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2023 Vol. 43, No. 5 Published: 2023-10-25

	1	Epidemiological Characteristics and Preventive Measures of Amblyopia Among Children Aged 7-12 years in Some Urban Areas of Kaifeng City
		Hu Tingting, Chao Xiaorui, Xie Yanyan
		DOI: 10.3969/j.issn.1001-8131.2023.05.001
		Objective To analyze the epidemiological characteristics of amblyopia in children aged 7-12 years old in some urban areas of Kaifeng City,and to explore the preventive measures.Methods Stratified random cluster sampling method was used to select 34690 children from 5 primary schools in part of Kaifeng City.All the children with uncorrected visual acuity were examined.Mydriasis optometry and fundus examination were further carried out for children with uncorrected visual acuity < 0.7,and amblyopia was diagnosed according to the "amblyopia diagnosis expert consensus（2011）".The prevalence of amblyopia children with different ages,genders and types of amblyopia was statistically analyzed.The influencing factors of amblyopia were analyzed by univariate and multivariate logistic regression.Results Among 34690 children in Kaifeng City,298 cases were amblyopia,and the prevalence rate was 0.84%.The prevalence of amblyopia in male and female was 0.86% and 0.85%,respectively;The prevalence of amblyopia was 0.75%,0.82% and 1.02% in 7-8 years old,9-10 years old and 11-12 years old;The percentages of ametropia,anisometropia,strabismus and form deprivation amblyopia were 45.97%,34.22%,12.75% and 7.04%,respectively;Univariate analysis showed that there were significant differences in the proportion of strabismus,amblyopia family history and premature birth history between the two groups（P<0.05）;Multivariate logistic regression analysis showed that strabismus（P=0.020,or=4.170）,family history of amblyopia（P=0.018,or=3.550）and preterm birth history（P=0.007,or=2.399）were the independent influencing factors of amblyopia.Conclusion The prevalence of amblyopia in children aged 7-12 years old in some urban areas of Kaifeng City is 0.84%,and refractive factors are the main causes of amblyopia.And strabismus,amblyopia family history,premature birth history are the independent influencing factors of amblyopia.We should effectively control the relevant factors and implement targeted amblyopia prevention measures to reduce the prevalence of amblyopia in Kaifeng City.
		2023 Vol. 43 (5): 1-4 [Abstract] ( 104 ) HTML (1 KB) PDF (413 KB) ( 144 )

	4	Analysis of Application Value of Irbesartan Hydrochlorothiazide Combined with Metoprolol in Elderly Patients with Heart Failure
		He Lei, Xing Ying, Wang Haiyang
		DOI: 10.3969/j.issn.1001-8131.2023.05.002
		Objective To explore the efficacy of Irbesartan hydrochlorothiazide combined with metoprolol in elderly patients with heart failure.Methods 74 elderly patients with heart failure were selected and divided into a combination group（n=37）and a single group（n=37）according to the random number table method.The single group was given metoprolol,and the combined group was given metoprolol + Irbesartan hydrochlorothiazide.The curative effect,B-type brain natriuretic peptide（BNP）,heart rate（HR）,6-min walking test,high-sensitivity C-reactive protein（hs-CRP）level and adverse reactions were compared between the two groups.Results Compared with 72.97%（27/37）of the single group,the total effective rate of the combined group94.59%（35/37）washigher（P<0.05）;Compared with the single group,the HR of the combined group after treatment was lower,the 6-min walking test was longer,and the levels of BNP and hs-CRP were lower（P<0.05）;The incidence of adverse reactions in the combined group 8.11%（3/37）was lower than that in the single group 27.03%（10/37）（P<0.05）.Conclusion Irbesartan and hydrochlorothiazide combined with metoprolol in the treatment of elderly patients with heart failure can improve the curative effect,improve thecardiac function,and cardiac function,and is safe and reliable.
		2023 Vol. 43 (5): 4-6 [Abstract] ( 84 ) HTML (1 KB) PDF (443 KB) ( 69 )

