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Quick Search     Adv Search 2022 Vol. 42, No. 4 Published: 2022-08-25 1 To Test Levels of IL-17 and IL-10 in NSCLC Patients’ Peripheral Blood and Its Clinical Significance Ma Weijiang, Liu Xin, Yang Limin, Yang Zhen, He Meng DOI: 10.3969/j.issn.1001-8131.2022.04.001 Objective To test the levels of interleukin-17（IL-17）and interleukin-10（IL-10）in non-small cell lung cancer（NSCLC）patients’ peripheral bloodand analyze it’s relationship with clinical staging. Methods Collected peripheral blood of 23 cases of NSCLC patients and 15 healthy volunteers in our department,segregated serum,tested the levels of IL-17 and IL-10 with ELISA,and analyzedit’s relationship with clinical stage. Results From healthy groups to III - IV stage NSCLC patients,IL-17 levels werereduceingcontinually,and the levels of III-IV stage patients were lesser than healthy volunteers obviously,the difference was statistical significant（P<0.05）,however,there were no obvious difference between healthy volunteersand I-II stage patients、I-II stage and III-IV stage patients;III-IV stage patients’ IL-10 levels were higher than another two groups,the difference wasstatistical significant（P<0.05）,there were no obvious difference betweenhealthy volunteers and I-II stage patients. Conclusion IL-17 and IL-10 is participating in the occurrence and development of NSCLC,IL-17 and IL-10 may plays antitumor and promote tumor effect,respectively. 2022 Vol. 42 (4): 1-2 [Abstract] ( 161 ) HTML (1 KB)  PDF (462 KB)  ( 124 ) 3 Toxic Effects of Shikonin in Different Concentrations on Cultured Rat Cardiomyocytes Chen Juying, Huang Wendong, Gao Qi, Lian Xiaoshan DOI: 10.3969/j.issn.1001-8131.2022.04.002 Objective To explore the toxic effects of rat cardiomyocytes treated with different concentrations of shikonin. Methods Select neonatal rats born from 1 to 3 births,and culture the cardiomyocytes of their ventricles.and the cardiomyocytes were treated with shikonin in different concentration gradients（1×10-7mol/L,1×10-6mol/L,1×10-5mol/L）by MTT method for 48h,Cytotoxicity after 72h. Results Using MTT test results,it was found that the cytotoxicity test effect was 48h,72h,and when the shikonin concentration was 10-5mol/L,the cardiomyocytes had significant toxicity（P<0.05）,and the shikonin concentration was 1×10-7mol/L.At L,1×10-6mol/L,cardiomyocytes had no significant toxicity（P>0.05）. Conclusions hikonin has certain cytotoxicity.When the concentration of shikonin is less than 1×10-6mol/L,it does not show obvious toxicity.When the concentration of shikonin is 10-5mol/L,the cardiomyocytes are treated for 48h and 72h.Rat cardiomyocytes have obvious toxicity. 2022 Vol. 42 (4): 3-5 [Abstract] ( 160 ) HTML (1 KB)  PDF (403 KB)  ( 165 ) 6 Correlation Between Endocrine and Metabolic Disorders and Condition in Patients With Optic Neuromyelitis Fan Guina, Ma Junbao, Wan Dongsheng DOI: 10.3969/j.issn.1001-8131.2022.04.003 Objective To observe the endocrine-related indicators and endocrine disorders in patients with optic neuromyelitis in different conditions,and to analyze the correlation between endocrine and metabolic disorders and optic neuromyelitis patients. Methods The clinical data of 40 patients with acute treatment of optic neuromyelitis were retrospectively analyzed and included them in the observation group.The clinical data of 40 patients with remission of optic neuromyelitis diagnosed and treated in our hospital during the same period were collected.They were included in the control group.The levels of total thyroxine（TT4）and adrenocorticotropic hormone（ACTH）in the two groups were compared.The effects of TT4 and ACTH levels on the condition of neuromyelitis patients were analyzed and explored the predictive value of TT4 and ACTH levels in the patients with neuromyelitis. Results The level of TT4 in the observation group was lower than that in the control group,and the level of ACTH was higher than that in the control group.The difference was statistically significant（P<0.05）.Logistic regression analysis showed that low expression of endocrine hormone TT4 and overexpression of ACTH were the influencing factors of patients’ condition with optic neuromyelitis（OR>1,P<0.05）;by drawing ROC curve found that the single detection of endocrine hormones TT4 and ACTH levels for the prediction of optic neuromyelitis disease AUC were 0.774 and 0.860,respectively,all have certain predictive value. Conclusion Most patients with optic neuromyelitis are associated with endocrine and metabolic disorders,which may be related to the aggravation of the disease during treatment.It is recommended that the level of endocrine indicators of patients with optic neuromyelitis can be monitored during the treatment to guide the prediction of the risk of aggravation of the patient and make active interventions. 