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2022 Vol. 42, No. 2 Published: 2022-04-25

	1	Effects of Carvedilol Combined With Nicorandil on Plasma Heme Oxygenase 1,Immunity/Inflammation and Oxidative Stress in Patients With Coronary Heart Disease
		Yue Huijuan
		DOI: 10.3969/j.issn.1001-8131.2022.02.001
		Objective To explore the effects of carvedilol combined with nicorandil on plasma heme oxygenase 1（HO-1）,immune function,inflammatory response and oxidative stress in patients with coronary heart disease（CHD）.Methods A total of 96 CHD patients treated were enrolled.They were divided into experimental group and control group,48 cases in each group.Both groups underwent general treatment.The control group was treated with nicorandil,while experimental group was treated with carvedilol on basis of control group.The curative effect,cardiac function,levels of HO-1,matrix metalloproteinase-9（MMP-9）,immune function,inflammatory response and oxidative stress indexes were compared between the two groups.Results After treatment,the total response rate of experimental group was higher than that of control group（93.75% vs 79.17%）（P<0.05）.The improvement of cardiac function indexes in experimental group was better than that in control group（P<0.05）.HO-1 level in experimental group was higher than that in control group,while MMP-9 level was lower than that in control group（P<0.05）.The levels of C-reactive protein（CRP）,interleukin 6（IL-6）and tumor necrosis factor-α（TNF-α）in experimental group were lower than those in control group（P<0.05）.The levels of CD4⁺ and CD4⁺/CD8⁺ in experimental group were higher than those in control group,while levels of CD8+,immunoglobulin A（IgA）,IgG and IgM were lower than those in control group（P<0.05）.The levels of superoxide dismutase（SOD）and glutathione peroxidase（GSH-Px）in experimental group were higher than those in control group,while level of malondialdehyde（MDA）was lower than that in control group（P<0.05）.Conclusion The clinical curative effect of carvedilol combined with nicorandil is better on CHD patients,which can regulate immunity,reduce inflammation and improve oxidative stress.
		2022 Vol. 42 (2): 1-4 [Abstract] ( 212 ) HTML (1 KB) PDF (483 KB) ( 169 )

	5	Effects of Clopidogrel Combined With Aspirin on Cerebral Hemodynamics and Cytokines in Patients With Transient Ischemic Attack
		Wei Lisha
		DOI: 10.3969/j.issn.1001-8131.2022.02.002
		Objective To observe the effects of clopidogrel combined with aspirin on cerebral hemodynamics and cytokines in patients with transient ischemic attack（TIA）.Methods 140 TIA patients were divided into observation group and control group according to the random number table method,with 70 cases in each group.Control group was treated with aspirin on the basis of conventional treatment,and observation group was combined with clopidogrel on the basis of control group.The clinical efficacy,and middle cerebral artery hemodynamic indicators（peak flow rate,average flow rate,peak flow rate difference,flow rate difference）and serum cytokines [hypersensitive C-reactive protein（hs-CRP）,interleukin-6（IL-6）,tumor necrosis factor（TNF-α）,transforming growth factor-β1（TGF-β1）] before treatment and after 2 weeks of treatment and occurrence of bleeding events during treatment（cerebral hemorrhage,mucocutaneous hemorrhage,gum bleeding,gastrointestinal bleeding）were compared between the two groups.Results After 2 weeks of treatment,the total effective rate in observation group was higher than that in control group（P<0.05）.The peak flow rate and average flow rate of the two groups were higher than those before treatment,and the indexes in observation group were higher than those in control group,and the peak flow rate difference and flow rate difference were lower than those before treatment,and the indexes in observation group were lower than those in control group（P<0.05）.The serum levels of hs-CRP,IL-6,TNF-α and TGF-β1 in the two groups were lower than those before treatment,and the levels in observation group were lower than those in control group（P<0.05）.There were no serious bleeding events such as cerebral hemorrhage in both groups,and there was no statistically significant difference in the incidence rate of mucocutaneous hemorrhage,gum bleeding and gastrointestinal bleeding（P>0.05）.Conclusion Clopidogrel combined with aspirin for patients with TIA can effectively improve cerebral hemodynamics and relieve inflammatory response without increasing the risk of bleeding.It has a definite efficacy and high safety.
		2022 Vol. 42 (2): 5-7 [Abstract] ( 178 ) HTML (1 KB) PDF (416 KB) ( 162 )

