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2022 Vol. 42, No. 5
Published: 2022-10-25
1
A Practical Study of Laihezi Decoction in the Treatment of Intestinal Flatulence after Anorectal Surgery
Chen Yu, Liu Jingyuan, Shi Qinchuan, Li Yanru, Liu Yumei
DOI: 10.3969/j.issn.1001-8131.2022.05.001
Objective
To study the relationship between trans-erucate and MMC.
Methods
The isolated trans-erucate was used to treat the smooth muscle of rats to observe the change of symptoms.106 rats were randomly divided into two groups and treated with different methods.The degree of symptom relief was compared and analyzed.The effect of trans-sinapate on MMC was summarized.
Results
The Treatment Group treated mechanical flatulence significantly better than the control group,and can effectively prevent the occurrence of urinary clay.
Conclusion
Single Chinese medicine extracted from Semen Raphani trans-mustard Salt,acting on the gastrointestinal smooth muscle of rats,can effectively promote the intestinal phase response to increase the activity of Ach,thereby achieving the role of treatment of flatulence,and also has the remarkable effect to the urine storage which causes because of the intestinal distension.
2022 Vol. 42 (5): 1-3 [
Abstract
] (
206
)
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3
The Effect of Pramipexole Combined With Dopaserizide on Daily Living Ability and Serum Biochemical Indexes in Patients With Parkinson
Song Jiangfeng, Qian Kun, Lv Qianqian
DOI: 10.3969/j.issn.1001-8131.2022.05.002
Objective
To investigate the effect of pramipexole combined with dopasense on the ability of daily living and serum biochemical indicators of Parkinson's patients.
Method
Select 120 Parkinson's patients received to carry out the study.According to the simple random grouping method,all patients were divided into observation group（60 cases）and control group（60 cases）.The control group was treated with dopasrazide,and the observation group was treated with pramipexole on this basis.The daily activities of the two groups were compared,and the serum biochemical indicators of the two groups were compared.
Results
Before treatment,there was no significant difference in NMS and MMSE scores between the two groups of patients（
P>
0.05）;after treatment,the MMSE score of the observation group was higher than that of the control group,and the NMS score of the observation group was lower than that of the control group,and the difference was significant（
P<
0.05）Before the intervention,the serum biochemical indicators（serum Hcy level,ICF-I level）of the two groups were not significantly different（
P>
0.05）.After the intervention,the observation group's serum Hcy level and ICF-I level were better than those of the control group.Significant（
P<
0.05）.
Conclusion
For Parkinson's disease,the treatment effect of pramipexole combined with dopasrazide can improve its cognitive function,reduce adverse reactions,and effectively reduce the level of inflammation in patients.This treatment plan is worthy of popularization and application.
2022 Vol. 42 (5): 3-3 [
Abstract
] (
191
)
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6
Can Preventive Injection of Nicorandil Reduce No Reflow During PCI in Patients With Acute STEMI
Zhou Can
DOI: 10.3969/j.issn.1001-8131.2022.05.003
Objective
To investigate whether prophylactic intracoronary administration of nicodil can reduce the incidence of NRP in STEMI patients undergoing PCI.
Methods
A total of 280 patients with persistent acute STEMI and suitable for inpatient PCI who received treatment were selected and divided into observation group（140 cases）and control group（140 cases）according to the double-blind method.The incidence of NRP,interleukin 6 and the levels of hs-CRP,cTnT and CK-MB were observed every 4 hours before and after PCI.And major adverse cardiovascular events at day 30.
Results
The incidence of NRP in the observation group was 24%,which was significantly lower than that in the control group（P<0.05）.Seven days after surgery,The observation group NT-proBNP（607.31±82.20）ng·L
-1
,CK-MB（328.00±77.95）U·L
-1
,cTnI（3.14±0.55）μg·L
-1
were significantly less than the control group NT-proBNP（734.47±82.60）ng·L
-1
,CK-1MB（440.89±88.94）U·L
-1
,cTnI（4.48±1.00）μg·L
-1
（P<0.05）.Before surgery,there were no significant differences in NT-proBNP,CK-MB and cTnI between the two groups（P>0.05）.At 7 days after operation,LVEF in the observation group was significantly higher than that in the control group（P<0.05）.At 7 days postoperatively,WMSI in the observation group was significantly lower than that in the control group（P<0.05）.Before surgery,there was no significant difference in LVEF and WMSI between the two groups（P>0.05）.The observation group（0 cases of hypotension and 6 cases of major cardiac adverse events）were significantly lower than the control group（14 cases of hypotension and 28 cases of major cardiac adverse events）（P<0.05）.