2022 Vol. 42 (4): 6-8 [Abstract] ( 173 ) HTML (1 KB)  PDF (592 KB)  ( 154 ) 9 Application of Dexmedetomidine Nasal Drops Combined With Sevoflurane Inhalation in Children's Lower Abdominal Surgery Zeng Defeng, Ye Su, Wei Xiangjie DOI: 10.3969/j.issn.1001-8131.2022.04.004 Objective To explore the clinical effect of dexmedetomidine nasal drops combined with sevoflurane inhalation anesthesia induction in children's lower abdominal surgery. Methods 88 children who underwent abdominal were selected as the research objects,according to the anesthesia method,they were divided into observation group and control group,each with 44 cases,The observation group was given dexmedetomidine nasal drip combined with sevoflurane inhalation,and the control group was given sevoflurane inhalation.The indexes,hemodynamic indexes,satisfaction degree of sedation,The indexes,hemodynamic indexes,satisfaction degree of sedation,postoperative restlessness score and adverse reactions during the recovery period of anesthesia were compared between the two groups of children. Results The staying time,eye-opening time,and extubation time of the observation group were better than those of the control group（P<0.05）.Two hours after skin incision,the observation group’s average arterial pressure and heart rate index were better than those of the control group（P<0.05）The sedation satisfaction degree of the observation group was significantly higher than that of the control group（P<0.05）,and the postoperative restlessness scores of the observation group were lower than those of the control group after 5 minutes and 15 minutes after waking up（P<0.05）. Conclusion Dexmedetomidine nasal drops combined with sevoflurane inhalation applied to children's lower abdominal surgery has a clear effect,helps stabilize hemodynamics,effectively improves children's postoperative restlessness,and has high safety. 2022 Vol. 42 (4): 9-11 [Abstract] ( 173 ) HTML (1 KB)  PDF (403 KB)  ( 216 ) 12 Efficacy Evaluation of Transradial Approach PCI Combined With Tirofiban in The Treatment of Patients With Acute ST-Segment Elevation Myocardial Infarction Li Xiuhua DOI: 10.3969/j.issn.1001-8131.2022.04.005 Objective To explore the efficacy of transradial approach（TRA）percutaneous coronary intervention（PCI）combined with tirofiban in the treatment of patients with acute ST-segment elevation myocardial infarction（ASTEMI）. Methods 84 patients with ASTEMI were selected and divided into groups according to different treatment plans,with 42 cases in each group.The control group was treated with TRA-PCI,and the observation group was treated with TRA-PCI combined with tirofiban.The coronary angiography measurementresultsbefore and after surgery,serum troponin I（cTnI）and creatine kinase mixed isoenzyme（CK-MB）levels before and 24 hours after surgery,cardiac function indexes 1 week after surgery,and the incidence of bleeding and thrombocytopenia were compared. Results The acquisition rate of TIMI myocardial perfusion grade（TMPG）level 3 in the observation groupafter surgery was higher than that in the control group（P<0.05）;The serum cTnI and CK-MB levels in the observation group at 24 hour after surgerywere lower than those in the control group（P<0.05）;One weekafter surgery,the left ventricular ejection fraction（LVEF）of the observation group was higher than that of the control group（P<0.05）;The thrombocytopenia was not found in the two groups,and there was no significant difference in the incidence of bleeding between the two groups（P>0.05）. Conclusion The treatment of ASTEMI patients with TRA-PCI combined with tirofiban can improve postoperative myocardial tissue perfusion, reduce the level of postoperativeserum myocardial biochemical markers after surger,improve cardiac function,and has high safety. 2022 Vol. 42 (4): 12-13 [Abstract] ( 186 ) HTML (1 KB)  PDF (444 KB)  ( 168 ) 14 Effect of Amoxicillin,Lansoprazole,Clarithromycin Combined With Clostridium Butyricum on Serum Inflammatory Factors in Children With Chronic Gastritis and HP Infection Liu Juan, Yang jun, Sun Lu DOI: 10.3969/j.issn.1001-8131.2022.04.006 Objective To study the effect of amoxicillin,lansoprazole,clarithromycin combined with clostridium butyricum on serum inflammatory factors in children with chronic gastritis and HP infection. Methods A total of 80 children with chronic gastritis complicated with HP infection were randomly divided into control group and study group,40 cases in each group.The control group was treated with the traditional triple therapy of amoxicillin + lansoprazole + clarithromycin,and the study group was given the treatment of clostridium butyricum on the basis of the