	8	Effects of Nasal Endoscopic Low-Temperature Plasma Ablation of Adenoid on Lmmune Function in OSAHS Children
		Li Ying
		DOI: 10.3969/j.issn.1001-8131.2022.02.003
		Objective To explore the effects of nasal endoscopic low-temperature plasma ablation of adenoid on immune function in children with obstructive sleep apnea-hypopnea syndrome（OSAHS）.Methods A total of 88 children confirmed with OSAHS in the hospital were enrolled.According to simple random grouping method,they were divided into observation group and control group,44 cases in each group.The control group underwent adenoid dissection,while observation group was treated with nasal endoscopic low-temperature plasma ablation of adenoid.After surgery,curative effect between the two groups was compared.The serum immunoglobulin G（IgG）,immunoglobulin A（IgA）and immunoglobulin M（IgM）were detected by enzyme linked immunosorbent assay.The peripheral blood T lymphocyte subsets（CD3⁺,CD4⁺,CD8⁺,CD4⁺/CD8⁺）were detected by Beckman flow cytometry.The occurrence of postoperative complications in both groups was observed and recorded.Results The difference in total response rate of treatment between observation group and control group was not statistically significant（93.18% vs 86.36%）（P>0.05）.After surgery,levels of serum IgG,IgA and IgM,and peripheral blood CD3⁺,CD4⁺ and CD4⁺/CD8⁺ in observation group were significantly higher than those in control group（P<0.05）.The difference in incidence of postoperative complications between observation group and control group was not statistically significant（2.27% vs 11.36%）（P>0.05）.Conclusion There is no difference in curative effect and complications between nasal endoscopic low-temperature plasma ablation of adenoid and adenoid dissection in the treatment of OSAHS children,with few effects on immune function.
		2022 Vol. 42 (2): 8-10 [Abstract] ( 177 ) HTML (1 KB) PDF (388 KB) ( 134 )

	11	Clinical Effect Observation of Esomeprazole in the Treatment of Peptic Ulcer
		Wang Dongfang
		DOI: 10.3969/j.issn.1001-8131.2022.02.004
		Objective This study was aimed to investigate the clinical effects of esomeprazole in the treatment of peptic ulcer and influence on serum levels of inflammatory factors and gastrointestinal hormones.Methods 80 patients with peptic ulcer were enrolled in this study and randomly assigned to receive omegaprazole quadruple therapy（control group,40 cases）or esomeprazole quadruple therapy（observation group,40 cases）.Clinical effects of the two groups were compared.Meanwhile,serum inflammatory factors [interleukin-8（IL-8）,tumor necrosis factor-α（TNF-α）],gastrointestinal hormones [gastrin（GAS）,plasma motilin（MOT）,somatostatin（SS）],Hp clearance rate and drug safety were observed.Results After treatment,the total response rate in the observation group was 95.00%,higher than 87.50% in the control group（P>0.05）.After treatment,IL-8,TNF-α,GAS and MOT significantly decreased,while SS significantly increased in the 2 groups.Besides,IL-8,TNF-α,GAS and MOT were lower,and SS was significantly higher in the observation group than in the control group（P<0.05）.The Hp clearance rate was significantly higher in the observation group than in the control group after treatment（P<0.05）.No significant difference was found between the 2 groups in the total incidence of adverse drug reactions（P>0.05）.Conclusion The clinical effect of esomeprazole in the treatment of patients with peptic ulcer is definite.It has significant advantages in lower inflammatory factor levels and regulating serum gastrointestinal hormones.Besides,it can effectively improve the Hp clearance rate,with certain safety.
		2022 Vol. 42 (2): 11-13 [Abstract] ( 200 ) HTML (1 KB) PDF (399 KB) ( 159 )

