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Quick Search     Adv Search 2023 Vol. 43, No. 1 Published: 2023-02-25 1 The Effect of Hyperbaric Oxygen in Obstructive Sleep Apnea Hypopnea Syndrome：a Meta-Analysis Huang Ping, Yang Hao, Liu Hanyun, Li Yuhong DOI: 10.3969/j.issn.1001-8131.2023.01.001 Objective To evaluate the efficacy of hyperbaric oxygen in patients with OSAHS.Methods PubMed,Embase,Web of science,Cochran Library,CNKI,VIP,Wanfang and China Biomedical Literature Database were searched to collect randomized controlled trials of hyperbaric oxygen in treatment of obstructive sleep apnea hypopnea syndrome from inception to March 2021.Two researchers independently completed the literature screening,data extraction and quality evaluation of the included literature.RevMan5.4 software and Stata16.0 software were used to perform meta-analysis.Results A total of 6 RCTs involving 512 patients were included.The results of meta-analysis showed that hyperbaric oxygen in improving AHI（SMD=-2.05,95%CI[-2.88~-1.22],P<0.00001）,SaO2（MD=7.49,95%CI[5.65~9.33],P<0.00001）,the longest apnea time（MD=-4.31,95%CI[-4.95~-3.67],P<0.00001）,snoring（RR=0.21,95%CI[0.06~0.71],P=0.01）,daytime drowsiness（RR=0.10,95%CI [0.01~0.76],P=0.03）and nocturnal awakening（RR=0.19,95%CI [0.05~0.68],P=0.01）and other effects was better than the control group,and the difference was statistical significance.Conclusion The therapeutic effect of hyperbaric oxygen in patients with OSAHS is definite.However,due to the small number of included literature,large heterogeneity and all from Chinese literature,so more studies are needed to prove the efficacy of HBOT on OSAHS. 2023 Vol. 43 (1): 1-4 [Abstract] ( 143 ) HTML (1 KB)  PDF (1317 KB)  ( 135 ) 5 Peripheral Blood Expression of PD-L1 and PD-1 Associated With Tumor Immune Escape in Cutaneous Squamous Cell Carcinoma Patient Yang Xueqi, Li Dan, Min Wei DOI: 10.3969/j.issn.1001-8131.2023.01.002 Objective To clarify the expression of PD-L1 in Cutaneous Squamous Cell Carcinoma（cSCC）,and discuss their possible roles in tumor immune escape.Methods First,we used immunohistochemistry method to examined the expression of PD-L1 molecule in age-matched normal subject samples,precancerous lesion samples and clinical skin cSCC tissue samples.And immunofluorescence was applied to detect the expression of PD-L1 in primary epithelial cells and skin squamous cell line A431.In addition,we also detected the expression of PD-L1 in the peripheral blood CD14 positive cells and PD -1 in peripheral T cells of cSCC patients by flow cytometry method,then analyzed the differences in PD-L1 expression levels in different populations.Results Immunohistochemical results showed a significant upregulation of PD-L1 in actinic keratinized tissues and squamous cell carcinoma tissues and a significant down-regulation of PD-L1 in normal skin tissues.Resultsof immunofluorescence showed a strongly difference of PD-L1 between primary epithelial cells and skin squamous cell.Furthermore,the increase of PD-L1 was no strongly associated with gender,age,and tumor risk factors.In addition（P>0.05）,the results also proved a significant high expression of co-inhibitory molecules such as PD-L1 in peripheral blood CD 14 positive cells and PD-L1 ligands PD-1 in peripheral T cells of cSCC.Conclusion Our results suggest that PD-L1 plays an important role in the occurrence of cSCC and the immune escape of tumors,and it provides the possibility for PD-L1 molecules to be used as a potential target for early diagnosis and immunotherapy of cSCC. 2023 Vol. 43 (1): 5-8 [Abstract] ( 161 ) HTML (1 KB)  PDF (818 KB)  ( 187 ) 9 Comparison of the Effects of Total Arch Replacement and Right Hemiarch Replacement on the Prognosis of Patients With Acute Stanford Type A Aortic Dissection Pan Junhui, Zhang Xiangli, Mei Yongcheng, Yu Sen DOI: 10.3969/j.issn.1001-8131.2023.01.003 Objective To study the effect of total arch replacement and right hemiarch replacement on the prognosis of patients with acute Stanford A aortic dissection.Methods The clinical data of 66 patients with acute Stanford A aortic dissection were retrospectively analyzed.They were divided into total arch group（n=36 cases,total aortic arch replacement）and right half arch group（n=30 cases,Application of right aortic arch replacement）.Compare the perioperative indicators [cardiopulmonary bypass,aortic occlusion,selective cerebral perfusion time,ICU stay time],laboratory indicators [C- reactive protein（CRP）,D- dimer（D-D）] before and 48 hours after operation,and compare the prognosis of the two groups [perioperative death,second operation and complications within one year after operation].Results There was no significant difference in ICU stay time between the two groups（P>0.05）.Other perioperative indicators in the right half arch group were significantly lower than those in the total arch group（P<0.05）.The CRP and D-D levels in the two groups increased 48 hours after operation compared with those before operation,while those in the right half arch group were lower than those in the full arch group at the same time,and the differences were statistically significant（P<0.05）.However,there was no significant difference in prognosis between the two groups（P>0.05）.Conclusion Right hemi-arch replacement can reduce the waiting time of cardiopulmonary bypass,reduce the hypothermia injury,relieve the stress and inflammatory reaction of the body,and be beneficial to the postoperative recovery of patients. 