control group.The treatment course was 14 days.Gastrointestinal symptom rating score（GSRS）was used to evaluate the gastrointestinal symptoms of the children,and the HP eradication rate,serum inflammatory factor levels [high sensitivity C-reactive protein（CRP）,interleukin-6（IL-6）,interleukin-8（IL-8）]and gastrointestinal adverse reactions of the two groups were analyzed and compared. Results After treatment,the GSRS score of the study group was significantly lower than that of the control group（P<0.05）.The eradication rate of HP in the study group was 87.5%,which was significantly higher than that of the control group（67.5%）（P<0.05）.The levels of CRP,IL-6 and IL-8 in the study group after treatment were lower than those in the control group（P<0.05）.The incidence of digestive system adverse reactions in the study group was 17.5%,which was lower than that of the control group（52.5%）（P<0.05）. Conclusion The application of amoxicillin,lansoprazole,clarithromycin combined with clostridium butyricum in the treatment of children with chronic gastritis with HP infection can effectively alleviate the symptoms of chronic gastritis,improve the eradication rate of HP,reduce the level of serum inflammatory factors,and reduce adverse drug reactions. 2022 Vol. 42 (4): 14-16 [Abstract] ( 266 ) HTML (1 KB)  PDF (433 KB)  ( 220 ) 17 Efficacy and Safety Analysis of Propylthiouracil in the Treatment of Hyperthyroidism Jiao Dongan, Feng Mingjie, Zhou Hui, Li Junming DOI: 10.3969/j.issn.1001-8131.2022.04.007 Objective To investigate the efficacy and safety of propanthiouracil in the treatment of hyperthyroidism. Methods A total of 120 patients with hyperthyroidism who were admitted to the outpatient department of endocrinology or hospitalized in the ward of endocrinology department were collected and randomly divided into study group and control group,60 patients in each group.Methimazole was added to the control group and propyl thiouracil was added to the study group.The treatment effect,thyroid function related indexes and adverse drug reactions were compared between the two groups. Results The hypermetabolism-related symptoms and signs of hyperthyroidism patients were significantly improved after treatment with propylthiouracil,and the probability of symptom reduction was significantly higher than that of control group.In addition,serum FT3,FT4,TPOAb and TgAb in observation group were against control group,while TSH was higher than control group（P<0.05）.A total of 3 patients in the observation group had gastrointestinal adverse reactions during medication,which improved spontaneously after drug withdrawal,and the incidence of adverse reactions was significantly lower than that in the control group（P<0.05）. Conclusion For patients with hyperthyroidism,the application of propylthiouracil in the treatment of clinical effect is good,the symptoms of hypermetabolism are significantly reduced,but also significantly improve the thyroid function,less adverse reactions,high safety,is the preferred drug for the treatment of hyperthyroidism. 2022 Vol. 42 (4): 17-18 [Abstract] ( 144 ) HTML (1 KB)  PDF (473 KB)  ( 171 ) 19 The Influence of Abdominal Wall Thickness in Patients With Chronic Liver Disease on Liver Stiffness Measured By 2D-SWE Han Bin, Zhang Shumei, Li Hailing, Zhi Jianfang, Gao Hongbo DOI: 10.3969/j.issn.1001-8131.2022.04.008 Objective To investigate the effect of abdominal wall thickness in patients with chronic liver disease on the detection of liver stiffness by 2D-SWE. Methods A total of 2395 patients with chronic liver disease were collected.Collect the patient's general information,such as age,gender,BMI;ultrasound detection collects the patient's abdominal wall thickness（AWT）,non-muscle layer thickness（NMT）and liver stiffness（LS）,and calculates the patient's NMT/AWT ratio. Results Among the 2395 patients,691 patients（28.85%）were classified as invalid liver stiffness group（standard deviation of liver stiffness/median liver stiffness>0.1）.The average age and average BMI of the LS effective group were lower than the LS ineffective group,the number of women in the effective group was lower than that of the ineffective group,the AWT of the ineffective group was significantly higher than that of the effective group,and the NMT/AWT ratio was significantly lower than that of the effective group.Univariate regression analysis showed that age,gender,BMI,abdominal wall thickness and NMT/AWT ratio are closely related to the reliability of LS measurements. Conclusion The increase in AWT and the increase in the NMT/AWT ratio reduce the confidence level of the LS value measured by 2-D-SWE.When operating accurately,the operator can also select the penetrating power mode,which may improve the reliability of the measurement. 