Conclusion
The results of this study will determine the effectiveness of prophylactic intracoronary administration of nicodil to reduce the incidence of NRP during PCI in patients with acute STEMI.
2022 Vol. 42 (5): 6-8 [
Abstract
] (
182
)
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9
The Effect of Atorvastatin Calcium Tablet on Neurologic Function and Serum Inflammatory Factors in Patients with Acute Ischemic Stroke
Guo Yuchang
DOI: 10.3969/j.issn.1001-8131.2022.05.004
Objective
To study the effect of atorvastatin calcium tablet on nerve function and serum inflammatory factors in patients with acute ischemic stroke.
Methods
A total of 124 patients with acute ischemic stroke were randomly divided into two groups：the control group（62 cases）and the observation group（62 cases）.Both groups received routine treatment.The control group was treated with aspirin enteric coated tablets.The observation group was treated with atorvastatin calcium tablets on the basis of the control group.Changes of menstrual function,motor function and serum inflammatory factors.
Results
After 3 months of treatment,the NIHSS score of the control group was higher than that of the observation group,and the FMA score was lower than that of the observation group（
P<
0.05）;the levels of TNF - α,IL-1 β,IL-6,CRP,GFAP,NSE and S100 β protein in the serum of the observation group were lower than that of the control group,and the difference was statistically significant（
P<
0.05）.
Conclusion
Atorvastatin can effectively reduce the level of inflammatory factors in serum,reduce the inflammatory response,promote the recovery of nerve function and motor ability,and improve the therapeutic effect.
2022 Vol. 42 (5): 9-11 [
Abstract
] (
185
)
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11
Effect of Nicergoline Tablets Combined With Batroxobin in the Treatment of Transient Ischemic Attack
Li Yanan, Zhao Jun, Chen Cong
DOI: 10.3969/j.issn.1001-8131.2022.05.005
Objective
To investigate the effect of nicergoline tablets combined with batroxobin in patients with transient ischemic attack（TIA）.
Methods
94 TIA patients were selected and divided into a control group and an observation group according to a random number table method,with 47 cases in each group.The control group was treated with routine + nicergoline tablets,and the observation group was treated with routine + batroxobin + nicergoline tablets,the treatment lasted for 2 weeks.The hemorheological indexes [whole blood viscosity（WBV）,plasma viscosity（PV）,hematocrit（HCT）,fibrinogen（FIB）] and serological indexes [matrix metalloproteinase-9（MMP-9）,angiotensin Ⅱ（ANG Ⅱ）,vascular endothelial growth factor（VEGF）] of the two groups before treatment and at 2 weeks of treatment were compared,and the times and duration of attack between the two groups were compared.
Results
Compared with before treatment,the levels of WBV,PV,HCT and FIB in both groups at 2 weeks of treatment were lower,and compared with the control group,the observation group was lower,with statistical significant differences（
P
<0.05）;compared with before treatment,the levels of serum ANG Ⅱ,MMP-9 and VEGF in both groups at 2 weeks of treatment were lower,and compared with the control group,with statistical significant differences（
P
<0.05）;compared with the control group,the times was fewer and duration was shorter of TIA in the observation group,with a statistical significant difference（
P
<0.05）.
Conclusion
Nicergoline tablets combined with batroxobin in the treatment of TIA can improve the hemorheology and serum indexes of patients,and can reduce the times of TIA and shorten the duration of symptoms.
2022 Vol. 42 (5): 11-13 [
Abstract
] (
200
)
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14
Analysis of The Significance of NT-proBNP and CTNⅠJoint Test in The Differential Diagnosis of Different Types of Arrhythmia
Zhao Zhenyan, Yu Xiaohan
DOI: 10.3969/j.issn.1001-8131.2022.05.006
Objective
To explore the significance of N-terminal pro-brain natriuretic peptide（NT-ProBNP）and cardiac troponin I（cTnI）joint test in the differential diagnosis of different types of arrhythmia.
