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2023 Vol. 43, No. 2 Published: 2023-04-25

	1	Bioinformatics-based Analysis of The Role of miR-152 in The Pathogenesis of Pre-eclampsia
		Yang Qianwen, Tao Feng, Chen Hongbo
		DOI: 10.3969/j.issn.1001-8131.2023.02.001
		Objective To analyze the differentially expressed miRNAs associated with preeclampsia,select miR-152 predicted target genes and perform bioinformatics analysis to explore the molecular mechanisms involved in the pathogenesis of preeclampsia. Methods The most significantly upregulated miR-152 in the dataset GSE103542 was selected as the study target,and its target genes were predicted and taken for intersection.GO functional annotation and KEGG pathway enrichment analysis of the intersecting target genes were performed using the DAVID network online enrichment tool,and the STRING website was used to analyze their protein interactions. Results The 418 intersecting target genes obtained are mainly involved in biological processes such as bioadhesion,cell adhesion and cell developmental regulation;in cell composition,they are mainly involved in plasma membrane components,lattice protein vesicles;in molecular functions,they are mainly involved in calcium binding,ion binding.KEGG signaling pathway enrichment analysis showed that it was mainly involved in signaling pathways regulating stem cell pluripotency and TGF signaling pathway.Protein interaction analysis showed that IGF1R,SMAD3,RPS6KB1 and PPP2CA were the key nodes of the protein interaction network. Conclusion miR-152 may affect trophoblast proliferation,invasion and apoptosis through the TGF signaling pathway in multiple ways in the development of pre-eclampsia.
		2023 Vol. 43 (2): 1-4 [Abstract] ( 164 ) HTML (1 KB) PDF (468 KB) ( 151 )

	5	Efficacy of Doxthelline Combined with Methyl Johnson in COPD Patients with Acute Exacerbation and Its Effect on Serum Inflammatory Factor Levels
		Zhao Li
		DOI: 10.3969/j.issn.1001-8131.2023.02.002
		Objective To analyze the value of chronic obstructive pulmonary disease patients with acute exacerbation and the serum inflammatory factor level and clinical efficacy as the goal of the combined treatment of doxophylline and mJ. Methods 74 Patients were divided into two groups according to the random table method 1：1.The control group（n=37）was treated with polytheophylline,and the observation group（n=37）was treated with polytheophylline,with therapeutic efficacy,serum inflammatory factor and lung function,and the effects of different drug treatment were analyzed. Results After treatment as the judgment time,the clinical efficacy analysis,the control group was lower than the observation group,i.e.83.78% <97.30%（P<0.05）.Before treatment as the determination time,the difference between pulmonary function index and inflammatory factor level was small（P>0.05）;after treatment as the determination time,and the observation group was better than the control group（P<0.05）. Conclusion The clinical treatment effect of doxophylline combined with methylJohnson in patients with acute exacerbations is relatively significant,which is conducive to the decline of the level of inflammatory factors,the improvement of pulmonary respiratory function,and the high clinical application value.
		2023 Vol. 43 (2): 5-7 [Abstract] ( 169 ) HTML (1 KB) PDF (458 KB) ( 123 )

	8	Effect of Two Blood Purification Methods on CRP,IL-6,TNF-and Hemodynamics in Uremic Patients With MODS
		Huo Aijing
		DOI: 10.3969/j.issn.1001-8131.2023.02.003
		Objective To investigate the effects of different blood purification methods on inflammatory factors and hemodynamics in patients with MODS. Methods 82 patients with MODS were divided into two groups according to the random number table method.41 patients in the observation group were treated with hemodialysis combined with hemoperfusion（HD + HP）,and 41 patients in the control group were treated with hemodialysis（HD）.Toxin clearance,tumor necrosis factor-（TNF-）,interleukin-6（IL-6）,interleukin-1（IL-1）and C reactive protein（CRP）,carotid blood flow and peripheral resistance,and were analyzed. Results After the treatment of the patients in both groups,The serum contents of creatinine,blood urea nitrogen,parTH and 2-microglobin were significantly lower than before treatment（P<0.05）,And the observation group was compared with the control group,The content of the above index decreased more significantly（P<0.05）,Higher clearance rate of toxins;No comparison of serum TNF-,IL-6,IL-1,CRP and hemodynamic index levels（P>0.05）,post-treatment,TNF-,IL-6,IL-1,and CRP were significantly decreased in both groups（P<0.05）,However,the observation group decreased more significantly than the control group（P<0.05）,And through the treatment,The blood flow velocity in the observation group,The blood flow was all significantly greater than that of the control group,Peripheral resistance was significantly smaller than that in the control group（P<0.05）. Conclusion HD + HP treatment for uremia with MODS is better than HD treatment,which can effectively slow down the inflammatory response and has some positive significance for the patient hemodynamics.
		2023 Vol. 43 (2): 8-10 [Abstract] ( 144 ) HTML (1 KB) PDF (425 KB) ( 117 )