2022 Vol. 42 (4): 19-21 [Abstract] ( 225 ) HTML (1 KB)  PDF (407 KB)  ( 169 ) 22 Effects of TIPS on Vascular Recanalization and Survival Rate in Patients With Liver Cirrhosis Complicating Portal Venous Thrombosis Li Yuntao DOI: 10.3969/j.issn.1001-8131.2022.04.009 Objective To investigate the effects of transjugular intrahepatic portosystemic shunt（TIPS）on vascular recanalization and survival rate in patients with liver cirrhosis complicating portal venous thrombosis. Methods 110 patients with liver cirrhosis complicating portal venous thrombosis receiving TIPS were enrolled.All patients received half year follow-up.Then the postoperative blood vessel recanalization,varicose vein relief,rebleeding,survival and death were recorded. Results After TIPS treatment,93 cases were successful and 17 cases failed.The success rate was 84.55%. Results：85 patients with successful operation had main portal vein thrombosis before operation,and the recanalization rate was 94.12%;30 patients with left portal vein thrombosis,and the recanalization rate was 26.67%;38 patients with right portal vein thrombosis,and the recanalization rate was 73.68%;47 patients with superior mesenteric vein thrombosis,and all patients were relieved after operation.The remission rate of patients with successful operation was higher than that of patients with failure（P<0.05）.There were 7 cases of main portal vein thrombosis,7 cases of left and right portal vein thrombosis,and 7 cases of superior mesenteric vein thrombosis in patients with failed operation.The postoperative bleeding rate was 7.53% in patients with successful operation,and the total remission rate was 86.02%.The total bleeding rate of patients with failed operation was 52.94%,and the varicose vein did not relieve until the end of follow-up.The remission rate of varicose vein in patients with successful operation was higher than that in patients with failed operation,and the re bleeding rate was lower than that in patients with failed operation（P<0.05）.A total of 16 patients died,the overall survival rate was 85.45%.The survival rate of successful operation was higher than that of failure operation（P<0.05）. Conclusion TIPS is an important treatment method for patients with cirrhosis combined with portal vein thrombosis.In clinical practice,reasonable selection of surgery based on indications can effectively reduce postoperative bleeding,improve the rate of vascular recanalization and survival rate, which is worthy of recommendation. 2022 Vol. 42 (4): 22-24 [Abstract] ( 230 ) HTML (1 KB)  PDF (399 KB)  ( 141 ) 25 The Relationship Between Nrf2 and NQO1 in Preeclampsia and the Effect of NQO1 on the Invasiveness of htr-8 / svneo Cells Wu Guohong DOI: 10.3969/j.issn.1001-8131.2022.04.010 Objective To investigate the relationship between nuclear factor E2 related factor 2（Nrf2）and quinone oxidoreductase-1（NQO1）in preeclampsia and the effect of NQO1 on the invasiveness of htr-8 / svneo cells. Methods 74 cases of preeclampsia and 74 cases of normal pregnant women were selected.The plasma samples were collected one day before cesarean section.The levels of Nrf2 and NQO1 were measured by enzyme-linked immunosorbent assay（ELISA）,and Pearson correlation analysis was performed.Htr-8 / svneo cells were pretreated with Nrf2 inducer（TBHQ）,NQO1 inducer（2-hbas）,Nrf2 inhibitor（ml385）and NQO1 inhibitor（dicoumarol）,respectively.Then,htr-8 / svneo cells were pretreated with hydrogen peroxide or blank treatment for 4 h.The relative expression level of NQO1 mRNA and Nrf2 and NQO1 mRNA in htr-8 / svneo cell model were detected to analyze the invasiveness of htr-8 / svneo cells. Results The levels of Nrf2 and NQO1 in preeclampsia patients were lower than those in the control group,the difference was statistically significant（P<0.05）;the expression levels of Nrf2 and NQO1 in preeclampsia patients were positively correlated（P<0.05）;compared with the control group,the relative expression levels of Nrf2 and NQO1 protein and NQO1 mRNA in cells of hydrogen peroxide group and TBHQ group were higher,and the difference was statistically significant（P<0.05）;ml385 There was no significant difference in the relative expression levels of Nrf2,NQO1 protein and NQO1 mRNA between the two groups（P > 0.05）;compared with the hydrogen peroxide group,the relative expression levels of Nrf2 and NQO1 proteins and NQO1 mRNA in the cells of the hydrogen peroxide combined with ml385 group were lower,and the difference was statistically significant（P<0.05）. Conclusion The decrease of plasma Nrf2 and NQO1 levels in patients with preeclampsia may lead to the decrease of antioxidant capacity.Under oxidative stress,Nrf2 can activate NQO1 in htr-8 / svneo cells,thus enhancing cell invasion. 