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2023 Vol. 43, No. 4
Published: 2023-08-25
1
A Single-center Retrospective Study of Pregnancy Outcomes Associated with Systemic Lupus Erythematosus
Lin Jiayi, Wu Yingying, Zhu Yan
DOI: 10.3969/j.issn.1001-8131.2023.04.001
Objective
To investigate the pregnancy outcome and related factors of adverse pregnancy outcome in patients with systemic lupus erythematosus.
Methods
The clinical characteristics and laboratory data of 66 pregnant women with SLE were retrospectively analyzed.The groups were divided into normal group and SLE group,and the SLE group was further divided into adverse pregnancy outcome group（APO）and normal pregnancy outcome group（NPO）.
Results
The incidence of premature rupture of membranes,hypoalbuminemia,hyperuricemia and hypokalemia in SLE group was significantly higher than that in N group.The incidence of APO in SLE group was significantly higher than that in N group.The incidence of lupus nephritis and hypoalbuminemia in APO group were higher than those in NPO group.Total protein and Albumin in APO group were lower than those in NPO group,while alkaline phosphatase,γ-glutamyltransferase and uric acid were higher than those in NPO group.The positive rate of urinary occult blood and urinary protein in APO group was higher than that in NPO group.
Conclusion
1.Pregnant women with SLE are more prone to APO events.2.Among pregnant women with SLE,pregnant women with APO are more likely to have low serum Tp,Alb levels,high UA,and double positive features of urinary protein/urinary occult blood.
2023 Vol. 43 (4): 1-5 [
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101
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6
Effects of Non-invasive Ventilator Combined with Low-flow Oxygen Inhalation on Arterial Blood Gas in Elderly Patients with Acute Outbreak of COPD
Zhang Xuejiao, Wang Jintao
DOI: 10.3969/j.issn.1001-8131.2023.04.002
Objective
To investigate the effect of non-invasive ventilator combined with low-flow oxygen inhalation on arterial blood gas in elderly patients with acute outbreak of chronic obstructive pulmonary disease（COPD）.
Methods
A total of 80 elderly patients with COPD were selected and divided into two groups according to random envelope method,the control group（n=40 cases,low flow oxygen therapy）and the observation group（n=40 cases,low flow oxygen therapy + non-invasive ventilator ventilation therapy）.The pulmonary function indexes,arterial blood gas indexes and hospitalization indexes of COPD patients before and 14 days after treatment were compared between the two groups.
Results
After 14 days of treatment,the FEV1,VC and PEF50 in the observation group were higher than those in the control group（
P<
0.05）.After 14 days of treatment,the arterial blood pH of the observation group was no different from that of the control group（
P>
0.05）,PaO2 was higher than that of the control group（
P<
0.05）,and PaCO
2
was lower than that of the control group（
P<
0.05）.The total days of hospitalization and ICU stay in the observation group were less than those in the control group（
P<
0.05）,and there was no difference in the intubation rate between the observation group and the control group（
P>
0.05）.
Conclusions
Low-flow oxygen therapy combined with non-invasive ventilator ventilation in the treatment of elderly COPD patients can improve lung function,arterial blood gas,and reduce hospitalization days,and it is worthy of clinical promotion.
2023 Vol. 43 (4): 6-8 [
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131
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9
The Value of Torasemide Combined With GIK In The Treatment of Intracranial Hypertension Caused by Severe Craniocerebral Trauma
Zhang Ming, Shang Yun, Wang Yangming
DOI: 10.3969/j.issn.1001-8131.2023.04.003
Objective
To observe the value of torasemide combined with GIK in the treatment of intracranial hypertension caused by severe craniocerebral trauma.
Methods
The clinical data of 142 patients with intracranial hypertension caused by severe craniocerebral trauma treated were retrospectively analyzed,and they were divided into control group and observation group according to the medication regimen.67 cases in the control group were treated with torasemide;75 cases in the observation group were treated with torasemide combined with GIK.The GOS scores of the two groups after treatment were compared.The intracranial pressure（ICP）before treatment,30min,1h and 2h after treatment were compared.The levels of CVP,MAP,CPP and oxidative stress indexes（T-AOC,SOD,MDA）were compared between the two groups before and after treatment.The incidence of adverse drug reactions after treatment was compared between the two groups.
