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Quick Search     Adv Search 2022 Vol. 42, No. 6 Published: 2022-12-25 1 Effect of Butylphthalide Combined With Shenmai Injection on Nerve and Vascular Endothelial Function in Acute Cerebral Infarction Ma Junbao, Li Dashan, Sun Xiaopin DOI: 10.3969/j.issn.1001-8131.2022.06.001 Objective To study the effect of butylphthalide combined with Shenmai injection on nerve and vascular endothelial function in acute cerebral infarction. Methods A total of 110 patients diagnosed with acute cerebral infarction.According to the random number table method,they were divided into control group and observation group,with 55 cases in each group.The control group was treated with Shenmai injection,and the observation group was treated with butylphthalide on the basis of the control group.The curative effect,neurological function,vascular endothelial function and adverse reactions of the two groups were observed. Results The total effective rate of the observation group was 96.36%（53 / 55）,which was higher than that of the control group[85.45%（47/55）]（P<0.05）.After treatment,the levels of HDL and NO increased,and the levels of TC,ET,LDL and VEGF decreased in the two groups,and the improvement of the above indexes in the observation group was better than that in the control group（P<0.05）.After treatment,NIHSS and mRSscores of the observation group were lower than those of the control group,and Barthel index scores of the observation group were higher than those of the control group,the difference was significant（P<0.05）.There was no significant difference in the incidence of adverse reactions between the two groups（P>0.05）. Conclusion Butylphthalide combined with Shenmai injection in the treatment of acute cerebral infarction can effectively improve the neurological function and vascular endothelial function of patients,promote the rehabilitation of patients,improve the treatment effect,with safety. 2022 Vol. 42 (6): 1-3 [Abstract] ( 220 ) HTML (1 KB)  PDF (419 KB)  ( 156 ) 4 Effects of Liraglutide and Empagliflflozin Added to Insulin Therapy in Patients With Type 2 Diabetes：A Randomized Controlled Study Zheng Yu DOI: 10.3969/j.issn.1001-8131.2022.06.002 Objective To investigate the clinical efficacy of liraglutide and empagliflozin combined with insulin in the treatment of type 2 diabetes. Methods A total of 180 patients with type 2 diabetes who were treated in our hospital were selected and divided into observation group（90 cases）and control group（90 cases）according to the double-blind method.The observation group was treated with liraglutide combined with insulin,and the control group was treated with empagliflozin combined with insulin.Participants received 0.9 mg/d liraglutide or 10 mg/d epagliflozin for 24 weeks.The HbA1c（glycated hemoglobin）,GA（glycated albumin）,and PPG（postprandial plasma glucose）of the two groups after 24 weeks of treatment were compared. Results The HbA1c（glycated hemoglobin）（6.80±0.14）% of the observation group after 24 weeks of treatment was less than the HbA1c（glycated hemoglobin）（7.73±0.83）% of the control group after 24 weeks of treatment.The difference was statistically significant（P<0.05）.GA（glycated albumin）（18.32±0.42）% after 24 weeks of treatment was less than that of the control group after 24 weeks of treatment（19.49±0.29）%,the difference was statistically significant（P<0.05）,the observation group was treated After 24 weeks,PPG（postprandial plasma glucose）（159.01±8.89）% was less than that of the control group after 24 weeks of treatment（172.16±10.64）%,the difference was statistically significant（P<0.05）. Conclusion In patients with inadequate control of type 2 diabetes,in addition to ongoing insulin therapy,liraglutide is more effective than empagliflozin in reducing the levels of glycosylated hemoglobin and glycosylated albumin,which is worthy of clinical promotion. 2022 Vol. 42 (6): 4-6 [Abstract] ( 210 ) HTML (1 KB)  PDF (414 KB)  ( 151 ) 7 Study on Pulmonary Infection in 150 Patients With Severe Craniocerebral Injury in ICU Based on Logistic Regression Analysis Dou Jingjing, Zhang Yan, Wang Jiaoping DOI: 10.3969/j.issn.1001-8131.2022.06.003 Objective To analyze the related factors of pulmonary infection in 150 patients with severe craniocerebral injury in intensive care unit（ICU）based on logistic regression. Methods 150 patients with severe craniocerebral injury treated in ICU were selected as the research object.The pulmonary infection and baseline data were recorded,and the influencing factors of pulmonary infection in patients with severe craniocerebral injury in ICU were analyzed. Results Among 150 patients with severe craniocerebral injury,41 patients（27.33%）had pulmonary infection,and 109 patients（72.67%）had no pulmonary infection.There were statistically significant differences in GCS score,early mechanical ventilation,smoking history and tracheotomy between the two groups（P<0.05）.Logistic regression analysis showed that low GCS score,early mechanical ventilation,smoking history and tracheotomy were the influencing factors of pulmonary infection in ICU patients with severe craniocerebral injury（OR>1,P<0.05）. Conclusion Pulmonary infection in ICU patients with severe craniocerebral injury is affected by GCS score,early mechanical ventilation,smoking history and tracheotomy. 