	7	Application of Ambroxol Combined with Moxifloxacin In The Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease in Acute Exacerbation
		Li Shujun
		DOI: 10.3969/j.issn.1001-8131.2023.05.003
		Objective To investigate the efficacy of ambroxol combined with moxifloxacin in the treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）.Methods A total of 80 patients with AECOPD were included in the study.According to the treatment method,moxifloxacin+conventional treatment were included in the control group（40 cases）,and moxifloxacin+ambroxol+conventional treatment were included in the observation group（40 cases）.Both groups were treated for 12 days.The levels of serum inflammatory factors [C-reactive protein（CRP）and procalcitonin（PCT）] before and after 12 days of treatment were compared between the two groups;The disappearance time of cough,sputum and lung moist rales and the incidence of adverse reactions during treatment were compared between the two groups.Results The levels of CRP and PCT in the two groups decreased after 12 days of treatment compared with those before treatment,and the decrease in the observation group was greater（P<0.05）;The disappearance time of cough,expectoration and lung moist rales in the observation group was shorter than that in the control group（P;The incidence of adverse reactions was compared between the two groups（P>0.05）.Conclusion Ambroxol combined with moxifloxacin can effectively alleviate the inflammatory reaction and clinical symptoms of AECOPD patients,without increasing adverse reactions.
		2023 Vol. 43 (5): 7-9 [Abstract] ( 113 ) HTML (1 KB) PDF (284 KB) ( 55 )

	9	Effects of Laparoscopic Minimally Invasive Therapy on Serum Bilirubin and γ-GT in Patients with Common Bile Duct Stones
		Yin Pengchang, Jiao Guanghui, Zhao Liangzhu
		DOI: 10.3969/j.issn.1001-8131.2023.05.004
		Objective To investigate the effect of laparoscopic minimally invasive therapyon serum bilirubin and γ-GT in patients with common bile duct stones.Methods A total of 120 patients with common bile duct stones were selected and randomly divided into the experimental group and the control group according to the drawing method,with 60 cases in each group.The experimental group was given laparoscopic choledocholithiasis,and the control group was given traditional choledocholithotomy.The perioperative indexes of the two groups were compared.Before and after surgical treatment,the differences of γ-GT,TBIL,DBIL and IBIL between the two groups were compared,and the differences of postoperative complication rate and recurrence rate between the two groups were compared.Results The blood loss,operation time and hospital stay in the experimental group were smaller than those in the control group（P<0.05）.There was no significant difference between the two groups in the one-time stone clearance rate（P>0.05）,The levels of hγ-GT,TBIL,DBIL and IBIL in the two groups at 24 hours after operation were lower than those before operation,and those in the experimental group were lower than those in the control group（P<0.05）.There was no significant difference in the incidence of postoperative complications and the recurrence rate of stones between the two groups（P>0.05）.Conclusions The application of laparoscopic minimally invasive therapyin the treatment of common bile duct stones can help reduce intraoperative injury and liver function,shorten operation time,accelerate postoperative recovery,and improve prognosis.
		2023 Vol. 43 (5): 9-11 [Abstract] ( 105 ) HTML (1 KB) PDF (428 KB) ( 63 )

	12	Application Value and Safety of Dissecting and Exposing the Recurrent Laryngeal Nerve at the Entrance To the Larynx in Thyroid Lobectomy
		Li huili, Kong weibo, Chang yongke
		DOI: 10.3969/j.issn.1001-8131.2023.05.005
		Objective To investigate the applicationeffect of exposing recurrent laryngeal nerve at the laryngeal entrance in thyroid lobectomy.Methods A total of 94 case patientswho underwent thyroidlobectomy were selected and divided into a control group and an experimental group according to the random number table method,with 47 cases in each group.The control group was exposed below the thyroid artery,while the experimental group exposed the recurrent laryngeal nerve at the laryngeal entrance.The changes of perioperative indexes,thyroid function [thyroxine（T4）,free thyroxine（FT4）,parathyroid hormone（PTH）],vocal cord function[fundamental frequency,harmonic generation ratio（HNR）,normalized noise energy（NNE）],and the incidence of complications of the two groupswere compared.Results Compared with the control group,the operation time and hospitalization time of the experimental group were shorter,the amount of intraoperative blood loss was less,and the pain score on the first day after operationwas lower（P<0.05）;Compared with the control group,the levels of FT4,PTH and T4 in the experimental group3 days after operation were higher（P<0.05）;Compared with the control group,the fundamental frequency and NNE of the experimental group one month after operation were lower,and the HNR was higher（P<0.05）;The complication rate of the the experimental group 8.51%（4/47）was lower than that of the control group 25.53%（12/47）（P<0.05）.Conclusion Anatomical exposure of the recurrent laryngeal nerve into the larynx has a significant effect in thyroid lobectomy,which can improve the perioperative indicators,improve the thyroid function and vocal cord function,and can reduce the incidence of complicatios.It is worthy of further clinical application.
		2023 Vol. 43 (5): 12-14 [Abstract] ( 81 ) HTML (1 KB) PDF (416 KB) ( 65 )