Results
After treatment,the GOS score of the observation group was significantly higher than that of the control group（
P<
0.05）.ICP decreased significantly in both groups,and the observation group was significantly lower than the control group（
P<
0.05）.The MDA level of the two groups decreased significantly,and the observation group was higher than that of the control group（
P<
0.05）.The levels of CVP,CPP,T-AOC and SOD were significantly increased in both groups,and the observation group was significantly higher than the control group（
P<
0.05）.There was no significant difference in MAP level and the incidence of adverse drug reactions between the two groups before and after treatment（
P>
0.05）.
Conclusions
Torasemide combined with GIK is effective in the treatment of intracranial hypertension caused by severe craniocerebral trauma.It can effectively control the symptoms of intracranial hypertension,reduce oxidative stress,and improve the prognosis of patients.It has high popularization and application value.
2023 Vol. 43 (4): 9-11 [
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79
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12
Value Explorationof Digestive Endoscopytechnology in Early Diagnosis and Treatment of Digestive Tract Tumors
Li Jin, Kou Qiongya, Zhang Lina
DOI: 10.3969/j.issn.1001-8131.2023.04.004
Objective
To study the value of digestive endoscopy technologyin the early diagnosis and treatment of digestive tract tumors（DTT）.
Methods
88 patients with DTT were selected and randomly divided into a digestive endoscopy Group（n=44）and a traditional group（n=44）.The traditional group received traditional endoscopyexamination and surgical open surgery treatment,while the digestive endoscopy group received digestive endoscopyexamination and endoscopic mucosal resection（EMR）treatment.The positive detection rate of DTT,image quality score,perioperative index and incidence of complications of the two groupswere compared.
Results
The positive detection rate of DTT in the digestive endoscopy group 95.45%（42/44）was higher than that in the traditional group 68.18%（30/44）（
P<
0.05）;Compared with the traditional group,the imaging scores of morphology,capillaries and gastric foveaclassification in the digestive endoscopy group were all lower（
P<
0.05）;Compared with the traditional group,the operation time and hospitalization days of the digestive endoscopy group were shorter,and the amount of intraoperative blood loss was less（
P<
0.05）;The incidence of complications of the digestive endoscopy group 2.27%（1/44）was lower than that of the traditional group（18.18%（8/44）（
P<
0.05）.
Conclusion
In the early diagnosis and treatment of DTT,digestive endoscopytechnology can improve the image quality and positive detection rate,reduce the amount of bleeding during operation,decrease the occurrence risk of adverse events after operation,shorten the length ofhospital stay,and have outstanding clinical diagnosis and treatment value.
2023 Vol. 43 (4): 12-14 [
Abstract
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122
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15
Application of Pyloric-vagus-preserving Gastrectomy in Early Gastric Cancer
Ye Xiang
DOI: 10.3969/j.issn.1001-8131.2023.04.005
Objective
To investigate the effects of Application of pyloric-vagus-preserving gastrectomy in early gastric cancer.
Methods
According to the principle of completely random,120 cases of early gastric cancer patients for surgical treatment in our hospital were randomly divided into DG group and PPG group.PPG group were given the pyloric-vagus-preserving gastre ctomy,and DG group were treated with conventional distal gastrectomy.To record food block and dumping syndrome and other complications occurrence of the two groups of patients after reflux;and respectively measuring body weight,serum albu-min,serum cholesterol,and other indicators of recovery and the occurrence of gall-stones of two groups of patient after 1 month,3 months,6 months,12 months,18 months and 24 months;periodic endoscopy,were observed in patients with esopha- gitis,gastritis and food residue retention occurrence;surgery after the patients were followed up for a period of five years,the two groups were observed and recorded five years after cancer recurrence and 5-year survival rate.