2022 Vol. 42 (6): 7-8 [Abstract] ( 156 ) HTML (1 KB)  PDF (421 KB)  ( 154 ) 9 Risk Factors of Ventilator-associated Pneumonia in Emergency Patients with Severe Mechanical Ventilation Wu Pei DOI: 10.3969/j.issn.1001-8131.2022.06.004 Objective To investigate the risk factors of ventilator-associated pneumonia（VAP）in emergency patients with severe mechanical ventilation（MV）. Methods a total of 86 patients admitted to the emergency intensive care unit were selected by convenience sampling.The patient data were collected and analyzed to analyze the risk factors of VAP in emergency severe MV patients. Results The incidence of VAP in emergency severe MV patients was 26.74%（23/86）.Multivariate analysis shows that: Tracheotomy（β=2.636,OR=13.953,95%CI=4.126-47.184）,age ≥60 years（β=2.197,OR=9.000,95%CI=2.903-27.905）,MV time ≥7d（β=2.294,OR=9.917,95%CI=3.288-29.913）,hormone use（β=2.618,OR=13.714,95%CI=4.411-42.641）,length of stay in ICU≥7d（β=2.628,OR=13.846,95%CI=4.325-44.329）and gastric tube duration ≥2d（β=2.324,OR=10.212,95%CI=3.071-33.963）were the risk factors for VAP in emergency patients with severe MV（P<0.05）. Conclusion The occurrence of VAP in emergency patients with severe MV is related to tracheotomy,age,MV time,use of hormones,time of ICU admission and time of gastric tube indplacement. 2022 Vol. 42 (6): 9-11 [Abstract] ( 157 ) HTML (1 KB)  PDF (375 KB)  ( 157 ) 12 Effects of Different Anesthesia Methods on Perioperative Neurocognitive Disorders and Inflammatory Factor IL-6 in Elderly Patients Undergoing Total Hip Replacement Wu Xianping, Yang Yanping, Chen Xian, Wu Yanfang, Jiang Ying DOI: 10.3969/j.issn.1001-8131.2022.06.005 Objective To study the effects of different anesthesia methods on perioperative neurocognitive disorders（PND）and inflammatory factors in elderly patients undergoing total hip replacement. Methods 72 patients with total hip replacement were randomly divided into general anesthesia group and peripheral nerve block group according to different anesthesia methods.The cognitive function of patients was measured by MMSE score 24 hours before operation（T0）,24 hours after operation（T1）,1 week after operation（T2）,1 month after operation（T3）,3 months after operation（T4）and half a year after operation（T5）.The expression level of serum IL-6 factor was measured by venous blood from patients at T0,T1 and T2.Adverse reactions such as agitation,nausea,vomiting and vertigo were recorded. Results Compared with the general anesthesia group,IL-6 in the peripheral nerve block group decreased significantly at 24 hours（T1）and 1 week（T2）after operation,and MMSE score increased significantly at the same time（P<0.05）;Among them,4 patients in the general anesthesia group developed PND at 24 hours（T1）and 1 week（T2）after operation,and 2 patients still had PND at 1 month（T3）and 3 months（T4）,while there was no PND in the peripheral nerve block group.The incidence of nausea and vomiting after general anesthesia was significantly lower than that after general anesthesia（P<0.05）. Conclusion Different anesthesia methods have different effects on postoperative cognitive function and inflammatory factors in elderly patients undergoing total hip replacement.Peripheral nerve block can reduce the occurrence of perioperative neurocognitive disorder. 2022 Vol. 42 (6): 12-14 [Abstract] ( 166 ) HTML (1 KB)  PDF (430 KB)  ( 149 ) 15 Effects of Hemodialysis on Inflammatory Factors and Renal Function in Diabetic Renal Failure Li Chunli DOI: 10.3969/j.issn.1001-8131.2022.06.006 Objective To investigate the effect of hemodialysis on diabetic renal failure. Methods 70 patients with diabetic renal failure were selected and divided into two groups by random number table method,35 cases in each group.The control group received routine hemodialysis,and the observation group received on-line hemodiafiltration.The levels of inflammatory factors and renal function were compared between the two groups. Results The levels of Tumor necrosis factor-α（TNF-α）,C-reactive protein（CRP）and Inter leukin-6（IL-6）in the observation group were lower than those in the control group.The difference was statistically significant（t=6.638,5.796,19.575,all P=0.000）.In observation group,24-hour Urinary Protein Quantity（24hUPQ）,Serum creatinine（Scr）,CystatinC（cystatin inc）were determined at 24h after treatment.CysC）and Blood urea nitrogen（BUN）levels were lower than those in the control group,with statistical significance（P<0.05）. Conclusion Hemodialysis can reduce the level of inflammatory factors and improve renal function in diabetic renal failure patients,and the effect of on-line hemodiafiltration is better than that of conventional hemodialysis. 