	15	Epidural Anesthesia Combined with Low Dose Intravenous AnesthesiaEffect on Hemodynamic Stability and Adverse Reactions in Patients with Total Hip Replacement
		Chen Ganxian, Yuan Guichan, Yu Zhibin
		DOI: 10.3969/j.issn.1001-8131.2023.05.006
		Objective To study the clinical effect of epidural anesthesia combined with low dose intravenous anesthesia on patients undergoing total hip replacement.Methods 40 patients who received total hip arthroplasty were selected and divided into control group and observation group according to the different anesthesia methods selected during the operation.20 patients in the control group received epidural anesthesia during the operation,and 20 patients in the observation group received epidural anesthesia combined with low-dose intravenous anesthesia during the operation.The anesthesia effect,adverse reaction caused by anesthesia,onset time of anesthesia,total block time,total recovery time of anesthesia,total hospitalization time,blood rheology,blood pressure,heart rate and partial pressure of cerebral oxygen before and after anesthesia were compared between the two groups.Results The total effective rate of surgical anesthesia in the observation group was higher than that in the control group,and there was a statistically significant difference between the two groups（P<0.05）;The adverse reactions caused by anesthesia in the observation group were less than those in the control group,and the data between the groups were statistically significant（P<0.05）;The onset time of anesthesia,the time of complete anesthesia,the time of complete recovery from anesthesia,and the total time of hospitalization in the observation group were shorter than those in the control group,and the data between the groups were statistically significant（P<0.05）;The changes of hemorheology,blood pressure,heart rate and partial pressure of cerebral oxygen in the observation group before and after anesthesia were smaller than those in the control group,and the data between the groups were statistically significant（P<0.05）.Conclusion Epidural anesthesia combined with low dose intravenous anesthesia can minimize the adverse effects on hemorheology,blood pressure,heart rate and partial pressure of cerebral oxygen,reduce related adverse reactions,shorten the onset of anesthesia and the time of awakening,and significantly improve the anesthetic effect.
		2023 Vol. 43 (5): 15-17 [Abstract] ( 84 ) HTML (1 KB) PDF (402 KB) ( 60 )

	18	Correlation Between Serum GLP-1 Expression Level and Adverse Maternal and Infant Outcomes in Patients with Gestational Diabetes in the Middle and Late Stages
		Li Guangduo
		DOI: 10.3969/j.issn.1001-8131.2023.05.007
		Objective To study the relationship between the adverse maternal and infant outcomes of pregnant women with diabetes in the middle and late stages and the level of serum glucagon like peptide-1（GLP-1）expression.Methods 104 cases of pregnant women with diabetes in the middle and late stages of pregnancy were selected as research objects,and the incidence of adverse maternal and infant outcomes was analyzed.The correlation between the expression of GLP-1 in serum of pregnant women with diabetes in the middle and late stages of pregnancy and adverse maternal and infant outcomes was analyzed.Results Among 104 cases of gestational diabetes in the middle and late stages,19 cases had macrosomia,12 cases had fetal distress,11 cases had neonatal asphyxia,4 cases had placental abruption,and 3 cases had premature rupture of membranes.The incidence of adverse maternal and infant outcomes was 47.12%（49/104）;The level of GLP-1 in patients with poor maternal and infant outcomes was lower than that in patients with good maternal and infant outcomes,the difference was statistically significant（P<0.05）;Logistic regression analysis showed that the low level of GLP-1 expression was the influencing factor for the poor maternal and infant outcomes of pregnant women with diabetes in the middle and late stages（OR>1,P<0.05）.Conclusion The low level of serum GLP-1 expression in patients with diabetes in the middle and late pregnancy can increase the risk of adverse maternal and infant outcomes.Therefore,reasonable measures can be taken to monitor and regulate the dynamic balance of blood glucose in patients,so as to promote the return of GLP-1 expression to normal,which has positive significance for improving maternal and infant outcomes in patients with diabetes in the middle and late pregnancy.
		2023 Vol. 43 (5): 18-20 [Abstract] ( 92 ) HTML (1 KB) PDF (453 KB) ( 58 )