Results
①Incidence of postoperative complications of PPG group were significantly lower than DG group,and the difference above was statistically significant（
P<
0.05）.②The incidence of gallstones with PPG group were significantly lower than DG group,and the above difference was statistically significant（
P<
0.05）.③Postoperative residual esopha- gitis and gastritis incidence of patients PPG group were 6.8%,28.9%,which all were lower than DG group of patients（8.1%,31.1%）;Food retention rate and the incidence of bile reflux of PPG group were 8.5% and 0.0% ,which all was significantly lower than DG group（19.7%,8.2%）,and above differences were statistically significant（
P<
0.05）.④DG postoperative 5-year recurrence rate was 6.6%,mainly in the submucosa carcinoma,5-year survival rate was 91.8%;PPG group tumor recurrence after five years was 5.1%,almost all of the submucosa carcinoma 5-year survival rate was 93.2%;but more than two groups showed no significant difference（
P
=0.72 recurrence rate,P5=0.61）.
Conclusion
pyloric-vagus-preserving gastrec-tomy in the clinical treatment of early gastric cancer can be effective in preventing re-flux,food block and dumping syndrome and other postoperative complications,gallstones and bile reflux occurs,and it has important clinical value in improving the patient's quality of life.
2023 Vol. 43 (4): 15-17 [
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126
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18
Effect of CRRT on Nutrition and Micro Inflammation in Patients with Severe Infection
Ma Yan, Ding Yong, Wang Chenmeng
DOI: 10.3969/j.issn.1001-8131.2023.04.006
Objective
To investigate the effect of continuous renal replacement therapy（CRRT）on nutrition and micro inflammation in patients with severe infection.
Methods
80 cases of severe infection patients were selected to carry out the study.The control group and the observation group were set up according to the complete regionalization method.The control group was given conventional hemodialysis,and the observation group was given CRRT treatment.The clinical related indicators,malnutrition status,body micro inflammation degree,inflammatory factor level and prognosis of the two groups were compared.
Results
There was no significant difference in HR,bun and Cr levels between the two groups before treatment（
P>
0.05）;After treatment,the levels of HR,bun and Cr in the two groups were significantly lower than those in the control group（
P<
0.05）;The total incidence of malnutrition in the observation group was 10.00%,which was lower than 30.00% in the control group（
P<
0.05）;CRP and TNF were detected before treatment in both groups-αThere was no significant difference in the levels of IL-6 and IL-6（
P>
0.05）;After treatment,CRP and TNF in the two groups were significantly higher than those in the control group-α.The levels of IL-6 and IL-6 in the observation group were lower than those in the control group（
P<
0.05）;The Apache Ⅱ score of the observation group was（16.65±2.95）points,which was lower than（24.27±4.12）points of the control group,the difference was statistically significant（
P<
0.05）,and the difference in the incidence of complications between the two groups was not statistically significant（
P>
0.05）.
Conclusion
CRRT in the treatment of patients with severe infection can obtain exact clinical effect,improve the malnutrition state of the body,alleviate the degree of micro inflammation,reduce the inflammatory reaction,and can present a good prognosis.
2023 Vol. 43 (4): 18-20 [
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121
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21
Clinical Observation of Percutaneous Intraluminal Balloon Angioplasty and Vascular Stent Implantation in the Treatment of Lower Extremity Arteriosclerosis Obliterans
Zhang Guobing
DOI: 10.3969/j.issn.1001-8131.2023.04.007
Objective
To observe the clinical effect of percutaneous transluminal balloon angioplasty（PTA）and vascular stent implantation in patients with lower extremity arteriosclerosis obliterans（ASO）.
Methods
A total of 60 ASO patients treated in our hospital were selected and divided into two groups according to the random number table method,30 cases in each group.The control group was treated with PTA,and the observation group was treated with PTA and vascular stent implantation.The clinical efficacy,ankle/brachial index（ABI）,claudication distance,quality of life,complications and target lesion revascularization rate（TLR）were compared between the two groups.
