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Quick Search     Adv Search 2024 Vol. 44, No. 2 Published: 2024-04-25 1 The Mechanism of Psyllium-red Peony Root in the Treatment of Glaucoma Was Studied Based on Network Pharmacology and Molecular Docking Lu Hai, Xiang Chenyue, Ma Yiping DOI: 10.3969/j.issn.1001-8131.2024.02.001 Objective To explore the mechanism of plantagus-red Peony root in the treatment of glaucoma by network pharmacology and molecular docking technology. Methods The active ingredient targets of Plantagina plantagina and red Peony root and glaucoma related targets were collected through TCMSP,Gene Cards and other databases.The STRING database and Cytoscape software were used to construct the protein interaction network diagram,and the visual network diagram of drug-active ingredient-target-disease was drawn.The DAVID database was used for GO functional enrichment analysis and KEGG pathway enrichment analysis.PyMolWin software was used for molecular docking. Results A total of 75 intersection targets between drug pair and glaucoma disease were obtained.The core targets were AKT1,CASP3 and TP53.GO functional enrichment analysis obtained 232 information,and KEGG pathway enrichment analysis identified 207 related pathways.Molecular docking results showed that the key targets were in stable conformation with the active ingredients of the drug. Conclusion The Plantagina Rpeony drug pair may act on AKT1,CASP3,TP53 and other targets,through PI3K-Akt signaling pathway,neurotrophic factor signaling pathway and other related pathways,thereby regulating intraocular pressure and protecting the optic nerve. 2024 Vol. 44 (2): 1-4 [Abstract] ( 74 ) HTML (1 KB)  PDF (1615 KB)  ( 82 ) 5 Application of Combined Detection of Brain Natriuretic Peptide and Urinary Microalbumin/Creatinine Ratio in the Diagnosis of Heart Failure Huang Zufeng, Li Duo, Zhai Xueyan DOI: 10.3969/j.issn.1001-8131.2024.02.002 Objective To analyze the efficacy of combined detection of brain natriuretic peptide（BNP）and urinary microalbumin/creatinine ratio（UACR）in the diagnosis of heart failure. Method A retrospective analysis was conducted on 74 patients with heart failure who were included in the observation group.Additionally,68 healthy individuals who underwent physical examinations at our hospital during the same period were included in the control group.Venous blood was collected from the two groups,and the differences in BNP and UACR were measured and compared;Draw a receiver operating curve（ROC）to analyze the efficacy of combining BNP and UACR in diagnosing heart failure.The results showed that the BNP and UACR of the observation group were（145.79±8.67）pg/mL and（36.89±4.47）mg/g,which were higher than those of the control group（76.21±6.05）pg/mL and（24.53±2.21）mg/g,with a statistical difference（P<0.05）;The ROC results showed that the area under the curve（AUC）of the combined detection of BNP and UACR was 0.914（95% CI：0.864~0.965）,which was higher than the 0.870（95% CI：0.807~0.932）and 0.820（95% CI：0.743~0.897）detected by the two alone. Conclusion BNP and UACR are abnormally high expressed in the body of patients with heart failure.The combination of the two can effectively diagnose heart failure and has high clinical application value,which can be vigorously promoted. 2024 Vol. 44 (2): 5-7 [Abstract] ( 85 ) HTML (1 KB)  PDF (491 KB)  ( 38 ) 8 Correlation Analysis of Serum miR-210 and IL-17 Levels with Poor Collateral Circulation in Patients with Acute Cerebral Infarction Wang Ting DOI: 10.3969/j.issn.1001-8131.2024.02.003 Objective To analyze the correlation between serum micrornA-210（miR-210）and interleukin-17（IL-17）levels and poor collateral circulation in patients with acute cerebral infarction（ACI）. Methods A total of 68 patients with ACI were prospectively included as research objects.The main examination items were serum miR-210 and IL-17 levels,and the collateral circulation was evaluated according to the results of cerebrovascular angiography.The patients were divided into poor and good group.The correlation between serum miR-210 and IL-17 and poor collateral circulation in ACI patients was analyzed,and the predictive value of serum miR-210 and IL-17 for poor collateral circulation in ACI patients was evaluated. Results Among the 68 ACI patients included,there were 18 cases of poor collateral circulation and 50 cases of good collateral circulation.The expression of miR-210 and IL-17 in poor collateral circulation group was lower than that in good group（P<0.05）.Logistic regression analysis showed that low level of serum miR-210 and high level of IL-17 were associated with the occurrence of poor collateral circulation in ACI patients（P<0.05）.Receiver operating characteristic（ROC）curve showed that the area under the curve（AUC）of the combined prediction of serum miR-210 and IL-17 for poor collateral circulation in ACI patients was 0.864. Conclusion Low level of serum miR-210 and high level of IL-17 are associated with poor collateral circulation in ACI patients.Combined detection of serum miR-210 and IL-17 has a high predictive value for poor collateral circulation in ACI patients. 