	20	The Effect of Dienogest in the Treatment of Ovarian Endometriosis on Cyst Diameter Related Pain and Ovarian Reserve
		Tian Huazhong
		DOI: 10.3969/j.issn.1001-8131.2023.05.008
		Objective To evaluate the effects of drug treatment of ovarian endometriosis on cyst diameter,related pain and ovarian reserve,such as the antral follicle count（AFC）and anti-Müllerian hormone（AMH）measurement.Methods A total of 32 patients were selected and all received 6 months of dienogest.Before treatment and at the end of 6 months of treatment,the patient's cyst diameter,number of AFCs of affected ovaries,number of AFCs of unaffected ovaries,AMH and VAS scores were compared.Results The diameter of the cyst before treatment was（4.05±0.75）cm,the AFC of the affected ovaries（4.16±1.66）,and the VAS score（6.80±0.85）were compared with the diameter of the cyst after 6 months of treatment（2.66±0.71）.）cm,AFC of the affected ovary（8.32±2.33）,VAS score（0.87±0.54）,the diameter of the cyst was significantly reduced after 6 months of treatment,the number of AFCs of the affected ovary was significantly increased,and the VAS score was significantly reduced.And the differences were statistically significant（P<0.05）.Drug treatment with dienogest significantly reduced the diameter and associated pain of endometriosis,AFC was significantly improved,and AMH did not change significantly.Conclusion Our findings indicate that carbocysteine has a positive effect on the frequency and duration of acute attacks in patients with bronchiectasis,and it is well tolerated.
		2023 Vol. 43 (5): 20-22 [Abstract] ( 94 ) HTML (1 KB) PDF (399 KB) ( 56 )

	23	To Analyze the Effect and Safety of Dinoprostone Suppository and Oxytocin in Term Induced Labor
		Miao Yixuan
		DOI: 10.3969/j.issn.1001-8131.2023.05.009
		Objective To compare and analyze the effect and safety of dinoprostone suppository and oxytocin in term induced labor.Methods 82 pregnant and lying in women were randomLy selected.The pregnant and lying in women were divided into control group and observation group by random number table.The control group（n=41）was given oxytocin,and the observation group（n=41）was given dinoprostol suppository.The effect of labor induction,delivery mode,induced labor time,postpartum hemorrhage and adverse reactions of the two groups were compared,The birth process of the two groups of naturally delivered pregnant women was compared.Results The effect of induced labor in the observation group was significantly better than that in the control group,and the total effective rate of induced labor in the two groups was significantly different（P<0.05）.The vaginal delivery rate in the observation group was higher than that in the control group,and the cesarean section rate was lower than that in the control group.There was a statistically significant difference between the two groups in delivery methods（P<0.05）.Compared with the two groups,the time of induced labor in the observation group was shorter,and the amount of postpartum hemorrhage was less.The difference between the two groups was statistically significant（P<0.05）.The first stage of labor,the second stage of labor and the total stage of labor in the observation group were shorter than those in the control group（P<0.05）,and there was no significant difference in the third stage of labor between the two groups（P>0.05）.There was no significant difference in the total incidence of adverse reactions between the two groups（>0.05）.Conclusion Dinoprostone suppository can effectively shorten the induced labor time,improve the natural labor rate,shorten the labor process,and has high drug safety,which is worthy of clinical application.
		2023 Vol. 43 (5): 23-25 [Abstract] ( 86 ) HTML (1 KB) PDF (410 KB) ( 61 )

	26	Study on the Expression of Serum Troponin I,Creatine Kinase and Troponin T in Patients with Pregnancy Induced Hypertension
		Huang Yanan
		DOI: 10.3969/j.issn.1001-8131.2023.05.010
		Objective To investigate the expression of serum troponin I,creatine kinase and troponin T in patients with pregnancy induced hypertension.Methods 60 patients with gestational hypertension were selected as the observation group,and 60 pregnant women with normal gestational blood pressure in the same period were selected as the control group.The general data,serum troponin I,creatine kinase and troponin T levels of the two groups were compared,and their correlation with patients' blood pressure was analyzed.The sensitivity and specificity of pregnancy induced hypertension were analyzed by ROC curve.Results There was no significant difference in age,gestational week,pregnancy times and parity between the two groups（P>0.05）.The serum troponin I,creatine kinase and troponin T in the observation group were higher than those in the control group（P<0.05）;ROC curve showed that serum troponin I,creatine kinase and troponin T had predictive value for the onset of pregnancy induced hypertension（P<0.05）,and were positively correlated with the blood pressure level of patients with pregnancy induced hypertension（P<0.05）.Conclusion The levels of serum troponin I,creatine kinase and troponin T in patients with hypertensive disorder complicating pregnancy are high.The levels of serum troponin I,creatine kinase and troponin T are positively correlated with the blood pressure levels in patients with hypertensive disorder complicating pregnancy,which is helpful to predict hypertensive disorder complicating pregnancy.
		2023 Vol. 43 (5): 26-28 [Abstract] ( 79 ) HTML (1 KB) PDF (466 KB) ( 67 )