Results
The postoperative health survey short form（SF-36）score of the observation group was higher than that of the control group,and the TLR was lower than that of the control group,with statistical differences（
P<
0.05）.There was no statistical difference in the total incidence（
P>
0.05）.
Conclusion
The treatment effect of PTA or PTA combined with vascular stent implantation in ASO patients is similar,but PTA combined with vascular stent implantation in ASO patients can reduce TLR and improve the quality of life of patients,which can be used as a more effective interventional operation for the treatment of ASO.
2023 Vol. 43 (4): 21-23 [
Abstract
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100
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24
Effect of Continuous Intensive Insulin Pump Therapy on Blood Glucose Control and Neonatal Delivery Outcome in Patients with Gestational Diabetes Mellitus
Wu Yang, Shi Lifang, Feng Chunyan
DOI: 10.3969/j.issn.1001-8131.2023.04.008
Objective
To investigate the effect of continuous intensive insulin pump therapy on blood glucose control and neonatal delivery outcome in patients with gestational diabetes mellitus（GDM）.
Methods
70 GDM patients were randomly divided into control group and observation group,35 cases in each group;The control status of fasting plasma glucose（FPG）and plasma glucose 2 hours after meal（2hPG）were compared between the two groups.
Results
FPG and 2hPG decreased after treatment,and the decrease in observation group was more obvious than that in control group（
P<
0.05）.The total adverse outcome of neonatal delivery in the observation group（14.29%）was significantly lower than that in the control group（37.14%）（
P<
0.05）.The total incidence of adverse events in the observation group（20.00%）was significantly lower than that in the control group（42.86%）（
P<
0.05）.
Conclusion
Continuous intensive treatment of GDM patients with insulin pump can effectively control blood glucose,reduce the incidence of adverse neonatal outcomes and maternal adverse events.
2023 Vol. 43 (4): 24-26 [
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140
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27
Changes of Coagulation Function in Elderly Bedridden Patients and Its Predictive Value for DVT Formation
Qu Xiaodong, Yang Guang, Gong Hongmei
DOI: 10.3969/j.issn.1001-8131.2023.04.009
Objective
To analyze the changes of coagulation function in elderly bedridden patients and its predictive value for deep vein thrombosis（DVT）.
Methods
58 patients who underwent lower limb fracture surgery and developed DVT after surgery were selected as DVT group,and 65 patients who underwent lower extremity fracture surgery at the same time and did not have DVT after surgery were selected as non DVT group.The changes of five indexes of coagulation function before operation and 3 days after operation during bed rest were observed.Binary Logistic regression was used to analyze the correlation between coagulation function indexes and DVT.Receiver operating characteristic（ROC）curve was used to evaluate the predictive efficacy of coagulation function indexes for DVT.
Results
The levels of PT,APTT,TT,FIB and D-D in the DVT group were significantly higher than those in the non-DVT group（
P<
0.05）.Logistic analysis showed that FIB（OR=2.363,95%,CI：1.462-3.820）and D-D（OR=1.013,95%,CI：1.007-1.019）were independent risk factors for DVT（
P<
0.05）.ROC curve analysis showed that the AUC of FIB was 0.694,the best cut-off value was 4.23g/L,the AUC of D-D was 0.797,the best cut-off value was 501.95μg/L,and the AUC of combined prediction was 0.918.
Conclusions
The coagulation function of elderly patients with lower extremity fracture increased during postoperative bed rest.FIB and D-D are independent risk factors for DVT,which have certain predictive value for DVT.
2023 Vol. 43 (4): 27-29 [
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149
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30
Study on the Correlation Between the Number of Abortions,Genital Tract Infection and Preterm Premature Rupture of Membranes
Lu Cuiqin
DOI: 10.3969/j.issn.1001-8131.2023.04.010
Objective
To explore the relationship between the number of abortions,reproductive tract infections and preterm premature rupture of membranes,and to analyze their influence on pregnancy outcome.