	11	Study on Serum FGF-23 and ADP Levels in Predicting Premature Delivery in Patients with Gestational Diabetes Mellitus
		Yang Yaqi
		DOI: 10.3969/j.issn.1001-8131.2023.02.004
		Objective To analyze the value of serum fibroblast growth factor-23（FGF-23）and adiponectin（ADP）levels in predicting premature delivery in patients with gestational diabetes mellitus. Methods 70 patients with gestational diabetes mellitus in our hospital were prospectively selected as the research objects.They were followed up to delivery,and the incidence of premature birth was counted.A general information questionnaire was designed to inquire and record the general information of the patients and the laboratory indexes [serum triglyceride（TG）,total cholesterol（TC）,total cholesterol（TC）] at the time of diagnosis of gestational diabetes mellitus Fasting blood glucose（FPG）,FGF-23,ADP],to analyze the value of serum FGF-23,ADP levels in predicting premature delivery in patients with gestational diabetes mellitus. Results There were 17 cases of premature delivery and 53 cases of no premature delivery in 70 cases of gestational diabetes mellitus;The level of serum FGF-23 in the occurrence group was higher than that in the non occurrence group,and the level of serum ADP was lower than that in the non occurrence group（P<0.05）;Multivariate logistic regression analysis showed that high serum FGF-23 level and low ADP level were associated with premature delivery in patients with gestational diabetes mellitus（P<0.05）;The receiver operating characteristic curve（ROC）was drawn.The results showed that the area under the curve（AUC）of serum FGF-23,ADP levels and combined detection in predicting premature delivery in patients with gestational diabetes mellitus was more than 0.7,and the value of combined diagnosis was the best. Conclusion The serum levels of FGF-23 and ADP have higher value in predicting premature delivery in patients with gestational diabetes mellitus.
		2023 Vol. 43 (2): 11-13 [Abstract] ( 118 ) HTML (1 KB) PDF (442 KB) ( 103 )

	14	Effect of Prednisone Acetate Combined with Azathioprine on Serum Chemokine Levels in Patients with Autoimmune Hepatitis
		Wang Wei, Zhai Xuemin, Liu Pengfei
		DOI: 10.3969/j.issn.1001-8131.2023.02.005
		Objective To investigate the effect of prednisone acetate combined with azathioprine on serum chemokine levels in patients with autoimmune hepatitis（AIH）. Methods 86 AIH patients diagnosed were selected and divided into observation group：control group（cases）=43：43 by random parity number.The control group was treated with prednisone acetate alone,The observation group was treated with azathioprine combined with the control group for 6 months.Before and after treatment,the serum levels of CCR6,CCL20,CXCL10,GGT and lgg4 in the two groups were observed.The incidence of adverse reactions in the two groups was recorded. Results the serum levels of CCR6,CCL20 and CXCL10 in the observation group were significantly lower than those in the control group（P<0.05）.The serum GGT and lgg4 levels in the observation group were significantly lower than those in the control group（P<0.05）.The incidence of adverse reactions in the observation group was 48.84%,It was significantly lower than 72.09% of the control group（χ²=4.864,P=0.027）. Conclusion prednisone acetate combined with azathioprine in the treatment of autoimmune hepatitis can reduce the level of serum chemokines,improve liver function,improve the clinical efficacy and reduce the incidence of adverse reactions.
		2023 Vol. 43 (2): 14-15 [Abstract] ( 140 ) HTML (1 KB) PDF (472 KB) ( 98 )

