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2024 Vol. 44, No. 1
Published: 2024-02-25
1
NLK Promotes the Proliferation,Migration,Invasion,and EMT of Bladder Cancer Cells by Regulating Paxillin
Lu Jianjun, Yu Qin, Chen Lixiong
DOI: 10.3969/j.issn.1001-8131.2024.01.001
Objective
This research was intended to exploring the effect and mechanism of kinase（NLK）and paxillin on proliferation,migration,invasion,and epithelial mesenchymal transition（EMT）of bladder cancer cells,and providing theoretical basis for basic research,clinical prevention and treatment of bladder cancer.
Methods
The expression of NLK in bladder cancer tissue was analyzed by bioinformatics analysis.The proliferation,migration and invasion of bladder cancer cells were detected by EdU staining assay,clone formation assay,and transwell assay.RNA pull down assay was used to detect the interaction between NLK and paxillin in bladder cancer cells.Western blot assay was used to detect the expressions of NLK,p-paxillin,and EMT-related proteins in bladder cancer cells.
Results
NLK and p-paxillin were highly expressed in bladder cancer;NLK interacted with paxillin;NLK downregulation inhibited the proliferation,migration,invasion,EMT,and p-paxillin expression of bladder cancer cells;paxillin overexpression reversed the effect of silencing NLK on proliferation,migration,invasion,EMT,and p-paxillin expression in bladder cancer cells.
Conclusion
NLK promoted the proliferation,migration,invasion and EMT of bladder cancer cells by regulating paxillin,providing theoretical basis for basic research,clinical prevention and treatment of bladder cancer.
2024 Vol. 44 (1): 1-7 [
Abstract
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81
)
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8
Relationship Between Cerebral Blood Flow,Serum NT-3,BDNF and Functional Recovery in Patients with Acute Cerebral Infarction and Hemiplegia after Intervention
Deng Xingming
DOI: 10.3969/j.issn.1001-8131.2024.01.002
Objective
To explore the relationship between cerebral blood flow,serum neurotrophic factor-3（NT-3）,brain-derived neurotrophic factor（BDNF）and functional recovery in patients with acute cerebral infarction（ACI）and hemiplegia after intervention.
Methods
A total of 60 patients with ACI admitted to the hospital.After admission,all underwent routine treatments（anti-coagulation,anti-platelet,lipid regulation,removal of oxygen free radicals,promoting circulation and removing stasis）and comprehensive rehabilitation therapy.After 4 weeks of continuous intervention,cerebral blood flow [anterior cerebral artery（ACA）,middle cerebral artery（MCA）],levels of serum NT-3 and BDNF,and functional recovery [National Institutes of Health Stroke Scale（NIHSS）,Fugl-Meyer Assessment Scale（FMA）] were compared before and after treatment.
Results
After treatment,cerebral blood flow of ACA and MCA was increased（
P<
0.05）.After treatment,level of serum NT-3 was decreased,while BDNF level was increased（
P<
0.05）.After treatment,NIHSS score was decreased,while FMA score was increased（
P<
0.05）.ACA,MCA and BDNF were negatively correlated with NIHSS score,while positively correlated with FMA score（
P<
0.05）.NT-3 was positively correlated with NIHSS score,while negatively correlated with FMA score（
P<
0.05）.
Conclusion
The cerebral blood flow,levels of serum NT-3 and BDNF significantly improve in patients with acute cerebral infarction and hemiplegia after intervention,which can better reflect the recovery level of limb function and motor function.
2024 Vol. 44 (1): 8-10 [
Abstract
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60
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11
Clinical Value of Atorvastatin Calcium Combined with Fenofibrate in the Treatment of Coronary Atherosclerotic Heart Disease
Hou Bin, Zheng Fangfang
DOI: 10.3969/j.issn.1001-8131.2024.01.003
Objective
To analyze the clinical value of atorvastatin calcium combined with fenofibrate in the treatment of coronary atherosclerotic heart disease（CHD）.