2024 Vol. 44 (2): 8-10 [Abstract] ( 78 ) HTML (1 KB)  PDF (472 KB)  ( 26 ) 11 Application Effect of Standard Large Trauma Craniotomy Combined with Sub-low Temperature in Severe Craniocerebral Trauma Shen Jiangyi, Yang Ronggang, Liu Xu DOI: 10.3969/j.issn.1001-8131.2024.02.004 Objective To analyze the effect of standard large trauma craniotomy combined with mild-hypothermia in severe craniocerebral trauma. Methods 76 cases of patients with severe craniocerebral trauma were selected,and they all were divided into an experimental group（n=38）and a control group（n=38）according to the method of random number table.The control group was treated with standard large trauma craniotomy,while the experimental group was treated with standard large trauma craniotomy combined with mild-hypothermia.The clinical efficacy,intracranial pressure level,national institute of health stroke scale（NIHSS）score,immune function（CD8+、CD4+）level and complicationsoccurrence rate of the two groups were compared. Results The total effective rate 94.74%（36/38）of the experimental groupwas higher than73.68%（28/38）of the control group（P<0.05）;After 1d,2d and 3d of treatment,the levels of intracranial pressure in the experimental group was lower than that in the control group（P<0.05）;After treatment,the NIHSS score of the experimental group was lower than that of the control group（P<0.05）;After treatment,the level of CD8+ in the experimental group was lower than that in the control group,while the level of CD4+ was higher than that in the control group（P<0.05）;The occurrence rate of complications 5.26%（2/38）in the experimental group waslower than 26.32%（10/38）in the control group（P<0.05）. Conclusion The standard large traumacraniotomy combined with mild-hypothermia in the treatment of severe craniocerebral trauma can improve the clinical efficacy,decrease the level of intracranial pressure,improve the state of neurological injury,improve the immune function and reduce the occurrence ofpostoperative complications. 2024 Vol. 44 (2): 11-13 [Abstract] ( 72 ) HTML (1 KB)  PDF (437 KB)  ( 30 ) 14 Relationship between Peripheral Blood NLR,PLR and Prognosis of Newly Diagnosed Multiple Myeloma Patients Chen Yi, Zheng Ximing, Zhang Airong DOI: 10.3969/j.issn.1001-8131.2024.02.005 Objective To investigate the relationship between peripheral blood neutrophil to lymphocyte count ratio（NLR）and platelet to lymphocyte count ratio（PLR）and prognosis of newly diagnosed multiple myeloma（MM）patients. Methods The general data of 86 newly diagnosed MM patients wereretrospectively analyzed.General data（gender,age,ISS stage）of the patients were collected,and the levels of granulocyte count,lymphocyte count,platelet count,Hb,ALB,Cr,Ca,β2 microglobulin were detected,and NLR and PLR were calculated.According to the levels of NLR and PLR,patients were divided into high NLR group（NLR≥2.54,n=32）,low NLR group（NLR<2.54,n=54）,high PLR group（PLR≥135,n=41）and low PLR group（PLR<135,n=45）.Kaplan-Meier curve was used to determine the overall survival time（OS）of patients,and Log-Rank test was performed to analyze the survival of patients with different NLR and PLR levels.A risk assessment model was established,and the diagnostic efficacy of NLR and PLR in evaluating the prognosis of newly diagnosed MM patients was analyzed by receiver operating characteristic curve（ROC）. Results The levels of ISS staging,Ca,Cr and β2 microglobulin between high NLR group and low NLR groupwere significant differences（P<0.05）.There were significant differences in ISS stage,Cr and β2 microglobulin levels between high PLR group and low PLR group（P<0.05）.The survival time of high NLR group was（13.28±1.99）months,and that of low NLR group was（36.15±5.42）months.The survival time of high NLR group was shorter than that of low NLR group（χ2=13.984,P=0.000<0.05）.The survival time of high PLR group was（25.31±3.79）months,and that of low PLR group was（33.26±4.98）months.The survival time of high PLR group was shorter than that of low PLR group（χ2=8.767,P=0.003<0.05）.Based on the ROC curve analysis the AUC value of NLR and PLR combined detection mode was the highest,which was 0.923,and the sensitivity was 92.85%、the specificity was 85.71%. Conclusion The levels of NLR and PLR in peripheral blood are closely related to the prognosis of newly diagnosed MM patients.The levels of NLR and PLR in patients with MM were negatively correlated with the prognosis and survival time.At the same time,the combined detection of NLR and PLR has high clinical value in evaluating the prognosis of newly diagnosed MM patients. 2024 Vol. 44 (2): 14-17 [Abstract] ( 52 ) HTML (1 KB)  PDF (660 KB)  ( 28 ) 18 The Expression and Clinical Significance of Serum PC,hs-CRP and NT-proBNP in Different Coronary Artery Diseases of Coronary Heart Disease Yang Fan, Sun Jun, Yang Dongbo DOI: 10.3969/j.issn.1001-8131.2024.02.006 Objective To investigate the expression and clinical significance of serum plasma protein C（PC）,highly sensitive C-reactive protein（hs-CRP）and amino-terminal B-type brain natriuretic peptide（NT-proBNP）in coronary heart disease（CHD）and coronary artery disease. Methods 80 cases of CHD patients and 80 cases of healthy people who underwent physical examination were selected as observation group and control group .According to clinical classification,CHD was divided into stable angina pectoris group（n=24）,unstable angina pectoris group（n=31）and myocardial infarction group（n=25）.Serum levels of PC,hs-CRP and NT-proBNP