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Quick Search     Adv Search 2021 Vol. 41, No. 5 Published: 2021-10-25 1 Effects of Thrombolysis Time on Surgical Efficacy and Adverse Events in Patients With Acute ST-Segment Elevation Myocardial Infarction Yuan Hui Objective To investigate the effects of thrombolysis time on surgical efficacy and adverse events in patients with acute ST-segment elevation myocardial infarction（STEMI）. Methods Using a retrospective research method,76 STEMI patients were set as the research subjects.After thrombolysis,both groups of patients were given coronary angiography to confirm the culprit vessels and performed percutaneous coronary intervention（PCI）.The patients were divided into two groups according to the different thrombolysis time.Patients with thrombolysis within 6 h of onset were selected as group A（n=40）,and patients with thrombolysis within 6h to 12h of onset were set as group B（n=36）.The left ventricular end-diastolic dimension（LVEDD）,left ventricular end-systolic dimension（LVESD）and left ventricular ejection fraction（LVEF）],vascular recanalization rate and incidence rate of major adverse cardiovascular events（MACE）were compared between the two groups after surgery. Results The LVEDD and LVESD of the two groups were decreased while the LVEF was increased.The recovery status of cardiac function of LVEDD [（53.22±4.88）mm VS（57.24±4.96）mm],LVEF [（40.13±4.05）mm VS（45.86±4.27）mm] and LVEF [（65.15±5.25）% VS（57.95±5.48）%] in group A were significantly better than those in group B（P<0.05）.Comparison of postoperative vascular recanalization rate between the two groups showed that the recanalization rate of group A was significantly higher than that of group B（87.5% VS 55.6%）（P<0.05）.The incidence rate of MACE of group A was lower than that of group B（5% VS 13.9%）（P>0.05）. Conclusion The earlier the thrombolysis time,the better the recovery of cardiac function in STEMI patients,the higher the vascular recanalization rate,and the lower the incidence of MACE. 2021 Vol. 41 (5): 1-2 [Abstract] ( 141 ) HTML (1 KB)  PDF (217 KB)  ( 161 ) 3 Retrospective Study of Simvastatin Tablets Combined With Enalapril Folic Acid Tablets in the Treatment of Patients With Hypertension and Hyperhomocysteinemia Li Guangyun Objective To explore the efficacy of simvastatin tablets combined with enalapril folic acid tablets in the treatment of patients with hypertension and hyperhomocysteinemia（HHT）. Methods The clinical data of 60 patients with HHT were retrospectively analyzed.30 patients were treated with enalapril folic acid tablets as the conventional group,and 30 patients treated with simvastatin tablets and enalapril folic acid tablets as the combined group.The curative effects of the two groups were compared and the levels of diastolic blood pressure（DBP）,systolic blood pressure（SBP）,serum Hcy,tumor necrosis factorα（TNF-α）,C-reactive protein（CRP）and matrix metalloproteinase-9（MMP-9）levels were compared between the two groups before and after treatment. Results The total effective rate of the combined group was 93.33% higher than that of the conventional group 66.67%（P<0.05）;after treatment,the levels of DBP,SBP and serum Hcy in the combined group were lower than those in the conventional group（P<0.05）;after treatment,the levels of TNF -α,CRP and MMP-9 in the combined group were lower than those in the conventional group（P<0.05）. Conclusion Simvastatin tablets combined with enalapril folic acid tablets in the treatment of HHT patients can reduce the levels of serum Hcy and inflammatory factors,improve the effect of blood pressure control,with a significant effect. 2021 Vol. 41 (5): 3-4 [Abstract] ( 219 ) HTML (1 KB)  PDF (239 KB)  ( 204 ) 5 Effect of Hemoperfusion Combined With Penehyclidine Hydrochloride on Oxidative Stress in Patients With Severe Acute Organophosphorus Pesticide Poisoning Wang Qiuju, Guo Huimin, Li Haiyan Objective To observe the effects of hemoperfusion combined with penehyclidine hydrochloride on oxidative stress in patients with severe acute organophosphorus pesticide poisoning. Methods A total of 60 patients with severe acute organophosphorus pesticide poisoning were selected.According to the random number table method,they were divided into hemoperfusion group and combined group,30 cases each.The hemoperfusion group received blood perfusion treatment,while the combination group was treated with penehyclidine hydrochloride on this basis.After treatment,the treatment