Abstract：Objective To analyze the distribution of pathogens in fetal membranes of patients with histologic acute chorioamnionitis（HAC）and the maternal and infant outcomes. Methods 8704 pregnant women were selected as the study objects,and the clinical data of mothers and infants were analyzed retrospectively.The distribution of pathogenic bacteria in fetal membrane tissue of patients with confirmed HAC and the maternal and infant outcomes were analyzed. Results Among 8704 pregnant women,614 women were diagnosed as HAC,175 women with HAC had positive pathogens by fetal membrane tissue culture,and a total of 180 strains of 26 bacteria were isolated.The distribution and number of pathogenic bacteria in women with HAC in Phase I were 24（92.31%）,159（88.33%）,and 21（11.67%）,respectively.The number of pathogenic bacteria in women with HAC in Phase I was higher than that in women with HAC in Phase Ⅱ（26.92%）.Escherichia coli was the main pathogenic bacteria in fetal membrane tissue of HAC,with a total of 107（59.44%）The second was enterococcus faecalis,18 strains（10.00%）;The incidences of premature rupture of membranes and normal delivery in HAC group were 13.52% and 7.17% lower than those in non HAC group（19.06% and 59.37%,P<0.05）,while the incidences of placental abruption,stillbirth,premature delivery,spontaneous abortion and other pregnancy outcomes in HAC group were 3.26%,2.28%,25.90%,4.40%,43.49% higher than those in non HAC group（0.57%,0.10%,9.20%,0.70%,11.00%,P<0.05）;194 pregnant women and neonates were accompanied by asphyxia or respiratory distress syndrome,51 of whom were diagnosed by HAC.The incidence of neonatal respiratory distress syndrome in HAC group was 21.57% lower than that in non HAC group（41.26%,P<0.05）,while the incidence of neonatal asphyxia was 78.43% higher than that in non HAC group（58.74%,P<0.05）. Conclusion There are 180 strains of pathogenic bacteria in the fetal membrane tissue of HAC pregnant women with 26 strains,and the number of phase I is more than that of phase Ⅱ.Escherichia coli is the main strain of HAC.HAC can increase the incidence of placental abruption,stillbirth,premature delivery,spontaneous abortion and other adverse pregnancy outcomes,as well as the incidence of postpartum neonatal asphyxia.
王琳. 组织学急性绒毛膜羊膜炎患者的胎膜组织病原菌分布及母婴结局分析[J]. 哈尔滨医药, 2024, 44(1): 23-26.
Wang Lin. Distribution of Pathogenic Bacteria in Fetal Membranes of Patients with Histologic Acute Chorioamnionitis and Analysis of Maternal and Infant Outcomes. journal1, 2024, 44(1): 23-26.
2024, Vol. 44 