2022 Vol. 42 (6): 15-16 [Abstract] ( 143 ) HTML (1 KB)  PDF (431 KB)  ( 176 ) 17 Clinical Efficacy of Somatostatin Analogues Combined With Everolimus in the Treatment of Pancreatic Neuroendocrine Tumors Chen Xiaolan, Shang Qingling, Li Hui DOI: 10.3969/j.issn.1001-8131.2022.06.007 Objective To observe the clinical efficacy of somatostatin analogists combined with everolimus in the treatment of pancreatic neuroendocrine tumors. Methods A total of 54 patients with pancreatic neuroendocrine tumor admitted to our hospital were selected and divided into observation group（n=27）and control group（n=27）according to random number table method.The control group was treated with somatostatin analogue,and the observation group was treated with somatostatin analogue combined with everolimus.The treatment effect,time to progression,recurrence rate 1-3 years after operation,serum CgA level and the incidence of related complications were compared between the two groups. Results The time to progression in the observation group was significantly longer than that in the control group,and the 1-3 years recurrence rate was significantly lower than that in the control group（P<0.05）.After 3 months of treatment,the serum CGA level in the observation group was significantly lower than that in the control group（P<0.05）.However,the incidence of adverse reactions（mainly oral inflammation）in the observation group was significantly higher than that in the control group（P<0.05）. Conclusion The clinical efficacy of somatostatin analogue combined with everolimus in the treatment of pancreatic neuroendocrine tumors is better than that of somatostatin analogue alone,which can prolong the time to progression and reduce disease recurrence in patients.However,the incidence of adverse reactions in patients taking everolimus is higher,which needs to be solved clinically. 2022 Vol. 42 (6): 17-19 [Abstract] ( 173 ) HTML (1 KB)  PDF (427 KB)  ( 130 ) 20 Clinical Efficacy of Subtotal Resection of Benign Tumors in the Superficial Lobe of Parotid Gland in The Treatment of Benign Tumors in the Superficial Lobe of Parotid Gland Huang Jing, Lei Jianming DOI: 10.3969/j.issn.1001-8131.2022.06.008 Objective To investigate the clinical effect of subtotal resection of benign tumors in the superficial lobe of parotid gland. Methods 52 patients with benign tumors of superficial parotid gland treated were randomly divided into two groups.The control group was treated with total parotidectomy and the observation group was treated with subtotal parotidectomy.The operation indexes,complications,facial nerve injury and quality of life were compared. Results The operation time,incision length,intraoperative bleeding,anatomical branches of facial nerve and hospital stay in the observation group were less than those in the control group（P<0.05）;The incidence of complications such as subcutaneous effusion or salivary fistula,facial depression deformity,temporary facial paralysis,ototemporal nerve syndrome and earlobe numbness in the observation group was significantly lower than that in the control group（P<0.05）;The degree 1,degree 2,degree 3 and degree 4 of facial nerve and the total incidence in the observation group were lower than those in the control group（P<0.05）;The SF-36 scores of 8 dimensions in the observation group were higher than those in the control group（P<0.05）. Conclusion Subtotal resection of benign tumors in the superficial lobe of parotid gland has significant clinical effect,which can preserve the parotid gland tissue to the greatest extent,avoid facial nerve injury,reduce the probability of complications and improve the quality of life. 2022 Vol. 42 (6): 20-22 [Abstract] ( 146 ) HTML (1 KB)  PDF (404 KB)  ( 122 ) 23 Related Factors of Chronic Pain After Thoracoscopic Lobectomy in Patients With Lung Adenocarcinoma Jin Hongling DOI: 10.3969/j.issn.1001-8131.2022.06.009 Objective To investigate the occurrence of chronic pain after thoracoscopic lobectomy in patients with lung adenocarcinoma,and to analyze the related factors inducing chronic pain after thoracoscopic lobectomy in patients with lung adenocarcinoma. Methods 70 patients with lung adenocarcinoma who underwent thoracoscopic lobectomy were selected as the research objects.All patients were followed up for 6 months.The incidence of chronic pain after thoracoscopic lobectomy in patients with lung adenocarcinoma during the follow-up period was counted,The influencing factors of chronic pain after thoracoscopic lobectomy in patients with lung adenocarcinoma were analyzed. Results After thoracoscopic lobectomy in 70 patients with lung adenocarcinoma,34 patients had chronic pain,the incidence rate was 48.57%;Postoperative lung cancer patients with chronic pain,diabetes,postoperative anxiety,postoperative drainage tube placement time greater than 4D,postoperative analgesia with PCIA compared with no patients,the difference was statistically significant（P<0.05）.The multivariate Logistic regression model showed that diabetes,postoperative anxiety,postoperative drainage tube placement time greater than 4D,and postoperative analgesia without PCIA were risk factors for chronic pain after thoracoscopic lobectomy in patients with lung adenocarcinoma（OR>1,P<0.05）. Conclusion the risk of chronic pain is higher in patients with lung adenocarcinoma after thoracoscopic lobectomy.Factors such as diabetes,postoperative anxiety,postoperative drainage tube placement time and postoperative PCIA analgesia