were detected in all patients.Coronary angiography was carried out in the observation group,and the patients were divided into single-branch lesion group（n=22）,double-branch lesion group（n=34）and multi-branch lesion group（n=24）according to the number of coronary lesions.The levels of serum PC,hs-CRP and NT-proBNP in control group and observation group,different clinical types（stable angina pectoris group,unstable angina pectoris group,myocardial infarction group）and different coronary lesions（single-branch disease group,double-branch disease group,multi-branch disease group）were compared.A risk assessment model was established,and the diagnostic efficacy of serum PC,hs-CRP and NT-proBNP in detecting myocardial infarction was evaluated by receiver operating characteristic curve（ROC）. Results Compared with the control group,the level of serum PC in the observation group was lower,the level of hs-CRP and NT-proBNP was higher（P<0.05）.Compared with unstable angina group and myocardial infarction group,the level of serum PC in stable angina group was higher,and the level of hs-CRP and NT-proBNP was lower（P<0.05）.The level of serum PC in multi-branch disease group was significantly lower than that in single-branch disease group and double-branch disease group,and the level of hs-CRP and NT-proBNP in multi-branch disease group was higher（P<0.05）.According to ROC curve analysis,the combined detection of serum PC,hs-CRP and NT-proBNP in the established risk assessment model had the highest AUC value,which was 0.958,and the sensitivity and specificity were 96.00% and 84.00%. Conclusion The more severe the coronary lesions in CHD patients,the lower the serum level of PC,hs-CRP,NT-proBNP levels.The serum levels of PC,hs-CRP and NT-proBNP have certain clinical value in the evaluation of different degrees of coronary lesions of CHD.The combined detection of serum PC,hs-CRP and NT-proBNP has high diagnostic efficacy in the diagnosis of coronary heart disease myocardial infarction. 2024 Vol. 44 (2): 18-20 [Abstract] ( 53 ) HTML (1 KB)  PDF (596 KB)  ( 32 ) 21 Clinical Analysis of Microsurgical Treatment of HIV Patients with Brain Tumors Xu Jisheng DOI: 10.3969/j.issn.1001-8131.2024.02.007 Objective To explore the clinical effect of microsurgery in the treatment of AIDS virus（HIV）complicated with brain tumors. Methods 60 patients with HIV and brain tumor were randomly divided into two groups with 30 cases each.The control group was treated with traditional craniotomy,and the observation group was treated with microsurgery.Compare the treatment effect of the two groups. Results The total effective rate of the observation group was higher than that of the control group.The score of the National Institutes of Health Stroke Scale（NIHSS）[（9.76±1.23）] was lower than that of the control group[（11.31±1.45）],and the score of Barthel Index（BI）[（78.79±7.45）] was higher than that of the control group [（70.54±7.23）],with statistical difference（P<0.05）;Postoperative tumor necrosis factor in observation group- α（TNF- α）[（5.14±1.05）ng/L],interleukin-6（IL-6）[（24.56±3.25）ng/L] and central nervous system specific protein（S100 β）[（8.14±1.13）mg/L] level and complication rate [6.67%（2/30）] were lower than those in the control group [（7.58±1.12）ng/L,（28.79±3.32）ng/L,（12.34±2.05）mg/L,26.67%（8/30）],with statistical difference（P<0.05）. Conclusion Microsurgery can improve the treatment effect of HIV patients with brain tumors,reduce the neurological damage,speed up the normalization of serological indicators,and have fewer complications. 2024 Vol. 44 (2): 21-23 [Abstract] ( 80 ) HTML (1 KB)  PDF (458 KB)  ( 29 ) 24 The Relationship between Serum Lp（a）Level and The Degree of Coronary Artery Disease in Patients with Coronary Heart Disease and T2DM Wang Dongdong, Chen Zhaojin DOI: 10.3969/j.issn.1001-8131.2024.02.008 Objective To investigate the relationship between the level of lipid protein a[Lp（a）] and the degree of coronary artery disease in patients with coronary heart disease（CHD）and type 2 diabetes mellitus（T2DM）. Method A total of 123 patients diagnosed with T2DM were selected,110 of whom were confirmed by coronary angiography（CAG）with CHD,and divided into moderate stenosis group（30 cases）and severe stenosis group（80 cases）according to the degree of coronary artery stenosis.According to the range of coronary artery lesions,the patients were divided into single-vessel lesion group（25 cases）,double-vessel lesion group（55 cases）and multi-vessel lesion group（30 cases）.In addition,30 volunteers with normal coronary artery artery treated in our hospital during the same period were selected as the control group,and the levels of blood lipid,apolipoprotein A1（ApoA1）,Apolipoprotein B（ApoB）and Lp（a）in each group were measured. Results Compared with the control group,TG and Lp（a）levels were higher in the CHD with T2DM group,but HDL-C level was lower than that in the control group（P<0.05）.The Lp（a）levels in control group,moderate stenosis group and severe stenosis group were（115.20±54.09）mg/L,（158.90±65.12）mg/L and（183.20±55.45）mg/L,with severe stenosis group>moderate stenosis group>control group.Lp（a）levels in control group,single arm group,double arm group and multi-arm lesion group were（115.20±54.09）mg/L,（128.90±68.23）mg/L,（186.47±91.23）mg/L,（261.90±109.47）mg/L.Multibranch lesion group>double-branch lesion group>single-branch lesion group（P<0.05）,but there was no significant difference in Lp（a）level between single-branch lesion group and control group（P>0.05）.When Lp（a）>147.82mg/L,the AUC of CHD with T2DM was 0.821（0.747-0.881）,and the sensitivity and specificity were 77.27% and 83.33%,respectively（P<0.05）. Conclusion The level of Lp（a）in CHD patients with T2DM increases with the severity of coronary artery stenosis and the increase of coronary artery number.Lp（a）can be used as an important auxiliary index to determine the severity of coronary artery lesions to assist clinical diagnosis and treatment. 