2023 Vol. 43 (1): 9-10 [Abstract] ( 143 ) HTML (1 KB)  PDF (426 KB)  ( 105 ) 11 Logistic Regression Analysis of Related Factors of Cerebral Infarction in Patients With Moyamoya Disease After Bypass Surgery Gao Zhiang DOI: 10.3969/j.issn.1001-8131.2023.01.004 Objective To investigate the influential factors of cerebral infarction in patients with moyamoya disease after bypass surgery.Methods Clinical data of 42 patients with moyamoya disease who had cerebral infarction after bypass surgery were retrospectively analyzed and included in the incidence group.The clinical data of 42 patients with moyamoya disease without cerebral infarction after bypass surgery were also collected during the same period.The baseline data of patients were consulted and the data required for the study were recorded,and the possible influencing factors were included to analyze the influencing factors that might lead to cerebral infarction in patients with moyamoya disease after bypass surgery.Results There were no significant differences in age,sex,smoking history,drinking history,hyperlipidemia,family history,Suzuki stage,preoperative diastolic blood pressure,surgical method and bypass side between the occurrence group and the non-occurrence group（P>0.05）.The proportion of history of hypertension and diabetes in the occurrence group was higher than that in the non-occurrence group,and the preoperative systolic blood pressure in the occurrence group was higher than that in the non-occurrence group,with statistical significance（P<0.05）.Logistic regression analysis showed that history of hypertension,diabetes mellitus and high preoperative systolic blood pressure were risk factors for cerebral infarction in patients with moyamoya disease after bypass surgery（OR>1,P<0.05）.Conclusion The influential factors of cerebral infarction in patients with moyamoya disease after bypass surgery may be hypertension,diabetes mellitus and high preoperative systolic blood pressure. 2023 Vol. 43 (1): 11-13 [Abstract] ( 164 ) HTML (1 KB)  PDF (402 KB)  ( 130 ) 14 Relationship Between Quantitative Parameters of 18F- Fluorodeoxyglucose PET-CT and Pulmonary Function in Patients With Idiopathic Interstitial Pneumonia Zhao Jie, Liang Yan, Zhang Xiao DOI: 10.3969/j.issn.1001-8131.2023.01.005 Objective To explore the relationship between quantitative parameters of 18F- fluorodeoxyglucose（18F-FDG）PET-CT and pulmonary function of patients with idiopathic interstitial pneumonia（IIP）.Methods 25 patients with IIP diagnosed and treated in our hospital were retrospectively analyzed as the observation group,and 25 patients with normal lung function in the same period were selected as the control group.The general data such as gender,age and course of disease were compared between the two groups.The quantitative parameters of PET-CT in patients with different lung function levels were compared,and Pearson correlation analysis was used to analyze the relationship between the quantitative parameters of PET-CT and the severity of lung function.Results There was no significant difference in general data of sex,age,course of disease,body mass index（BMI）,smoking history and education level between the two groups（P>0.05）.The forced expiratory volume per second（FEV1%）decreases,the smaller PaO2 is,the higher the lung function grade（GOLD）is.The larger the maximum diameter of the lesion,the smaller the maximum standard uptake value（SUVmaxP<0.05）.Pearson correlation analysis showed that the maximum diameter of lesions was negatively correlated with PaO2 and FEV1%,positively correlated with GOLD（P<0.05）,and SUVmaxwas positively correlated with FEV1% and PaO2,negatively correlated with GOLD（P<0.05）.Conclusion The quantitative parameters of PET-CT,such as the maximum lesion diameter and SUVmax,are related to the lung function of IIP patients,and clinicians can evaluate the progress of the disease. 2023 Vol. 43 (1): 14-15 [Abstract] ( 134 ) HTML (1 KB)  PDF (441 KB)  ( 123 ) 16 Correlation Analysis Between Changes of Serum Levels of hs-CRP,EMPs and APN and QRS Score of ECG in STEMI Patients Li Junxia DOI: 10.3969/j.issn.1001-8131.2023.01.006 Objective To observe and explore the serum high sensitivity C-reactive protein in patients with ST-segment elevation myocardial infarction（STEMI）,Hs-CRP）,Endothelial microparticles,EMPs）and plasma adiponectin（APN）levels and their correlation with QRS score of electrocardiogram.Methods 100 patients with STEMI were studied.According to the number of blood vessels with diameter stenosis higher than 150%,the single vessel lesions were group A,double vessel lesions were group B and three vessel lesions were group C.The levels of serum hs-CRP,EMPs,APN and QRS score of electrocardiogram were compared among the three groups,and the correlation among these indexes was analyzed.Results The levels of serum hs-CRP,EMPs,APN and QRS score of electrocardiogram were the highest in group C,followed by group B and group A（P<0.05）.Pearson correlation factor analysis,The QRS score of ECG was positively correlated with the levels of serum hs-CRP,EMPs and APN（r=0.732,0.689 and 0.423,all P<0.05）.Conclusion The QRS score of ECG in STEMI patients is positively correlated with the levels of serum hs-CRP,EMPs and APN,which can fully evaluate the severity of coronary artery disease in STEMI patients. 