	16	The Value of Ultrasound-guided Fogarty Thrombectomy Balloon Block of Internal Iliac artery for Cesarean Section of Placenta Previa
		Guo Yanna
		DOI: 10.3969/j.issn.1001-8131.2023.02.006
		To investigate the value of ultrasound-guided Fogarty balloon occlusion of the internal iliac artery for placenta previa cesarean section. Methods 62 patients with placenta previa undergoing cesarean section was selected divided into observation group and 31 control group.The observation group performed ultrasound-guided Fogarty thrombolysis balloon block in the internal iliac artery,and the control group performed conventional PTA ordinary dilated balloon block to compare the differences in intraoperative and postoperative indicators between the two groups. Results During cesarean section,the intraoperative transfusion rate（41.94%）,blood transfusion and operation time were lower than the control group（P 0.05）.The postoperative hysterectomy rate and adverse outcome rate in the observed group were lower than that in the control group.
		2023 Vol. 43 (2): 16-18 [Abstract] ( 157 ) HTML (1 KB) PDF (445 KB) ( 127 )

	19	Effect of early micro-feeding support therapy on intestinal function and growth of very low birth weight infants
		Chang Yuling
		DOI: 10.3969/j.issn.1001-8131.2023.02.007
		Objective To explore the effect of early micro-feeding support therapy on intestinal function and growth of very low birth weight infants. Methods 96 cases of very low birth weight newborns were randomly divided into treatment group and routine group,with 48 cases in each group.Among them,the newborns in the treatment group were given early micro-feeding,while those in the routine group were given routine feeding.The intestinal function [gastrointestinal motility（red stool discharge time）,complete meconium discharge time and abdominal distension relief time] of the two groups were compared.The levels of intestinal flora（lactobacillus,bifidobacteria）and GAStrointestinal hormones [gastrin（gas）,motilin（MTL）] were compared between the two groups before and after 7 days of treatment.The growth and development of newborns（recovery time of birth weight,growth rate of head circumference and growth rate of body length）were compared between the two groups. Results The time of complete discharge of red feces and meconium,the time of relieving abdominal distension and recovering birth weight in the treatment group were shorter than those in the routine group,and the difference was statistically significant（P<0.05）.The levels of Lactobacillus,Bifidobacterium and gastrointestinal hormone in the two groups of very low birth weight infants after 7 days of treatment were all higher than those before treatment,and the difference was statistically significant（P<0.05）,and the treatment group was higher than the routine group at the same time,and the difference was statistically significant（P<0.05）.The growth rate of head circumference and body length in treatment group was faster than that in routine group,and the difference was statistically significant（P<0.05）.Conclusion Early micro-feeding support therapy can promote the secretion of gastrointestinal hormones,regulate the balance of intestinal flora,improve the intestinal function and promote the growth and development of children.
		2023 Vol. 43 (2): 19-21 [Abstract] ( 89 ) HTML (1 KB) PDF (425 KB) ( 119 )

	22	Clinical Value of Free Fetal DNA in Peripheral Blood For the Diagnosis of Chromosome Aneuploidy
		Liu Yang, Seng Xueyan, Liu Yi
		DOI: 10.3969/j.issn.1001-8131.2023.02.008
		Objective To analyze the clinical value of free fetal DNA（cffDNA）in peripheral blood for the diagnosis of chromosome aneuploidy. Methods 4525 pregnant women who were tested cff-DNA were selected.All 4525 pregnant women were tested for cff-DNA in peripheral blood.The low-risk pregnant women were followed up to 3 months after the birth of their newborns.,and the high-risk pregnant women were subjected to puncture sampling,for chromosome karyotype analysis and diagnosis.The detection results of cff-DNA in peripheral blood and the results of interventional prenatal diagnosis of chromosomal aneuploidy were analyzed,the sensitivity specificity and accuracy of cff-DNA in peripheral blood for the diagnosis of chromosomal aneuploidy were calculated,and the consistency between CFF DNA in peripheral blood for the diagnosis of chromosomal aneuploidy and interventional prenatal diagnosis was calculated. Results 60 cases of chromosome aneuploidy were found among 4525 pregnant women tested by cff-DNA in peripheral blood,including 4 cases of sex chromosome abnormality,5 cases of 13-trisomy abnormality,11 cases of 18-trisomy abnormality and 40 cases of 21-trisomy abnormality;60 pregnant women with chromosomal aneuploidy detected by cff-DNA in peripheral blood were detected by amniotic fluid puncture analysis,and 58 cases of chromosomal aneuploidy were confirmed;The pregnant women without chromosome abnormality detected by cff-DNA in peripheral blood were followed up until 3 months after the birth of their newborn,and no children with chromosomal abnormalities were found;Taking the results of interventional prenatal diagnosis as the gold standard,the diagnostic sensitivity of cff-DNA in the peripheral blood was 100.00%（58/58）,the specificity was 99.96%（4465/4467）,and the accuracy was 99.96%（4523/4525）;The results of cff-DNA diagnosis of chromosomal aneuploidy in peripheral blood and interventional prenatal diagnosis have excellent consistency（Kappa value=0.983,P value=0.000）. Conclusion The cff-DNA in peripheral blood belongs to non-invasive prenatal screening technology,which has a high accuracy in the diagnosis of chromosome aneuploidy and is conducive to the detection of chromosome aneuploidy.It can provide important guidance for prenatal intervention of birth defects and has an important impact on promoting eugenics birth.
		2023 Vol. 43 (2): 22-24 [Abstract] ( 68 ) HTML (1 KB) PDF (393 KB) ( 111 )