may increase the risk of postoperative chronic pain. 2022 Vol. 42 (6): 23-25 [Abstract] ( 182 ) HTML (1 KB)  PDF (351 KB)  ( 129 ) 26 Influencing Factors of Coronary Artery Calcification in Uremic Hemodialysis Patients Wang Lanfang DOI: 10.3969/j.issn.1001-8131.2022.06.010 Objective To explore the influencing factors of coronary artery calcification in uremic hemodialysis patients. Methods The data of 45 patients with coronary artery calcification in uremic hemodialysis were retrospectively analyzed and included in the occurrence group.45 patients without coronary artery calcification in uremic hemodialysis in the same period were included in the non occurrence group.The baseline data and laboratory indexes of the two groups were statistically analyzed.The influencing factors of coronary artery calcification in uremic hemodialysis patients were analyzed by univariate and multivariate analysis. Results There was significant difference in hyperphosphatemia,diabetes and dyslipidemia between the two groups（P<0.05）.Multivariate Logistics regression analysis showed that hyperphosphatemia,diabetes and dyslipidemia were risk factors for coronary calcification in hemodialysis patients with uremia（OR>1,P<0.05）. Conclusion The risk factors of coronary calcification in hemodialysis patients may be hyperphosphatemia,diabetes and dyslipidemia. 2022 Vol. 42 (6): 26-27 [Abstract] ( 189 ) HTML (1 KB)  PDF (420 KB)  ( 132 ) 28 Observation on The Application of Countermeasures Based on Logistic Analysis in The Prevention of Chemotherapeutic Drug Extravasation Qi Yangyang, Shang Qingling DOI: 10.3969/j.issn.1001-8131.2022.06.011 Objective To observe the application of countermeasures based on Logistic analysis in the prevention of chemotherapeutic drug extravasation. Methods 74 patients with chemotherapeutic drug extravasation were taken as the observation objects and classified as the observation group.74 patients without chemotherapeutic drug extravasation in the same period were included as the control group at a ratio of 1：1.Analyze the risk factors affecting patients' chemotherapeutic drug extravasation,and develop corresponding nursing countermeasures based on Logistic analysis.A total of 122 patients who received chemotherapy drugs were selected as the research subjects,and they were divided into study group and conventional group with 61 cases in each group by completely randomized method.The conventional nursing intervention was still used in the conventional group,while the nursing intervention based on Logistic analysis was used in the study group.The preventive effects of chemotherapeutic drug extravasation in the study group and the conventional group were counted after 1 month of intervention. Results Logistic regression analysis showed that chemotherapy knowledge,adverse psychological reaction and intravenous infusion time were all risk factors affecting patients' chemotherapeutic drug extravasation（P<0.05）.After 1 month of nursing intervention based on Logistic analysis,the prevention effect of chemotherapeutic drug extravasation in the study group was significantly better than that in the control group（P<0.05）. Conclusions Logistic analysis shows that chemotherapy knowledge,adverse psychological reaction and intravenous infusion time will all affect the chemotherapeutic drug extravasation,and nursing intervention can effectively prevent chemotherapeutic drug extravasation. 2022 Vol. 42 (6): 28-30 [Abstract] ( 139 ) HTML (1 KB)  PDF (419 KB)  ( 155 ) 31 Effect of Breath Training Device Combined With Bedside Sitting on Diaphragm Function of ICU Patients With Mechanical Ventilation Wu Xuting, Ling Chaomin, Chen Xiaolin DOI: 10.3969/j.issn.1001-8131.2022.06.012 Objective To explore the effect of breath training device combined with bedside sitting on diaphragm function of ICU patients with mechanical ventilation. Methods A total of 100 cases of ICU patients were retrospectively selected as the research objects.According to the random method,the research objects were divided into control group（48 cases）and observation group（52 cases）.The observation group received the nursing mode of breath training device combined with bedside sitting method,and the intervention time was two weeks.After two weeks,the improvement of arterial blood gas indexes,diaphragm mobility,mechanical ventilation time,ICU stay and quality of life（SF-36）were observed in both groups. Results ① Arterial blood gas indexes：after intervention,the improvement degree of PaCO2,PACO2,PaO2 and PAO2 in observation group was better than that in control group（P<0.05）.② Diaphragm mobility：after intervention,diaphragm mobility in the observation group was higher than that in the control group（P<0.05）.③Duration of mechanical ventilation and ICU hospitalization：after intervention,the duration of mechanical ventilation and ICU hospitalization in the observation group were less than those in the control group（P<0.05）.