2023 Vol. 43 (1): 16-18 [Abstract] ( 134 ) HTML (1 KB)  PDF (415 KB)  ( 132 ) 19 Application Value of DTI and T2WI Sequence in Patients With Multi-Segmental Cervical Spondylotic Myelopathy Wang Can DOI: 10.3969/j.issn.1001-8131.2023.01.007 Objective To explore the application value of diffusion tensor imaging（DTI）and T2WI sequence in patients with multilevel cervical spondylotic myelopathy（MCSM）.Methods 96 patients with MCSM who received anterior cervical decompression and fusion were selected.All patients underwent MRI before and 6 months after operation,and the DTI and T2WI sequence images were observed.The nerve root anisotropy score（FA）and apparent diffusion coefficient（ADC）were measured.The JOA scores of patients before and 6 months after operation were evaluated by cervical JOA scale.Pearson correlation analysis was used to analyze the correlation between FA,ADC values and JOA scores after operation.Results Among 96 patients,there were 11 cases with low signal on T1WI and high signal on T2WI before operation,and 3 cases with low signal on T1WI and high signal on T2WI after operation.Six months after the operation,JOA score and FA value of all patients were significantly higher than those before operation,and ADC value was significantly lower than that before operation（P<0.05）.There is a positive correlation between postoperative JOA score and FA value（P<0.05）,but there is no significant correlation between postoperative JOA score and ADC（P>0.05）.Conclusion DTI and T2WI sequence detection can reflect the pathological changes of patients' cervical vertebrae,and can play a role in evaluating postoperative recovery. 2023 Vol. 43 (1): 19-20 [Abstract] ( 98 ) HTML (1 KB)  PDF (284 KB)  ( 133 ) 21 Effect of Serum MMP-2 and IL-6 Levels on the Prognosis of Advanced Gastric Cancer Patients With Neoadjuvant Chemotherapy Zhao Yongchun, Liu Jinyun, Liu Xiaorui DOI: 10.3969/j.issn.1001-8131.2023.01.008 Objective To observe the expression of serum matrix metalloproteinase-2（MMP-2）and interleukin-6（IL-6）in patients with advanced gastric cancer（AGC）,and to analyze their effects on the prognosis of neoadjuvant chemotherapy.Methods A total of 70 patients with AGC were selected,and all patients received 3 courses of neoadjuvant chemotherapy.The effect of 3 courses of treatment was observed and recorded as a short-term prognosis indicator,and the patients were divided into a poor prognosis group and a good prognosis group.The baseline data and serum MMP-2 and IL-6 levels of both groups were investigated and compared,and the effects of serum MMP-2 and IL-6 levels on the prognosis of neoadjuvant chemotherapy were analyzed.Results After 3 courses of chemotherapy,33 of the 70 patients had poor prognosis,accounting for 47.14%.Compared with the good prognosis group,the serum MMP-2 and IL-6 levels were higher of patients in the poor prognosis group（P<0.05）.Logistic regression analysis showed that the overexpression of serum MMP-2 and IL-6 at admission was an influencing factor for the poor prognosis of AGC patients with neoadjuvant chemotherapy（OR>1,P<0.05）.Conclusion The overexpression of serum MMP-2 and IL-6 suggests that patients with AGC have a higher risk of poor prognosis after neoadjuvant chemotherapy. 2023 Vol. 43 (1): 21-23 [Abstract] ( 137 ) HTML (1 KB)  PDF (428 KB)  ( 158 ) 24 Observation of Curative Effect of Cataract Phacoemulsification and Intraocular Lens Implantation Under Topical Anesthesia in the Treatment of Complicated Cataract Peng Yan DOI: 10.3969/j.issn.1001-8131.2023.01.009 Objective To investigate the efficacy of phacoemulsification and intraocular lens implantation under topical anesthesia in the treatment of combined cataract.Methods A retrospective analysis of 240 patients（253 eyes）who underwent cataract phacoemulsification and intraocular lens implantation under topical anesthesia.Assess the patient's visual acuity recovery after surgery,The intraocular pressure,anterior chamber angle,anterior chamber depth transformation and astigmatism were compared before and after surgery,and the incidence of intraoperative and postoperative complications was calculated.Results 163 eyes had uncorrected visual acuity ≥0.5 on the first day after operation,accounting for 64.03%,211 eyes had uncorrected visual acuity ≥0.5 on the seventh day after operation,accounting for 83.39%,and 227 eyes had uncorrected visual acuity ≥0.5 one month after operation,accounting for 89.72% ;The mean intraocular pressure of the patients after operation was（18.71±2.80）mmHg,which was higher than that before operation（34.61±5.19）mmHg decreased significantly;compared with preoperative,the depth of the central anterior chamber of the patients was significantly increased,and the angle of the chamber was widened;the astigmatism of the patients at 1 and 3 months after surgery was significantly higher than that before surgery.Compared with preoperative,there were significant decreases;intraoperative complications accounted for 5.92% of iris prolapse,5.13% of posterior capsular rupture,postoperative complications were mainly corneal edema,accounting for 9.48%.Conclusion The clinical effect of cataract phacoemulsification and intraocular lens implantation for cataract patients under topical anesthesia is remarkable,which can not only effectively improve the patients'vision,reduce the patients' intraocular pressure and astigmatism,but also effectively reduce the occurrence of intraoperative and postoperative complications.It has high safety and is worthy of clinical promotion and application. 