	14	Clinical Observation of Infection Index in Patients With Pulmonary Infection and Fever Treated With Doxycycline
		Shao Jingtian, Huang Yan, Huang Lixian
		DOI: 10.3969/j.issn.1001-8131.2022.02.005
		Objective To investigate the effect of doxycycline on the improvement of infection index in patients with pulmonary infection and fever.Methods A total of 70 patients were randomly divided into the experimental group and the control group,35 patients in each group.Both groups were given general supportive treatment.The control group was treated with azithromycin and the experimental group was treated with doxycycline.The clinical treatment efficiency,the disappearance time of fever symptoms,the level of pulmonary infection indexes and the occurrence of adverse reactions during medication were compared between the two groups.Results The total effective rate of experimental group was 94.29%,which was significantly higher than that of control group（85.71%）.The duration of fever and the time when the body temperature dropped to normal after medication were significantly shorter than those in the control group（P<0.05）.WBC count,CRP,procalcitonin and interleukin-6 indexes were significantly improved after doxycycline treatment compared with control group（P<0.05）.There was no significant difference in the incidence of adverse reactions between the two groups during treatment（P<0.05）.Conclusion The treatment of doxycycline in patients with pulmonary infection with fever can not only rapidly and effectively reduce fever,improve the symptoms of infection,but also significantly reduce the level of infection indicators in blood,with definite efficacy and high safety,which is worthy of extensive clinical promotion.
		2022 Vol. 42 (2): 14-15 [Abstract] ( 164 ) HTML (1 KB) PDF (462 KB) ( 269 )

	16	Effects and Prognostic Factors of Minimally Invasive Plate Fixation in the Treatment of Ulnar Fractures
		Wang Lin
		DOI: 10.3969/j.issn.1001-8131.2022.02.006
		Objective The aim of this study was to analyze the effects and prognostic factors of minimally invasive plate fixation in the treatment of ulnar fractures.Methods 70 patients with ulnar fractures were enrolled in the study.According to the surgical method,they were divided into the observation group（treated by minimally invasive plate fixation,n=40）and control group（treated by open reduction and plate internal fixation,n=30）.The perioperative parameters and complications were compared.The wrist function was evaluated with the Gartland-Werly score,and according to the Gartland-Werly score,patients in the observation group were divided into the good prognosis group（0~8 points）and the poor prognosis group（≥ 9 points）,and the influencing factors of prognosis were analyzed.Results The surgical time,wound healing time,length of hospital stay,length of incision and the incidence of complications in the observation group were shorter,smaller or lower than those in the control group（P<0.05）.The scores of wrist function in the observation group at 3 months and 6 months after surgery were lower than those in the control group（P<0.05）.There were significant differences in age,postoperative time to start exercising,with other fractures on the same side and the rate of malunion between the good prognosis and the poor prognosis group（P<0.05）.Logistic regression analysis showed that age and postoperative exercise time were independent risk factors for prognosis（P<0.05）.Conclusion The effect of minimally invasive plate fixation is better than that of open reduction and internal fixation in the treatment of ulnar fractures.The former is conducive to the recovery of wrist function.Age and postoperative exercise time are independent risk factors for the prognosis,and targeted intervention measures should be taken after surgery.
		2022 Vol. 42 (2): 16-18 [Abstract] ( 187 ) HTML (1 KB) PDF (412 KB) ( 126 )

	19	Effect of Closed Reduction and Percutaneous Hollow Nail Internal Fixation on Knee Joint Function and Complications in Patients With Patella Fracture
		He Junqi
		DOI: 10.3969/j.issn.1001-8131.2022.02.007
		Objective To investigate the effect of closed reduction and percutaneous hollow nail internal fixation on knee joint function and complications in patients with patella fractures.Methods 88 patients with patella fractures were included in the study.According to the parity generation method,they were divided into a control group（44 cases）and an observation group（44 cases）.The control group received open reduction Kirschner wire tension band fixation,and the observation group received closed reduction percutaneous hollow nail fixation.The pain degree and knee joint function of the two groups before and 6 months after the operation were compared,and the complications were recorded.Results Before surgery,there was no significant difference between the two groups of patients’ VAS scores and Lysholm scores（P>0.05）;after surgery,the VAS scores of the two groups decreased,while Lysholm scores increased,and the observation group was better than the control group.There was statistical significance（P<0.05）;the complication rate of the observation group was 6.82%（3/44）compared with 22.72%（10/44）in the control group,and there was no statistical significance（P>0.05）.Conclusion The use of closed reduction and percutaneous hollow nail fixation for patients with patella fractures is consistent with the principle of minimally invasive surgery.It can fix the fracture and cause less damage to the soft tissues.It can effectively relieve the pain of the patient and promote the recovery of knee joint function.The safety is high,and it has promotion significance.
		2022 Vol. 42 (2): 19-20 [Abstract] ( 177 ) HTML (1 KB) PDF (463 KB) ( 143 )