2024 Vol. 44 (2): 24-27 [Abstract] ( 56 ) HTML (1 KB)  PDF (611 KB)  ( 32 ) 28 Correlation Analysis of Female Genital HPV Infection,Cervical Lesions and Vaginal Microecology Lin Yuehuan, Zhan Xuemei, Hu Xingjun, Wang Rong DOI: 10.3969/j.issn.1001-8131.2024.02.009 Objective To explore and analyze the correlation between female genital HPV infection,cervical lesions and vaginal microecology,and to provide a new basis for the prevention and treatment of cervical lesions. Methods Data of 8067 female patients with TCT and HPV testing were retrospectively analyzed,and the correlation between genital HPV infection,cervical lesions and vaginal microecology in women in Jiangmen area was analyzed. Results Among the 8067 women included in the study,3267 cases had little or no vaginal microecological lactobacillus,accounting for 40.50%,1323 cases had abnormal cleanliness,accounting for 16.40%,2237 cases had bacterial vaginosis,accounting for 27.73%,1579 cases had candida infection,accounting for 19.70%,223 cases had trichomonas infection,accounting for 2.76%.Rank correlation test showed that HPV infection and cervical lesions were closely correlated with vaginal microecology（Lactobacillus,cleanliness,bacterial vaginosis,trichomonas infection）（P<0.05）,but had no significant correlation with vaginal candida infection（P>0.05）. Conclusion Female vaginal microecology is closely related to HPV infection and cervical lesions.Imbalance of vaginal microecology,reduction of dominant bacteria,imbalance of bacterial flora,pathogen invasion and abnormal cleanliness increase the risk of HPV infection and cervical lesions.Therefore,prevention of HPV infection and cervical lesions can be started from improving female vaginal microecology. 2024 Vol. 44 (2): 28-30 [Abstract] ( 64 ) HTML (1 KB)  PDF (388 KB)  ( 33 ) 31 Evaluation of Trastuzumab Combined with Anthracycline Drugs Using Two-dimensional Dot Tracking Technology The value of Cardiotoxicity in Patients with Breast Cance Dong Yan, Xie Yanlin, Gan Man DOI: 10.3969/j.issn.1001-8131.2024.02.010 Objective To explore the value of two-dimensional dot tracking technique in early monitoring left ventricular systolic function in evaluating the cardiac toxicity of patients with breast cancer after treatment with trastuzumab combined with anthracycline drugs. Methods 50 cases of postoperative breast cance,All patients were treated with trastuzumab combined with anthracycline drugs.Routine monitoring of electrocardiogram,two-dimensional echocardiography,and two-dimensional spot tracking technology before,during,and after treatment.The main outcome measures were left ventricular ejection fraction（LVEF）and overall longitudinal strain（GLS）.30 healthy volunteers served as the control group. Results （1）GLS significantly decreased in the middle and late stages of chemotherapy compared to the control group and before chemotherapy（P<0.05）;（2L）There was no significant difference in LVEF between the pre chemotherapy group and the control group in the middle and late stages of chemotherapy. Conclusions The global longitudinal strain value（GLS）measured by two-dimensional spot tracking technology can evaluate the small changes of drug induced left ventricular dysfunction in breast cancer patients after treatment,and detect the damage of myocardial function as soon as possible。 2024 Vol. 44 (2): 31-33 [Abstract] ( 67 ) HTML (1 KB)  PDF (435 KB)  ( 32 ) 34 Research on AIDS Cognition of College Students in Heilongjiang Province and Adjustment of Prevention and Control Policies Ma Jing, Yu lan, Li Ting, Wang Lin, Zhang Xiaolin, Li Yi DOI: 10.3969/j.issn.1001-8131.2024.01.011 Objective To understand the cognition of AIDS,general characteristics of behavior as well as the identification of AIDS-related high-risk behaviors among college students in Heilongjiang province,and to provide more efficient and targeted suggestions for carrying out the AIDS prevention work in colleges and in universities. Method Students who enrolled in local universities or secondary vocational colleges were the target group,and stratified multistage cluster random sampling method was used to select the final sample.The questionnaire survey as well as qualitative interviews and focus group interviews were conducted among the target sample. Result There is still room for improving college students' cognition and awareness of AIDS.Theme lecture mode used widely in college AIDS education showed little effect.So it is suggested that AIDS cognitive education should be included in the credit system management and Strengthening relative education should be provided for students. Conclusions The paper explored the formation of multi-sectoral joint action of college AIDS prevention mechanism on the purpose of providing a reference and executable practice mode for AIDS prevention and control as well as improving the health level of students in universities and colleges in Heilongjiang Province. 