	29	Efficacy of Singulair Combined with Interferon in the Treatment of Respiratory Syncytial Virus Bronchiolitis and Its Influence on Inflammatory Markers
		Lu Yijuan, Lu Junfang, Zhang Ke
		DOI: 10.3969/j.issn.1001-8131.2023.05.011
		Objective To observe the effect of Singulair combined with interferon（IFN）on RSV bronchiolitis and its influence on the level of inflammatory markers.Methods A total of 60 cases of RSV bronchiolitis were randomLy divided into single group and combined group according to odd-even number method,with 30 cases in each group.The single group was treated with Singulair,and the combination group was treated with Singulair and IFN.The clinical therapeutic effect of the two groups was observed,and the regression time of cough,wheezing,pulmonary wheezing sound and wet rales was observed 7 days after medication.The changes of inflammatory indexes（CysLTs,hs-CRP,IL-4,IL-8）before and after treatment were compared between the two groups,and the adverse reactions of the children after medication were recorded.Results After 7 days of treatment,the effective rate of the combined group was significantly higher than that of the single group（P<0.05）.The regression time of cough and other discomfort in the combined group was shorter than that in the single group,and the difference was significant（P<0.05）.Before treatment,there were no significant differences in the levels of CysLTs,hs-CRP,IL-4 and IL-8 in the two groups（P>0.05）.After 7 days of treatment,serum levels of CysLTs,hs-CRP,IL-4 and IL-8 in the two groups were significantly decreased compared with before treatment（P<0.05）.The decrease of the combined group was more obvious than that of the single group at the same time（P<0.05）.There was no significant difference in the adverse reactions such as nausea and vomiting between the two groups after treatment（P>0.05）.Conclusions The treatment of RSV bronchiolitis with Singulair combined with IFN can improve the curative effect,reduce the level of respiratory inflammation,and the medicines and ways are safe,which is suitable for clinical application.
		2023 Vol. 43 (5): 29-31 [Abstract] ( 92 ) HTML (1 KB) PDF (441 KB) ( 59 )

	32	Clinical Characteristics,Drug Resistance of Isolated Strains and Serotype Analysis of Invasive Pneumococcal Disease in Some Children in Zhengzhou Areas
		Yu Huaxing, Sun Jie, Xie Zhuangzhuang
		DOI: 10.3969/j.issn.1001-8131.2023.05.012
		Objective To investigate the clinical characteristics,drug resistance and serotypes of invasive pneumococcal disease（IPD）in children in our hospital.Methods The clinical data of 340 children diagnosed with IPD were collected,and their clinical characteristics,drug resistance of isolated strains and serotype distributionwere analyzed.Results Among the 340 children patients,there were 172 males（50.59%）and 168 females（49.41%）,with a male-to-female ratio of 1.02：1 and with age from 5 months old to 14 years old.There were 151 cases（44.41%）<2 years old,135 cases（39.71%）of 2~5 years old and 54 cases（15.88%）of 5~14 years old.The high incidence season of IPD was in winter and spring,222 cases（65.29%）in total.Sepsis-induced pneumonia was the most common type of infection[189 cases（55.59%）],followed by 73 cases（21.47%）of non-infected bloodstream infections and 55 cases（16.18%）of meningitis.44 cases（12.94%）of children patients were with underlying diseases and 158 cases（46.47%）were with risk factors for drug resistance.The SP strains isolated from the children patients had a resistance rate of 0 to Vancomycin and Levofloxacin,and the resistance rates of 23.03% and 10.09% to Cefotaxime and Amoxicillin respectively,and had the resistance rates of up to 90.94%,90.04% and 88.41% to Erythromycin,Clindamycin,and Tetracycline.SP common serotypes were 19F（25.00%）,19A（17.35%）,1（15.29%）,6B（13.82%）,and 23F（10.59%）.There were no statistically significant differences in the coverage rates of PCV7,PCV11 and PCV13 among children from 5 months to 14 years old（P=0.246,0.221,0.606）,and there were no statistically significant differences in the coverage rates of the three vaccines（χ²=0.262,P>0.05）.Conclusion IPD is prevalent in children with age<2 years old.Sepsis-induced pneumonia is the most common type of SP infections.IPD is more likely to occur in children with underlyingdiseases and a certain risk of drug resistance.The drug resistance rate of SP strains is high in Erythromycin,Clindamycin,and Tetracycline.PCV13 vaccine can cover more IPD serotypes.
		2023 Vol. 43 (5): 32-35 [Abstract] ( 96 ) HTML (1 KB) PDF (513 KB) ( 101 )