Methods
A total of 82 cases of CHD patient were selected and divided into a combination group（n=41）and a single group（n=41）by random number table method.The single group was treated with atorvastatin calcium,and the combined group was treated with fenofibrate on the basis of a single group.The therapeutic effect,blood lipid levels [total cholesterol（TC）,high-density lipoprotein cholesterol（HDL-C）,triglyceride（TG）],carotid intimax-media thickness（IMT）,vascular endothelial function [nitric oxide（NO）,endothelin-1（ET-1）],cardiac function [left ventricular end-systolic diameter（LVESD）,and left ventricular ejection fraction（LVEF）] were compared between the two groups Number and the incidence of adverse reactions.
Results
The total effective rate of the combination group95.12%（39/41）was higher than that of the single group 80.49%（33/41）（
P<
0.05）.After treatment,the TC and TG levels in the combination group were lower than those in the single group,and the HDL-C level was higher than those in the single group（
P<
0.05）.After treatment,the level of carotid IMT in the combination group was lower than that in the single group（
P<
0.05）.After treatment,the ET-1 level in the combination group was lower than that in the single group,and the NO level was higher than that in the single group（
P<
0.05）.After treatment,the LVEF level in the combination group was higher than that in the single group,and the LVESD level was lower than that in the single group（
P<
0.05）.There was no significant difference in adverse reactions between the two groups（
P>
0.05）.
Conclusion
Fenofibrate combined with atorvastatin calcium in the treatment of CHD patients can improve the efficacy,reduce the blood lipid levels and carotid IMT thickness,and improve the vascular endothelial function and cardiac function,which is safe and reliable.
2024 Vol. 44 (1): 11-14 [
Abstract
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60
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14
The Predictive Value of the Expression Levels of CK20,CDX2 and CK7 in Colorectal Cancer Postoperative Efficacy and Prognosis
Li Wenli, Wang Jing, Sun Wuxia
DOI: 10.3969/j.issn.1001-8131.2024.01.004
Objective
To explore the predictive value of CK20,CDX2,CK7 tissue expression levels for postoperative curative effect and prognosis of colorectal cancer.
Methods
The basic data of 60 patients with colorectal cancer were collected and analyzed retrospectively.All patients underwent radical resection of rectal cancer.Immunohistochemical SP method was used to detect the expression of CK20,CDX2 and CK7 in tumor tissues,and the patients were followed up for one year.By reexamining colonoscopy,the patients were divided into a good prognosis group（n=26）and a poor prognosis group（n=34）according to whether the tumor recurred or metastasized after operation.Univariate analysis and multivariate Logistic regression analysis were used to analyze the influencing factors of the prognosis of colorectal cancer patients.
Results
Compared with before operation,after operation,the positive expression rates of CK20 and CK7 in colorectal cancer（80.00%,83.33%）decreased,but the positive expression rate of CDX2（76.66%）increased（
P<
0.05）.The Logistic regression model showed that the mass size（
P=
0.034,OR=1.411）,CK20（
P=
0.024,OR=1.850）,CDX2（
P=
0.013,OR=1.540）,CK7（
P=
0.012,OR=1.540）.
Conclusion
The expression levels of CK20,CDX2 and CK7 play an important role in the occurrence and development of colorectal cancer,and have certain clinical application value in evaluating the postoperative curative effect and prognosis of colorectal cancer.
2024 Vol. 44 (1): 14-16 [
Abstract
] (
70
)
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17
Effects of Low-dose Donepezil Hydrochloride Combined with Memantine Hydrochloride on Cognitive Function in Patients with Alzheimer’s Disease
Liu Fan, Liu Xiaopeng, Zhou Yu
DOI: 10.3969/j.issn.1001-8131.2024.01.005
Objective
To analyze the effects of donepezil hydrochloride combined with memantine hydrochloride on cognitive function in patients with Alzheimer's disease（AD）.
Methods
86 cases of patients with AD were selected,and all of them were randomly divided into an experimental group and a conventional group,with 43 patients in each group.The conventional group was given low-dose donepezil hydrochloride,and the experimental group was combined with memantine hydrochloride on the basis of the conventional group.The curative effect,the Alzheimer's disease behavioralpathology scale（BEHAVE-AD）score,the Alzheimer's Disease Assessment Scale（ADAS-cog）,Mini Mental State Assessment Scale（MMSE）,the inflammatory factors [interleukin-6（IL-6）,tumor necrosis factor-α（TNF-α）,C-reactive protein（CRP）] levels and the occurrence rate of adverse reactionsof the two groups were compared.