Methods
57 patients with preterm preterm premature rupture of membranes（PPROM）in our hospital were selected as the research objects,and 55 patients with term premature rupture of membranes（TPROM）during the same period were selected as reference,and the patients were collected Relevant data,conduct univariate and multivariate analysis of PPROM,compare the pregnancy outcomes of PPROM patients and TPROM patients,including maternal outcomes（puerperal infection,cesarean section,postpartum hemorrhage）and neonatal outcomes（Agper score<7 points,newborn Asphyxia,neonatal infection）.
Results
PPROM patients had more than one abortion and the incidence of reproductive tract infections were higher than those of TPROM patients（
P<
0.05）;the number of abortions>1 time and genital tract infection are independent risk factors for PPROM（
P<
0.05）;The incidence of neonatal Agper score<7,neonatal asphyxia,and neonatal infection in PPROM patients was higher than that of TPROM patients（
P<
0.05）.
Conclusion
Frequent abortions and genital tract infections are important factors in the occurrence of PPROM,which can increase the incidence of neonatal asphyxia and infection,and affect the developmental status of newborns.This suggests that clinical attention should be paid to pregnant women with abortions>1 and genital tract infections.Check and understand the state of pregnancy,deal with any abnormalities in time,strengthen health education during pregnancy,maintain personal hygiene,prevent reproductive tract infections,and reduce the incidence of PPROM.
2023 Vol. 43 (4): 30-31 [
Abstract
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106
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32
The Value of Real-time Ultrasound Elastography Combined with Color Doppler Ultrasound in the Differential Diagnosis of Benign and Malignant Cervical Space-occupying Lesions
Xia Xinguang
DOI: 10.3969/j.issn.1001-8131.2023.04.011
Objective
To explore the diagnostic value of color Doppler ultrasound combined with real-time ultrasound elastography technology in benign and malignant cervical space occupying lesions.
Method
100 patients with cervical space occupying lesions were selected,all of whom underwent real-time ultrasound elastography and transvaginal color Doppler ultrasound examination.Using pathological results as the "gold standard" to analyze pathological examination,single and combined examination results;Analyze the diagnostic value of single and combined examinations in cervical space occupying lesions and calculate consistency.
Results
Compared with single examination,the sensitivity,accuracy and negative predictive value of combined examination were higher in the diagnosis of cervical space-occupying lesions（
P<
0.05）.Kappa test showed that the real-time ultrasound elastic imaging technology,joint examination and "gold standard" were in good agreement（kappa=0.817,0.955,
P=
0.000,0.000）;The consistency between color Doppler ultrasound and "gold standard" is acceptable（kappa value=0.570,
P=
0.000）.
Conclusion
The application of real-time ultrasound elastography combined with color Doppler ultrasound in the diagnosis of cervical space-occupying lesions is of high value.The detection rate of benign and malignant lesions is high,and the consistency is strong.It is helpful for clinical diagnosis and worthy of popularization and application.
2023 Vol. 43 (4): 32-34 [
Abstract
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118
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35
Influenceof Diazepam Combined with Phenobarbital Treatmenton Symptom Control Duration of Febrile Convulsion in Children
Jin Dan, Chen Qisheng
DOI: 10.3969/j.issn.1001-8131.2023.04.012
Objective
To study the influence of diazepam combined with phenobarbital treatmenton the symptom control duration of febrile convulsion in children.
Methods
104 cases of febrile convulsion in children were selected and randomly divided into a combined drug group（n=52）and a single drug group（n=52）.The single drug group used diazepam,and the combined drug group added phenobarbital on this basis.The therapeutic effect,drug onset time,convulsion improvement time,body temperature recovery time,hospitalization time,myocardial enzyme levels [creatinephosphate kinase（CK）,lactate dehydrogenase（LDH）,creatine kinase isoenzyme（CKI）],brain nerve related factors [neuropeptide Y（NPY）,neurotrophic factor（BDNF）] andchanges of adverse reactions occurrence rate of the two groups were compared.