	36	Comparison of Feasibility of Different Arch Expansion Therapies in Adult Patients with Transverse Growth Deficiency of Maxillary Dental Arch Stenosis
		Lin Ruifeng, Wang Lei, Li JuanJuan
		DOI: 10.3969/j.issn.1001-8131.2023.05.013
		Objective To compare the feasibility of different arch expansion therapies in adult patients with transverse growth deficiency of maxillary dental arch stenosis.Methods 86 patients who needed maxillary arch expansion were randomly divided into group A（43 cases）and group B（43 cases）.Group A was treated withmicroimplant-assisted rapid palatal expansion（MARPE）while group B was given rapid maxillary expansion（RME）.The anterior and posterior midpalatal suture widths,nasal cavity width,nasal base bone width,maxillary alveolar width,width between first molars,left and right molar inclinations,and left and right alveolar ridge heights were measured and compared between the two groups before treatment and after 3 months of treatment.Results After 3 months of arch expansion therapy,the anterior and posterior midpalatal suture widths,nasal cavity width,nasal base bone width,maxillary alveolar width,width between first molars and width of first tooth apex were significantly enhanced in the two groups compared to before treatment（P<0.05）,and the above indicators in group A were significantly wider than those in group B at the same time point（P<0.05）.The inclinations of left and right molars in group A had no significant changes compared with those before treatment（P>0.05）,but were significantly lower than those in group B（P<0.05）.The inclinations of left and right molars in group B were increased after 3 months of treatment compared to before treatment（P<0.05）.Conclusion Compared with RME,MARPE can better effectively develop the midpalatal suture in adults with transverse growth deficiency of maxillary dental arch stenosis,and MARPE has better expansion effect and can reduce the side effects caused by correction force during dental arch expansion.
		2023 Vol. 43 (5): 36-39 [Abstract] ( 97 ) HTML (1 KB) PDF (371 KB) ( 73 )

	39	Clinical Effect of Different Medium Acting Glucocorticoids on Nasal polyps with Allergic Rhinitis after Operation
		Guo Xiaoran, Yang Xuehua, Liu Shuai
		DOI: 10.3969/j.issn.1001-8131.2023.05.014
		Objective To investigate the clinical effect of different medium acting glucocorticoids on nasal polyps with allergic rhinitis after operation.Methods 90 patients with nasal polyps combined with allergic rhinitis were selected as the research objects,and randomly divided into two groups of 45 patients in each group.The patients in the two groups were treated with medium acting glucocorticoid after operation.The control group was treated with prednisone,and the observation group was treated with methylprednisolone.The therapeutic effect,bleeding rate,olfactory function score and airway resistance of the two groups were compared.Results There was no significant difference in the total effective rate between the two groups（P>0.05）.The postoperative bleeding rate in the observation group was significantly lower than that in the control group（P<0.05）;The scores of olfactory function and airway resistance in the two groups were significantly lower than those in the control group（P<0.05）.Conclusion Both prednisone and methylprednisolone can improve the therapeutic effect in patients with nasal polyps and allergic rhinitis after surgery,but methylprednisolone can reduce the incidence of postoperative bleeding,promote the repair of nasal mucosa,improve the olfactory function of patients,and reduce airway resistance,which is worthy of clinical application and promotion.
		2023 Vol. 43 (5): 39-41 [Abstract] ( 79 ) HTML (1 KB) PDF (394 KB) ( 55 )