2024 Vol. 44 (2): 34-36 [Abstract] ( 73 ) HTML (1 KB)  PDF (487 KB)  ( 52 ) 37 Value of DCE-MRI Quantitative Parameters Combined with Serum VEGF and ProGRP Levels in Differential Diagnosis of Benign and Malignant Lung Lesions Han Shuliang, Yang Jie, Guo Mengke, Xu Ke DOI: 10.3969/j.issn.1001-8131.2024.02.012 Objective To evaluate the value of quantitative parameters of dynamic enhanced magnetic resonance imaging（DCE-MRI）combined with serum vascular endothelial growth factor（VEGF）and ProGRP levels in the differential diagnosis of benign and malignant lung lesions. Methods 95 patients with suspected lung cancer were retrospectively selected and divided into benign lesions（46 cases）and malignant lesions（49 cases）according to the biopsy results,and were included in the benign group and malignant group,respectively.The imaging findings of the two groups were compared.Quantitative parameters of DCE-MRI [rate constant（Kep）,volume transfer constant（Ktrans）,extracellular space volume ratio（Ve）] and serum levels of VEGF and ProGRP were compared between the two groups.To analyze the diagnostic value of DCE-MRI quantitative parameters combined with serum VEGF and ProGRP levels in malignant lung lesions. Results The proportion of irregular shape,edge burr sign,uneven internal enhancement and early enhancement rate ≥60% in the malignant group was higher than that in the benign group（P<0.05）.The levels of Kep,Ktrans,Ve and serum VEGF and ProGRP in the malignant group were higher than those in the benign group.The AUC for the combined diagnosis of malignant lung lesions was 0.898,the optimal diagnostic sensitivity was 91.84%,the specificity was 86.96%,and the Yoden index was 0.788. Conclusion Quantitative parameters Kep,Ktrans,Ve and serum VEGF and ProGRP levels of DCE-MRI are closely related to malignant lung lesions.The combined detection has certain diagnostic value,and can be used as an effective method for differentiating benign and malignant lung lesions. 2024 Vol. 44 (2): 37-39 [Abstract] ( 45 ) HTML (1 KB)  PDF (625 KB)  ( 37 ) 40 Characteristics and Differential Value of Multi-phase CT Scanning for Gastric Stromal Tumor and Gastric Schwannoma with Diameter≤5cm Wei Minggang, Zhang Junling, Guo Xiaorang DOI: 10.3969/j.issn.1001-8131.2024.02.013 Objective To analyze the characteristics and differential value of multi-phase computed tomography（CT）for gastric stromal tumor（GIST）and gastric schwannoma（GS）with diameter≤5cm. Methods A total of 60 patients with suspected GIST or GS with diameter≤5cm who underwent multi-phase CT scanning were retrospectively analyzed.Taking the surgical and pathological results as the gold standard,the accuracy,sensitivity and specificity of multi-phase CT scanning in discriminating GIST and GS with diameter≤5cm were analyzed.The scanning characteristicsof CT images（lesion location,tumor morphology,growth mode,density,boundary,tissue necrosis,tissue calcification,tissue ulcer）were analyzed and compared by radiologists. Results The accuracy,sensitivity,specificity,positive predictive value,negative predictive value and Kappa value of GIST and GS with diameter≤5cm were 95.00%（57/60）,98.11%（52/53）,71.43%（5/7）,96.30%（52/54）,83.33%（5/6）and 0.741 respectively.Among the characteristics of multi-phase CT scanning,there were significant differences in tumor morphology and border between GIST and GS with diameter≤5cm（P<0.05）.There were no significant differences in lesion location,growth pattern,density,boundary,tissue necrosis,tissue calcification and tissue ulcer（P>0.05）. Conclusions When GIST and GS with diameter≤5cm are examined and differentiated by multi-phase CT scanning,there are obvious differences in tumor morphology and boundary scan characteristics between them,which has certain differential diagnostic value and provides reference basis for clinical differential diagnosis. 2024 Vol. 44 (2): 40-42 [Abstract] ( 79 ) HTML (1 KB)  PDF (423 KB)  ( 29 ) 43 Effect of Painless Delivery on the Labor Process of Primipara and Umbilical Blood Gas Index of Newborn Wang Xueqin, Hao Yujuan, Ding Qing DOI: 10.3969/j.issn.1001-8131.2024.02.014 Objective To study the effect of painless delivery on the labor process of primipara and umbilical blood gas index of newborn. Methods A total of 60 primiparas were selected as research objects.According to their fertility intention,the primiparas were divided into painless delivery group（n=27）and conventional delivery group（n=33）.Ropivacaine and sufentanil were used for analgesia in the painless delivery group,while no analgesia was used in the conventional delivery group.The general condition,pain condition,umbilical blood gas index of newborn,maternal and infant outcome were compared between the two groups. Results The first time of getting out of bed in painless labor group was shorter than that in conventional labor group,and the second stage of labor and total stage of labor were longer than that in conventional labor group,the difference was statistically significant（P<0.05）.There was no significant difference in the first stage of labor,the third stage of labor and the length of hospital stay between the two groups（P>0.05）.There was statistically significant difference in VAS scores between the two groups before and after delivery（P<0.05）,and painless delivery group scored lower.There was no significant difference in PaO2,BE,pH and lactic acid between the two groups（P>0.05）.There was no significant difference in the maternal and infant outcomes between the two groups（P>0.05）. Conclusions Painless delivery is helpful to alleviate the pain of primipara in labor,promote the activity of getting out of bed as soon as possible,and has little impact on the umbilical blood gas index of newborn.It does not significantly lead to adverse maternal and infant outcomes,but can prolong the labor process. 