Results
The total effective rate 93.02%（40/43）of the experimental group washigher than 72.09%（31/43）of the conventional group（
P<
0.05）;After treatment,the BEHAVE-AD score of the experimental group was lower than that of the conventional group（
P<
0.05）;After treatment,the ADAS-cog score of the experimental group was lower than that of the conventional group,while the MMSE score was higher than that of the conventional group（
P<
0.05）;After treatment,the levels of IL-6,TNF-α and CRP in the experimental groupwereall respectivelylower than thosein the conventional group（
P<
0.05）;The occurrence rate of adverse reactions of the experimental group was 6.98%（3/43）,which was not significantly different from that of the conventional group11.63%（5/43）（
P>
0.05）.
Conclusion
The combination of donepezil hydrochloride and memantine hydrochloride for AD patientshas a significant effect,which can improve the clinical symptoms,cognitive function and mental state,alleviate the inflammatory reactions,and has the safety.
2024 Vol. 44 (1): 17-19 [
Abstract
] (
82
)
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20
Effect of Arthroscopic Meniscus Repair and Suture on Meniscus Injury of Knee Joint and Its Influence on Joint Range of Motion
Han Yanming, Jiao Wenchang, Wang Ke
DOI: 10.3969/j.issn.1001-8131.2024.01.006
Objective
To investigate the clinical effect of arthroscopic meniscus repair and suture on meniscus injury of knee joint and its influence on joint range of motion.
Methods
A total of 105 patients with meniscus injury of knee joint were selected,among which 55 patients treated with arthroscopic meniscus repair and suture were included in the study group,and 50 patients treated with arthroscopic meniscectomy were included in the control group.The surgical indexes of the two groups were analyzed and the therapeutic effects of the two groups were compared two months after surgery.The knee function and pain of the two groups were compared before and two months after surgery,and the incidence of complications within two months after surgery was recorded.
Results
There were no significant differences in surgical indexes between the two groups（
P>
0.05）.Two months after surgery,the excellent and good rate of clinical treatment in the study group（70.9%）was significantly higher than that in the control group（52.0%）（
P<
0.05）.Two months after surgery,the knee function evaluation of both groups was significantly higher than that before surgery,and the study group was significantly higher than the control group（
P<
0.05）.Two months after surgery,VAS scores of both groups were significantly lower than those before surgery,and the study group was significantly lower than the control group（
P<
0.05）.Two months after surgery,the incidence of postoperative complications in the study group（10.9%）was significantly lower than that in the control group（26.0%）（
P<
0.05）.
Conclusions
Arthroscopic meniscus repair and suture can effectively improve the clinical treatment effect of patients with meniscus injury,reduce the degree of pain,improve the knee joint function,and have a low incidence of postoperative complications,with good safety.
2024 Vol. 44 (1): 20-22 [
Abstract
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123
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23
Distribution of Pathogenic Bacteria in Fetal Membranes of Patients with Histologic Acute Chorioamnionitis and Analysis of Maternal and Infant Outcomes
Wang Lin
DOI: 10.3969/j.issn.1001-8131.2024.01.007
Objective
To analyze the distribution of pathogens in fetal membranes of patients with histologic acute chorioamnionitis（HAC）and the maternal and infant outcomes.
Methods
8704 pregnant women were selected as the study objects,and the clinical data of mothers and infants were analyzed retrospectively.The distribution of pathogenic bacteria in fetal membrane tissue of patients with confirmed HAC and the maternal and infant outcomes were analyzed.