	25	Compare the Effect of Percutaneous Transhepatic Gallbladder Drainage and Percutaneous Transperitoneal Gallbladder Drainage Guided by B-ultrasound on Subsequent Laparoscopic Cholecystectomy（LC）
		Wang Jinqiang
		DOI: 10.3969/j.issn.1001-8131.2023.02.009
		Objective Compare the effect of ultrasound-guided percutaneous cholecystostomy（PC）related to catheter placement path on subsequent laparoscopic cholecystectomy（LC）. Methods A total of 140 patients with acute calculous cholecystitis who received scheduled LC after PCwere selected and divided into observation group and control group according to the double-blind method.The observation group was patients who received a predetermined LC after percutaneous transhepatic gallbladder drainage（PHGD）,and the control group was a patient who received predetermined LC after percutaneous transperitoneal gallbladder drainage（PPGD）. Results All 140 patients underwent puncture and drainage and were followed up.The pain score during puncture,pain score 12h after puncture,fever,chills and local hemorrhage at the PC site in the observation group were better than those of the control group within 24 hours after puncture,and the differences were statistically significant.（P<0.05）.All 140 patients underwent laparoscopic cholecystostomy and were followed up.Among them,the observation group had 36 cases of mild postoperative adhesions and 34 had severe postoperative adhesions;the control group had 48 cases of mild postoperative adhesions and 22 had severe postoperative adhesions.example.The operation duration,intraoperative blood loss,severe adhesion rate and hospital stay of the observation group were better than those of the control group,and the difference was statistically significant（P<0.05）. Conclusion PHGD guided by B-ultrasound is superior to PPGD,followed by LC,which is used for the treatment of acute calculous cholecystitis.It has the advantages of short operation time,less intraoperative bleeding,and short hospital stay.It is worthy of clinical promotion.
		2023 Vol. 43 (2): 25-28 [Abstract] ( 119 ) HTML (1 KB) PDF (533 KB) ( 142 )

	29	Retrospective Analysis of Clinical Features of Orbital Cyst in Children
		Yu Jiawei, Xing Yue, Wang Xiaohui
		DOI: 10.3969/j.issn.1001-8131.2023.02.010
		Objective To investigate the clinical characteristics and pathological diagnosis of orbital cyst in children. Methods A total of 96 children with orbital cystwere retrospectively analyzed in terms of clinical manifestations,imaging manifestations,pathological diagnosis and treatment. Results 96 patients with orbital cysts ranged.The onset time of the patient was the shortest at birth and the longest was 4 years.The masses of 96 patients were all palpable on the skin surface,and most of them had fair activity.None of them had abscess or surrounding tissue inflammation.Of the 96 patients,72 underwent orbital CT examination,of which 61 showed low density in cysts,8 showed dermoid cysts,2 showed uneven density,and 1 showed high density in cysts.Postoperative pathological examination was performed on 88 of the 96 patients,including 64 dermoid cyst,16 sebaceous cyst and 8 Calcifying elioma of Malherbe.All cases underwent complete surgical resection,and no recurrence was found in outpatient review. Conclusion Orbital cyst has early onset and obvious clinical symptoms.For patients suspected of dermoid cyst,sebaceous cyst or calcified epithelioma,detailed imaging examination should be improved,individualized surgical treatment should be performed as soon as possible,and postoperative pathological examination should be carried out to provide reference for prognosis and diagnosis and treatment of orbital cyst.
		2023 Vol. 43 (2): 29-31 [Abstract] ( 161 ) HTML (1 KB) PDF (1091 KB) ( 118 )