2024 Vol. 44 (2): 43-45 [Abstract] ( 59 ) HTML (1 KB)  PDF (434 KB)  ( 24 ) 46 The Relationship Between Coagulation Function and Gestational Age in Premature Infants Liu Jing, Huang Xichun, Wang Lijun DOI: 10.3969/j.issn.1001-8131.2024.02.015 Objective To investigate the changes of coagulation function in premature infants at different gestational ages,and analyze the relationship between gestational age and coagulation function. Methods A total of 90 preterm infants hospitalized were selected for the study.They were divided into early preterm infants group（n=30）,middle preterm infants group（n=30）and late preterm infants group（n=30）according to their gestational age.Venous blood was drawn from each group after birth,and the results of blood coagulation function within 2 hours were detected.The coagulation function indexes of the three groups of preterm infants were statistically analyzed,and the relationship between each index and gestational age was analyzed. Results There were significant differences in the values of PT,APTT,TT and FIB among preterm infants of different gestational ages（P<0.05）.Through analysis of variance,there were significant differences in the values of PT,APTT and TT among the three groups of preterm infants（P<0.05）;The values of PT,APTT and TT of preterm infants in the three groups were negatively correlated with gestational age（r=-0.67,-0.31,-0.32,all P<0.05）,and the FIB value was positively correlated with gestational age（r=0.33,P<0.05）. Conclusion The coagulation function of premature infants with different gestational ages is different.It is significant to detect the levels of PT,APTT,TT and FIB.PT,APTT and FIB are all related to gestational age.When PT and APTT are prolonged and FIB is reduced,it is necessary to go to a hospital with good reputation as soon as possible,pay attention to the review of coagulation function,and give targeted treatment plans. 2024 Vol. 44 (2): 46-48 [Abstract] ( 44 ) HTML (1 KB)  PDF (421 KB)  ( 38 ) 49 The Efficacy of Budesonide Formoterol and Breztri Aerosphere in the Treatment of Moderate to Severe COPD and Their Impact on Lung Function Yang Jinling, Guo Xianling DOI: 10.3969/j.issn.1001-8131.2024.02.016 Objective To explore the efficacy of budesonide formoterol and Breztri Aerosphere in the treatment of moderate to severe COPD and their impact on lung function. Methods A total of 120 patients with moderate and severe COPD were selected as the study objects.The 120 patients were randomly divided into control group and observation group,with 60 cases in each group.The treatment method of observation group was Breztri Aerosphere,and the treatment method of control group was budesonide formoterol inhalation aerosol.Conventional lung function indexes,blood gas analysis,efficacy,adverse reactions and quality of life were compared between the two groups before intervention and one month after intervention. Results （1）After one month of intervention,the FVC,FEV1,and FEV1% of patients in the observation group were higher than those in the control group（P<0.05）;（2）After one month of intervention,the PaO2,SaO2,and pH values of patients in the observation group were higher than those in the control group,while PaCO2 was lower than that in the control group（P<0.05）;（3）After one month of intervention,the clinical efficacy of the observation group was better than that of the control group（P<0.05）.There was no significant difference in adverse reactions（P>0.05）;（4）The quality-of-life scores of both groups of patients decreased（P<0.05）,and the observation group scored better than the control group（P<0.05）. Conclusion Compared with budesonide formoterol inhalation aerosol,Breztri Aerosphere is more conducive to promoting the recovery of lung function and improving the blood gas condition in patients with moderate and severe COPD,with more obvious curative effect,high safety,and contributing to the improvement of patients' quality of life,so it is worth promoting. 