effect,changes of cholinesterase,changes of stress indicators（SOD,LDH）were observed. Results The cure rate of the combined group was higher than that of the hemoperfusion group,and,the coma time,the total amount of clodidine,atropine,and the length of hospital stay were lower than the hemoperfusion group,the differences were statistically significant（P<0.05）.After treatment,the cholinesterase activity in the combination group was higher than that in the hemoperfusion group（P<0.05）,and the cholinesterase activity returned to normal time was shorter than the hemoperfusion group（P<0.05）.There were no significant differences in SOD,and LDH in the two groups before treatment（all P>0.05）.After treatment,the LDH in the combination group were all not significant.After treatment,and LDH in the combination group were lower than those in the hemoperfusion group（all P<0.05）,and SOD was higher than those in the hemoperfusion group（P<0.05）. Conclusion Hemoperfusion combined with penehyclidine hydrochloride in the treatment of severe acute organophosphorus pesticide poisoning has a significantly improved effect,and can improve the level of stress indicators with high safety. 2021 Vol. 41 (5): 5-7 [Abstract] ( 117 ) HTML (1 KB)  PDF (325 KB)  ( 161 ) 8 Short Term Efficacy of Transcatheter Arterial Embolization for Hepatic Hemangioma and Its Influence on Liver Function Zhang Danyang Objective To study the short-term effect of transcatheter arterial embolization（TACE）on hepatic hemangioma and its influence on liver function. Methods The clinical data of 53 patients with hepatic hemangioma diagnosed who received transcatheter arterial embolization（TAE）in the interventional radiology department of our hospital were retrospectively collected.The success rate of Tae operation,the curative effect and complications after 10 days of treatment,the size of hemangioma and liver function indexes before and after 3,6,9 months of Tae were observed. Results The success rate of TAE was 100%.The diameter of hepatic hemangioma was（8.97±2.64）cm before treatment.The diameter of hepatic hemangioma was significantly decreased in 3 months,6 months and 9 months after treatment（P<0.05）.The total effective rate was 83.02% after 10 days of treatment.The serum levels of alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,total bilirubin（TBIL）and direct bilirubin（DBIL）were significantly higher than those before Tae（P<0.05）.The levels of serum ALT,AST,TBIL and DBIL on the 3rd and 7th days after TAE were significantly higher than those before Tae（P<0.05）.The levels of alt,AST,TBIL and DBIL on the 10th day after TAE were lower than those on the 3rd and 7th days after TAE（P<0.05）.There was no significant difference in alkaline phosphatase（ALP）,gamma glutamyl transpeptidase（GGT）and indirect bilirubin（ibil）levels after TAE（P>0.05）. Conclusion Transcatheter arterial embolization for hepatic hemangioma has a reliable short-term effect.Although it may lead to abnormal liver function in a short time,it can recover within 10 days. 2021 Vol. 41 (5): 8-9 [Abstract] ( 148 ) HTML (1 KB)  PDF (352 KB)  ( 154 ) 10 PFNA and Plate Internal Fixation in the Treatment of Intertrochanteric Fractures Wu Haitao Objective To analyze the clinical effect of proximal femoral nail（PFNA）and plate fixation in the treatment of intertrochanteric fracture. Methods 86 patients with intertrochanteric fracture in our hospital from October 2017 to May 2019 were selected and randomly divided into PFNA group（n=43）and plate fixation group（n=43）.The plate fixation group was treated with plate fixation,and the PFNA group was treated with PFNA internal fixation.The perioperative conditions,incidence of complications and Harris hip function scale（Harris）scores before operation,6 months after operation and 12 months after operation were compared between the two groups. Results Compared with plate fixation group,PFNA group had less intraoperative blood loss,shorter operation time,hospitalization time and fracture healing time（P<0.05）;Harris score of PFNA group was higher than that of plate fixation group at 6 months and 12 months after operation（P<0.05）;the incidence of complications in PFNA group was 2.33%（1/43）and that of plate fixation group was 11.63%（5/43）,with no significant difference（P>0.05）. Conclusion The use of PFNA internal fixation for patients with intertrochanteric fractures of the femur can improve the perioperative condition,accelerate the fracture prognosis and functional recovery process,and has safety. 