Methods
126 patients with arrhythmia were selected.The patients were divided into ventricular early group（n=45）,atrial fibrillation group（n=40）,atrial flutter group（n=20）,and ventricular tachycardia group（n=21）.In addition,40 healthy people who underwent routine physical examination in our hospital during the same period were selected as the control group.All selected subjects were tested for NT-ProBNP and cTnI,and the levels of NT-ProBNP and cTnI were compared in the five groups.In addition,the accuracy of different indicators in the differential diagnosis of different types of arrhythmia was compared.
Results
Compared with the five groups,the control group
<
ventricular tachycardia group
<
ventricular early group
<
atrial fibrillation group
<
atrial flutter group;compared with the five groups of cTnI,the control group
<
ventricular early group
<
atrial fibrillation group
<
atrial flutter group
<
ventricular tachycardia group,The difference was statistically significant（
P<
0.05）.the accuracy of NT-ProBNP and cTnI combined in the diagnosis of different types of arrhythmia was higher than that of a single test of each index,and the difference was statistically significant（
P<
0.05）.
Conclusion
The use of NT-ProBNP and cTnI joint test in the differential diagnosis of different types of arrhythmia is helpful to make accurate judgments and improve the accuracy of diagnosis.
2022 Vol. 42 (5): 14-16 [
Abstract
] (
175
)
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16
Efficacy of Ipratropium Bromide Combined with Ceftazidime in the Treatment of Chronic Obstructive Pneumonia
Zhang Ruimei, Li Mingming, Ma Kaiyue
DOI: 10.3969/j.issn.1001-8131.2022.05.007
Objective
To analyze the therapeutic effect of ipratropium bromide combined with ceftazidime on chronic obstructive pneumonia.
Methods
A total of 92 patients with chronic obstructive pneumonia were selected as the study subjects.They were divided into control group and observation group by random number table method,with 46 cases in each group.Both groups received conventional treatment.On this basis,the control group was treated with ceftazidime for injection,and the observation group was treated with ipratropium bromide inhalation aerosol combined with ceftazidime for injection.Both groups were treated for 2 weeks.The levels of inflammatory indicators（IL-6,TNF-α,CRP）and pulmonary function indicators（FEV1/FVC,MMEF,PEF）before treatment and 2 weeks after treatment were compared between the two groups,and the incidence of adverse reactions during treatment was recorded.
Results
After 2 weeks of treatment,the levels of serum IL-6,TNF-α and CRP in the two groups were lower than those before treatment,and the observation group was lower than the control group,the difference was statistically significant（
P<
0.05）.After 2 weeks of treatment,the levels of FEV1/FVC,MMEF and PEF in the two groups were higher than those before treatment,and the observation group was higher than the control group,and the difference was statistically significant（
P<
0.05）.During the treatment period,there was no statistically significant difference in the incidence of adverse reactions between the two groups（
P<
0.05）.
Conclusion
Ipratropium bromide combined with ceftazidime in the treatment of chronic obstructive pneumonia can effectively reduce the degree of inflammation in the body and improve lung function.
2022 Vol. 42 (5): 16-18 [
Abstract
] (
198
)
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142
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19
Effect of Methyldopa Combined with Labetalol on Hemodynamics and Pregnancy Outcome in Patients with Preeclampsia
Guo Xiaoli
DOI: 10.3969/j.issn.1001-8131.2022.05.008
Objective
To analyze the effect of methyldopa combined with labetalol on hemodynamics and pregnancy outcome in patients with preeclampsia.
Methods
78 cases of preeclampsia were selected and divided into observation group（n=39）and control group（n=39）according to the drawing method.On the basis of conventional treatment,the control group was treated with magnesium sulfate,and on the basis of the control group,the observation group was treated with methyldopa and labetalol.The clinical efficacy,hemodynamics and pregnancy outcome were compared between the two groups.
Results
Compared with the control group,the clinical total effective rate of the observation group was higher（
P<
0.05）.After 1 week of treatment,map and peripheral resistance of the two groups were lower than those before treatment,and cardiac index was higher than that before treatment,and the observation group was better than the control group（
P<
0.05）.Compared with the control group,the total incidence of adverse pregnancy outcomes in the observation group was lower（
P<
0.05）.