2024 Vol. 44 (2): 49-51 [Abstract] ( 86 ) HTML (1 KB)  PDF (604 KB)  ( 46 ) 55 Study on the Expression Level of ki-67 in Non-small Cell Lung Cancer,EGFR Mutation and Clinical Correlation DOI: 10.3969/j.issn.1001-8131.2024.02.018 Objective To investigate the expression level of cell proliferation-associated antigen（ki-67）in non-small cell lung cancer（NSCLC）and the mutation of vascular endothelial growth factor receptor（EGFR）and its clinical correlation. Methods 56 patients with NSCLC were collected and divided into groups according to whether ki-67 was positive or not.Tissue samples were collected after surgical resection or biopsy.Immunohistochemistry and Super-ARMS were used to determine the expression of ki-67 and EGFR mutation,respectively.Spearman analyzed the correlation between ki-67 expression level and EGFR mutation and clinic. Results Except gender,age,histological type,lymph node metastasis and distant metastasis,the proportion of moderate/low differentiation and TNM stage Ⅲ+Ⅳ in ki-67 positive group was higher than that in ki-67 negative group,and the difference was statistically significant（P<0.05）.The ratio of wild type in ki-67 positive group was higher than that in ki-67 negative group,and the difference was statistically significant（P<0.05）.Spearman correlation showed that the expression level of ki-67 was negatively correlated with EGFR mutation（r=-0.382,P=0.004）,but positively correlated with differentiation degree and TNM stage（r=0.356,P=0.007;r=0.306,P=0.022）. Conclusion ki-67 expression and EGFR mutation can both participate in the occurrence and progress of NSCLC,and there is a correlation between ki-67 expression and EGFR mutation,which suggests that they can play a synergistic role.Therefore,the combination of clinical features,ki-67 expression and EGFR mutation can provide key guidance for clinical diagnosis and treatment. 2024 Vol. 44 (2): 55-56 [Abstract] ( 49 ) HTML (1 KB)  PDF (502 KB)  ( 26 ) 71 Effects of Ulinastatin Combined with Linezolid on Inflammatory Reaction and Lung Function Indicators in Patients with Severe Pneumonia Ma Yingying DOI: 10.3969/j.issn.1001-8131.2024.02.024 Objective To study the effect of ulinastatin combined with Linezolid on inflammatory reaction and lung function indicators in patients with severe pneumonia. Methods 96 patients with severe pneumonia were selected and divided into two groups according to different treatment methods,with 48 cases in each group.The control group was treated with Linezolid,and the observation group was treated with ulinastatin combined with Linezolid for 4 weeks.Compare the clinical efficacy,inflammation levels,lung function,and adverse reactions between the two groups.The total effective rate of the observation group was 95.83%（46/48）,which was statistically significant（P<0.05）compared to 83.33%（40/48）of the control group;After treatment,in the observation group,the level of Calcitonin（PCT）was（340.57±57.34）ng/L,the level of C-reactive protein（CRP）was（10.02±3.21）mg/L,and tumor necrosis factor（TNF-α）The level was（10.87±8.21）pg/mL,lower than the control group's（510.36±62.37）ng/L,（25.69±5.31）mg/L,and（19.45±8.10）pg/mL;The index of forced expiratory volume（FEV1）in 1s was（50.02±0.25）%,the index of forced Vital capacity（FVC）was（67.38±8.97）%,and the index of maximum expiratory peak flow rate（PEF）was（2.05±0.35）L·s-1,which was higher than that of the control group（45.31±1.15）%,（59.57±7.66）%,（1.54±0.27）L·s-1,with statistical significance（P<0.05）;There was no statistically significant difference in adverse reactions between the two groups（P>0.05）. Conclusion The combination of Linezolid and ulinastatin can effectively alleviate the clinical symptoms,improve the lung function,reduce the inflammatory reaction in patients with severe pneumonia,and improve the clinical efficacy,which is safe and reliable. 2024 Vol. 44 (2): 71-73 [Abstract] ( 54 ) HTML (1 KB)  PDF (447 KB)  ( 36 ) 87 Effect of Capsule Shell Change on the Dissolution Curve of Cefalexin Capsules Wang Wei DOI: 10.3969/j.issn.1001-8131.2024.02.030 Objective To the effect of capsule shell change on the similarity of dissolution curves of cefalexin capsules. Methods According to the second method（plasma method）of Chinese pharmacopoeia（2020 edition）,the solubility of cefaxime capsules and reference preparations in different pH dissolution media was determined,the similarity of dissolution curves between cefalexin capsules and reference preparations was compared by the method of similarity factor in the non-model dependent method. Results The dissolution curves of cefalexin capsules were compared with those of the reference preparation,and the dissolution curves of two batches of cefalexin capsules were similar to those of the reference preparation,the dissolution curve of another batch of cefalexin capsules in Ph6.8 phosphate medium was not similar to that of the reference preparation. Conclusion The effect of the change of the capsule shell on the similarity of the dissolution curve of cefalexin capsules was studied. 2024 Vol. 44 (2): 87-89 [Abstract] ( 68 ) HTML (1 KB)  PDF (530 KB)  ( 28 ) 90 Two Scoring Systems to Assess the Occurrence of Pressure Ulcers in Patients with Acute Cerebral Infarction During Bed Rest Sun Qiuju DOI: 10.3969/j.issn.1001-8131.2024.02.031 Objective To compare the value of Braden Scale,Acute Physiological and Chronic Health Score-ⅱ（APACHE-Ⅱ）in assessing the risk of pressure sore in patients with acute cerebral infarction during bed rest. Methods 70 patients with acute cerebral infarction were selected.When the patients were awake,Braden scale and APACHE-Ⅱ scale were used to evaluate the risk of pressure sores during bed rest,and the general information and the occurrence of pressure sores were analyzed.Compare the above two scales to evaluate the occurrence value of pressure sore in patients with acute cerebral infarction. Results There were 13 cases（18.57%）of 70 cases with acute cerebral infarction in bed and 57 cases（81.43%）without pressure sores.The Braden score of the occurrence group was lower than that of the non-occurrence group,and the APACHE-Ⅱ score was higher than that of the non-occurrence group（P<0.05）.The ROC curve graph showed that the AUC of Braden scale and APACHE-Ⅱ scale in assessing the risk of pressure sores in patients with acute cerebral infarction during bed rest was 0.814 and 0.832,respectively,which was ideal,and the AUC of APACHE-Ⅱ scale was greater than that of Braden scale. Conclusion APACHE-Ⅱ has a higher value than Braden scale in assessing the risk of pressure sore during bed rest in patients with acute cerebral infarction. 