	32	Clinical Application Value of Prenatal Echocardiography in Diagnosis of Fetal Pulmonary Artery Stenosis and Postpartum Follow-up Analysis
		Ma Minya, Liu Liu, Kang Mao, Jing Qiao
		DOI: 10.3969/j.issn.1001-8131.2023.02.011
		Objective To explore the diagnostic points and change rules ofprenatal echocardiography（UCG）for fetal pulmonary artery stenosis,and analyze short-term UCG follow-up results after surgery. Methods Ultrasound findings of 57 fetuses with pulmonary artery stenosis diagnosed by prenatal UCG were analyzed retrospectively.UCG image characteristics of fetal pulmonary artery stenosis were summarized.Infants were followed up after birth,andUCG image characteristics at 1 month and 3 months after birth were analyzed. Results There were 51 neonates with different degrees of pulmonary artery stenosisconfirmed by UCG,including 39 cases of pulmonary valve stenosis and 12 cases of main pulmonary artery stenosis.6 cases were misdiagnosed by prenatal UCG.UCG of prenatal pulmonary valve stenosis was characterized by right cardiac enlargement,pulmonary valve thickening,mild to moderate pulmonary valveregurgitation,decreasedof the ratio of the inner diameter of theaortato the pulmonary artery,and turbulent blood flow signals seen by ultrasound.UCG of prenatal main pulmonary artery stenosis was characterized by pulmonary artery diameter smaller than the aorta diameter,with different degrees of intracardiac malformations.The pulmonary artery flow velocity,tricuspid regurgitation velocity and right atrial diameter of fetuses in severe stenosis group were larger than those in mild stenosis group and moderate stenosis group（P<0.05）.Thepulmonary artery to aortic diameter ratio and right ventricular diameter were smaller thanmild stenosis group and moderate stenosis group（P<0.05）.1 month after birth,ultrasound of infants with pulmonary valve stenosis showed pulmonary valvethickening,echo enhancementand valve expansion.Ultrasound of infants with pulmonary artery stenosis showedpulmonary artery wall thickening.3 months after birth,the right atrial/ventricular diameter,tricuspid regurgitation velocity and pulmonary artery pressure of the infants recovered,compared with those at 1 month after birth（P<0.05）. Conclusion Prenatal UCG has high clinical application value in diagnosis of fetal pulmonary artery stenosis.UCG follow-up of fetuses before and after birth is beneficial tocondition and prognosis evaluation.
		2023 Vol. 43 (2): 32-34 [Abstract] ( 130 ) HTML (1 KB) PDF (645 KB) ( 157 )

	35	The Effect of GnRH-combined Therapy in Patients with Adenomyosis on Indicators Related to Serum Recurrence
		Wang Siyu
		DOI: 10.3969/j.issn.1001-8131.2023.02.012
		The target of adenomyosis and the combination of GnRH-（gonadotropin-releasing hormone agonist）and Manchester therapy. Methods 60 adenomyoses were selected,namely control group（n=30）and observation group（n=30）.Choose the former;on the basis,add GnRH-treat the latter and analyze different methods. Results After treatment,the uterine size,menstrual visual simulation score（VAS）and menstrual blood loss（PBAC）were significantly lower（P<0.05）,serum VEGF,MMP-2MMP-9（P<0.05）,and complication rate（P<0.05）. Conclusion For adenomyosis,the treatment effect of GnRH-a combined with Manchester,is significantly higher than that of Manchester,which can effectively reduce the uterine volume,reduce the level of inflammatory factors,and have the final effect of controlling recurrence factors,so as to promote the recovery of patients' condition faster.
		2023 Vol. 43 (2): 35-37 [Abstract] ( 138 ) HTML (1 KB) PDF (422 KB) ( 106 )