Conclusion
The combined treatment of methyldopa and labetalol in patients with preeclampsia has definite effect,which can effectively regulate the hemodynamics of patients and improve the pregnancy outcome,which is worthy of clinical application.
2022 Vol. 42 (5): 19-21 [
Abstract
] (
152
)
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21
Clinical Observation of LARS Artificial Ligament Enhanced Repair of Acute Closed Achilles Tendon Rupture
Zhuang Jichuan, Guo Yang
DOI: 10.3969/j.issn.1001-8131.2022.05.009
Objective
To study the clinical effect of acute closed Achilles tendon rupture repaired by the Reinforcement of Ligament Advanced Reinforcement System（LARS）.
Methods
14 patients with acute closed Achilles tendon rupture underwent LARS artificial ligament enhancement repair.There were 13 males and 1 female.The patients were 29-67 years old（mean 42.79 years old）,with 6 cases on the left and 8 cases on the right.
Results
All 14 patients were followed up for 6 months.After surgery,13 patients had primary wound healing and 1 patient had secondary wound healing.No Achilles tendon rupture occurred at the last follow-up,and the subcutaneous slide of Achilles tendon was good.The American Foot and Ankle Surgery Association（AOFAS）ankle and hind foot function scores were used to evaluate the good and excellent rate of 100% at 1 month after surgery（68.1±2.1）,2 months after surgery（86.4±7.1）and 3 months after surgery（91.6±1.1）.
Conclusion
LARS artificial ligament enhancement repair acute closed Achilles tendon rupture is safe and effective,patients can carry weight early,accelerate recovery and return to exercise.
2022 Vol. 42 (5): 21-23 [
Abstract
] (
225
)
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148
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26
Effects of Extensive Hysterectomy on Bladder Function in Early Cervical Cancer By Retaining Pelvic Autologous Nerves
Yao Li, Wu Ali, Li Ying
DOI: 10.3969/j.issn.1001-8131.2022.05.011
Objective
To explore the effects of extensive hysterectomy on bladder function of early cervical cancer by retaining pelvic autologous nerves.
Methods
90 cases of cervical cancer patients were selected as the test subjects,according to the ethonectomy sampling method divided into 2 groups,control group and observation group of 45 cases,respectively,selected extensive hysterectomy treatment,retaining pelvic autologous nerve extensive hysterectomy treatment,and compared with postoperative female sexual function scale（FSFI）score,postoperative bladder residual urine volume,exhaust time,excretion time,urinary tract retention time,hospitalization rate,and statistics of urinary abnormality.
Results
The urination rate,detoo urination abnormality rate and FSFI score were lower than that of the control group（
P<
0.05）,the residual urine volume of the bladder after surgery was less than that of the control group（
P<
0.05）,and the urethra retention time,detoating time,exhaust time,and hospital stay were shorter than that of the control group（
P<
05）.
Conclusion
The extensive hysterectomy treatment of retaining pelvic autologous nerve in patients with cervical cancer has a significant effect,which can reduce the effect on postoperative sexual function and improve bladder function.
2022 Vol. 42 (5): 26-28 [
Abstract
] (
119
)
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138
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28
Analysis of Diagnostic Efficacy and Missed Diagnosis Factors of Colposcopy Cervical Biopsy in Cervical Precancerous Lesions
Zhao Yanfang, Hu Xingyun
DOI: 10.3969/j.issn.1001-8131.2022.05.012
Objective
To study the diagnostic efficacy and analyze the missed diagnosis factors of colposcopy cervical biopsy in cervical precancerous lesions.
Methods
A total of 318 patients who were transferred for colposcopy due to abnormal cervical cancer screening were prospectively enrolled as subjects.Localized biopsies of 4 biopsy sites of the cervix were performed for each patient under colposcope（including targeted biopsy and random biopsy in the lesion or suspected lesion area）in order to evaluate the diagnostic efficacy of targeted and random biopsy for cervical precancerous lesions.