2022 Vol. 42 (4): 25-27 [Abstract] ( 143 ) HTML (1 KB)  PDF (397 KB)  ( 177 ) 28 Analysis of the Effect of Positive Pressure Ventilation on Newborns With Respiratory Diseases Tan gailing, Huang yingxuan, Li Meiqing, Liu Ling DOI: 10.3969/j.issn.1001-8131.2022.04.011 Objective To investigate the clinical effect of noninvasive positive pressure ventilation in the treatment of neonatal respiratory diseases. Methods A retrospective analysis of 84 cases of neonatal respiratory diseases treated.According to different treatment methods,they were divided into nasal continuous positive airway pressure（nCPAP）group（observation group）and normal control group,42 cases in each group.Blood oxygen saturation（SpO2）,partial pressure of oxygen（PaO2）and partial pressure of carbon dioxide（PaCO2）before treatment and 24 hours after ventilation were compared between the two groups. Results Before treatment,there was no significant difference in SpO2,PaO2 and PaCO2 between the two groups（P>0.05）;After 24 hours of ventilation,SpO2 and PaO2 increased and PaCO2 decreased in both groups（P<0.05）,but SpO2 and PaO2 in the observation group were higher than those in the control group,and PaCO2 in the observation group was lower than that in the control group（P<0.05）.The hospitalization time of the observation group was shorter than that of the control group,and the apnea rate was lower than that of the control group（P<0.05）. Conclusion NCPAP is effective for newborns with respiratory diseases,with shorter hospital stay and lower apnea rate. 2022 Vol. 42 (4): 28-29 [Abstract] ( 102 ) HTML (1 KB)  PDF (292 KB)  ( 144 ) 30 Application Value of Color Doppler Ultrasound in the Diagnosis of Placental Implantation Dong Yan DOI: 10.3969/j.issn.1001-8131.2022.04.012 Objective To explore the value of color Doppler ultrasonography in the diagnosis of placental implantation and its subtypes. Methods The clinical data of 42 patients with suspected placental implantation by prenatal ultrasound in Guangzhou first people's Hospital in recent years were analyzed retrospectively.Firstly,the coincidence rate of color Doppler and MRI in the diagnosis of placental implantation was compared.Secondly,the ultrasonic imaging characteristics before delivery were analyzed and scored retrospectively according to the ultrasonic scoring system.By comparing and analyzing the score differences and intraoperative bleeding indexes between different placenta implantation groups,normal placenta groups and placenta implantation groups,to evaluate the value of ultrasound score in the diagnosis of placenta implantation,and to evaluate the value of ultrasound score in predicting the amount of intraoperative bleeding of pregnant women with placenta implantation. Results Among 42 pregnant women with suspected placental implantation before delivery,36 were diagnosed with placental implantation after delivery,and the diagnostic coincidence rate was 85.7%;38 pregnant women were examined by ultrasound and MRI at the same time before delivery.Among them,34 cases were diagnosed as placental implantation after delivery,of which the coincidence rate of ultrasound diagnosis was 89.4%,and 32 cases were diagnosed correctly by MRI,with a coincidence rate of .There was no significant difference in the diagnostic coincidence rate between the two methods;The ultrasound score of placenta implantation group was significantly higher than that of normal placenta group.The ultrasound score of placenta implantation group and penetrating placenta implantation group was significantly higher than that of Placenta Adhesion group;The higher the ultrasound score,the more intraoperative bleeding,and the difference between the groups was statistically significant. Conclusion The diagnostic coincidence rate of color Doppler ultrasonography in the diagnosis of placental implantation is high,and there is no significant difference compared with MRI,indicating that prenatal ultrasonography has important value in the diagnosis of placental implantation.The use of ultrasound scoring system can more Objectively evaluate the diagnosis and classification of placental implantation.It has important value in predicting its prognosis and is worthy of popularization. 