	38	Application effect and safety analysis of minimally invasive extraction in extraction of impacted mandibular wisdom teeth
		Cao Yuan
		DOI: 10.3969/j.issn.1001-8131.2023.02.013
		Objective To investigate the effect of minimally invasive extraction of impacted mandibular wisdom teeth and its safety. Methods 68 patients with impacted mandibular wisdom teethwere divided into two groups：observation group（n=34）and control group（n=34）,The observation group was treated with minimally invasive extraction.The operation time,detumescence time and postoperative pain were compared between the two groups;The intraoperative and postoperative complication rates were compared between the two groups. Results The operation time and detumescence time of the observation group were shorter than those of the control group,and the extraction integrity,mouth opening limitation and postoperative pain score of the observation group were lower than those of the control group（P<0.05）;The incidence of intraoperative and postoperative complications in the observation group were 5.88% and 2.94%,respectively,which were lower than 23.52% and 17.65% in the control group,with significant difference（P<0.05）. Conclusion Minimally invasive extraction of impacted mandibular wisdom teeth can achieve better results,shorten the operation time,effectively relieve the pain,and reduce the incidence of complications,which can be widely used in the process of wisdom tooth surgery.
		2023 Vol. 43 (2): 38-40 [Abstract] ( 162 ) HTML (1 KB) PDF (450 KB) ( 110 )

	41	Application of Cone-beam Computed Tomography in The Diagnosis and Treatment of C-shaped Root Canals in Mandibular Second Molars
		Ding Shuiqing, Ding Hao, Wang Xiaole
		DOI: 10.3969/j.issn.1001-8131.2023.02.014
		Objective To investigate the application value of CBCT in the diagnosis and root canal classification of C-shaped root canals in mandibular second molars. Methods The CBCT data of 208 patients were selected,and three-dimensional reconstruction images were obtained with the mandibular second molar as the center.The root canal morphology and typing characteristics of the mandibular second molars were analyzed. Results The incidence of C-shaped root canals was 38.94%.Type C1 was the most common type in the root canal orifice,and the more to the apical direction,the more types C3a and C3b.There was significant difference between the four levels of root canal configurations（P<0.05）.There was significant difference in the type of C-shaped root canal between unilateral and bilateral grooves at the level of root canal orifice and middle section（P<0.05）.There was significant difference in root canal configuration in the middle of root canal between people under 60 years old and people over 60 years old（P<0.05）. Conclusion CBCT could clearly display the three-dimensional configuration of C-shaped root canal system,and had high clinical value for accurately positioning and distinguishing difficult root canal types,and improving the treatment effect of C-shaped root canals.
		2023 Vol. 43 (2): 41-43 [Abstract] ( 100 ) HTML (1 KB) PDF (469 KB) ( 130 )

	44	Clinical Significance of Serum Immunoglobulin,Light Chain Quantification and Fructosamine in The Diagnosis of Multiple Myeloma
		Cao Xiaohan, Chen Weixian
		DOI: 10.3969/j.issn.1001-8131.2023.02.015
		Objective To investigate the clinical significance of serum immunoglobulin（Ig）,light chain（LC）quantification and fructosamine（FMN）in the diagnosis of multiple myeloma（MM）. Methods A total of 80 MM patients were selected as the MM group.At the same time,70 healthy persons who received physical examination in our hospital during the same period were selected as the control group.2-3mL fasting venous blood was collected from the two groups,FMN was measured by nitrotetrazolium blue colorimetry,and Ig and LC were measured by immune scattering turbidimetry.The Ig,FMN and LC were compared between the two groups,and the sensitivity and specificity of IgA,FMN and κ/λ for single and combined diagnosis of IgA MM were calculated. Results The IgA of patients with IgA type was higher than that of the IgG type,LC type and control group;the IgA of patients with IgG type and LC type was lower than that of the control group;the IgG of patients with IgG type was higher than that of the IgA type,LC type and control group;the IgG of patients with IgA type and LC type was lower than that of the control group;the FMN of patients with IgA type was higher than that of the IgG type,LC type and control group,and the differences were statistically significant（P<0.05）.The κ/λ of the IgAκ,IgGκ and LCκ was higher than that of control group,while the κ/λ of the IgAλ,IgGλ and LCλ was lower than that of control group,the differences were statistically significant（P<0.05）The diagnostic specificity of IgA,κ/λ and IgA+κ/λ was higher than that of FMN and IgA+FMN+κ/λ,and the differences were statistically significant（P<0.05）.The diagnostic sensitivity of FMN,κ/λ,IgA+κ/λ and IgA+FMN+κ/λ was higher than IgA,but there was no statistical significance（P>0.05）. Conclusion FMN has high sensitivity in the diagnosis of IgA MM.The combination of Ig and LC quantitative detection can reduce the rate of misdiagnosis and missed diagnosis and provide guidance for clinical diagnosis and treatment.
		2023 Vol. 43 (2): 44-46 [Abstract] ( 134 ) HTML (1 KB) PDF (367 KB) ( 144 )