2023 Vol. 43 (1): 24-26 [Abstract] ( 151 ) HTML (1 KB)  PDF (423 KB)  ( 203 ) 27 Comparative Study on Visual Acuity Improvement and Safety of Phacoemulsification and Small Incision non Phacoemulsification in Clinical Treatment of Cataract Geng Yujun DOI: 10.3969/j.issn.1001-8131.2023.01.010 2023 Vol. 43 (1): 27-29 [Abstract] ( 148 ) HTML (1 KB)  PDF (574 KB)  ( 151 ) 30 Clinical Efficacy of Modified Radical Mastectomy Combined With Autologous Skin Grafting in the Treatment of Breast Cancer and the Influence of Early Postoperative Prognosis Gao Siming, Liu Kuan, Li Bin DOI: 10.3969/j.issn.1001-8131.2023.01.011 Objective To analyze the clinical effect of autologous skin grafting combined with modified radical mastectomy on patients with breast cancer and its influence on early postoperative prognosis.Methods 94 patients with breast cancer were randomly divided into observation group（n=47）and control group（n=47）.The control group was treated with modified radical operation,Group A was treated with autologous skin grafting,and the operation indexes,skin flap necrosis,incidence of complications and recurrence rate within one year were compared between the two groups.Results Compared with the control group,the operation time of the observation group was significantly longer,the amount of blood loss during operation was significantly more,but the hospitalization time was significantly shorter（P<0.05）,and the difference of postoperative drainage time between the two groups was less（P>0.05）.The total incidence of skin flap necrosis,complications and recurrence rate in observation group were significantly lower than those in control group（P<0.05）.Conclusion The combined application of modified radical mastectomy and autologous skin grafting in the treatment of breast cancer patients can significantly shorten the hospitalization time,and at the same time reduce the probability and recurrence rate of postoperative complications,but it will take longer operation time and increase the amount of bleeding during operation.It is suggested that clinical application should be reasonable according to the actual situation. 2023 Vol. 43 (1): 30-32 [Abstract] ( 112 ) HTML (1 KB)  PDF (430 KB)  ( 119 ) 33 Immune Function and Growth Characteristics of Hp Positive Preschool Children Guo Ailing DOI: 10.3969/j.issn.1001-8131.2023.01.012 Objective To explore the immune function and growth characteristics of preschool Hp positive children.Methods 100 children infected with HP in our hospital were selected as the observation group,and 100 healthy children who received physical examination in our hospital in the same period were selected as the control group.HP antibody,T cell subsets,serum inflammatory factors and growth and development were detected in both groups of children,and the detection results were compared.All the children in observation group were given anti-infection treatment after diagnosis,and they were followed up by telephone for one year and two years.The survey contents were mainly the same as those before treatment.Results The levels of IgA,IgM and IgG in the observation group were significantly higher than those in the control group（P<0.05）;Compared with the control group,the level of CD8+in the observation group is higher,while the levels of CD4+and CD3+are lower,and the levels of IL-2 and TNF-α in the observation group are lower than those in the control group（P<0.05）.Compared with the control group,the height,body weight,chest circumference,iron,zinc,ALB and HB levels in the observation group were lower than those in the control group（P<0.05）.Compared with one year after treatment,The height,body weight,chest circumference,iron,zinc,ALB and HB levels of children in observation group were significantly higher after 2 years of treatment,and the growth and development indexes of children showed an increasing trend（P<0.05）.Conclusion HP infection will adversely affect the immune function level of preschool children's growth and development,so attention should be paid to HP infection in preschool children clinically. 