Results
Among the 318 patients,173（54.40%,173/318）were pathologically diagnosed with CIN II+,and 168（97.11%,166/173）were detected by colposcopy targeted biopsy with CIN II+.The sensitivity of colposcopy result with G2 as the threshold was lower than that with G1（71.43% and 97.11% respectively）.Randomized biopsy sites can increase the detection rate of targeted biopsies（
P<
0.05）.The detection rate of 1 biopsy site was lower than that of multiple biopsy sites（diagnostic sensitivity of 1,2,4 and 4 biopsy sites were 80.35%,97.69%,100.0%,100.0%,respectively）.
Conclusion
Colposcopy cervical biopsy has good diagnostic efficacy for cervical precancerous lesions.Incremental effect can be achieved through targeted biopsy and multiple biopsies during biopsy,and better diagnostic efficacy can be obtained by combining the results of cervical cancer screening and colposcopy diagnosis.
2022 Vol. 42 (5): 28-31 [
Abstract
] (
178
)
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32
The status quo and influencing factors of antiretroviral therapy compliance in AIDS patients
Tang Zhenqun, Chen Meimei, Xu Linlin
DOI: 10.3969/j.issn.1001-8131.2022.05.013
Objective
To investigate the status and influencing factors of antiretroviral therapy compliance in AIDS patients.
Methods
The clinical data of 150 AIDS patients who were followed up and managed by our center and were referred to designated hospitals for treatment were retrospectively analyzed.All of them received antiretroviral therapy for one year.In the good compliance group and the poor compliance group,the related factors affecting their treatment compliance were analyzed.
Results
Among the 150 patients,30 had poor treatment compliance,and 120 had good compliance;univariate analysis showed that low educational level,adverse reactions during treatment,lack of understanding of disease and treatment knowledge,negative attitude towards disease and patients.Poor treatment compliance was associated with a statistically significant difference（
P<
0.05）.Logistic regression analysis showed that low educational level,adverse reactions during treatment,lack of understanding of disease and treatment knowledge,and negative attitude towards disease were independent risk factors for patients' treatment compliance（
P<
0.05 and OR≥1）.
Conclusion
The compliance of AIDS patients with antiretroviral therapy needs to be improved.Low education level,adverse reactions during treatment,lack of understanding of disease and treatment knowledge,and negative attitude towards disease are independent influencing factors.Clinical interventions should be formulated for the above factors.To improve patient compliance with treatment.
2022 Vol. 42 (5): 32-34 [
Abstract
] (
152
)
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34
Investigation on Genetic Screening of Neonates With Hereditary Deafness and Mutation Rate of Deafness Genes
Guo Jia, Zhang Airong, Liu Wanyu
DOI: 10.3969/j.issn.1001-8131.2022.05.014
Objective
To investigate the genetic screening of hereditary deafness in newborns and the mutation rate of deafness genes.
Methods
148 newborns with normal delivery were selected from the Department of Obstetrics and Gynecology of our hospital,and the peripheral blood of the newborns behind the heel was collected,and the DNA in the blood spots was extracted.Four clinically common genes related to deafness and 9 mutation sites were tested.
Results
The blood samples of 148 newborns showed that there were 9 cases of single-gene and single-heterozygous mutations in the neonatal deafness gene,and the carrying rate was 6.08%,including 6 cases（4.05%）of heterozygous mutations in the
GJB2
gene;heterozygous mutations in the
SLC26A4
gene 3 cases（2.03%）.
Conclusion
Genetic screening of hereditary deafness and the mutation rate of deafness genes can be used as an important supplement to newborn hearing function screening,which is beneficial to detect late-onset and potential deaf children,so as to implement early treatment intervention and target carrier marriage And fertility has guiding significance.
2022 Vol. 42 (5): 34-36 [
Abstract
] (
125
)
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37
Analysis of the Incidence of Delirium and Related Factors in ICU Patients After General Anesthesia
Liu Junbo, Xu Hongying, Yang Limin
DOI: 10.3969/j.issn.1001-8131.2022.05.015
Objective
To investigate the occurrence of delirium in intensive care unit（ICU）patients after general anesthesia,and to analyze its related risk factors,in order to provide a reference for patients to take preventive measures.
Methods
156 patients after general anesthesia were selected.12 hours after the operation,the ICU Confusion Assessment Scale（CAM-ICU）was used to assess whether the patients had delirium.Multivariate Logistic regression analysis was used to explore the independent risk factors for delirium.