2021 Vol. 41 (5): 10-11 [Abstract] ( 126 ) HTML (1 KB)  PDF (410 KB)  ( 205 ) 12 Diagnostic Value of Vascular Ultrasound for Preoperative Deep Venous Thrombosis in Patients With lower Limb Fractures Gu Yuanyuan Objective To investigate the diagnostic value of vascular ultrasound for deep venous thrombosis（DVT）in patients with lower limb fractures. Methods A total of 325 patients with unilateral lower limb fractures who were treated in the hospital were selected as the subjects.All subjects underwent vascular ultrasonography and CT angiography before surgery.The detection of DVT by the two methods was compared. Results A total of 68 patients having 78 veins with thrombosis were detected by ultrasound,and 69 patients having 81 veins with thrombosis were detected by CT venography.A total of 78 blood vessels detected by the two methods were completely consistent.There was 1 iliac vein,1 posterior tibial vein,and 1 anterior tibial vein thrombosis not detected by ultrasound.Taking the results of CT venography as the standard,the sensitivity and misdiagnosis rate of ultrasound for DVT were 96.29% and 3.71%,respectively.There was no statistically significant difference in the detection rate of complete obstruction,incomplete obstruction,recanalization after organization or establishment of collateral circulation between ultrasound and CT venography（P>0.05）. Conclusion The diagnostic efficiency of ultrasound is comparable to that of CT venography in the diagnosis of DVT in patients with lower limb fractures,and it can provide a reference for clinical diagnosis. 2021 Vol. 41 (5): 12-13 [Abstract] ( 117 ) HTML (1 KB)  PDF (443 KB)  ( 204 ) 14 Application of Flexible Ureteroscopic Lithotripsy and Shuotongureteroscopic Lithotripsy in Patients With Failure of ESWL Treatment of Upper Ureteral Calculi He Xiaofeng Objective To compare the application effects of flexible ureteroscopic lithothripsy（FURL）and Shuotong ureteroscopic lithotripsy（STL）on patients with failure of extracorporeal shock wave lithotripsy（ESWL）treatment of upper ureteral calculi. Methods A retrospective analysis was performed on 76 patients with upper ureteral calculi who failed ESWL treatment.According to different treatment methods,the patients were divided into group A（STL,40 cases）and group B（FURL,36 cases）.The intraoperative surgical time and postoperative hospital stay,postoperative infection rate,stone clearance rate at 1 d and 1 month after surgery and clearance rates of stones with diameters larger than or less than 2 cm at 1 d and 1 month after surgery were compared between the two groups,and the causes were analyzed. Results The surgical time of group B was significantly shorter than that of group A（P<0.05）.The postoperative hospital stay of group B was slightly shorter than that of group A（P>0.05）.There was no significant difference in the total clearance rate at 1 month after surgery（P>0.05）,but the stone clearance rate in group A was significantly better than that in group B at 1 d after surgery（P<0.05）.The clearance rate of stones with diameter larger than 2cm in group A was significantly better than that in group B（P<0.05）,but there was no significant difference in the total clearance rate of stones with diameter less than 2cm（P>0.05）. Conclusion Both FURL and STL are significantly effective in treating upper ureteral calculi with failure of ESWL treatment.STL is better than FURL in treating stones with diameter larger than 2 cm. 2021 Vol. 41 (5): 14-15 [Abstract] ( 151 ) HTML (1 KB)  PDF (465 KB)  ( 165 ) 16 Comparative Study of Cisplatin Combined With Gemcitabine and Paclitaxel in the Treatment of Recurrent Nasopharyngeal Carcinoma Zhang Zhansheng, Cao Jing Objective To investigate the comparative study of cisplatin combined with gemcitabine and paclitaxel in the treatment of recurrent nasopharyngeal carcinoma. Methods 85 patients with recurrent nasopharyngeal carcinoma treated in our hospital from July 2018 to March 2020 were selected as the research objects.According to the random number table method,they were divided into group A（42 cases）and group B（43 cases）.Group A received cisplatin + paclitaxel（TP）regimen,and group B received cisplatin + gemcitabine（GP）regimen.The short-term efficacy,tumor markers [platelet-derived growth factor（PDGF-BB）,serum epithelial cadherin（SE-CAD）] and toxicity reactions were observed in the two groups. Results The short-term efficacy of the two groups was compared（P>0.05）;after treatment,the levels of PDGF-BB and SE-CAD in the two groups were decreased,compared with those before treatment（P<0.05）;the levels of PDGF-BB and SE-CAD in the two groups after treatment were compared（P>0.05）;the gastrointestinal reaction in group B was lower than that in group A（P>0.05）. Conclusion GP and TP regimens have good efficacy in recurrent nasopharyngeal carcinoma,which can inhibit tumor growth.However,compared with TP Regimen,GP regimen has less gastrointestinal reaction and higher safety. 