2023 Vol. 43 (1): 33-35 [Abstract] ( 120 ) HTML (1 KB)  PDF (425 KB)  ( 136 ) 36 Relationship Between Serum VEGF and Hcy Expression and Macrosomia in Gestational Diabetes Mellitus Ding Yarui DOI: 10.3969/j.issn.1001-8131.2023.01.013 Objective To observe the expression of serum vascular endothelial growth factor（VEGF）and homocysteine（Hcy）in gestational diabetes mellitus（GDM）and analyze the relationship between the two and macrosomia.Methods 110 GDM patients who underwent regular prenatal examination and completed delivery were selected as the research objects.The birth weight of newborns was measured as the judgment standard of macrosomia and divided into two groups.They were divided into occurrence group and non occurrence group.The levels of serum VEGF and Hcy were measured one week before delivery.The baseline data of the two groups were investigated and recorded,and the serum VEGF and Hcy were analyzed Relationship between Hcy expression and macrosomia in patients with GDM.Results Among all 110 patients,23 had macrosomia,accounting for 20.91%;The levels of serum VEGF and Hcy in the occurrence group were significantly higher than those in the non occurrence group one week before delivery（P<0.05）;Logistic regression analysis showed that the overexpression of serum VEGF and Hcy was related to the occurrence of macrosomia in patients with GDM（or > 1,P<0.05）.Conclusion The overexpression of serum VEGF and Hcy is related to the occurrence of macrosomia in patients with GDM. 2023 Vol. 43 (1): 36-37 [Abstract] ( 129 ) HTML (1 KB)  PDF (451 KB)  ( 140 ) 38 Analysis of Efficacy and Side Effects of Captopril Combined With Alprostadil in the Treatment of Diabetic Nephropathy Gong Hui DOI: 10.3969/j.issn.1001-8131.2023.01.014 2023 Vol. 43 (1): 38-40 [Abstract] ( 109 ) HTML (1 KB)  PDF (418 KB)  ( 139 ) 41 Effect of Intraoperative Body Position on Surgical Effect in The Treatment of Upper Ureteral Calculi With Holmium Laser Under Ureteroscope Wang, Xuefeng DOI: 10.3969/j.issn.1001-8131.2023.01.015 2023 Vol. 43 (1): 41-42 [Abstract] ( 110 ) HTML (1 KB)  PDF (305 KB)  ( 127 ) 43 Study on the Status Quo of Neural Development and Early Intervention of Very Low Birth Weight Premature Infants at 1 Year Old When Catching Up With Growth Zeng Yan DOI: 10.3969/j.issn.1001-8131.2023.01.016 Objective To study the status quo of nerve development and early intervention of very low birth weight premature infants at the age of 1 year.Methods 120 premature infants with very low birth weight who were hospitalized in our hospital were selected as the research object.The follow-up time was 7-10 days after discharge and once every 40 weeks after correction of gestational age,once every month after correction of gestational age of 1-12 months,and the physical development of premature infants was evaluated.The Mental developmental index,MDI）,mental motor developmental index（PDI）and neurological developmental impairment（NDI）of premature infants were observed by infant intelligence development.The status quo of Gesell nerve development and the incidence of neurological sequelae were counted.Results After the intervention,the incidence of NDI was 1.67% at 12 months after correction,which was lower than 7.50% at 6 months（P<0.05）.The scores of PDI and MDI were higher than those of 6 months after correction（P<0.05）.After the intervention,the scores of each index of Gesell's nerve development status of premature infants with corrected age of 12 months were higher than those of 6 months（P<0.05）.The incidence of neurological sequelae was 3.33% at 12 months after correction,which was lower than 13.32% at 6 months（P<0.05）.Conclusion Early intervention measures for low birth weight premature infants can promote the status quo of neurological development and behavioral development during their 1-year-old catch-up growth period,reduce neurological sequelae,improve their prognosis,actively take intervention measures,and strengthen nutrition guidance to promote the healthy development of children. 2023 Vol. 43 (1): 43-45 [Abstract] ( 124 ) HTML (1 KB)  PDF (429 KB)  ( 189 ) 46 Effect of Pizotifen Tablet Combined With Yuntongding Capsule on Serum Inflammatory Factors and Vasoactive Substances in Migraine Patients Zhang Zhi, Yang Qingsong, Man Chunlu, Li Keke DOI: 10.3969/j.issn.1001-8131.2023.01.017 Objective To explore the influence of pizotifen combined with Yuntong Capsule on serum inflammatory factors and vascular substances in patients with low migraine.Methods 82 patients with migraine were selected as the research objects,and were randomly divided into two groups and given different treatment schemes.The patients treated with pizotifen tablets were taken as the control group.Pizotifen tablets combined with Yuntongding capsules were used as the study group.After 6 weeks of treatment,the therapeutic effects of the two groups were compared,and the changes of serum inflammatory factors and vasoactive substances in the two groups before and after treatment were compared.Results The treatment effect of the study group was significantly better than that of the control group（P<0.05）.Serumhs-CRP,il-6,il-1β,Hcy,et-1 and B2（TXB2 in the study group were lower than those in the control group（P<0.05）.The levels of 5- hydroxytryptamine（5-HT）,nitric oxide（NO）and dopamine（DA）were higher than those of the control（P<0.05）.Conclusion Pizotifen tablet combined with Yuntongding capsule can improve the therapeutic effect of migraine patients,Improve the level of inflammation and vasoactive substances. 