Results
Among 8704 pregnant women,614 women were diagnosed as HAC,175 women with HAC had positive pathogens by fetal membrane tissue culture,and a total of 180 strains of 26 bacteria were isolated.The distribution and number of pathogenic bacteria in women with HAC in Phase I were 24（92.31%）,159（88.33%）,and 21（11.67%）,respectively.The number of pathogenic bacteria in women with HAC in Phase I was higher than that in women with HAC in Phase Ⅱ（26.92%）.Escherichia coli was the main pathogenic bacteria in fetal membrane tissue of HAC,with a total of 107（59.44%）The second was enterococcus faecalis,18 strains（10.00%）;The incidences of premature rupture of membranes and normal delivery in HAC group were 13.52% and 7.17% lower than those in non HAC group（19.06% and 59.37%,
P<
0.05）,while the incidences of placental abruption,stillbirth,premature delivery,spontaneous abortion and other pregnancy outcomes in HAC group were 3.26%,2.28%,25.90%,4.40%,43.49% higher than those in non HAC group（0.57%,0.10%,9.20%,0.70%,11.00%,
P<
0.05）;194 pregnant women and neonates were accompanied by asphyxia or respiratory distress syndrome,51 of whom were diagnosed by HAC.The incidence of neonatal respiratory distress syndrome in HAC group was 21.57% lower than that in non HAC group（41.26%,
P<
0.05）,while the incidence of neonatal asphyxia was 78.43% higher than that in non HAC group（58.74%,
P<
0.05）.
Conclusion
There are 180 strains of pathogenic bacteria in the fetal membrane tissue of HAC pregnant women with 26 strains,and the number of phase I is more than that of phase Ⅱ.Escherichia coli is the main strain of HAC.HAC can increase the incidence of placental abruption,stillbirth,premature delivery,spontaneous abortion and other adverse pregnancy outcomes,as well as the incidence of postpartum neonatal asphyxia.
2024 Vol. 44 (1): 23-26 [
Abstract
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70
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26
Application of DNA Microarray Chip Method in the Identification of Non-Tuberculous Mycobacterium Species
Tan Jiao, Wang Yachun, Wang Yali, Xia Shuang, Cheng Meijin, Wang Wei
DOI: 10.3969/j.issn.1001-8131.2024.01.008
Objective
To investigate the isolation of non-tuberculous mycobacterium（NTM）in Henan Provincial Chest Hospital,and to provide a scientific basis for the infection and prevention of NTM in clinical work in this region.
Methods
1089 duplicate specimens（including sputum,lavage solution and sterile bodily fluids of non-respiratory specimens）of suspected mycobacterium tuberculosis infection in Henan Chest Hospital were detected by DNA microarray chip method,and the distribution characteristics of Mycobacterium species were analyzed.
Results
In 1089 specimens,878（80.62%）of Mycobacterium tuberculosis were detected,and 211（19.38%）were detected in NTM.Among them,there were 5 species of non-tuberculous Mycobacterium species,153 cases（72.51%）were detected in Intracellular Mycobacteria,28 cases（13.27%）of Mycobacterium avium ornithus,19 cases（9%）of Mycobacterium purpureum complex,10 cases（4.74%）of Mycobacterium Kansas,and 1 case（0.48%）of Mycobacterium diureum.Among the 211 specimens,127 males（60.19%）,84 female patients（39.81%）,and the age distribution was mainly elderly,103 cases over 60 years old（48.82%）,including 71 male patients（68.93%）and 32 female patients（31.07%）;
Conclusions
5 kinds of NTM were detected in patients with suspected Mycobacterium tuberculosis admitted to Henan Chest Hospital,and the top three NTM species were Mycobacterium intracellular,Mycobacterium avium and Mycobacterium turtle complex,and the infected population was mainly elderly men.
2024 Vol. 44 (1): 26-28 [
Abstract
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77
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29
The Value of Vitamin K,Rapid CRP and WBC in the Diagnosis of Diarrhea Infection in Children
Lu Hongwu, Ye Yanhua, Yuan Zhiling
DOI: 10.3969/j.issn.1001-8131.2024.01.009
Objective
To investigate the value of vitamin K,rapid C-reactive protein（CRP）and white blood cell count（WBC）in the diagnosis of diarrhea infection in children.