④SF-36：after intervention,the scores of pain,health status,vitality and social function in the observation group were higher than those in the control group（P<0.05）. Conclusion The implementation of breath training device combined with bedside sitting method can improve the arterial blood gas indexes,increase diaphragm mobility,reduce the duration of mechanical ventilation and hospital stay,and improve the quality of life of ICU patients with mechanical ventilation,which is of great significance for improving clinical nursing measures. 2022 Vol. 42 (6): 31-33 [Abstract] ( 153 ) HTML (1 KB)  PDF (422 KB)  ( 171 ) 34 Logistic Regression Analysis of Factors Affecting the Therapeutic Effect of Immunotherapy For Aplastic Anemia Feng Anchao DOI: 10.3969/j.issn.1001-8131.2022.06.013 Objective To investigate the therapeutic effect and influencing factors of immunotherapy for aplastic anemia（AA）. Methods 70 AA patients treated were selected.All patients were treated with immunotherapy（cyclosporine + antithymocyte globulin）for 6 months.The treatment effect was evaluated and recorded according to relevant standards,and divided into effective group and ineffective group;Design a general data questionnaire,ask and record the general data and laboratory related indicators of patients,and analyze the influencing factors of immunotherapy in AA patients. Results After 6 months of immunotherapy in 70 AA patients,45 cases were evaluated as effective,and the effective rate was 64.29%（45 / 70）;25 cases were evaluated as ineffective,and the ineffective rate was 35.71%（25 / 70）;Before treatment,the absolute value of neutrophils（ANC）and reticulocyte count（RET）in the ineffective group were lower than those in the effective group,and the hematopoietic area of bone marrow was smaller than that in the ineffective group（P<0.05）;Logistic regression analysis showed that high levels of RET and ANC and large hematopoietic area of bone marrow were the protective factors for the ineffective treatment of AA immunotherapy（or<1,P<0.05）. Conclusion High levels of ANC and RET and large hematopoietic area of bone marrow are the protective factors for the therapeutic effect of AA immunotherapy. 2022 Vol. 42 (6): 34-35 [Abstract] ( 148 ) HTML (1 KB)  PDF (453 KB)  ( 113 ) 36 Comparison of MRI and DTI in the Diagnosis of Acute Cervical Spinal Cord Injury Without Fracture and Dislocation Qiao Zhimin, Wang Houge, Liang Hongjie DOI: 10.3969/j.issn.1001-8131.2022.06.014 Objective To investigate the diagnostic value of magnetic resonance imaging（MRI）and magnetic resonance diffusion tensor imaging（DTI）in acute cervical spinal cord injury without fracture and dislocation. Methods Retrospective analysis treated the patients with acute cervical cord injury without fracture dislocation of the clinical data of 70 cases,adopt the X-ray and CT examination,fracture detection,then using MRI and DTI examination,confirmed that patients with cervical spinal injury,patients with measuring apparent diffusion coefficient（ADC）and anisotropic scores（FA）,The Japanese Orthopaedic Association evaluation treatment（JOA）score was recorded to analyze the correlation between apparent dispersion coefficient（ADC）and anisotropy score（FA）and JOA score. Results There were 12 grade ⅰ patients,21 grade ⅱ patients,22 grade ⅲ patients and 15 grade ⅳ patients in 70 patients with acute cervical spinal cord injury without fracture and dislocation.Different signal characteristics of patients at different levels;There were statistically significant differences in ADC and FA values among JOA grades（P<0.05）.Pearson correlation analysis showed that ADC value had no significant correlation with JOA score（r=0.197,P=0.058）.FA was positively correlated with JOA score（r=0.869,P=0.000）. Conclusion DTI can feedback the pathological process of cervical spinal cord injury without fracture and dislocation,evaluate the severity of patients' disease by FA index,and provide a basis for the judgment of prognosis. 2022 Vol. 42 (6): 36-38 [Abstract] ( 141 ) HTML (1 KB)  PDF (431 KB)  ( 151 ) 39 Analysis of Factors Influencing Delivery Mode and Pregnancy Outcome of Re-Pregnant Women With Scar Uterus Guo Lingyu DOI: 10.3969/j.issn.1001-8131.2022.06.015 Objective To explore the factors influencing the delivery mode of re-pregnant women with scar uterus and analyze the pregnancy outcome. Methods A retrospective analysis of 423 cases of re-pregnant women with scar uterus was conducted.According to the success of vaginal trial delivery,they were divided into vaginal delivery group and cesarean section group.Logistic regression model was used to analyze the related factors affecting delivery mode,and the pregnancy outcomes of vaginal delivery group and cesarean section group were observed. Results Among 423 re-pregnant women with scar uterus,203 cases met the vaginal trial delivery standard and voluntarily performed vaginal trial delivery,the vaginal trial delivery rate was 47.99%（203/423）,the success rate of vaginal delivery was 40.90%（173/423）,and the cesarean section rate was 59.10%（250/423）;Logistic regression analysis results showed that：prenatal BMI>30kg/m2（OR=1.951,95% CI=1.169-3.254）,time from last cesarean section ≤3 years（OR=2.664,95% CI=1.539-4.611）,thickness of uterine scar ≤4mm（OR=3.322,95% CI=1.971-5.599）,cervical Bishop score ≤3（OR=2.682,95% CI=1.580-4.552）,neonatal