Results
The total effective rate of the combined drug group 94.23%（49/52）washigher than that of the single drug group 73.08%（38/52）,with a statistical difference（
P<
0.05）;Compared with the single drug group,the drug onset time,convulsion improvement time,body temperature recovery time and hospitalization time of the combined drug group were shorter（
P<
0.05）;Compared with the single drug group,the levels of CK,CKI and LDH in the combined drug groupafter treatment were lower,with statistical differences（
P<
0.05）;Compared with the single drug group,the levels of NPY and BDNF in the combined drug groupafter treatment were lower,with statistical differences（
P<
0.05）;There was no significant difference in the incidence of adverse reactions between the combination group 3.85%（2/52）and the single drug group 11.54%（6/52）（
P>
0.05）.
Conclusion
Diazepam combined with phenobarbital in treating febrile convulsions in childrenhas obvious curative effect.It can improve clinical symptoms,regulate the level of myocardial enzymes and the expression of brain nerve factors,and is safe to use,which can be further promoted and applied in clinical practice.
2023 Vol. 43 (4): 35-37 [
Abstract
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134
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38
Relationship Between Th1/Th2 Balance and 25-hydroxy Vitamin D in Children with Recurrent Respiratory Tract Infection
Wang Ruifen, Li Yuehua
DOI: 10.3969/j.issn.1001-8131.2023.04.013
Objective
To investigate the relationship between Th1/Th2 balance and 25-hydroxy vitamin D（25（OH）D）in children with recurrent respiratory tract infection（RRTI）.
Methods
The clinical data of 68 children with RRTI were retrospectively analyzed,and the children with RRTI were included in the observation group.The children in the observation group were divided into observation group 1（n=42,respiratory tract infection occurred<5 times within 1 year of follow-up）and observation group 2（n=26,respiratory tract infection occurred ≥5 times within 1 year of follow-up）according to the prognosis difference,and 68 healthy children were selected as the control group.The levels of Th1,Th2,Th1/Th2 and 25（OH）D were compared between the two groups.Pearson analysis was used to analyze the correlation between Th1/Th2 balance and 25（OH）D.The differences of Th1/Th2 and 25（OH）D levels between observation group 1 and observation group 2 were compared,and the predictive efficacy of Th1/Th2 and 25（OH）D levels on prognosis was evaluated by ROC curve.
Results
Th1 and Th1/Th2 in the observation group were greater than those in the control group,and the difference was statistically significant（
P<
0.05）.Th2 and 25（OH）D in the observation group were significantly lower than those in the control group（
P<
0.05）,and the difference was statistically significant（
P<
0.05）.Pearson analysis showed that Th2 was positively correlated with 25（OH）D,while Th1,Th1/Th2 were negatively correlated with 25（OH）D（
P<
0.05）.The level of 25（OH）D in observation group 1 was higher than that in observation group 2,and the difference was statistically significant（
P<
0.05）.The AUC of Th1/Th2 was 0.651,95% CI=0.526-0.763,the sensitivity was 45.24%,the specificity was 84.62%,and the cutoff value was≤1.39.The AUC of 25（OH）D was 0.798,95% CI =0.683-0.885,the sensitivity was 92.86%,the specificity was 50.00%,and the cutoff value was>38.99mmol/L.
Conclusions
Th1/Th2 and 25（OH）D levels in children with RRTI are closely related,and the above indicators have a certain predictive effect on prognosis.In clinical diagnosis and treatment of children with RRTI,vitamin D supplementation can be given to improve the immune status,thereby improving the prognosis.
2023 Vol. 43 (4): 38-40 [
Abstract
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79
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41
Analysis of Drug Resistance Genes and Virulence Factors of Carbapenem-resistant Pseudomonas Aeruginosa Bloodstream Infection
Liu Jing, Han Jing, Wu Xiaosha, Ma Yuqin
DOI: 10.3969/j.issn.1001-8131.2023.04.014
Objective
To analyze the drug resistance genes and virulence factors of carbapenem-resistant pseudomonas aeruginosa（CR-PA）bloodstream infection（BSI）.