2022 Vol. 42 (4): 30-32 [Abstract] ( 156 ) HTML (1 KB)  PDF (485 KB)  ( 139 ) 33 Comparative Study of Different Surgical Procedures for Thyroid Cancer Wang Yuntao DOI: 10.3969/j.issn.1001-8131.2022.04.013 Objective To investigate the effect of total thyroidectomy and subtotal thyroidectomy in the treatment of thyroid cancer（TC）. Methods 74 patients with TC cancer were selected and divided into two groups according to the alternate grouping method.37 patients in group a received subtotal thyroidectomy,and 37 patients in group B received total thyroidectomy.The serum calcium and parathyroid hormone（PTH）levels before and 1 day after operation were compared between the two groups,and the incidence of postoperative complications was counted. Results The incision length of group A was shorter than that of group B,the amount of intraoperative blood loss was less than that of group B,and the operation and hospitalization time were shorter than those of group B,the difference was statistically significant（P<0.05）.The levels of serum calcium and PTH in two groups were lower than those before operation,but group A was higher than group B（P<0.05）.Compared with group A,the total incidence of postoperative complications in group B was higher,and the difference was not statistically significant（P>0.05）. Conclusion Compared with total thyroidectomy,subtotal thyroidectomy in the treatment of TC patients can shorten the recovery time,improve the serum calcium and PTH levels,without increasing the incidence of postoperative complications. 2022 Vol. 42 (4): 33-34 [Abstract] ( 141 ) HTML (1 KB)  PDF (288 KB)  ( 179 ) 35 Application of Ultrasound-guided Brachial Plexus Block in Upper Limb Surgery Zheng Mingqing DOI: 10.3969/j.issn.1001-8131.2022.04.014 Objective To investigate the effect of ultrasound-guided lower brachial plexus block anesthesia in upper limb surgery. Method 80 patients who underwent upper limb surgery were randomly divided into two groups,all underwent intermyogenic brachial plexus block anesthesia,the control group used traditional anatomical puncture positioning,and the observation group Using ultrasound-guided positioning,the two groups' anesthesia-related indicators,excellent anesthesia rate,intraoperative hemodynamics,and postoperative pain scores were compared between the two groups. Results The onset time of sensory block,the onset time of motor block,and the dose of anesthetic drugs in the observation group were less than those in the control group（P<0.05）;the excellent and good rate of anesthesia in the observation group was 97.50%,which was significantly higher than the control group’s 75.00%（P<0.05）;The MAP and HR of the observation group at the beginning of the operation,30min after the operation,and at the end of the operation were lower than those of the control group（P<0.05）,but the SpO2 levels of the two groups were equivalent（P>0.05）;the observation group was 6h after the operation The VAS pain scores at 12h and 24h were significantly lower than those of the control group（P<0.05）. Conclusion Ultrasound-guided intermuscular brachial plexus block has a significant effect in upper limb surgery.The block has a fast onset,stable intraoperative hemodynamics,and low postoperative pain score,which has positive clinical significance. 2022 Vol. 42 (4): 35-36 [Abstract] ( 194 ) HTML (1 KB)  PDF (292 KB)  ( 166 ) 37 Effect of Low Dose Sufentanil Combined With Ropivacaine on Hemodynamics and Analgesic Effect of Lower Extremity Fracture Surgery Fang Rui DOI: 10.3969/j.issn.1001-8131.2022.04.015 Objective To investigate the effect of low-dose sufentanil combined with ropivacaine on hemodynamics and analgesia in patients with lower extremity fracture surgery. Methods Selection 113 patients with lower limb fracture as the research object,by the simple randomized grouping were divided into group A（55 cases）and group B（58 cases）,A group of patients to give simple,pp because anesthesia,B group of patients given small doses sufentanil joint ROM pp because anesthesia,compared two groups of patients with sensory and motor block,effect and maintain time records of two groups of patients with T1（before anesthesia）,T2（2 h）after operation,T3（6 h）after surgery and T4（12 h）postoperative time points visual pain score（VAS）,The changes of hemodynamic indexes were compared between the two groups at the above time points. Results The onset time of sensory block and motor block in group B was lower than that in group A,and the maintenance time of sensory block and motor block was higher than that in group A（P<0.05）.VAS scores of patients in Group B at time points T2,T3,and T4 were lower than those in group A（P<0.05）.In group B,HR and MAP at Time T2,T3 and T4 were lower than those in group A,and HR at time T3 in group A was higher than other time points in the same group（P<0.05）. Conclusion The application of low-dose sufentanil combined with ropivacaine in lower limb fracture surgery can increase its hemodynamic stability,reduce circulatory system fluctuation,accelerate the onset time of block,prolong the maintenance time,and have significant analgesic effect,which can be widely used in clinical practice. 