Methods
Ninety children with diarrhea admitted to our hospital from January 2021 to October 2022 were selected and divided into bacterial diarrhea group（n=58）,viral diarrhea group（n=17）and non infectious diarrhea group（n=15）according to the different pathogens.Ninety healthy people in the same period were selected as the control group.The levels of vitamin K,CRP and WBC in each group were compared,and the diagnostic value of the above indicators for the type of diarrhea infection in children was evaluated.
Results
The levels of CRP and WBC in diarrhea group were higher than those in control group,while the levels of vitamin K in diarrhea group were lower than those in control group（
P<
0.05）;After treatment,the levels of CRP and WBC were lower than those before treatment,and the levels of vitamin K were higher than those before treatment（
P<
0.05）;CRP and WBC levels in bacterial diarrhea group were higher than those in viral diarrhea group and non infectious diarrhea group,while vitamin K levels were lower than those in viral diarrhea group and non infectious diarrhea group（
P<
0.05）;CRP and WBC levels in viral diarrhea group were higher than those in non infectious diarrhea group,while vitamin K levels were lower than those in non infectious diarrhea group（
P<
0.05）;The positive rates of CRP,WBC and vitamin K in bacterial diarrhea group were higher than those in viral diarrhea group and non infectious diarrhea group（
P<
0.05）;The levels of CRP,WBC and Vitamin K and the ROC curve of their combined diagnosis for children with bacterial diarrhea and non bacterial diarrhea showed that the best cut-off values of CRP,WBC and Vitamin K were 5.13 mg/L and 11.06 respectively×At 10
9
/L and 0.081 ng/mL,the AUC of combined diagnosis was 0.776,which was higher than that of single diagnosis（0.685,0.682,0.693,
P<
0.05）.
Conclusion
The combined detection of vitamin K,CRP and WBC has certain clinical significance in the diagnosis of bacterial diarrhea and non bacterial diarrhea in children.
2024 Vol. 44 (1): 29-32 [
Abstract
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76
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39
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32
Effects of Paroxetine Combined with Mirtazapine on Cognitive Function and HAMD Score in Patients with Poststroke Depression
Sun Xiaojing
DOI: 10.3969/j.issn.1001-8131.2024.01.010
Objective
To investigate the effects of paroxetine combined with Mirtazapine on cognitive function and Hamilton Depression Scale（HAMD）score in patients with poststroke depression（PSD）.
Methods
This was a prospective study.113 patients with poststroke depression were enrolled in this study.They were divided into observation group（n=57 cases）and control group（n=56 cases）by random number table.The control group received paroxetine treatment,and the observation group received paroxetine combined with mirtazapine treatment.Cognitive function [as assessed by Wisconsin card Sorting Test（WCST）],HAMD score and adverse effects were compared between the two groups.
Results
After treatment,WCST scores of both groups were improved,and scores of observation group were better than control group（
P<
0.05）.After treatment,HAMD scores in both groups were decreased,and the observation group was lower than the control group（
P<
0.05）.The adverse reactions of the two groups were compared（
P>
0.05）.
Conclusion
Paroxetine combined with mirtazapine can effectively improve cognitive function and depression in patients with PSD.
2024 Vol. 44 (1): 32-34 [
Abstract
] (
58
)
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50
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35
A Comparative Study of Salbutamol Sulfate and Procaterol in the Treatment of Children with Bronchial Asthma
Bai Xiaohang, Chang Zhendong, Mu Yanyan
DOI: 10.3969/j.issn.1001-8131.2024.01.011
Objective
To compare and analyze the research effect of salbutamol sulfate and procaterol in the treatment of children with bronchial asthma.
Methods
90 cases of children with bronchial asthma were selected and divided into an experimental group（n=45）and a control group（n=45）according to the random number table method.The control group was given procaterol drugs treatment,and the experimental group was was given salbutamol sulfate drugs treatment.The clinical efficacy,pulmonary function [forced vital capacity（FVC）,peak expiratory flow（PEF）,forced expiratory volume in the first second（FEV1）],asthma symptom score,symptom disappearance time（cough disappearance time,wheezing sound disappearance time,dyspnea disappearance time）and adverse reactions occurrence rate were compared between the two groups.