weight>35000g（OR=2.579,95% CI=1.322-5.95% CI=1.971-5.599）were independent risk factors of vaginal delivery in re-pregnant women with scarred uterus（P<0.05）;the amount of postpartum hemorrhage and hospitalization time in vaginal delivery group were less than those in cesarean section group（P<0.05）,and puerperal infection rate was lower than that in cesarean section group（P<0.05）;there was no significant difference in fetal distress rate,postpartum hemorrhage rate,neonatal asphyxia rate and Apgar score at 1 min after birth between the two groups（P>0.05）. Conclusion Prenatal BMI,time from last cesarean section,thickness of uterine scar,cervical Bishop score and neonatal weight are independent influencing factors of delivery mode of re-pregnant women with scar uterus.Compared with cesarean section,vaginal delivery can effectively reduce postpartum hemorrhage,reduce puerperal infection rate,and will not increase the incidence of fetal distress and neonatal asphyxia. 2022 Vol. 42 (6): 39-42 [Abstract] ( 134 ) HTML (1 KB)  PDF (453 KB)  ( 127 ) 43 Comparison of Catheter Directed Sclerotherapy and Surgical Resection in the Treatment of Ovarian Endometriosis and Its Effect on Ovarian Reserve Function Tian Huazhong DOI: 10.3969/j.issn.1001-8131.2022.06.016 Objective To compare the effect of catheter directed sclerosing agent（CDS）and surgical treatment on ovarian endometriosis and its effect on ovarian reserve function. Methods A total of 160 patients with ovarian endometriosis were selected and divided into observation group（80 cases）and control group（80 cases）according to double-blind method.The observation group was treated with CDS,and the control group was treated with surgical resection.Serum anti-Mullerian hormone（AMH）levels were compared before and after surgery.Serum cancer antigen 125（CA-125）levels,lesion size,recurrence and postoperative complications were observed and recorded. Results There was no significant difference in serum AMH between the observation group before operation（3.42±1.13）ng/ml and the observation group after operation（3.37±1.39）ng/mL（P>0.05）.The serum CA-125（26.05±7.85）U/mL and lesion size（20.06±2.97）mm in the observation group after operation were significantly lower than those before operation（63.65±20.91）U/mL and lesion size（48.62±4.20）mm in the observation group.The difference was statistically significant（P<0.05）.Serum AMH（1.78±0.64）ng/ml and serum CA-125（8.96±1.47）U/ml in control group were significantly lower than those before operation（3.21±1.13）ng/ml and serum CA-125（60.01±22.89）U/mL in control group.The difference was statistically significant（P<0.05）.There were no significant statistical differences in the number of patients with symptom remission and complications in the observation group and the control group（P>0.05）.The length of stay and the number of recurrent patients in the observation group were significantly lower than those in the control group,with statistical significance（P<0.05）. Conclusion CDS treatment is similar to surgical resection of ovarian endometriosis,but CDS method has better ovarian reserve function and shorter hospitalization time,which is worthy of clinical promotion. 2022 Vol. 42 (6): 43-45 [Abstract] ( 121 ) HTML (1 KB)  PDF (410 KB)  ( 144 ) 46 Expression of Trap 1 and EGF in Esophageal Carcinoma and Their Relationship With Clinicopathology Zhang Cuifen, Wang Yongfeng, Zhang Hongge DOI: 10.3969/j.issn.1001-8131.2022.06.017 Objective To study the expression levels of TRAP1 and EGF in esophageal cancer,and to analyze the correlation between these two indexes and Clinicopathology. Methods 48 patients with esophageal cancer treated were included in the observation group;At the same time,48 healthy people were included as the control group.The levels of TRAP1 and EGF in the tissues of patients were detected by immunohistochemical method,and the correlation between these two indexes and clinical cases was analyzed. Results The positive rates of TRAP1 and EGF in the observation group were higher than those in the control group.There was a positive correlation between these two indexes and TNM stage,location,lymphatic metastasis and degree of differentiation in the observation group（P<0.05）. Conclusion The levels of TRAP1 and EGF in patients with esophageal cancer are significantly different from those in normal population,which can be used as an important index for the diagnosis of esophageal cancer.At the same time,the close correlation between these two indexes and Clinicopathology also provides a new basis for more scientific and reasonable treatment of esophageal cancer. 