血清ALT、AST及免疫球蛋白水平对乙型肝炎患者病情严重程度的预测价值

doi:10.3969/j.issn.1001-8131.2025.03.011

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摘要目的探讨血清谷丙转氨酶（ALT）、谷草转氨酶（AST）及免疫球蛋白水平对乙型肝炎（HB）患者病情严重程度的预测价值。方法选取HB患者127例,参照相关标准评估患者病情严重程度,检测并对比不同病情严重程度的患者血清ALT、AST及免疫球蛋白水平,分析ALT、AST、免疫球蛋白水平与HB患者病情严重程度的关系及预测价值。结果 127例HB患者中轻度38例（29.92%）,中度59例（46.46%）,重度30例（23.62%）;重度HB患者ALT、AST、免疫球蛋白A（IgA）、免疫球蛋白M（IgM）、免疫球蛋白G（IgG）水平依次较中度、轻度患者高（P<0.05）;经Kendall's tau-b相关系数检验显示,ALT、AST、IgA、IgM、IgG水平与HB患者病情严重程度均呈正相关（r>0,P<0.05）;绘制ROC曲线显示,ALT、AST、IgA、IgM、IgG单独检测及各指标联合检测预测HB患者中重度病情的AUC均>0.70,均有诊断价值,且联合检测价值最高。结论血清ALT、AST、免疫球蛋白水平与HB患者病情严重程度有关,对HB患者病情严重程度具有较高预测价值,考虑未来可作为患者病情严重程度判断辅助指标之一。

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	黄辰璐
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关键词 ：乙型肝炎, 谷丙转氨酶, 谷草转氨酶, 免疫球蛋白, 预测价值

Abstract：Objective To explore the predictive value of serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),and immunoglobulin levels on the severity of hepatitis B(HB)in patients. Method 127 patients with HB were selected.The severity of the patients' condition was evaluated according to relevant standards,and serum ALT,AST,and immunoglobulin levels were detected and compared among patients with different severity levels.ALT,AST,and immunoglobulin levels were analyzed AST,The relationship and predictive value between immunoglobulin levels and the severity of HB patients. Result Among the 127 patients with HB,38 cases(29.92%)were mild,59 cases(46.46%)were moderate,and 30 cases(23.62%)were severe;Severe HB patients with ALT AST,The levels of immunoglobulin A(IgA),immunoglobulin M(IgM),and immunoglobulin G(IgG)were higher in moderate and mild patients,respectively(P<0.05);Kendall's tau-b correlation coefficient test showed that the levels of ALT,AST,IgA,IgM,and IgG were positively correlated with the severity of HB patients(r>0,P<0.05);Plotting ROC curves shows that the AUC of predicting moderate to severe illness in HB patients by detecting ALT,AST,IgA,IgM,and IgG separately or by combining various indicators is all greater than 0.70,indicating diagnostic value,with the highest value observed in combined detection. Conclusion Serum ALT AST、 The level of immunoglobulin is related to the severity of HB patients' condition and has high predictive value for the severity of HB patients' condition.It is considered to be one of the auxiliary indicators for judging the severity of patients' condition in the future.

Key words： Hepatitis B Alanine aminotransferase Aspartate transaminase immunoglobulin predictive value

收稿日期: 2025-02-20

PACS:

R575.1

引用本文:

黄辰璐, 黄芯怡. 血清ALT、AST及免疫球蛋白水平对乙型肝炎患者病情严重程度的预测价值[J]. 哈尔滨医药, 2025, 45(3): 40-42.
Huang Chenlu, Huang Xinyi. The Predictive Value of Serum ALT,AST,and Immunoglobulin Levels for the Severity of Hepatitis B in Patients. journal1, 2025, 45(3): 40-42.

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http://www.hrbyybjb.org.cn/CN/10.3969/j.issn.1001-8131.2025.03.011 或 http://www.hrbyybjb.org.cn/CN/Y2025/V45/I3/40