Results
The total effective rate of the experimental group 95.56%（43/45）was higher than that of the control group 77.78%（35/45）（
P<
0.05）;After treatment,the levels of FVC,PEF and FEV1 in the experimental group were respectively higher than those in the control group（
P<
0.05）;After treatment,the scores of asthma daytime symptoms and asthma nighttime symptoms in the experimental group were respectively lower than those in the control group（
P<
0.05）;The cough disappearance time,wheezing disappearance time and dyspnea disappearance time in the experimental group were respectively shorter than those in the control group（
P<
0.05）;There was no significant difference in the occurrence rate of adverse reactions between the two groups（
P>
0.05）.
Conclusion
Compared with the procaterol drugs treatment,salbutamol sulfate drugs treatment for children with the bronchial asthma can improve the curative effect,improve the pulmonary function and clinical symptoms.It is safe and reliable.
2024 Vol. 44 (1): 35-38 [
Abstract
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104
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38
Effect of Fasudil adjuvant therapy on cardiac function and BNP level in elderly patients with heart failure
Cai Chunsheng
DOI: 10.3969/j.issn.1001-8131.2024.01.012
Objective
To investigate the clinical effect of Fasudil in the adjuvant treatment of senile heart failure.
Methods
A total of 60 elderly patients with heart failure admitted to hospital were divided into two groups（30 cases in each group）by lottery Method The control group received routine treatment,on this basis,the observation group was added with sudil adjuvant treatment.The clinical efficacy of the two groups after 14 days of treatment was compared,and the changes of cardiac function（left ventricular end-diastolic diameter（LVEDD）,left ventricular end-systolic diameter（LVESD）,left ventricular ejection fraction（LVEF））and treatment-related indexes（brain natriuretic peptide（BNP）,cardiac natriuretic hormone（ANP））before and after treatment were observed between the two groups.
Results
Compared with the control group,LVEDD and LVESD in the observation group were lower and LVEF was higher after treatment,the difference was statistically significant（
t
=4.533,3.343,3.256,
P=
0.000,0.002,0.002）.The levels of BNP and ANP in the observation group were lower than those in the control group after treatment,and the difference was statistically significant（
t
=2.659,3.722,
P=
0.010,0.000）.
Conclusion
Fasudil has a good effect in the adjuvant treatment of senile heart failure.It can improve cardiac function,delay ventricular remodeling and alleviate the condition of heart failure.
2024 Vol. 44 (1): 38-40 [
Abstract
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48
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40
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41
Clinical Efficacy of Bevacizumab Combined with Anlotinib in The Treatment of Non-small Cell Lung Cancer and Its Influence on Immune Status
Ding Yanhua, Men Shuai, Zhang Jiangxia, Zhang Xu, Zhang Shancun, Liu Lu, Lv Hongwei, Xiao Zhenghong
DOI: 10.3969/j.issn.1001-8131.2024.01.013
Objective
To observe the clinical effect of bevacizumab combined with anlotinib in the treatment of non-small cell lung cancer（NSCLC）,and analyze its effect on immune status.
Method
A prospective randomized controlled study was conducted,selecting non-small cell lung cancer patients as the study subjects.The patients were divided into an observation group and a control group using a random number table method.The control group was treated with anlotinib,and the observation group was treated with anlotinib combined with bevacizumab.The clinical efficacy,T lymphocyte subsets（CD4+,CD3+,CD8+,CD4+/CD8+）,vascular endothelial growth factor（VEGF）level,KPS score,tumor marker level [serum carcinoembryonic antigen（CEA）,carbohydrate antigen 199（CA199）,CA125],survival time and adverse drug reactions were compared between the two groups.
Results
Before treatment,there was no statistical significant difference in various indicators between the two groups of patients（
P>
0.05）.After treatment,the disease control rate（DCR）,objective response rate（ORR）,CD4+,CD3+,CD4+/CD8+,and KPS scores of the observation group were significantly higher than those of the control group（
P<
0.05）.The levels of CD8+,VEGF,CEA,CA199,and CA125 in the observation group were lower than those in the control group（
P<
0.05）.Following up for 1 year,the median survival time of the observation group patients was 6 months,while the median survival time of the control group patients was 5 months.The total survival time of the observation group patients was significantly longer than that of the control group（lg rank=33.616,
P<
0.001）.There was no statistical significant difference in adverse reactions between the two groups（
P>
0.05）.