2022 Vol. 42 (6): 46-47 [Abstract] ( 133 ) HTML (1 KB)  PDF (443 KB)  ( 159 ) 48 Effects of Insulin on Glucose Metabolism in Patients With Gestational Diabetes Mellitus at 30 Weeks and More Than 30 Weeks of Gestation He Xiujin, Song Hongyan DOI: 10.3969/j.issn.1001-8131.2022.06.018 Objective To explore the effect of insulin on glucose metabolism in patients with gestational diabetes mellitus（GDM）at 30 weeks and more than 30 weeks of gestation. Methods A total of 96 patients with GDM were selected and divided into observation group and control group according to the different gestational weeks,with 48 cases in each group.The time point of insulin use in the observation group was ≥30 weeks of pregnancy,and the time point of insulin use in the control group was<30 weeks of pregnancy.Blood glucose levels,pregnancy outcomes,neonatal outcomes,and neonatal Apgar scores were collected and recorded in both groups. Results After treatment,the blood glucose level（fasting blood glucose,2h postprandial blood glucose,hemoglobin protein）of patients was significantly lower than that before treatment,and the blood glucose level of observation group was significantly higher than that of control group（P<0.05）.The incidence of preterm birth and pregnancy hypertension in the observation group was significantly higher than that in the control group（P<0.05）.There was no statistical significance in the incidence of cesarean section and hydramnios between the two groups（P>0.05）.The incidence of neonatal hypoglycemia,neonatal asphyxia and low body weight in the observation group was significantly higher than that in the control group,and the Apgar score in the observation group was significantly higher than that in the control group（P<0.05）.There was no statistical significance in the incidence of macrosomia between the two groups（P>0.05）. Conclusion Compared with 30 weeks before gestation,the use of insulin at 30 weeksand more than 30 weeks of gestation has relatively low improvement in blood glucose levels and maternal and infant outcomes in GDM patients.Clinically,GDM patients should be injected with insulin before 30 weeks of gestation. 2022 Vol. 42 (6): 48-50 [Abstract] ( 138 ) HTML (1 KB)  PDF (396 KB)  ( 121 ) 51 Clinical Observation on the Correction of High Myopia Patients With Refractive Power > -6.00D by Epithelial Excimer Laser Photorefractive Keratectomy Hua Jiannan, Shi Fangrong, Han Baojun DOI: 10.3969/j.issn.1001-8131.2022.06.019 Objective To study the clinical effect of epithelial excimer laser photorefractive keratectomy（TPRK）on high myopia patients with refractive power >-6.00 d. Methods 241 eyes of 181 patients with high myopia with refractive power greater than -6.00D were selected as the research objects.90 patients（118 eyes）in the control group and 91 patients（123 eyes）in the experimental group were randomly divided.Patients in the control group were treated with excimer laser in situ keratomileusis（FS-LASIK）assisted by femtosecond laser flap making.The experimental group was treated with TPRK,and the epithelial healing time was compared between the two groups.The changes of visual acuity（BCVA,corneal posterior surface height,diopter）were compared 3 months after operation.The incidence of surgical complications（infection,corneal penetration,corneal haze under the upper and lower skin）in the two groups were compared within 14 days after operation. Results After operation,the healing time of the epithelium in the experimental group was significantly longer than that in the control group（P<0.05）.Three months after operation,The BCVA and corneal posterior surface height of the two groups were significantly higher than those before treatment,but there was no significant difference between the two groups（P<0.05）.Compared with before treatment,the diopter of patients in both groups decreased significantly,but there was no significant difference between the two groups（P<0.05）.No postoperative complications occurred in the two groups within 14 days after operation. Conclusion The refractive power of TPRK is>-6.00 days after operation,the epithelial healing of the affected eye is slow,the visual recovery effect is excellent,and it has high safety. 2022 Vol. 42 (6): 51-52 [Abstract] ( 131 ) HTML (1 KB)  PDF (417 KB)  ( 143 ) 53 Evaluation of the Curative Effect of Nasal Endoscopy-Assisted Low-Temperature Plasma Ablation of Adenoids in Children With Adenoid Hypertrophy Guo Shuai DOI: 10.3969/j.issn.1001-8131.2022.06.020 Objective To analyze the effect of nasal endoscopy-assisted low-temperature plasma ablation of adenoids in children with adenoid hypertrophy. Methods A total of 73 children with adenoid hypertrophy were selected and divided into observation group（n=37）and control group（n=36）according to different surgical procedures.The control group underwent nasal endoscopy.For auxiliary adenoidectomy,the observation group underwent nasal endoscopic-assisted adenoidectomy with low-temperature plasma ablation.The total effective rate,operation-related conditions,postoperative pain degree,postoperative complications,and nasal cavity volume were compared between the two groups. Results The total effective rate of the observation group was 97.30%（36/37）and 91.67%（33/36）of the control group had no significant difference（P>0.05）;the blood loss in the observation group was less than that of the control group,and the operation time,pain time,and normal Ventilation time was shorter than that of the control group（P<0.05）;the observation NRS scores at 1d,3d,and 5d after surgery were lower than those of the control group（P<0.05）;the postoperative complication rate of the observation group was 5.41%（2/37）Compared with 8.33%（3/36）of the control group,there was no significant difference（P>0.05）;the nasal cavity volume of the two groups was larger than that of the preoperative 6 months after the operation,and the observation group was larger than the control group（P<0.05）. Conclusion Nasal endoscopy-assisted low-temperature plasma ablation of adenoids is effective in treating children with adenoid hypertrophy,which can shorten the rehabilitation process,relieve postoperative pain,improve nasal resistance,and is safe and reliable. 