2023 Vol. 43 (1): 46-47 [Abstract] ( 184 ) HTML (1 KB)  PDF (260 KB)  ( 132 ) 48 High-Risk Factors of Focal White Matter Injury in Late Preterm Infants and Their Influence on the Development of Nervous System Wang Yage DOI: 10.3969/j.issn.1001-8131.2023.01.018 Objective To analyze the high-risk factors of premature infants with focal white matter damage（PWMD）and its influence on the development of nervous system.Methods 86 premature infants were selected for retrospective study,43 premature infants with PWMD as the observation group and 43 premature infants with normal MBI as the control group.The gestational age,birth weight,clinical data and other factors of premature infants in PWMD were analyzed,the disease degree of premature infants in PWMD was observed,the high-risk influencing factors of PWMD were discussed,and the nerve development status of the two groups was compared,including mental development index,MDI）and periodontal disease index,PDI）.Results By Logistic regression analysis,The results showed that maternal infection during pregnancy,the choice of cesarean section and the history of fetal asphyxia were independent influencing factors of PWMD（P<0.05）.The nerve development of observation group is better than that of control group,and its MDI and PDI scores are lower than that of control group,with significant difference（P<0.05）.Conclusion There are many influencing factors of PWMD in premature infants,among which the high-risk factors are pregnancy infection,asphyxia history,cesarean section,However,gestational age and birth weight both affect the occurrence of PWMD disease and the development of children's nervous system,which needs attention. 2023 Vol. 43 (1): 48-50 [Abstract] ( 186 ) HTML (1 KB)  PDF (444 KB)  ( 151 ) 51 Correlation Between Vitamin D Deficiency and Asthmatic Bronchitis Dai Jiazhe, Yang Dongfu, Chen Zhensong DOI: 10.3969/j.issn.1001-8131.2023.01.019 Objective To explore the correlation between asthmatic bronchitis and vitamin D deficiency.Methods 50 children with asthmatic bronchitis were selected as the study group.According to the treatment scheme,they were divided into study group 1 and study group 2,with 25 cases in each group.50 healthy children who came to our hospital for physical examination in the same period were selected as the control group.Study group 1 was treated with routine treatment,and study group 2 was treated with vitamin D supplementation on the basis of group 1.The levels of vitamin D,IgE and IL-6 in the three groups were compared,and the therapeutic effects of the study group were analyzed and compared.Results Vitamin D in the study group was lower than that in the control group（P<0.05）;Compared with the control group,IgE and IL-6 water in the study group were higher on average（P<0.05）;The recurrence times of wheezing,the remission time of wheezing and cough and the disappearance time of pulmonary signs in study group 2 were less than those in study group 1（P<0.05）.Conclusion The incidence of asthmatic bronchitis is closely related to vitamin D deficiency,and may lead to the increase of IgE and IL-6 levels.Taking reasonable vitamin D supplementation can accelerate the remission of symptoms and reduce the recurrence rate of asthmatic bronchitis,which is worthy of popularization and application. 2023 Vol. 43 (1): 51-52 [Abstract] ( 137 ) HTML (1 KB)  PDF (433 KB)  ( 144 ) 53 Efficacy of Sodium Valproate in the Treatment of Epilepsy Children of Different Ages and Monitoring Analysis of Its Blood Concentration Liu Ruiting, Cui Nana DOI: 10.3969/j.issn.1001-8131.2023.01.020 Objective To explore the curative effect of sodium valproate on children with epilepsy of different ages and the monitoring effect of plasma drug concentration.Methods 90 children with epilepsy were selected as subjects.All children were treated with sodium valproate,and the plasma concentration of sodium valproate was monitored to analyze the distribution of the plasma concentration of sodium valproate in children of different ages.And evaluate the therapeutic effect of children with different plasma concentrations of sodium valproate.Results The results showed that the blood concentration of sodium valproate in children less than 3 years old was significantly higher than that in other two groups（P<0.05）.The blood concentration of sodium valproate（50-100μg/mL）in children aged 3-5 years and 6-12 years was significantly higher than that in children aged less than 3 years（P<0.05）.The poisoning rate of blood drug concentration > 100μg/mL was higher than that of the other two groups（P<0.05）,and the total effective rate of blood drug concentration<50μg/mL was significantly lower than that of the other two groups（P<0.05）.Conclusion There are obvious differences in serum concentration levels of epileptic children of different ages after receiving sodium valproate treatment,and there are also great differences in therapeutic effects for children with different serum concentration of sodium valproate.Therefore,it is necessary to adjust the medication regimen according to the specific situation of children and monitor the blood drug concentration in time to improve the therapeutic effect of sodium valproate. 