2022 Vol. 42 (4): 37-38 [Abstract] ( 152 ) HTML (1 KB)  PDF (463 KB)  ( 168 ) 39 Clinical Observation of FukeZhixueling Tablets Combined with Mifepristone and Mirena in the Treatment of Menopausal Functional Uterine Bleeding Shan Yuanyuan, Xu Yanhua, Liu Dongni DOI: 10.3969/j.issn.1001-8131.2022.04.016 Objective To analyze the clinical efficacy of FukeZhixueling tablets combined with mifepristone and Mirena in the treatment of DUB. Methods A total of 90 DUB patients received treatment were selected and randomly divided into observation group and control group,with 45 cases in each group.The control group was treated with FukeZhixueling tablets combined with mifepristone;The observation group was treated with Mirena on the basis of the treatment of the control group.Both groups were treated with the drug for 1 month.Analyze and compare the levels of FSH,LH,and P values between the two groups;calculate the effective rate of clinical treatment and the proportion of adverse reactions. Results After treatment,the FSH,LH,and P values of the observation group were significantly better than those of the control group（P<0.05）;the clinical efficacy of the observation group was 95.56%,which was significantly higher than the control group's 75.56%（P<0.05）;The adverse reaction in the observation group was 6.67%,which was lower than 22.2% in the control group（P<0.05）. Conclusion The treatment of DUB with Zhixueling tablets combined with mifepristone + Mirena can achieve better clinical effects and reduce the occurrence of adverse reactions.It is worthy of popularization and application. 2022 Vol. 42 (4): 39-41 [Abstract] ( 214 ) HTML (1 KB)  PDF (424 KB)  ( 200 ) 42 Comparison of Effects of Vitapex Paste and Zinc Oxide Root Canal Paste In the Treatment of Children With Chronic Diseases of Periapical Tissue of Deciduous Teeth Sinus Tract Li Xiaoxuan, Guiping Xue, Dongxu Su DOI: 10.3969/j.issn.1001-8131.2022.04.017 Objective To analyze the effects of Vitapex paste and zinc oxide root canal paste on children with chronic diseases of periapical tissue（DPT）of deciduous teeth sinus tract. Methods A total of 130 children patients with DPT of deciduous teeth sinus tract who were divided into the group A and the group B according to the random number table method,with 65 cases in each group.The group A was treated with Vitapex paste treatment while the group B was treated with zinc oxide root canal paste.The curative effect evaluation of non-acute reaction rate within one week after surgery and success rate of reexamination at half a year after surgery were compared between the two groups. Results The non-acute response rate was 93.85% in the group A and 90.77% in the group B,and there was no comparable difference in the overall curative effect between the two groups（P>0.05）.The success rate was 95.38% in the group A and was 92.31% in the group B,and there was no comparable difference in the efficacy evaluation between the two groups（P>0.05）. Conclusion Vitapex paste has similar effects with zinc oxide root canal paste in treating chronic DPT of deciduous teeth sinus tract,and the two methods have relatively mild response of children after root filling,thus parents can choose surgical methods according to their needs. 2022 Vol. 42 (4): 42-43 [Abstract] ( 142 ) HTML (1 KB)  PDF (322 KB)  ( 203 ) 44 Effect of Combined Therapy on Platelet Count and Immunological Indexes in Children With Immune Thrombocytopenia Liao Huiying, Lin Minyi, Li Meiqing, Tan Gailing, Li Wei, Liu Ling DOI: 10.3969/j.issn.1001-8131.2022.04.018 Objective To investigate the efficacy of IVIG combined with dexamethasone in the treatment of children with（ITP）. Methods A total of 50 children with IPT were collected.They were randomly divided into two groups：IVIG combined with dexamethasone（combined treatment group）and dexamethasone alone（treated alone group）,with 25 patients in each group.Children in the combined treatment group were treated with IVIG combined with dexamethasone,and children in the single treatment group were treated with dexamethasone alone.The platelet count,immunological indexes（IgM,IgG and IgA）and therapeutic effect were compared between the two groups before and after treatment,and the therapeutic effect was judged. Results The total effective rate of combined treatment group was higher than that of single treatment group.The levels of IgG,IgM and IgA in the combined treatment group were significantly lower than those in the single treatment group.The number of platelets in the combined treatment group was significantly higher than that in the dexamethasone group alone,and the differences were statistically significant（P<0.05）. Conclusion The combination of globulin and dexamethasone has a fast onset and strong effect,which can quickly increase the number of platelets in children with IPT.The combined treatment method is worthy of further clinical research and application. 