Methods
A total of 156 inpatients with pseudomonas aeruginosa（PA）BSI were selected as the research subjects,51 strains of CR-PA were obtained after culturing their blood,urine,sputum and other samples.The antibacterial drug susceptibility test results of CR-PA and the positive detection rate of drug resistance genes and virulence genes were analyzed.
Results
Among the 51 CR-PA strains,the antibacterial drugs with the resistance rate≥50% were cefepime , meropenem , amikacin,cotrimoxazole , gentamicin and imipenem from high to low. Antibacterial drugs with the resistance rate≥50% were piperacillin+tazobactampyocyanin, ciprofloxacin and ticarcillin from high to low. Among them,piperacillin+tazobactampyocyanin was the antibacterial drug with the lowest resistance rate and the highest drug sensitivity rate.Among the 51 strains of CR-PA,the positive rate of resistance gene ant（2''）-I（58.82%）and virulence gene plcH（100.00%）were the highest.And the drug resistance genes with a positive rate over 50.00% were aprA（98.04%）,exoS（92.16%）,algD（82.35%）,exoT（82.35%）,and exoU（68.63%）.
Conclusions
The drug resistance genes and virulence genes are widely distributed in CR-PA of BSI patients,and the clinical isolation rate of drug resistance gene ant（2''）-Ⅰ and virulence gene plcH is high.
2023 Vol. 43 (4): 41-43 [
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107
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44
Application of Ultrasound Combined with DR In the Localization of Soft Tissue Foreign Body Removal
Tan Yun, Zhang Li, Huang Yan
DOI: 10.3969/j.issn.1001-8131.2023.04.015
Objective
To explore and analyze the application effect of ultrasound combined with digital X-ray system（DR）in the localization of soft tissue foreign body removal.
Methods
92 cases in our hospital for soft tissue foreign bodies of the patients were divided into observation group and control group,control group given conventional surface positioning,observation group was given ultrasonic joint DR auxiliary real-time positioning,compared two groups of patients with foreign bodies,surgical success rate index and postoperative complications occurred;
Results
The success rate of foreign body removal in the observation group was 82.61%,which was significantly higher than that in the control group（54.35%）.The operation time and incision length were significantly shorter than those in the control group,the intraoperative blood loss was significantly lower than that in the control group,and the foreign body removal rate within 15 minutes was 76.09%,which was significantly higher than that in the control group（13.04%）.The incidence of postoperative complications was 2.17%,which was significantly lower than 19.57% in control group（
P<
0.05）.
Conclusion
Ultrasound combined with DR Positioning assisted soft tissue foreign body removal can significantly improve the success rate of foreign body removal,shorten the operation time and incision,reduce intraoperative blood loss,reduce the patient's bed,reduce complications,and promote postoperative recovery of patients,with significant advantages,and it is recommended to be promoted.
2023 Vol. 43 (4): 44-45 [
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130
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46
Evaluation of the Efficacy of Highly Selective Pterygoid Canal Neurotomy on Perennial Allergic Rhinitis
Fu Wenyuan, Tao Shudong
DOI: 10.3969/j.issn.1001-8131.2023.04.016
Objective
To investigate the clinical efficacy of highly selective pterygoid canal neurotomy in the treatment of perennial allergic rhinitis.
Methods
100 patients with perennial allergic rhinitis were randomly selected and divided into a control group and a study group,with 50 patients in each group.The control group received conventional functional endoscopic nasal cavity-sinus surgery,while the study group received endoscopic assisted highly selective pterygoid neurotomy (Preserve the orbital branch of the pterygoid canal nerve).The nasal symptom visual analogue scale（VAS） and rhinoconjunctivitis quality of life questionnaire（RQLQ） were used to statistically analyze the improvement of preoperative and postoperative quality of life,nasal congestion,sneezing,and runny nose in two groups of patients,and to analyze the difference in efficacy between the two treatment methods.