Results
Among 156 patients after general anesthesia,62 patients were confirmed to have delirium after CAM-ICU assessment,and the incidence of delirium was 39.74%;Univariate analysis showed that the delirium group had statistics in age,acute physiology and chronic health score Ⅱ（APACHE-Ⅱ）score,history of hypertension,mechanical ventilation time,length of stay in ICU,application of sedative drugs,etc.compared with the non-delirium group Difference（
P<
0.05）;According to multivariate Logistic regression analysis,Age,APACHE-Ⅱ score,history of hypertension,mechanical ventilation time ≥6 h,length of stay in ICU,and application of sedative drugs were all independent risk factors that affected the occurrence of delirium in ICU patients after general anesthesia（
P<
0.05）.
Conclusion
The incidence of delirium is higher in ICU patients after general anesthesia.Among them,patients with age ≥ 65 years of age,APACHE-Ⅱ score,history of hypertension,mechanical ventilation time ≥ 6 hours,ICU hospitalization time,and sedative drugs have more cases of delirium.Correct preventive measures can be taken according to the appeal factors to reduce the occurrence of delirium.
2022 Vol. 42 (5): 37-39 [
Abstract
] (
167
)
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144
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39
Application of High Frequency Electrocardiogram Combined With Exercise Stress Electrocardiogram in the Diagnosis of Occult Coronary Heart Disease
Du Juan
DOI: 10.3969/j.issn.1001-8131.2022.05.016
Objective
To explore the application effect of high frequency electrocardiogram combined with exercise stress electrocardiogram in the diagnosis of occult coronary heart disease（SMI）.
Methods
A total of 70 patients with suspected SMI were prospectively selected.They were examined by high-frequency ECG,exercise stress ECG,and coronary angiography（CAG）.The results of CAG were taken as the gold standard to analyze the accuracy,sensitivity,specificity and safety of high-frequency ECG,exercise stress ECG and their combination in the diagnosis of SMI Negative predictive value（NPV）,positive predictive value（PPV）.
Results
CAG examination showed that 58 out of 70 suspected SMI patients were diagnosed as SMI,accounting for 82.86%;The accuracy and sensitivity of high frequency ECG combined with exercise stress ECG in the diagnosis of SMI were higher than that of single examination,and the difference was statistically significant（
P<
0.05）;There was no significant difference in specificity,NPV and PPV between high frequency ECG and exercise stress ECG in the diagnosis of SMI（
P>
0.05）.
Conclusion
High frequency ECG combined with exercise stress ECG can improve the diagnostic efficiency of SMI and provide effective basis for the early treatment of SMI.
2022 Vol. 42 (5): 39-41 [
Abstract
] (
112
)
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172
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42
Effect of Insulin Aspart Combined With Metformin on Blood Glucose and Pregnancy Outcome in Patients With Gestational Diabetes Mellitus
Fan Lijun, Tian Li, Shi Xuemin
DOI: 10.3969/j.issn.1001-8131.2022.05.017
Objective
To observe the effect of insulin aspart combined with metformin on blood glucose and pregnancy outcome in patients with gestational diabetes mellitus（GDM）.
Methods
110 GDM patients admitted to our hospital were selected to carry out research,and the patients were divided into control group（55 cases）and observation group（55 cases）according to the same proportion.The observers were treated with metformin on the basis of control.The changes of blood glucose level and pregnancy outcome of pregnant women in the two groups were compared,and the neonatal complications were compared between the two groups.
Results
After treatment,the levels of FPG（4.26 0.67）mmol/L,1HPG（8.11 0.23）mmol/L and 2HPG（7.41 0.38）mmol/L in the observation group were lower than those in the control group（5.12 0.87）mmol/L and（8.46）The pregnancy outcome in the observation group was better than that in the control group.The total incidence of cesarean section,polyhydramnios and macrosomia in the observation group was 12.72%,which was lower than that in the control group（30.91%,
P<
0.05）.The incidence of neonatal complications in the observation group was 10.91%,which was lower than that in the control group（27.27%,
P<
0.05）.
Conclusion
Insulin aspart combined with metformin is used to treat GDM,It can reduce the blood sugar,and the combination of the two drugs has better therapeutic effect,so that the blood sugar of patients can be controlled in the normal range,and the pregnancy outcome can be improved and the complications can be reduced,which can be popularized and applied.
