Analysis of Traumatic Stress Response,Stone Clearance Effect and Safety of Percutaneous Nephrolithotomy in the Treatment of Upper Urinary Tract Calculi Complicated with Hypertension
Xiao Haiting, Du Wei, Tao Jiao, Cheng Shuanglei
Department of Urology,Nanyang Central Hospital,Nanyang 473000,China
Abstract：Objective To analyze the application value of percutaneous nephrolithotomy(PCNL)in the treatment of upper urinary tract calculi complicated with hypertension,and to explore its influence on perioperative indicators,stone clearance effect,inflammatory factor levels,traumatic stress response and safety. Methods 86 patients with upper urinary tract calculi from June 2024 to January 2026 were selected and randomly divided into two groups.The control group(n=43)received transurethral ureteroscopic holmium laser lithotripsy,and the observation group(n=43)received percutaneous nephrolithotomy.The perioperative indicators,stone removal effect,inflammatory factor levels,trauma stress response indicators and safety of the two groups were compared. Results There were significant differences in operative time and intraoperative blood loss between the two groups(P<0.05).Compared with the control group,the observation group exhibited higher stone clearance rates on days 3 postoperatively and at 1 month postoperatively(P<0.05).No significant differences were observed in preoperative levels of inflammatory factors or trauma stress markers between the two groups(P>0.05).On day 1 postoperatively,levels of C-reactive protein,tumor necrosis factor-α,interleukin-6,cortisol,adrenaline,and noradrenaline increased in both groups,with significantly higher values in the observation group(P<0.05).No statistically significant differences were found in hospitalization duration or complications between the groups(P>0.05). Conclusion Percutaneous nephrolithotomy for upper urinary tract calculi complicated by hypertension demonstrates superior efficacy compared to transurethral holmium laser lithotripsy;however,the latter Results in less bleeding and more effective reduction of inflammatory effects and traumatic stress responses,Clinical analysis should be conducted rationally,and selection should be made judiciously.
肖海亭, 杜薇, 陶娇, 程双蕾. 经皮肾镜碎石术治疗合并高血压的上尿路结石的创伤应激反应、结石清除效果及安全性分析[J]. 哈尔滨医药, 2026, 46(5): 27-30.
Xiao Haiting, Du Wei, Tao Jiao, Cheng Shuanglei. Analysis of Traumatic Stress Response,Stone Clearance Effect and Safety of Percutaneous Nephrolithotomy in the Treatment of Upper Urinary Tract Calculi Complicated with Hypertension. journal1, 2026, 46(5): 27-30.
2026, Vol. 46 