	42	Effect of Obesity on Sexual Function and Semen Parameters in Patients with Weight Loss
		Cheng Chongfeng, Wang Bin, Zhao Tong
		DOI: 10.3969/j.issn.1001-8131.2023.05.015
		Objective To explore the effect of weight loss on sexual function and semen parameters of obese patients.Methods 110 obese patients were randomly divided into control group and research group,with 55 cases in each group.The control group was treated with routine therapy,while the research group was treated with exenatide+orlistat.The erectile dysfunction rate of the two groups was observed,and the levels of body weight,body mass index（BMI）,blood lipids [low density lipoprotein cholesterol（LDL-C）,total cholesterol（TC）,triglyceride（TG）and high density lipoprotein cholesterol（HDL-C）],sexual function（IIEF-5 score）and semen parameters[proportion of sperm moving forward].Results After treatment,the body weight and BMI of the two groups were lower than those before treatment,and the study group was lower than the control group（P<0.05）.After treatment,TC and TG of both groups were lower than before treatment,HDL-C was higher than before treatment,and the study group was better than the control group（P<0.05）.The erectile dysfunction rate of the study group was lower than that of the control group（P<0.05）.After treatment,IIEF-5 score of the two groups was higher than that before treatment,and that of the study group was higher than that of the control group（P<0.05）.After treatment,the proportion of sperm moving forward,sperm concentration and sperm motility in both groups were higher than those before treatment,and the study group was higher than the control group（P<0.05）.Conclusion Weight loss has a definite effect on obesity patients,and can effectively improve their sexual function and semen parameters.
		2023 Vol. 43 (5): 42-44 [Abstract] ( 89 ) HTML (1 KB) PDF (416 KB) ( 70 )

	45	Dermatoscopic Characteristics of Male Hormonal Alopecia and Its Evaluation
		Xu Fengbo, Luo Ruijun, Xu Shuangjun
		DOI: 10.3969/j.issn.1001-8131.2023.05.016
		Objective To explore the dermatoscopic features of male hormonal alopecia and analyze its clinical value in evaluating the efficacy.Methods a total of 60 male patients with hormonal alopecia were admitted to the Department of Dermatology,and 50 physical examiners without hormonal alopecia were selected as the healthy control group;All subjects received dermatoscopic examination to explore the difference between the dermatoscopic characteristics of patients with elastohormonal alopecia（whether there are thin hair diameter,increased vellus hair,brown peritrichal sign,local hairless sign,pigmentation and yellow spot sign）and the healthy control group;Subsequently,all patients with hormonal alopecia received treatment.According to the treatment effect,the subjects were divided into good prognosis group and poor prognosis group.The difference of dermatoscopic characteristics between the two groups after treatment was compared,and the evaluation value of the above characteristics on the efficacy of patients with hormonal alopecia was evaluated.Results The proportion of patients with hormone induced alopecia with thinner hair diameter（>20%）,increased vellus hair,brown hair peritrichal sign,local non hair sign,pigmentation and yellow dot sign was higher than that of healthy control group,and the difference was statistically significant（P<0.05）;The proportion of patients with hormonal alopecia with thinner hair diameter（>20%）,brown peritrichal sign and local hairless sign decreased significantly compared with those before treatment（P<0.05）;The number of cases with increased vellus hair was significantly increased compared with that before treatment,and the difference was statistically significant（P<0.05）;However,there was no significant difference in the proportion of cases of pigmentation and yellow dot sign before and after treatment（P>0.05）;Finally,42 patients were included in the good effect group and 18 patients were included in the poor effect group;The results showed that the proportion of cases with hair diameter thinning（>20%）,vellus hair increase,brown hair peritrichosis sign,local hairless sign,pigmentation and yellow dot sign in patients with good prognosis and poor prognosis were statistically different（P<0.05）.Conclusion Dermatoscopic features of male patients with hormonal alopecia have significant value in evaluating the efficacy of patients,and are worthy of reference for clinical doctors and nurses.
		2023 Vol. 43 (5): 45-48 [Abstract] ( 88 ) HTML (1 KB) PDF (664 KB) ( 89 )