	21	The Effect of Fentanyl Combined With Dezocine and Ketorolac Tromethamine on the Pain and Sedation of Patients After LC
		Zhang Hua, He Baohong, Li Shuzhen
		DOI: 10.3969/j.issn.1001-8131.2022.02.008
		Objective To observe the effect of fentanyl combined with dezocine and fentanyl combined with ketorolac tromethamine（PCIA）on the pain and sedation of patients after laparoscopic cholecystectomy（LC）.Methods A total of 98 LC patients in the hospital were divided into study group and control group by random number table method,each with 49 cases.Patients in the control group used fentanyl combined with dezocine for analgesia,and patients in the study group used fentanyl combined with ketorolac tromethamine for analgesia.Compare the pain degree（VAS）and the degree of sedation（Ramsay sedation score）at 1h,2h,4h,8h,12h,24h,48h after the operation of the two groups of patients,and record the occurrence of adverse reactions during the analgesia of the two groups.Results The VAS scores of the study group at 1h,2h,4h,8h,12h,24h,48h after operation were lower than those of the control group,but the difference was not statistically significant（P>0.05）.There was no significant difference in Ramsay sedation score between the two groups of patients at 1h,2h,4h,8h,12h,24h,48h after operation（P>0.05）.There were no adverse reactions such as respiratory depression in both groups,the total incidence of adverse reactions in the study group was 16.32%,which was significantly lower thanthe control group（38.78%）（P<0.05）.Conclusion Fentanyl combined with ketorolac tromethamine intravenously controlled analgesia and fentanyl combined with dezocinehave similar effects.Both of which have good analgesic and sedative effects,but fentanyl combined with ketorolac tromethamine has fewer adverse reactions.
		2022 Vol. 42 (2): 21-23 [Abstract] ( 205 ) HTML (1 KB) PDF (437 KB) ( 137 )

	24	Relationship Between Serum S100 - β Protein Level and Prognosis in Patients With Severe Craniocerebral Injury
		Ning Wenling
		DOI: 10.3969/j.issn.1001-8131.2022.02.009
		Objective To investigate the relationship between the changes of serum central nerve specific protein（S100 - β）and prognosis in patients with severe craniocerebral injury.Methods The clinical data of 82 patients with severe craniocerebral injury were retrospectively analyzed.According to Glasgow Outcome Score（GOS）,there were 3 cases of grade I,6 cases of grade II,7 cases of grade III,42 cases of grade IV and 24 cases of grade v.66 patients（80.49%）with grade IV and V were included in the good prognosis group,and 16 patients（19.51%）with grade I,II and III were included in the poor prognosis group.S100 - β levels were compared between the two groups,and the relationship between S100 - β and prognosis was analyzed.result The level of S100 - β in patients with good prognosis was lower than that in patients with poor prognosis,the difference was statistically significant（P<0.05）;logistic regression analysis showed that the overexpression of serum S100 - β protein might be associated with poor prognosis in patients with severe craniocerebral injury（or>1,P<0.05）;receiver operating characteristic curve（ROC curve）was drawn,Results Showed that the level of serum S100 - β protein predicted the poor prognosis The AUC was 0.812.Conclusion The level of serum S100 - β protein is closely related to the prognosis of patients with severe craniocerebral injury.The level of S100 - β has a high predictive value for poor prognosis.The level of serum S100 - β protein can be detected before treatment,and corresponding intervention can be taken for those with high expression of S100 - β to improve the prognosis of patients.
		2022 Vol. 42 (2): 24-25 [Abstract] ( 116 ) HTML (1 KB) PDF (463 KB) ( 127 )