	89	Analysis of Psychological Elasticity and Its Influencing Factors in Patients with Multiple Myeloma
		Zhou Qin, Zhou Jing, Zhou Yang Ming Li, Nong Ganbin, Wen Qi, Liao Jie
		DOI: 10.3969/j.issn.1001-8131.2023.02.032
		Objective To explore the psychological elasticity of patients with multiple myeloma（MM）and its influencing factors. Methods A total of 240 patients with multiple myeloma were selected as the research objects.Mental resilience was assessed according to the Chinese Version of the Mental Resilience Scale（CD-RISC）,and logistic regression was used to analyze the factors affecting the resilience of the patients. Results The mental resilience score of the patients was tenacity（35.52±3.23）,self-reliance（24.42±3.62）,optimism（12.25±1.16）,and the total score was（72.19±3.45）;A total of 240 questionnaires were distributed and 210 were recovered,with a recovery rate of 87.50%,The patient’s age,course of illness,and medical insurance type have nothing to do with the patient’s mental flexibility（P>0.05）,The patient's gender,place of residence,marital status,occupational status,education level,income status,children's status,support for the elderly,hypertension,diabetes,hemoglobin,and blood creatinine are related to the patient's mental elasticity（P<0.05）;The patient’s gender,place of residence,marital status,occupational status,education level,income status,children’s status,support for the elderly,hypertension,diabetes,hemoglobin,and serum creatinine are independent risk factors that affect the patient’s mental elasticity（P<0.05）. Conclusion MM patients have low psychological flexibility.In nursing care,we should pay attention to unemployed men with rural education,low income,many or no children,more support for the elderly,many underlying diseases,unmarried or widowed men who are unemployed,and provide medical solutions based on the patient’s situation.,Strengthen the care and attention to the patients,and improve the patients' bad mood.
		2023 Vol. 43 (2): 89-91 [Abstract] ( 109 ) HTML (1 KB) PDF (581 KB) ( 123 )

	111	Discussion on The Role of Holistic Nursing Based on KBP Model in Patients with Dysphagia after Stroke
		Zhou Ying
		DOI: 10.3969/j.issn.1001-8131.2023.02.041
		Objective To explore the role of holistic nursing based on the KABP model in patients with dysphagia after stroke. Methods A total of 86 patients with swallowing dysfunction after stroke were taken as subjects.They were divided into a study group and a control group according to the random number table method,with 43 cases in each group.The control group adopted the conventional nursing model,and the research group combined KABP-based holistic nursing on the basis of conventional nursing.Before and after 4 weeks of intervention,the changes in swallowing function（WTDWT,SSA）,quality of life（QOL）,and self-efficacy（SUPPH）in the two groups were compared. Results After 4 weeks of intervention,the WTDWT and SUPPH scores of the study group were significantly higher than those before the intervention（P<0.05）,and were significantly higher than those in the control group at the same period（P<0.05）.The SSA score of the study group was significantly lower than that before the intervention（P<0.05）,and was significantly lower than that in the control group at the same period（P<0.05）.The QOL scores of the two groups were significantly higher than those before the intervention（P<0.05）,and the study group was significantly higher than the control group at the same period（P<0.05）. Conclusion KABP-based holistic nursing applied to patients with dysphagia after stroke can effectively improve their swallowing function,improve quality of life,and enhance self-care ability.
		2023 Vol. 43 (2): 111-113 [Abstract] ( 82 ) HTML (1 KB) PDF (435 KB) ( 113 )