2022 Vol. 42 (6): 53-55 [Abstract] ( 125 ) HTML (1 KB)  PDF (410 KB)  ( 184 ) 101 Evaluation of the Severity of Heart Failure by Cardiac Ultrasound He Haochao, Zhao Xiao, Tan Lingling DOI: 10.3969/j.issn.1001-8131.2022.06.043 Objective To explore the clinical value of cardiac ultrasound in evaluating the severity of heart failure（HF）. Methods A total of 80 HF patients were selected as the research objects,and they were divided into grade II（n=30）,grade III（n=26）,and grade IV（n=24）according to the New York Heart Association（NYHA）cardiac function classification.LVEF,LVESD and LVEDD were measured by cardiac ultrasound in all patients.The clinical value of cardiac color Doppler ultrasound in evaluating the severity of HF patients was analyzed. Results The LVEF level was the highest in grade II HF patients,and the LVESD and LVEDD levels were the lowest,followed by grade III.The LVEF level was the lowest in grade IV HF patients,and the LVESD and LVEDD levels were the highest.The difference among the three groups was statistically significant（P<0.05）.ROC results showed that the area under the curve（AUC）of LVEF,LVESD,LVEDD assessment of grade III and IV HF patients were all>0.70,which has certain predictive value. Conclusion Cardiac ultrasound can effectively assess the severity of HF patients,and provide an objective reference for clinical treatment plan formulation and prognosis evaluation of patients. 2022 Vol. 42 (6): 101-103 [Abstract] ( 130 ) HTML (1 KB)  PDF (476 KB)  ( 134 ) 104 Application of Microneedle and Plasma Fractional RF in the Treatment of Atrophic Acne Scars Hu Xiaofang, Li Huifang, Zhang Zhaohui DOI: 10.3969/j.issn.1001-8131.2022.06.044 Objective To explore the application of microneedle and Fractional RF in the treatment of atrophic?acne scars. Methods A total of 96 patients with atrophic acne scars were selected and divided into a test group（48 cases）and a control group（48 cases）according to the random number table method.The control group was treated with microneedle therapy,and the test group was treated with plasma Fractional RF.Efficacy,ECCA score and incidence of adverse reactions were compared between the two groups. Results The total effective rate in observation group was significantly higher than that in control group（P<0.05）,ECAA score after treatment was significantly lower than before,and observation group was significantly lower than control group（P<0.05）.Before and after treatment,the difference of ECAA in observation group was significantly higher than that in control group（P<0.05）.The pain score and duration of pain,erythema,and scab in the observation group were significantly higher than those in the control group（P<0.05）. Conclusion Microneedle and plasma Fractional RF are effective in the treatment of atrophic acne scars.Microneedle is safer,and plasma Fractional RF is better for scar repair.The corresponding surgical procedures should be selected according to the different demands of patients. 2022 Vol. 42 (6): 104-106 [Abstract] ( 161 ) HTML (1 KB)  PDF (436 KB)  ( 140 ) 125 Clinical Study on Treating Insomnia with Precise Activating Blood Circulation and Removing Stasis Combined with Acupuncture Therapy Xie Zhu, Lin Kailiang, Lin Qiuxuan, Cen Meiyuan DOI: 10.3969/j.issn.1001-8131.2022.06.053 Objective To explore the effect of precise activating blood circulation and removing stasis combined with acupuncture therapy on insomnia patients. Methods a total of 100 patients with insomnia were enrolled and randomly divided into two groups.33 patients whose number could be divisible by 3 were treated as control group and the rest were treated as treatment group.The control group was treated with conventional dialectical typing,and the treatment group was treated with conventional dialectical typing plus Xuefu Zhuyu Decoction plus acupuncture physiotherapy for 15 consecutive days.The clinical efficacy of the two groups was observed. Results There was no significant difference in the total effective rate between the two groups（P>0.05）.The clinical improvement rate of the treatment group was higher than that of the control group,the difference was statistically significant（P<0.05）.No obvious adverse reactions were observed in the two groups. Conclusion The treatment of insomnia patients with precise activating blood circulation and removing blood stasis combined with acupuncture and moxibustion has a significant effect,and the same treatment of specimens verifies the principle of "long illness with more blood stasis",and has no toxic side effects,which is worth learning from. 2022 Vol. 42 (6): 125-126 [Abstract] ( 200 ) HTML (1 KB)  PDF (515 KB)  ( 147 )

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