	26	Comparison of different modes of intracerebral hematoma puncture in the treatment of hypertensive intracerebral hemorrhage
		Zhai Guangchao
		DOI: 10.3969/j.issn.1001-8131.2022.02.010
		Objective To explore the effect of different modes of intracerebral hematoma puncture in the treatment of hypertensive intracerebral hemorrhage.Methods the clinical data of 86 patients with hypertensive intracerebral hemorrhage were retrospectively analyzed.43 patients with CT guided intracerebral hematoma puncture were included in the control group,and 43 patients with 3D printing operation guide assisted intracerebral hematoma puncture were included in the observation group.The levels of cerebral metabolic indexes,puncture conditions and hematoma clearance effect were compared between the two groups before and 5 days after operation.Results On the 5th day after operation,the levels of cerebral perfusion pressure（CPP）and cerebral oxygen uptake rate（CeO2）of the two groups were higher than those before operation,and the observation group was higher than that of the control group,with statistical significance（P<0.05）;the puncture accuracy of the observation group was higher than that of the control group,with statistical significance（P<0.05）;on the 5th day after operation,the hematoma clearance efficiency of the two groups was higher,with statistical significance（P<0.05）.Conclusion compared with CT guided intracerebral hematoma puncture,3D printing operation guide assisted intracerebral hematoma puncture can improve the puncture accuracy and hematoma clearance rate of patients with hypertensive intracerebral hemorrhage,and improve the level of brain metabolism,which is worthy of clinical promotion.
		2022 Vol. 42 (2): 26-28 [Abstract] ( 139 ) HTML (1 KB) PDF (431 KB) ( 200 )

	29	Effect of CRRT combined with Ulinastatin on inflammatory state and renal function in patients with acute septic shock
		Qian Qing
		DOI: 10.3969/j.issn.1001-8131.2022.02.011
		Objective To investigate the effect of continuous renal replacement therapy（CRRT）combined with ulinastatin on inflammatory state and renal function in patients with acute septic shock.Methods Retrospective analysis,50 cases of acute septic shock patients were selected as the control group（CRRT treatment）,and 48 cases of acute septic shock patients were selected as the observation group（CRRT combined with ulinastatin treatment）.The inflammatory status and renal function were compared between the two groups before and after treatment for 3 days.Results After 3 days of treatment,white blood cell count（WBC）,C-reactive protein（CRP）,procalcitonin（PCT）in the two groups were compared The levels of interleukin-6（IL-6）,interleukin-10（IL-10）,tumor necrosis factor（TNF - α）in the observation group were lower than those in the control group,and the difference was statistically significant（P<0.05）;after 3 days of treatment,the levels of bun and SCR in the two groups were lower than those before treatment,and the levels of the above indexes in the observation group were lower than those in the control group（P<0.05）. Conclusion CRRT combined with ulinastatin can effectively remove inflammatory substances and improve renal function in patients with acute septic shock,which has high clinical application value.
		2022 Vol. 42 (2): 29-30 [Abstract] ( 261 ) HTML (1 KB) PDF (462 KB) ( 218 )

	31	Effect of Responsible Midwifery Combined With Free Body Intervention on the Time of Labor and Pain Index of Primitive Women
		Bai Yuanyuan, Mao Lingyun, Wang Fang
		DOI: 10.3969/j.issn.1001-8131.2022.02.012
		Objective To explore the effect of responsible midwifery combined with free body intervention on the labor time and pain index of primiparas,so as to take effective measures to promote smooth delivery.Methods A total of 80 primiparas who gave birth were selected as the research objects,and were divided into two groups according to the random number table method,each with 40 cases.The control group used obstetric routine nursing and traditional delivery position,and the observation group used the intervention mode of responsible delivery combined with free position.The labor time and pain index were compared between the two groups.Results The first,second,and third stages of labor in the observation group were shorter than the control group.The visual analogue score（VAS）of the first,second,and third stages of labor in the observation group was lower than that of the control group.The difference was statistically significant（P<0.05）.Conclusion Responsible midwifery combined with free body intervention can effectively shorten the labor time of primiparas and reduce the pain index of labor,and the clinical application effect is significant.
		2022 Vol. 42 (2): 31-33 [Abstract] ( 143 ) HTML (1 KB) PDF (457 KB) ( 141 )