Conclusion
The combination of bevacizumab and anlotinib can improve the immune function and functional status of patients with non-small cell lung cancer,prolong the survival period,reduce the expression of tumor markers and VEGF,and has a good clinical effect.
2024 Vol. 44 (1): 41-44 [
Abstract
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113
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45
The Use of Muscle Relaxation Monitoring during Laparoscopic Sleeve Gastrectomy in Obese Patients
Wang hao, Long yun
DOI: 10.3969/j.issn.1001-8131.2024.01.014
Objective
to explore and analyse the application effect of muscle relaxation monitoring in guiding intraoperative deep muscle relaxation during laparoscopic sleeve gastrectomy and postoperative extubation in obese patients.
Methods
80 obese patients treated in our hospital from January 2022 to November 2023 were selected,all of whom were proposed to undergo laparoscopic sleeve gastrectomy.The patients were divided into the control group（conventional monitoring mode）and the observation group（muscle relaxation monitoring）,with 40 cases,and the application effects of different monitoring modes were analyzed.
Results
The total amount of muscarinic drugs used,postoperative awakening time,postoperative extubation time,end surgery（T2）lactate,leaving the anaesthesia recovery room（T3）lactate,blood glucose at 60min of surgery（T1）,end surgery（T2）blood glucose,leaving the anaesthesia recovery room（T3）blood glucose,and the total incidence of hypoxemia in the observation group were lower than those in the control group（
P
<0.05）.
Conclusion
It is worth recommending that obese patients undergoing laparoscopic sleeve gastrectomy be treated with muscle relaxation monitoring to ensure smooth perioperative blood glucose and lactic acid management,guide intraoperative deep myosin,minimize intraoperative myosin drug dosage,shorten postoperative awakening and extubation times,and lower the risk of postoperative hypoxemia.
2024 Vol. 44 (1): 45-47 [
Abstract
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61
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86
Clinical Study on the Therapeutic Effect of Non-invasive High-frequency Ventilation Mode on Bronchopulmonary Dysplasia
He Shaoting, Lin Hongquan, Wu Chunyan
DOI: 10.3969/j.issn.1001-8131.2024.01.029
Objective
To explore and analyze the therapeutic effect of non-invasive high-frequency ventilation mode on bronchopulmonary dysplasia;
Methods
Select 62 children with bronchopulmonary dysplasia were randomly divided into a study group and a control group,the control group was given constant-frequency ventilator ventilation,and the study group was given non-invasive high-frequency ventilation.The oxygen exposure time and ventilator use time were compared between the two groups before treatment,1d,2d,3d,4d,5d,and 6d after treatment,7dOI and blood gas analysis index levels;
Results
The oxygen exposure time and ventilator use time of the children in the study group were significantly shorter than those in the control group（
P<
0.05）,and there was no significant difference in the levels of OI indexes between the two groups before treatment（
P>
0.05）,the OI index levels of the children in the two groups showed an upward trend 1d,2d,3d,4d,5d,6d,and 7d after treatment,and the OI index levels of the children in the study group 3d,4d,5d,6d,and 7d after treatment were significantly higher than those in the control group（
P<
0.05）,and there was no significant difference in the levels of blood gas analysis indexes（PaO
2
and PaCO
2
）between the two groups before treatment（
P>
0.05）.On 6d and 7d,the PaO
2
index levels of the children in the two groups showed an upward trend,and the PaCO
2
index levels showed a downward trend,and the index levels of the children in the study group were significantly higher than those in the control group on 3d,4d,5d,6d,and 7d after treatment,and the index levels were significantly higher.lower than that in the control group（
P<
0.05）;
Conclusion
Non-invasive high-frequency ventilation mode in the treatment of BPD children can improve the clinical treatment effect,shorten the oxygen exposure time and ventilator use time,improve oxygenation,and promote the improvement of blood gas analysis,which is worthy of promotion.