Results
There was no statistically significant difference in the VAS score and RQLQ score of rhinitis symptoms between the two groups of patients before surgery（
P
>0.05）;The VAS score and RQLQ score of postoperative rhinitis symptoms in the control group were higher than those in the study group,with a statistically significant difference between the two groups（
P
<0.001）.
Conclusion
For perennial Allergic rhinitis cases,highly selective pterygoid neurotomy is a more effective surgical treatment compared to conventional functional endoscopic nasal cavity-sinus surgery.
2023 Vol. 43 (4): 46-49 [
Abstract
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119
)
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81
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83
The Value of MRI DWI Combined with PWI in the Diagnosis and Grading of Intracranial Glioma
Zhao Xiaopei, Yang Rongrong
DOI: 10.3969/j.issn.1001-8131.2023.04.029
Objective
To investigate the application value of MRI diffusion weighted imaging（DWI）combined with perfusion weighted imaging（PWI）in the diagnosis and grading of intracranial gliomas.
Methods
The data of 55 patients with intracranial glioma admitted to our hospital were reviewed.All patients were pathologically confirmed as intracranial glioma,including 21 cases of high-grade glioma and 34 cases of low-grade glioma.All patients received conventional MRI,DWI and PWI,and compared the detection rate of different methods and DWI combined with PWI.ADC and CBV were obtained,and the ADC and CBV were compared between the tumor parenchymal region and the corresponding region of the healthy side.The rADC value and rCBV were obtained,and the ROC curve was used to analyze the diagnostic efficacy of different grades of glioma.
Results
The detection rate of intracranial glioma by different methods was statistically significant（
P<
0.05）.The detection rate of DWI combined with PWI was higher than that of conventional MRI and DWI,and the detection rate of PWI was higher than that of conventional MRI（
P<
0.05）.ADC and CBV in the tumor parenchyma area were higher than those in the corresponding region of the healthy side,and the difference was statistically significant（
P<
0.05）.The rADC value of patients with high-grade glioma was lower than that of patients with low-grade glioma,and the rCBV value was higher than that of patients with low-grade glioma,and the difference was statistically significant（
P<
0.05）.According to ROC curve analysis,the AUC values of rADC,rCBV and combined judgment of glioma grading were 0.841,0.822 and 0.916,respectively.
Conclusions
MRI? DWI and PWI can effectively detect intracranial glioma,and the combined examination of DWI and PWI can improve the diagnostic efficacy of intracranial glioma grading.
2023 Vol. 43 (4): 83-85 [
Abstract
] (
107
)
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69
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124
Effect of Matrine on Proliferation Invasion and TGF-β1/Smad4 Protein Expression to colon cancer cell line SW620
Wan Liyan, Wang Hao, Jiang Hanwen, Chen Xiaohua, Chen Shuilian, Chen Zhishan, Yu Qian, Tian Ying, Tong Qiang
DOI: 10.3969/j.issn.1001-8131.2023.04.046
Objective
To investigate the effect of matrine on proliferation,invasion and TGF-β1,Smad4 protein expression in colon cancer cell line SW620.
Methods
The effect of matrine on proliferative activity in SW620 cells were evaluated by CCK8 assay and colony formation assay.The effect of matrine on migration and invasion ability in SW620 cells were evaluated by Transwell assay.Quantitative analysis the effect of matrine on Ki-67,E-cadherin,TGFβ1 and Smad4 proteins expression in SW620 cell blocks by Immunohistochemistry.
Results
The proliferation and invasion of SW620 cells were significantly weakened after matrine treatment.TGF-β1 and Smad4 proteins expression in SW620 cells were absent,matrine had no significant effect on the proteins expression of TGF-β1 and Smad4.
Conclusion
Matrine can inhibit the proliferation and metastasis of SW620 cells,but the TGF-β1/Smad4 signaling pathway mechanism may be independent.
2023 Vol. 43 (4): 124-127 [
Abstract
] (
86
)
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