	34	Prediction of Lymph Node Metastasis in Ovarian Cancer by Quantitative Parameters of Contrast-enhanced Ultrasound
		Wei Minhua
		DOI: 10.3969/j.issn.1001-8131.2022.02.013
		Objective To study the value of quantitative parameters of contrast-enhanced ultrasound（CEUS）in predicting lymph node metastasis of ovarian cancer.Methods The clinical data of 63 patients with ovarian cancer diagnosed were retrospectively analyzed and included in the ovarian cancer group;the clinical data of 62 patients with ovarian cancer complicated with lymph node metastasis diagnosed in our hospital during the same period were collected and included in the lymph node metastasis group.The quantitative parameters of CEUS,including transit time,development time,peak time and peak intensity,were recorded and compared between the two groups,and the value of transit time,development time,peak time and peak intensity in predicting ovarian cancer with lymph node metastasis was analyzed.Results The transit time,development time,peak time and peak intensity of lymph node metastasis group were lower than those of ovarian cancer group,the difference was statistically significant（P<0.05）;the receiver operating characteristic curve（ROC curve）was drawn,and the area under the curve（AUC）of CEUS quantitative parameters such as transit time,development time,peak time and peak intensity to predict ovarian cancer with lymph node metastasis was 0.817 、0.863、0.807、0.844.Conclusion CEUS parameters can predict lymph node metastasis of ovarian cancer and provide a basis for clinical diagnosis and treatment of ovarian cancer.
		2022 Vol. 42 (2): 34-35 [Abstract] ( 175 ) HTML (1 KB) PDF (481 KB) ( 150 )

	36	Nucleic Acid Test Results and Related Factors of HIV Among Men Who Have Sex With Men in Kaifeng From 2016-2020
		Wen Rui, Li Ning, Kong Weibin, Han Dan
		DOI: 10.3969/j.issn.1001-8131.2022.02.014
		Objective To explore nucleic acid test Resultsand related factors of HIV among men who have sex with men（MSM）in Kaifeng from 2016-2020.Methods A total of 1,460 MSM in Kaifeng from 2016-2020 were enrolled as the research subjects.The nucleic acid test Resultsof HIV were analyzed.The related influencing factors of HIV infection were analyzed by Univariate and multivariate Logistic regression analysis.Results The nucleic acid test Resultsof HIV showed that the positive rates of HIV among MSM in Kaifeng showing increasing trends（P<0.05）.Multivariate Logistic regression analysis showed that age not younger than 40 years old,low education level,local residence time shorter than 2 years,syphilis infection,and no persistent usage of condoms were independent risk factors of HIV infection among MSM（P<0.05）.Conclusion HIV infection rate is increasing among MSM in Kaifeng from 2016-2020,which is affected by age,education level,local residence time and syphilis infection.Clinically,targeted measures should be taken to curb HIV transmission.
		2022 Vol. 42 (2): 36-38 [Abstract] ( 160 ) HTML (1 KB) PDF (401 KB) ( 139 )

	39	Clinical Observation of Uterine Intramuscular Injection of Carboprost Tromethamine Injection in the Adjuvant Treatment of Postpartum Hemorrhage Due To Uterine Inertia After Spontaneous Delivery
		Zhang Wenjing
		DOI: 10.3969/j.issn.1001-8131.2022.02.015
		Objective To investigate the effect of uterine intramuscular injection of carboprost tromethamine injection in the adjuvant treatment of postpartum hemorrhage due to uterine inertia after spontaneous delivery.Methods 90 parturients with postpartum hemorrhage due to uterine inertia after spontaneous delivery were randomly divided into observation group and control group,45 cases in each group.The control group was given conventional treatment for postpartum hemorrhage,and the observation group was treated with uterine intramuscular injection of carboprost tromethamine injection based on the treatment of control group.Therapeutic effects of the 2 groups were compared.Results The total response rate of observation group was significantly higher than that of the control group（P<0.05）.Bleeding volume of the observation group at 2 hours and 24 hours after delivery was less than that of the control group（P<0.05）,the third stage of labor was shorter than the control group（P<0.05）,and postpartum decreased value of hemoglobin was lower than the control group（P<0.05）.Besides,levels of nitric oxide synthase（NOS）,serum nitric oxide（NO）and brain natriuretic peptide（BNP）in the observation group were significantly lower than those in the control group（P<0.05）.HR（heart rate）of both groups was increased significantly,while MAP（mean arterial pressure）,SBP（systolic blood pressure）and DBP（diastolic blood pressure）were significantly reduced at 24 hours after delivery.Meanwhile,MAP,SBP and DBP of the observation group at 24 hours after delivery were significantly higher than those of the control group,and HR was significantly lower than the control group（P<0.05）.The total incidence of adverse reactions in the observation group was 24.44%,significantly lower than 44.44% of the control group（P<0.05）.Conclusion Carboprost tromethamine is effective in the treatment of postpartum hemorrhage due to uterine inertia after spontaneous delivery.It can shorten the third stage of labor,improve postpartum hemorrhage,reduce NO,NOS and BNP levels,and stabilize hemodynamic indexes,with low incidence of adverse reactions.
		2022 Vol. 42 (2): 39-41 [Abstract] ( 135 ) HTML (1 KB) PDF (402 KB) ( 167 )

