Yu
DOI: 10.3969/j.issn.1001-8131.2026.02.012
Objective
To evaluate the efficacy of a structured "integration of physical and medical rehabilitation" model based on patient-reported outcomes(PROs)in the rehabilitation of patients with degenerative meniscal tears following arthroscopic meniscal repair.
Methods
A randomized controlled study was conducted,enrolling 72 patients admitted from January to August 2024,who were randomly divided into a control group(n=36)and an intervention group(n=36).The control group received routine home rehabilitation guidance postoperatively,while the intervention group underwent a 4-week,three-phase structured "integration of physical and medical rehabilitation" exercise program.Knee joint function(IKDC score),quality of life(KOOS total score),pain level(VAS score),range of motion,return to activity(Tegner score),and overall satisfaction were assessed preoperatively and at 1,3,and 6 months postoperatively.
Results
A total of 69 patients completed follow-up.The baseline characteristics of the two groups were comparable(
P>
0.05).Repeated-measure ANOVA revealed that the intervention group demonstrated significantly better outcomes than the control group in both IKDC scores and KOOS total scores at 3 and 6 months postoperatively.Additionally,the intervention group exhibited significantly superior VAS walking pain scores at all postoperative time points,greater joint range of motion at 6 months,higher Tegner scores,and higher overall satisfaction(
P=
0.044).
Conclusion
The structured "physiotherapy-integrated" rehabilitation model based on PROs effectively promotes functional recovery in patients with degenerative meniscus tears,significantly alleviates pain,improves quality of life and mobility,and enhances patient satisfaction,representing a superior postoperative rehabilitation strategy compared to conventional home-based rehabilitation.
2026 Vol. 46 (2): 44-48 [
Abstract
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124
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129
Research Progress on Chemical Constituents,Processing Technology and Pharmacological Effects of Sanguisorba officinalis L
Wang Chaoqun, Zhang Guiqun, Huo Jinhai
DOI: 10.3969/j.issn.1001-8131.2026.02.038
Sanguisorba officinalis L.tastes bitter,sour and astringent,and is slightly cold in nature.It enters the Liver and Large Intestine Meridians,and was first recorded in Shennong Ben Cao Jing(Shennong's Classic of Materia Medica).As a commonly used traditional Chinese medicine in clinical practice,it has the traditional efficacy of cooling blood to stop bleeding,detoxifying and promoting wound healing.This paper systematically reviews the relevant research literatures in recent years,and clarifies that the core chemical constituents of Sanguisorba officinalis L.include saponins(the total content of sanguisorbin Ⅰ/Ⅱ is 1.5 2.1 mg/g),tannins(the content of ellagic acid in carbonized Sanguisorba officinalis L.is up to 34.86 mg/g at maximum),flavonoids,etc.Among the processing technologies,carbonized Sanguisorba officinalis L.has the widest application.Orthogonal tests have confirmed that stir-frying at 250℃ for 14 minutes is the optimal process,which can significantly increase the content of hemostatic active ingredients.Modern pharmacological studies have verified that Sanguisorba officinalis L.and its active components possess various pharmacological effects such as hemostasis,wound repair,intestinal mucosal protection,anti-inflammation,antioxidation,antibacterial activity and immunoregulation.It is widely used in clinical fields including hemorrhagic diseases,skin injuries and inflammatory bowel diseases,and shows unique advantages in the protection against intestinal damage caused by tumor radiotherapy and chemotherapy,as well as the treatment of diabetic foot ulcers.Processing is an important link in the clinical application of Sanguisorba officinalis L.,and different processing methods significantly affect its chemical constituents and pharmacological activities.By comprehensively analyzing the characteristics of chemical constituents,the influence of processing technology,the mechanism of pharmacological effects and the expansion of clinical application of Sanguisorba officinalis L.,this paper points out the existing problems in current research,such as unclear synergistic mechanism of components and insufficient development of non-medicinal parts,so as to provide references for its further research,development and precise clinical application.
2026 Vol. 46 (2): 129-133 [
Abstract
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131
)
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134
Research Progress on Esketamine in the Prevention and Treatment of Chills after Spinal Anesthesia
Wang Yuanyuan, Zhang Lei
DOI: 10.3969/j.issn.1001-8131.2026.02.039
The occurrence of chills after spinal anesthesia is relatively common,mainly related to the inhibition of hypothalamic thermoregulation centers by anesthetic drugs,resulting in abnormal thermogenesis response.Chills not only cause discomfort and anxiety in patients,but can also increase the risk of complications,delay postoperative recovery,prolong hospital stay,and increase healthcare costs.In recent years,esketamine,as a dextrorotator of ketamine,has gained attention in perioperative management due to its unique pharmacological properties.Studies have shown that it may reduce the incidence of chills after neuraxial anesthesia by regulating body temperature regulation points or inhibiting the downward conduction of chills commands,and its psychomotor adverse effects are milder than ketamine.The purpose of this article is to review the current situation of chills after spinal anesthesia,explore the pharmacological properties of esketamine and its application in the prevention and treatment of chills,and evaluate its efficacy and safety,in order to provide reference for clinical practice.
2026 Vol. 46 (2): 134-136 [
Abstract
] (
102
)
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