	114	Effect of Jianpi Tongluo Decoction on Serum G-17,Pepsin Level and Immune Function in Patients with HP Positive Chronic Atrophic Gastritis of Spleen Stomach Deficiency Cold Type
		Li Changlu
		DOI: 10.3969/j.issn.1001-8131.2023.02.042
		Objective To explore the clinical effect and safety of Jianpi Tongluo Decoction in the treatment of Helicobacter pylori（HP）- positive chronic atrophic gastritis（CAG）of spleen stomach deficiency and cold type. Methods 88 patients with HP positive CAG treated were randomly divided into control group（44 cases）and observation group（44 cases）.The control group was treated with triple therapy,and the observation group was treated with Jianpi Tongluo Decoction for 1 month.The clinical efficacy,serum gastrin-17（G-17）,pepsin level,immune function and safety were compared between the two groups. Results the total effective rate of the observation group was higher than that of the control group（P<0.05）;G-17 [（386.74 ± 38.64）ng /L] and pepsinogen Ⅰ（PG Ⅰ）[（58.13±5.33）in the observation group after treatment μg/L] was higher than that in the control group [（342.89±35.79）ng/L,（54.15±5.25）μg/L],pepsinogen Ⅱ（PG Ⅱ）[（10.35±1.53）μg/L] was lower than that in the control group [（13.68±1.71）μg/L],with statistical difference（P<0.05）;After treatment,CD4+ [（45.85±4.82）%] and CD4+/CD8+ [（1.85±0.28）] in the observation group were higher than those in the control group [（41.41±4.56）%,（1.58±0.26）],and CD8+ [（24.85±2.11）%] were lower than those in the control group [（26.23±2.27）%]（P<0.05）;There were no serious adverse reactions in both groups. Conclusion Jianpi Tongluo Decoction can improve the therapeutic effect of HP positive CAG of spleen stomach deficiency cold type,correct the abnormal immune function of patients,and accelerate the normalization of G-17,PG Ⅰ and PG Ⅱ.It is safe and reliable.
		2023 Vol. 43 (2): 114-116 [Abstract] ( 148 ) HTML (1 KB) PDF (427 KB) ( 157 )

	127	Research Progress on the Immunoregulatory Role of CD155 in Malignant Tumors
		Liu Xue, Guo Lingchuan
		DOI: 10.3969/j.issn.1001-8131.2023.02.047
		CD155,a glycoprotein of immunoglobulin superfamily,is up-regulated in a variety of malignant tumor cells and associated with patient prognosis.Recently,the immunoregulatory role of CD155 has attracted extensive attention in tumors.CD155 could interact with co-stimulatory receptors（CD226）and co-inhibitory receptors（TIGIT and CD96）,regulating function of tumor infiltrating lymphocytes.Immunotherapy of targeting CD155 signaling is expected to improve the prognosis of tumor patients and has great potential for clinical application.This article will review the research progress of CD155 from the aspects of the relationship between CD155 and the prognosis of malignant tumor patients,immunoregulatory role and related immunotherapy.
		2023 Vol. 43 (2): 127-129 [Abstract] ( 107 ) HTML (1 KB) PDF (487 KB) ( 152 )

	130	The Role and Research Progress of Integrin in Osteoarthritis
		Jiang Hao, Liu Juncai, Fei Jun
		DOI: 10.3969/j.issn.1001-8131.2023.02.048
		Osteoarthritis,also known as osteoarthropathy,is caused by fibrosis of articular cartilage by a variety of factors.Chaps,ulcers and prolapse lead to degenerative diseases with joint pain as the main symptom.The etiology is not clear,and its occurrence is related to age,obesity,inflammation,trauma and genetic factors.Integrins are large,transmembrane heterodimer proteins that are necessary for the growth,differentiation,and survival of animal cells.In order to enable cells to respond to the dynamic extracellular environment,integrins have evolved a highly sensitive receptor activation mechanism,mainly regulated by tertiary and quaternary structural changes.Many studies have confirmed that chondrocytes express integrin α5β1,αVβ3,αVβ5,α6β1,α1β1,α2β1,α10β1 and α3β1.Some integrin ligands may be biomarkers for the progression of OA.This paper reviews the progress of the research of integrins and their extracellular ligands in osteoarthritis,especially the functional roles of osteoarthritis cartilage.To clarify the role of integrins and ligands in osteoarthritis cartilage and provide theoretical basis for further treatment of arthritis in the future.
		2023 Vol. 43 (2): 130-135 [Abstract] ( 123 ) HTML (1 KB) PDF (646 KB) ( 122 )

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