2021 Vol. 41 (5): 16-18 [Abstract] ( 128 ) HTML (1 KB)  PDF (527 KB)  ( 233 ) 19 Effect of Flexible Ureteroscope Holmium Laser Lithotripsy and Percutaneous Nephrolithotomy on Postoperative Inflammatory Response in Patients With Complex Upper Ureteral Calculi Ma Pengde, Sha Wen, Ji Chuanbiao, Liu Lin, Lu Caiguang, Wu Xinwei, Huang Changming Objective To explore the effects of flexible ureteroscope holmium laser lithotripsy and percutaneous nephrolithotomy on postoperative inflammatory response in patients with complex upper ureteral calculi. Methods Totally 70 patients with complex upper ureteral calculi admitted to this hospital were selected for retrospective analysis,and the patients were divided into flexible ureteroscope holmium laser lithotripsy group（the flexible ureteroscope group,35 cases）and percutaneous nephrolithotomy group（the nephroscope group,35 cases）.The effects of the two surgical methods and the influence on postoperative inflammatory response of patients were compared and analyzed. Results There were no significant differences in the incidence rates of postoperative blood loss and infection between the two groups（P>0.05）.The surgical time in the flexible ureteroscope group was significantly longer than that in the nephroscope group（P<0.05）,and the intraoperative blood loss and hospitalization cycle were significantly shorter than those in the nephroscope group（P<0.05）.Compared with before surgery,the peripheral blood white blood cell count（WBC）,C-reactive protein（CRP）,cortisol（Cor）,interleukin-6（1L-6）and interleukin-10（1L-10）in the two groups were significantly improved（P<0.05）,but the increases of various indicators of inflammatory response in the flexible ureteroscope group were significantly lower than those in the nephroscope group（P<0.05）. Conclusion Flexible ureteroscope holmium laser lithotripsy has milder body’ s inflammatory response than percutaneous nephrolithotomy in the treatment of complex upper ureteral calculi,and it can shorten the hospitalization cycle,and has less intraoperative blood loss and much safety. 2021 Vol. 41 (5): 19-20 [Abstract] ( 156 ) HTML (1 KB)  PDF (507 KB)  ( 175 ) 21 The Correlation Between Stigma and Self-Esteem in Young Breast Cancer Patients Cao Wanya, Cui Dan, Yan Liuliu Objective To explore the correlation between stigma and self-esteem in young breast cancer patients. Methods A total of 74 young breast cancer patients who were treated were selected as the research objects.The self-esteem level of the patients was assessed by RSES and grouped according to the assessment results.All patients were assessed for stigma,compared the level of stigma of patients,and analyzed the correlation between stigma and self-esteem. Results Among 74 young breast cancer patients,31 had low self-esteem,accounting for 41.89%;25 had moderate self-esteem,accounting for 33.78%.There were 18 patients with high self-esteem level,accounting for 24.32%,and there were no statistically significant differences in the age,body mass index,surgical method,education level,marital status,occupational status,and family monthly income of patients in different self-esteem groups（P>0.05）.The social impact scale（SIS）scores of the medium self-esteem level group and the high self-esteem level group were lower than the low self-esteem level group,and the SIS score of the high self-esteem level group was lower than that of the medium self-esteem level group,the difference was statistically significant（P<0.05）.According to Pearson analysis,the stigma of young breast cancer patients was negatively correlated with the level of self-esteem（r=-0.456,P<0.05）. Conclusion The level of stigma in young breast cancer patients will affect the level of self-esteem,that is,high stigma may lead to a decrease in the level of self-esteem of patients.Therefore,reasonable interventions can be taken accordingly to reduce patients’ stigma and improve self-esteem. 