	42	Study on the Effect of Lung Recruitment Under Deep Neuromusclar Block Panasonic Reopening on Pulmonary Complications After Laparoscopic Gynecological Surgery
		Zhou Yinfeng, Cheng Zhou, Chen Yong
		DOI: 10.3969/j.issn.1001-8131.2022.02.016
		Objective To investigate the effect of deep muscle panasonic reopening on the pulmonary complications after laparoscopic gynecological surgery.Methods Patients who underwent gynecological laparoscopic surgery were randomly divided into observation group and control group（n=45）.Both groups received endotracheal intubation under general anesthesia and deep muscle relaxation induction before intubation,while the control group was given mechanical ventilation.The observation group had intermittent pulmonary reextension on this basis.The changes of hemodynamics and lung function in each period of artificial pneumoperitoneum in two groups were observed.The number and proportion of pulmonary adverse reactions within 72 hours after operation were compared between the two groups.Results There were no significant differences in pulmonary compliance and oxygenation index at pneumoperitoneum completion,oxygenation index at pneumoperitoneum 45min and hypoxemia between the two groups（P>0.05）.The lung compliance and oxygenation index at pneumoperitoneum for 45min,pneumoperitoneum for 90 min,ventilated air,pulmonary infection,atelectasis,pneumothorax,dyspnea and cough in the observation group were significantly lower than those in the control group（P<0.05）.Conclusion In patients undergoing deep muscle panasonic laparoscopic gynecological surgery,pulmonary reopening can effectively improve the lung function during artificial pneumoperitoneum and significantly reduce postoperative pulmonary complications,which is worthy of wide promotion.
		2022 Vol. 42 (2): 42-43 [Abstract] ( 132 ) HTML (1 KB) PDF (445 KB) ( 166 )

	44	The Application Value of Circulating Procalcitonin and N/L in the Early Diagnosis of Infantile Pneumonia
		Lei Tao, Jiang Tao, Liu Houcun
		DOI: 10.3969/j.issn.1001-8131.2022.02.017
		Objective To investigate the value of Neutrophil lymphocyte ratio（N/L）in the early diagnosis of pediatric pneumonia.Methods 112 children with pneumonia admitted to our hospital from August 2018 to August 2019 were selected as research objects.PCT was detected by roche CobasE411 electrochemical luminescence method,and the neutrophil count（N）and lymphocyte count（L）were detected by automatic hematometer.Then the NLR was calculated according to the following formula：NLR=N/L.PCT and NLR levels were compared between the control group and the children group（low,medium and high risk groups）.The levels of relevant indicators in the survival group and the death group;Specificity and sensitivity of PCT combined with NLR in diagnosis of pediatric pneumonia.Results （1）PCT and NLR levels in each PSI group（low risk group,medium risk group and high risk group）were significantly higher than those in the control group,and with the increase of PSI score,PCT and NLR levels also increased significantly,and the differences were statistically significant（F values were 6.562 and 15.592,P values were 0.028 and 0.000,respectively）.（2）serum PCT and NLR levels in the death group were significantly higher than those in the survival group（all P<0.05）.（3）the ROC curves of two indicators of pct-based NLR were analyzed,and the Resultsshowed that：the area differences below the curves of the two indicators were statistically significant（all P<0.01）.When the PCT was 0.86ng/mL,the sensitivity was 92.0% and the specificity was 81.2%.The sensitivity and specificity of NLR at 11.28 were 71.9% and 77.8% respectively.Conclusion PCT and NLR have high clinical value in evaluating the condition and prognosis of infantile pneumonia.
		2022 Vol. 42 (2): 44-46 [Abstract] ( 141 ) HTML (1 KB) PDF (298 KB) ( 127 )

