Abstract：Objective To analyze the application effect of dexmedetomidine preemptive analgesia in severe burn patients. Methods 86 severe burn patients diagnosed and treated were selected and randomly divided into two groups,with 43 patients in each group.Observation group injected 10 minutes before anesthesia 1μg/kg dexmedetomidine,followed by 0.5 μg Pump at a rate of 1g/（kg·h）,discontinue medication 30 minutes before surgery,and inject the same amount of physiological saline into the control group in the same manner.Compare the sedative and analgesic effects,serum inflammatory factor levels,and hemodynamics between the two groups. Results The analgesic onset time of the observation group was（2.06±0.41）minutes,shorter than the control group's（4.89±0.95）minutes,the analgesic duration was（123.48±10.67）minutes,and longer than the control group's（95.31±8.46）minutes,with a statistical difference（P<0.05）;Before anesthesia（T0）,two groups of C-reactive protein（CRP）and tumor necrosis factor- α（TNF- α）、There was no statistically significant difference in levels of interleukin-6（IL-6）,heart rate（HR）,and mean arterial pressure（MAP）（P>0.05）;30 minutes after the start of surgery（T1）and at the end of surgery（T2）,the observation group showed CRP and TNF- α、 IL-6,HR,and MAP were lower than the control group,with statistical differences（P<0.05）. Conclusion Dexmetomidine can exert preemptive analgesic effects in severe burn patients,reduce inflammatory reactions,stabilize patient hemodynamics,and has high clinical application value.It can be vigorously promoted and applied.
2024, Vol. 44 