	49	Predictive Value of Inflammatory Prognostic Index Combined with IL-11 for Immune Related Adverse Reactions in Advanced Non-small Cell Lung Cancer
		Ma Hongwu, Wu Weixuan, Fan Haoqin, Chen Xueyan
		DOI: 10.3969/j.issn.1001-8131.2023.05.017
		Objective To investigate the predictive value of inflammatory prognostic index（IPI）combined with peripheral blood interleukin-11（IL-11）for immune-related adverse reactions（irAE）in advanced non-small cell lung cancer（NSCLC）.Methods The clinical data of 85 patients with NSCLC were retrospectively selected.According to the occurrence of irAE,the patients were divided into irAE group（n=26）and non-irAE group（n=59）.The clinical data of patients were collected.Multivariate logistic regression was used to analyze the relationship between IPI combined with IL-11 and irAE in NSCLC patients.ROC curve was further drawn to analyze the predictive value of IPI,IL-11 alone and combined detection for irAE in NSCLC patients.Results The levels of CRP,IL-6,IL-11,LDH,NLR,PLR and IPI in the two groups were significantly correlated（P<0.05）.Further analysis showed that IL-11,LDH and IPI were independent risk factors for irAE in NSCLC patients.ROC curve results showed that the area under the curve of IL-11 and IPI alone in predicting irAE in NSCLC patients was 0.731 and 0.786,respectively（P<0.05）.The area under the curve of the combined detection was the largest,which was 0.890（P< 0.05）.Conclusion IPI combined with IL-11 level is of great value in predicting irAE in NSCLC patients.
		2023 Vol. 43 (5): 49-51 [Abstract] ( 99 ) HTML (1 KB) PDF (392 KB) ( 73 )

	90	Application of Ultra-low Frequency Transcranial Magnetic Stimulation Combined with Sensory Integration Training in Children with Autism
		Shi ke
		DOI: 10.3969/j.issn.1001-8131.2023.05.034
		Objective To investigate the effect of ultra-low frequency transcranial magnetic stimulation combined with sensory integration training in children with autism（ASD）.Methods 76 children with ASD were selected and randomly divided into two groups,38 cases in each group.The control group was intervened by sensory integration training,and the observation group was intervened by ultra-low frequency transcranial magnetic stimulation on the basis of the control group.The two groups were intervened continuously for 3 months.The scores of Autism Behavior Checklist（ABC）and Childhood Autism Rating Scale（CARS）were compared before and 3 months after intervention.Results After 3 months of intervention,the scores of ABC and CARS in the two groups were lower than those before intervention,and the scores of ABC and CARS in the observation group were lower than those in the control group,with a statistically significant difference（P<0.05）.Conclusion Ultra low frequency transcranial magnetic stimulation combined with sensory integration training can correct the abnormal behavior of children with ASD and alleviate the symptoms of ASD.
		2023 Vol. 43 (5): 90-92 [Abstract] ( 92 ) HTML (1 KB) PDF (304 KB) ( 71 )

	132	Analysis of the effect of Tongqiao Biyan granules combined with desloratadine in the treatment of allergic rhinitis
		Mao Rui, Yao Jing
		DOI: 10.3969/j.issn.1001-8131.2023.05.050
		Objective To study the efficacy of Tongqiao Biyan granules combined with desloratadine in the treatment of allergic rhinitis.Methods A total of 100 patients with allergic rhinitiswere selected and divided into an observation group and a control group by random number table method,with 50 cases in each group.The control group was treated with desloratadine,while the observation group was treated with Tongqiao?Biyan?granules combined with desloratadine.The medication information of the two groups was investigated for 1 month.The immunological indexes,RQLQ,SFAR score and effective treatment rate of the two groups of patients before and after treatment were compared,and the safety was evaluated.Results The effective treatment rate in the observation group was significantly higher than that in the control group（P<0.05）,and the differences in serum lgE,INF-γ,IL-4,and IL-6 before and after treatment were also significantly higher than those in the control group（P<0.05）.The RQLQ and SFAR scores of the observation group were lower than those of the control group,and the RQLQ and SFAR scores after treatment were lower than those before treatment.There were significant differences between the two groups（P<0.05）.There was no significant difference in adverse reaction rate between the two groups（P>0.05）.Conclusions Tongqiao Biyan granules combined with desloratadine has better efficacy in the treatment of allergic rhinitis,can relieve clinical symptoms,regulate immunological indicators,improve the quality of life of patients,and does not increase the risk of adverse reactions,which is worthy of application and promotion.
		2023 Vol. 43 (5): 132-134 [Abstract] ( 121 ) HTML (1 KB) PDF (415 KB) ( 62 )

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