2024 Vol. 44 (2): 90-91 [Abstract] ( 92 ) HTML (1 KB)  PDF (513 KB)  ( 34 ) 115 Effect of Yanghuanwu Decoction Ice Stimulation Combined with RTMS onDysphagia after Stroke Niu Xuekang, Lin Lili, Wang Yaqing, Du Yupeng, Zhao Jun DOI: 10.3969/j.issn.1001-8131.2024.02.040 Objective To evaluate the effect of Buyang Huanwu decoction ice stimulation combined with repetitive transcranial magnetic stimulation（rTMS）on dysphagia after stroke. Methods 45 stroke patients with dysphagia were selected from the Department of Rehabilitation and Department of Neurology.The patients were randomly divided into control group（sham transcranial magnetic stimulation+routine ice stimulation+routine treatment）,traditional Chinese medicine group（Buyang Huanwu decoction ice stimulation+sham transcranial magnetic stimulation+routine treatment）and combination group（Buyang Huanwu decoction ice stimulation+high frequency rTMS+routine treatment）.The deglutition function before and after treatment was evaluated by means of standardized swallowing assessment（SSA）and videofluoroscopic swallowing study（VFSS）. Results after treatment,the curative effect of the combined group was better than that of the traditional Chinese medicine group and the control group（P<0.05）,and that of the three groups was better than that before treatment（P<0.05）.There was no significant difference in the curative effect between the traditional Chinese medicine group and the control group. Conclusion Chinese medicine ice stimulation combined with high frequency（5Hz）repetitive transcranial magnetic stimulation can effectively improve dysphagia after stroke,and the effect of chinese medicine ice stimulation alone is better than that of ice stimulation alone. 2024 Vol. 44 (2): 115-118 [Abstract] ( 71 ) HTML (1 KB)  PDF (859 KB)  ( 44 ) 122 Clinical Effect of Acupuncture and Manipulation in Patients with Thoracic Facet Joint Disorder Duan Zhujun, Meng Qingyu, Yu Haiyan DOI: 10.3969/j.issn.1001-8131.2024.02.042 Objective To investigate the clinical effect of acupuncture therapy in patients with thoracic facet joint disorders. Methods Selected 110 cases of thoracic small joint disorders,using random number table method will be divided into massage group and acupuncture combined massage group,both groups are included in 55 cases,technique massage group patients with massage treatment,acupuncture combined massage group patients with acupuncture combined massage treatment,two groups of patients are treated for 1 week.Clinical efficacy,pain level,joint mobility,and quality of life were recorded in both groups. Results The therapeutic effect of acupuncture was 96.36% and 83.64%,significant（P<0.05）.After treatment,the pain grading index（PRI）and current pain intensity（PPI）scale in the acupuncture and massage group were lower compared with the manipulation group,showing a statistically significant difference（P<0.05）.The joint mobility of acupuncture combined with massage group was better than that of the massage manipulation group,and the difference was statistically significant（P<0.05）.After treatment,the quality of life of acupuncture combined with massage group improved better than the manipulation group,with a statistically significant difference（P<0.05）. Conclusion The treatment of thoracic small joint disorder has a good effect,which can improve the joint mobility of patients,reduce the pain level and improve the quality of life. 2024 Vol. 44 (2): 122-124 [Abstract] ( 58 ) HTML (1 KB)  PDF (610 KB)  ( 32 ) 131 Dapagliflozin In The Treatment of Heart Failure Zhao Qidi, Huang Xingtao DOI: 10.3969/j.issn.1001-8131.2024.02.045 Heart failure is the final stage of various cardiovascular diseases.Cardiac stimulant,diuretic,vasodilators combined with sympathetic nerve inhibition and renin-angiotensin-aldosterone system inhibition are the means of clinical heart failure treating.To a certain extent,they delay the progression of heart failure.But the recurrence rate and mortality of heart failure patients are still very high.In recent years,with the widespread use of the diabetes drug-dapagliflozin,we have found that it can benefit patients with heart failure.Dapagliflozin was approved for the treatment of heart failure in February 2021 and has been widely used in clinical practice.A review of the latest research progress of the sodium glucose cotransporter-2 inhibitor dapagliflozin in the field of heart failure is presented. 2024 Vol. 44 (2): 131-134 [Abstract] ( 94 ) HTML (1 KB)  PDF (760 KB)  ( 59 )

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