	47	Determination of Prulifloxacin by Miniaturized Nonaqueous Titration
		Liu Xiuqing, Ren Chunxiao
		DOI: 10.3969/j.issn.1001-8131.2022.02.018
		Objective To explore the determination of prulifloxacin by miniaturized non-aqueous titration.Methods The miniaturized non-aqueous titration method and the major non-aqueous titration method were used to determine the content of rulifloxacin,and the accuracy and precision of the two Methodswere compared.Results Constant and miniaturized Methodswere used to repeat the measurement for 6 times,respectively.The mean value of the data measured by the constant method was 95.8%,and the relative standard deviation was 0.8%.The stability test showed that there was no significant difference between each data within 0-5h（P>0.05）.Conclusion Using miniaturized non-water drop to determine drug content can stabilize energy consumption and control method is practical.
		2022 Vol. 42 (2): 47-48 [Abstract] ( 119 ) HTML (1 KB) PDF (477 KB) ( 166 )

	90	Clinical Value of ECG Scatter Chart in the Diagnosis of Atrial Fibrillation With Wide QRS Wave
		Zhang Chongchong
		DOI: 10.3969/j.issn.1001-8131.2022.02.038
		Objective To investigate the clinical value of ECG scatter chart in the diagnosis of atrial fibrillation with wide QRS.Methods 86 cases of patients with atrial fibrillation with wide QRS wave clinical data were retrospectively analysed,all patients were examined by dynamic electrocardiogram（ecg）,and drawing according to the Resultsof the dynamic electrocardiogram ecg scatterplot,to as the "gold standard",transesophageal echocardiography（ecg scatterplot diagnosis analysis atrial fibrillation with wide clinical application value of QRS wave,and compare different types of atrial fibrillation with wide QRS wave B line slope.Results Among the 86 patients with atrial fibrillation with wide QRS wave,44 cases（51.16%）were classified as indoor differential conduction,34 cases（39.53%）as ventricular prephase contraction,and 8 cases（9.30%）as ventricular extravasation.Ecg scatterplot of atrial fibrillation with wide QRS wave the total accuracy of diagnosis was 95.34%（82/86）,ecg scatterplot to indoor difference conduction,contracts before sexual period,ventricular escape bo diagnosis accuracy is 98.84%,95.35% and 96.51% respectively,specific degree 100.00%,96.15% and 97.44%,respectively,sensitivity of 97.73%,94.12% and 87.50% respectively,and the consistency of transesophageal echocardiography（tee）good（Kappa value=0.976,0.903,0.804）;There were statistically significant differences in indoor differential conduction,ventricular prephase contraction and the slope of B-line of ventricular escape wave（P<0.05）.Conclusion ECG scatter map plays an active role in the diagnosis of atrial fibrillation with wide QRS,and can improve the diagnostic accuracy of different types of atrial fibrillation with wide QRS.It can be used as a diagnostic means of atrial fibrillation with wide QRS clinically.
		2022 Vol. 42 (2): 90-91 [Abstract] ( 173 ) HTML (1 KB) PDF (444 KB) ( 208 )

	121	Clinical study on Ganmai Dazhao Decoction and Suanzaoren Decoction in the Treatment of Depression of Liver Depression and Spleen Deficiency Type
		Luo huanbin, Pang Wei, Zhang Changchun, Guo Dong
		DOI: 10.3969/j.issn.1001-8131.2022.02.053
		Objective To study the clinical efficacy of Ganmai Dazhao Decoction and Suanzaoren Decoction in the treatment of depression of liver depression and spleen deficiency,and summarize the clinical treatment experience.Methods 94 patients with depression diagnosed as liver depression and spleen deficiency in our hospital were randomly divided into two groups,47 cases in each group.The control group was treated with fluoxetine hydrochloride,and the observation group was treated with Ganmai Dazhao Decoction and Suanzaoren Decoction on the basis of the control group.The TCM symptom scores of the two groups before and after treatment were observed and compared Depression score and sleep quality score.Results There was no significant difference in TCM syndrome score,HAMD score and PSQI score between the two groups before treatment（P>0.05）;After treatment,the TCM syndrome score,HAMD score and PSQI score of the two groups were significantly lower than those before treatment（P<0.05）;The scores of TCM syndrome,HAMD and PSQI in the observation group were significantly lower than those in the control group（P<0.05）.Conclusion Ganmai Dazhao Decoction and Suanzaoren Decoction have significant clinical efficacy in the treatment of liver depression and spleen deficiency depression.They can significantly improve TCM syndrome,reduce the degree of depression and improve sleep quality.They have important clinical application value.
		2022 Vol. 42 (2): 121-122 [Abstract] ( 158 ) HTML (1 KB) PDF (511 KB) ( 194 )

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