Abstract：Objective To investigate the expression differences and correlations of Ki-67 and p53 in colorectal high-grade intraepithelial neoplasia(HGIN)and adenocarcinoma tissues,thereby providing a reference for clinical risk assessment of malignant transformation. Methods A total of 72 patients with colorectal lesions admitted to our hospital from January 2018 to December 2025 were retrospectively enrolled,including 27 cases of high-grade intraepithelial neoplasia and 45 cases of adenocarcinoma.The protein expressions of Ki-67 and p53 in lesion tissues were detected using the immunohistochemical SP method.Fisher’s exact test was used to correct statistical Results in small-sample subgroups,and Spearman’s rank correlation analysis was applied to assess correlations between indicators. Results The positive expression rate of Ki-67 in the adenocarcinoma group was significantly higher than that in the HGIN group(P<0.05).In the HGIN subgroup with malignant tendency,the positive rates of both Ki-67 and p53 were higher than those in the subgroup without malignant tendency(P<0.05).The nature of the lesion was significantly positively correlated with Ki-67 expression,and Ki-67 expression was also significantly positively correlated with p53 expression(P<0.001). Conclusion Combined detection of Ki-67 and p53 can accurately assess the risk of malignant transformation in colorectal high-grade intraepithelial neoplasia,assist in clinical pathological differential diagnosis and individualized treatment,and has high clinical application value.
曲城圆, 叶青龙, 陈静. 结直肠高级别上皮内瘤变与腺癌组织中Ki-67、p53的表达及相关性研究[J]. 哈尔滨医药, 2026, 46(5): 16-18.
Qu Chengyuan, Ye Qinglong, Chen Jing. Expression and Correlation of Ki-67 and p53 in High-Grade Intraepithelial Neoplasia and Adenocarcinoma of the Colorectum. journal1, 2026, 46(5): 16-18.
2026, Vol. 46 