2022 Vol. 42 (4): 44-45 [Abstract] ( 169 ) HTML (1 KB)  PDF (281 KB)  ( 168 ) 88 Evaluation of Diagnostic Efficacy of Dynamic Contrast-Enhanced MRI Quantitative Parameters in Hepatocellular Carcinoma Pang Yanqiong, Wang Haoran, Zhang Yinxia DOI: 10.3969/j.issn.1001-8131.2022.04.040 Objective To explore the diagnostic efficiency of dynamic enhancement quantitative parameters of Magnetic Resonance Imaging,MRI）in hepatocellular carcinoma. Methods 112 patients with liver space-occupying lesions admitted to our hospital from July 2018 to June 2020 were divided into experimental group（51 cases with hepatocellular carcinoma）and control group（61 cases with benign liver tumor）according to different diseases.Comparing the initial Area under curve,iAUC）,rate constant,Kep）,extra vascular extra cellular volume fraction（ve）,volume transfer con-stant（ktrans）of normal liver tissues and lesions between the two groups,and observing the diagnostic efficacy of various quantitative parameters. Results iAUC,Ve,Kep,Ktrans in the two groups were higher than those in normal tissues（P<0.05）.IAUC,Kep,Ktrans in experimental group were higher than those in control group（P<0.05）.Compared with the control group,there was no significant difference in Ve（P>0.05）.The specificity,sensitivity and cut-off value of Ktrans were 66.7%,81.9% and 0.209 respectively.The specificity,sensitivity and cut-off value of Kep were 58.4%,75.3% and 0.468 respectively.The specificity,sensitivity and threshold of iAUC were 58.4%,81.7% and 24.825,respectively. Conclusion Dynamic enhancement of quantitative parameters by MRI in the differential diagnosis of hepatocellular carcinoma has better diagnostic efficiency and is worthy of application and popularization. 2022 Vol. 42 (4): 88-89 [Abstract] ( 188 ) HTML (1 KB)  PDF (509 KB)  ( 149 ) 109 Application of QingreTongfei Decoction in the Treatment of Severe Pneumonia With Retention of Heat-Phlegm in the Lung Liu Cheng, Zhang Qingfang, Zhu Qing DOI: 10.3969/j.issn.1001-8131.2022.04.049 Objective To explore the application of QingreTongfei Decoction in the treatment of severe pneumonia with retention of heat-phlegm in the lung. Methods A total of 84 patients with severe pneumonia with retention of heat-phlegm in the lung were randomly divided into western medicine group and traditional Chinese medicine group,42 cases in eacsh group.The western medicine group was treated with conventional western medicine,and the traditional Chinese medicine group was treated with QingreTongfei Decoction on the basis of the western medicine group.The TCM symptom score,blood gas index and inflammatory factor levels were compared between the two groups after treatment. Results After treatment,expectoration,shortness of breath,tongue condition and pulse condition of the two groups decreased,and the scores of TCM group were lower than those of western medicine group（P<0.05）.After treatment,PaO2 and OI of TCM group were higher than those of western medicine group,PaCO2 of TCM group was lower than that of western medicine group（P<0.05）.After treatment,the levels of IL-6,TNF - α and IL-10 in TCM group were lower than those of western medicine group（P<0.05）. Conclusion QingreTongfei Decoction has better curative effect in the adjuvant treatment of severe pneumonia with retention of heat-phlegm in the lung,which can reduce TCM symptom score,improve blood gas index,and reduce inflammatory reaction. 2022 Vol. 42 (4): 109-111 [Abstract] ( 146 ) HTML (1 KB)  PDF (409 KB)  ( 206 ) 133 Prevention and Treatment of Knee Osteoarthritis With Psychosomatic Exercise Therapy Zhang Wanru, An Yufang DOI: 10.3969/j.issn.1001-8131.2022.04.060 Psychosomatic medicine is a new discipline,which diagnoses,treats and recovers diseases by studying the relationship among physiology,psychology and society and their correlation with health and disease.More and more studies have shown that knee osteoarthritis（KOA）is a psychosomatic disease.Three interrelated factors affect the occurrence and development of KOA,including physiological factors（joint degeneration,muscle weakness,inflammation,etc.）,psychological factors（tension,anxiety,depression,fear,sleep disorders,etc.）and social factors（reduced social interaction,lack of social support,deterioration of social relations,etc.）.With the rise of exercise therapy in the prevention and treatment of musculoskeletal diseases,the application of psychosomatic exercise therapy to KOA can release the pain,improve joint function,mood,sleep quality and social life of KOA patients,in line with the treatment needs of KOA patients. 2022 Vol. 42 (4): 133-135 [Abstract] ( 108 ) HTML (1 KB)  PDF (637 KB)  ( 220 )

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