2023 Vol. 43 (1): 53-55 [Abstract] ( 150 ) HTML (1 KB)  PDF (412 KB)  ( 147 ) 56 Effect of Aspirin Combined with Dydrogesterone on Endometrial Receptivity and Insulin Resistance in Obese Patients with PCOS Wei Chunhua, Li Haiyan, Zhu Shuping DOI: 10.3969/j.issn.1001-8131.2023.01.021 Objective To observe the effects of aspirin combined with dydrogesterone on endometrial receptivity（ER）and insulin resistance（IR）in patients with obesity polyovary syndrome（PCOS）.Methods 110 cases of obese PCOS patients treated in our hospital were selected as the research objects,and they were divided into experimental group and control group with 55 cases each according to the random number table method.The control group was treated with dydrogesterone,and the experimental group was treated with aspirin in the control group.Before and after one cycle of treatment,observe the levels of sex hormones [testosterone（T）,luteinizing hormone（LH）,follicle stimulating hormone（FSH）],ER ultrasound examination indicators [Endometrial thickness,uterine artery blood flow pulsation index（PI）,resistance index（RI）] and insulin index [insulin resistance index（HOMA-IRI）,insulin secretion function index（HOMA-β）] of the two groups.The total incidence of adverse drug reactions in the two groups during the course of treatment and the difference in the pregnancy rates of the two groups within six months after treatment were analyzed.Results After one cycle of treatment,the levels of sex hormones（T,LH,FSH）,ER ultrasound examination indicators（PI,RI）,and insulin indicators（HOMA-IRI,HOMA-β）in the two groups were significantly lower than before treatment.And the experimental group was significantly lower than the control group at the same time（both P<0.05）.The endometrial thickness of the two groups was significantly higher than before treatment,and the experimental group was significantly higher than the control group at the same time（both P<0.05）.During the course of treatment,there was no significant difference in the overall incidence of adverse drug reactions between the two groups of patients（P>0.05）.Within six months after treatment,the pregnancy rate in the experimental group was significantly higher than that in the control group at the same time（P<0.05）.Conclusions Aspirin combined with dydrogesterone can achieve good results in the treatment of obese PCOS patients.Sex hormone levels tend to decrease,ER will increase,and insulin secretion will decrease.It can increase the pregnancy rate of patients,and the drug is safe,which is worthy of clinical popularization. 2023 Vol. 43 (1): 56-58 [Abstract] ( 216 ) HTML (1 KB)  PDF (399 KB)  ( 181 ) 109 Analysis of the Clinical Efficacy and Safety of Chinese Herbal Decoction Pieces Combined With Granules in the Treatment of Essential Hypertension Based on Chinese Herbal Formulas Guo Weiwei, Yang Li, Yao Gang DOI: 10.3969/j.issn.1001-8131.2023.01.044 Objective To explore the clinical efficacy and safety of Chinese herbal decoction pieces combined with granules in the treatment of essential hypertension based on Chinese herbal formulas.Methods In this study,subjects with essential hypertension were selected and randomly divided into two groups,each with an equal number of 66 cases.The control group was given Chinese medicine decoction pieces,and the observation group was given Chinese medicine granules combined treatment.The efficacy of the two groups of patients was compared;the scores of TCM symptoms,blood pressure and adverse reactions during the treatment of the two groups were recorded;the compliance of the two groups of patients before and after the treatment was observed;the two groups of patients were followed up for one year,and the two groups of patients had adverse events The cumulative incidence was recorded.Results After treatment,by comparing the two groups of TCM symptom scores,it was found that the scores of the two groups were reduced,and the scores of the observation group were lower than those of the control group,but the difference between the two was not significant（P>0.05）;After treatment,both the medication compliance and the total effective rate of the two groups of patients were significantly increased,and the compliance and effective rate of the observation group were significantly better than those of the control group（P<0.05）;Comparing the blood pressure of the two groups,it was found that both systolic and diastolic blood pressures decreased in the two groups,and the decrease in the observation group was more significant（P<0.05）;One-year follow-up found that 5 cases（7.58%）in the observation group had adverse events;13 cases（19.70%）in the control group had adverse events,the difference was statistically significant（P<0.05）.Conclusion For patients with essential hypertension,the clinical efficacy of the treatment of Chinese herbal medicine and the combination of Chinese medicine granules is equivalent,but the blood pressure improvement effect of the combined granules treatment is more significant.In addition,it can improve compliance and has a higher clinical application value. 