2024 Vol. 44 (1): 86-88 [
Abstract
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66
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89
Analysis of Risk Factors of Delayed Bleeding after Endoscopic Submucosal Dissection for Digestive Tract Lesions
Liu Weihua, Jiang Haibo
DOI: 10.3969/j.issn.1001-8131.2024.01.030
Objective
To investigate the risk factors of delayed bleeding after endoscopic submucosal dissection（ESD）for digestive tract lesions.
Methods
Clinical data of 160 patients with digestive tract lesions treated with ESD were retrospectively analyzed,and relevant clinical,endoscopic and pathological data of the patients were analyzed.Patients were divided into bleeding group and non-bleeding group according to whether delayed bleeding occurred.The above data were compared between the two groups,and the risk factors of delayed bleeding after ESD were summarized.
Results
There was no significant difference between the two groups in terms of age,gender,complications,and whether they had taken anticoagulant drugs in the past（
P>
0.05）.The size of lesions and the proportion of surface ulcers in bleeding group were higher than those in non-bleeding group（
P<
0.05）.Total resection of the two groups was compared（
P>
0.05）.The operation time and the proportion of obvious bleeding in the bleeding group were higher than those in the non-bleeding group（
P<
0.05）.Lesion size,surface ulcers,operation time and obvious bleeding during operation were all related factors affecting delayed bleeding after digestive tract lesions（
P<
0.05）.
Conclusions
Patients with digestive tract lesions with large lesions,surface ulcers,long operation time and obvious bleeding during operation have higher risk of postoperative delayed bleeding,and should be treated as soon as possible.
2024 Vol. 44 (1): 89-91 [
Abstract
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67
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54
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92
Study on Effect of Different Atomization Dosing Sequences on the Wheezing Relief Time of Infants with Pneumonia
Yan Lin, LinXiumei, Zhang Xiaoshuang, LiPeiling, Chen Xiangui
DOI: 10.3969/j.issn.1001-8131.2024.01.031
Objective
To explore the effects of different atomization dosing sequences on the asthmatic remission time of Infantile Asthmatic Pneumonia,and to provide theoretical basis for improving nursing operation process.
Method
A total of 475children with asthmatic pneumonia who met the inclusion criteria were randomLy divided into two groups.The children in both groups were treated according to the consensus of experts in the diagnosis and treatment of children's asthmatic pneumonia.The observation group was treated with atomization inhalation,first adding 2mL normal saline to lubricate the wall of the atomization cup and shaking it well,and then adding other atomization drugs.In the control group,conventional atomization drug dosing method was used.To compare the time of beginning relief of wheezingand the time of complete disappearance of wheezing,the average atomization time and tube plugging time of the first atomization cup during use.
Results
The time of remission and complete disappearance of wheezing in the observation group was earlier than those in the control group（
P<
0.05）.The average atomization time of the observation group was shorter than that of the control group,and the use time of the atomization cup was significantly prolonged,with statistical significance（
P<
0.01）.
Conclusion
During atomization inhalation treatment,add normal saline to lubricate the inner wall of the atomization cup,which can shorten the atomization time of children,ensure the atomization effect,significantly shorten the wheezing time of children,and prolong the service life of the atomization cup.
2024 Vol. 44 (1): 92-94 [
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66
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44
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134
Research Progress on the Screening Methods For Hydroxychloroquine Retinal Toxicity
Zhong Yongfang, Wang Haibin
DOI: 10.3969/j.issn.1001-8131.2024.01.046
Long-term excessive use of hydroxychloroquine (HCQ) can lead to retinal damage, a well-established ocular side effect that can cause severe and irreversible central vision loss in advanced stages. However, early lesions are usually asymptomatic and therefore difficult to detect. With the development of automated visual field and retinal technology, early lesions can be detected before significant visual impairment occurs. Therefore, sensitive and effective screening for early retinopathy is essential. This article will focus on reviewing the screening methods for retinal toxicity in HCQ in order to improve the understanding of retinal toxicity screening in HCQ.
2024 Vol. 44 (1): 134-137 [
Abstract
] (
64
)
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51
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