2022 Vol. 42 (5): 42-43 [
Abstract
] (
134
)
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148
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44
Effect of RT PA Intravenous Thrombolytic Therapy on Acute Cerebral Infarction In Different Age Groups
Wang Yongli
DOI: 10.3969/j.issn.1001-8131.2022.05.018
Objective
To compare the efficacy of recombinant tissue plasminogen activator（RT PA）intravenous thrombolysis in patients with acute cerebral infarction at different ages.
Methods
The clinical data of 50 patients with acute cerebral infarction aged 76~91 who received RT PA intravenous thrombolytic therapy were retrospectively analyzed;The clinical data of 50 patients with acute cerebral infarction aged 60~75 who received RT PA intravenous thrombolytic therapy in the same period were included in group B;The curative effects of the two groups at the end of 7 days were compared;The laboratory indexes [D-Dimer（D-D）,fibrinogen（FIB）] of the two groups before treatment and at the end of 7 days were compared;Adverse reactions were compared between the two groups.
Results
At the end of 7 days,the effective rate of group B was higher than that of group A（
P<
0.05）;After 7 days of treatment,D-D and FIB of two groups were lower than before treatment,and group B was lower than group A,the difference was statistically significant（
P<
0.05）;During the treatment,there was no significant difference in the incidence of adverse reactions between the two groups（
P>
0.05）;
Conclusion
rt-PA intravenous thrombolytic therapy in different age groups has good curative effect,can effectively reduce the D-D,FIB levels,does not increase adverse reactions,has good safety,and the younger the age,the better the therapeutic effect.
2022 Vol. 42 (5): 44-45 [
Abstract
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187
)
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112
The Rules of Acupoint Selection in the Treatment of Knee Osteoarthritis with Acupuncture and Moxibustion：Based on Data Mining Technology
Li Lingling, Huang Hailiang
DOI: 10.3969/j.issn.1001-8131.2022.05.050
Many studies have shown that acupuncture and moxibustion has a significant effect on the treatment of knee osteoarthritis and its side effects are small.So,there is an urgent need to find a core prescription for acupuncture and moxibustion for knee osteoarthritis.
Objective
To discusses the rules of acupoint selection in the treatment of knee osteoarthritis by acupuncture and moxibustion in China,based on data mining technology and to provide some reference for clinical treatment.
Methods
Randomized controlled trials about acupuncture and moxibustion in the treatment of knee osteoarthritis were retrieved from databases of CNKI,Wanfang Data,VIP and so on,from inception to January 2022.Establish a database of acupuncture prescriptions using Microsoft Excel 2019 for descriptive analysis,and the clustering analysis and association rule analysis are carried out by IBM SPSS Statistics 26.0 and IBM SPSS Modeler 18.0 software.
Restults
Ultimately,122 studies involving 122 prescriptions,45 acupoints,total frequency 895 times were included.High frequency acupoints（frequency>10）are Dubi,Neixiyan,Xuehai,Yanglingquan,Zusanli and Liangqiu;High frequency meridians are the stomach channel of foot-yangming and the spleen channel of foot-taiyin;Specific points are mainly Wushuxue、Bahuixue and Xixue;5 clusters including Dubi-Neixiyan,Zusanli-Weizhong,Yanglingquan-Yinlingquan-Xuehai-Liangqiu-Heding,Sanyinjiao-Taixi and Guanyuan-Sshenshu-Xiyangguan were gotten by cluster analysis.The combination of acupoints with strongest support are Dubi-Neixiyan,Dubi-Liangqiu-Neixiyan,Dubi-Zusanli-Neixiyan,Dubi-Xuehai-Neixiyan,Dubi-Yanglingquan-Neixiyan and so on by relevance principle analysis.
Conclusion
The rules of acupoint selection in the treatment of knee osteoarthritis with acupuncture and moxibustion showed that main points focus on local points and the lower limbs meridian syndrome differentiation points,and pay attention to local acupoint selection,differentiation of acupoints along meridian and application of special acupoints such as Wushuxue,Bahuixue,Xixue.But in the clinical,doctor should also be combined with the specific syndromes of patients and syndrome differentiation.
2022 Vol. 42 (5): 112-117 [
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