2023 Vol. 43 (1): 109-112 [Abstract] ( 202 ) HTML (1 KB)  PDF (511 KB)  ( 176 ) 113 Influence of Pharmaceutical Care Led by Clinical Pharmacists on Rationality of Chinese Patent Medicines for Promoting Blood Circulation and Removing Blood Stasis Liu Jun, Yuan Yuzhe, Zhang Jigui DOI: 10.3969/j.issn.1001-8131.2023.01.045 Objective To explore the influence of clinical pharmacist led pharmaceutical care on the rationality of the use of Chinese patent medicines for promoting blood circulation and removing blood stasis.Methods 480 patients treated with Chinese patent medicine for promoting blood circulation and removing blood stasis were selected as the research objects,and they were randomly divided into observation group and control group with 240 cases in each group.The observation group was given pharmaceutical care led by clinical pharmacists,while the control group was given routine pharmaceutical care.Before and after the intervention,the rational drug use,drug understanding,drug compliance and satisfaction of the two groups were compared.Results the rate of irrational drug use in the observation group was 28.33%,which was significantly lower than that in the control group（45.42%）（P<0.05）;Before the intervention led by clinical pharmacists,There was no significant difference in drug understanding and drug compliance between the two groups（P>0.05）.After the intervention,the drug understanding and drug compliance of the two groups were higher than those before the intervention,and the wide intervention was significantly higher than that of the control group（P<0.05）;After the intervention led by clinical pharmacists,the total satisfaction of the observation group was 93.33%,which was significantly higher than that of the control group（82.50%）（P<0.05）;After clinical pharmacist led intervention,the incidence of adverse reactions in the observation group（12.08%）was significantly lower than that in the control group（19.17%）（P<0.05）.Conclusion Chinese medicine can improve the rationality of Chinese medicine. 2023 Vol. 43 (1): 113-115 [Abstract] ( 154 ) HTML (1 KB)  PDF (393 KB)  ( 108 ) 116 Application of Bushen Huayu Decoction Combined With Traditional Chinese Medicine Fumigation in Elderly Patients With Kidney Deficiency and Blood Stasis Syndrome After Hip Fracture Surgery Gao Lei DOI: 10.3969/j.issn.1001-8131.2023.01.046 Objective To explore the application value of Bushen Huayu Decoction Combined with traditional Chinese medicine fumigation in elderly patients with kidney deficiency and blood stasis syndrome after hip fracture surgery.Methods 84 patients with hip fractures treated surgically were selected as the research object,According to the outpatient number,single and double numbers were divided into control group（single number）and observation group（double number）,with 42 cases in each group;the control group was treated with Bushen Huayu decoction after operation,and the observation group was treated with traditional Chinese medicine fumigation on the basis of the control group for 2 months.The TCM syndrome scores of the two groups before and 2 months after treatment were compared,and the postoperative recovery of the two groups were recorded（swelling elimination time of affected limb,fracture healing time and complete weight-bearing time）;hip function [assessed by Harris hip function score（Harris score）] and activities of daily living [assessed by modified Barthel Index（MBI）] were compared between the two groups before and 2 months after treatment.Results After 2 months of treatment,the total score of TCM syndromes in the two groups was lower than that before treatment,and the observation group was lower than that in the control group（P<0.05）;the swelling elimination time,fracture healing time and complete weight-bearing time of the affected limb in the observation group were shorter than those in the control group,and the difference was statistically significant（P<0.05）;after 2 months of treatment,the Harris score of the two groups was higher than that before treatment,and that of the observation group was higher than that of the control group（P<0.05）;after 2 months of treatment,the MBI score of the two groups was higher than that before treatment,and that of the observation group was higher than that of the control group.Conclusion The application of Bushen Huayu Decoction Combined with traditional Chinese medicine fumigation in elderly patients with kidney deficiency and blood stasis syndrome after hip fracture operation can reduce the score of traditional Chinese medicine syndrome,promote postoperative recovery,improve hip joint function and improve the ability of daily living. 2023 Vol. 43 (1): 116-118 [Abstract] ( 153 ) HTML (1 KB)  PDF (408 KB)  ( 138 ) 128 Research Progress of Mesenchymal Stem Cells in Scar Formation and Therapeutic Applications Fan Yongmei, Lv Kaiyang, Zeng Yueqin, Liu Wenjun DOI: 10.3969/j.issn.1001-8131.2023.01.051 Cicatrix is a series of damage and repair reactions in the damaged part after the body's skin tissue is subjected to trauma or burns and other adverse stresses，and finally ends in connective tissue repair，forming a tissue form that is not exactly the same as normal skin structure and function.Mesenchymal stem cells（MSCs）can secrete various growth factors，promote cell regeneration and repair，and can promote angiogenesis in cicatrix tissues and reduce local inflammation；degrade abnormally accumulated collagen and reshape cicatrix tissue；it has a two-way regulatory effect on the immune function of local tissues.Therefore，the application of MSCs in the prevention and treatment of cicatrix has broad application prospects.This article reviews the literature published in recent years，and reviews the research directions and clinical applications of MSCs on cicatrix tissue treatment mechanisms such as regeneration and healing，anti-inflammatory effects，anti-fibrosis effects，and immune regulation. 2023 Vol. 43 (1): 128-131 [Abstract] ( 156 ) HTML (1 KB)  PDF (471 KB)  ( 138 )

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