2021 Vol. 41 (5): 21-23 [Abstract] ( 141 ) HTML (1 KB)  PDF (549 KB)  ( 233 ) 24 Effect of Transurethral Green Laser Vaporization of Prostate on Benign Prostatic Hyperplasia and Bladder Function Guan Tianyou, Guo Zhixin, Wang Jun, Xiang Chaojie Objective To investigate the effect of transurethral plasma resection of the prostate on patients with benign prostatic hyperplasia（BPH）and the effect of bladder function. Methods A total of 192 patients with BPH in our hospital were selected.They were divided into experimental group（n=96）and control group（n=96）according to different surgical plans.The control group received open surgery,and the experimental group received transurethral plasma resection of the prostate.The excellent and good rate,perioperative condition,bladder function before and 3 months after operation,and the incidence of complications were compared between the two groups. Results The excellent and good rate of of the experimental group（95.83%）（92/96）was higher than that of the control group 84.38%（81/96）（P<0.05）,the blood loss during the operation was less than that of the control group,and the operation time and hospital stay were shorter than those of the control group（P<0.05）.Three months after operation,Qmax and MUCP of the experimental group were higher than those of the control group（P<0.05）,the complication rate of the experimental group was 5.21%（5/96）lower than that of the control group（13.54%）（13/96）（P<0.05）. Conclusion Transurethral plasma resection of the prostate has a good clinical effect in the treatment of BPH patients.It can effectively shorten the operation time,reduce intraoperative blood loss,reduce the incidence of complications,promote the recovery of bladder function,and shorten the recovery process of patients. 2021 Vol. 41 (5): 24-25 [Abstract] ( 107 ) HTML (1 KB)  PDF (555 KB)  ( 149 ) 26 Observation on the Preventive Effect of Vitamin A and C Combined With Ferrous Succinate and Folic Acid Tablets on Preeclampsia Pan Yuping, Cheng Jinhua, Fang Qiuxiang, Jin Bo Objective To explore the preventive effect of vitamin A and C combined with ferrous succinate and folic acid tablets on preeclampsia. Methods 152 pregnant women with high risk of preeclampsia from October 2016 to October 2019 in our hospital were selected as the research objects.According to the random number table,they were divided into observation group and control group with 76 cases each.Both groups of parturients received routine perinatal examination and health care.The control group received placebo treatment on the basis of routine care,and the observation group received vitamin A and C combined with ferrous succinate and folic acid tablets on the basis of routine care.The differences in blood pressure（SBP,DBP）,placental hemodynamic indexes（PI,RI,S/D）,preeclampsia incidence,and maternal and infant outcomes between the two groups of pregnant women before and after treatment were compared. Results After treatment,the levels of SBP,DBP,PI,RI,and S/D of pregnant women in the two groups were significantly lower than before treatment（P<0.05）,and the observation group was significantly lower than the control group during the same period（P<0.05）.The incidence of preeclampsia,placental abruption,and neonatal asphyxia in the observation group was significantly lower than that of the control group（P<0.05）,and the Apgar score of newborns was significantly higher than that of the control group（P<0.05）. Conclusion Vitamin A and C combined with succinate folic acid tablets can improve pregnant women's blood pressure and placental hemodynamics,effectively prevent the occurrence of preeclampsia,and contribute to good maternal and infant outcomes. 2021 Vol. 41 (5): 26-28 [Abstract] ( 162 ) HTML (1 KB)  PDF (599 KB)  ( 222 ) 29 Natural Pregnancy and Its Influencing Factors in Patients With Ovarian Endometriosis Wang Liya, Chao Yang Objective To investigate the natural pregnancy and its influencing factors in patients with ovarian endometriosis（EMT）. Methods 68 cases of ovarian EMT patients were selected as the research objects.All patients were treated with surgery.The patients with natural pregnancy were included in the pregnancy group,and the non pregnant patients were included in the non pregnancy group.The age,body mass index（BMI）,lesion location,cyst diameter and whether to accept gonadotropin stimulation were compared between the two groups GnRH-a treatment,American Society of reproductive medicine EMT（R-AFS）stage,EMT fertility（EFI）score. Results Among the 68 patients,50 cases were naturally pregnant and 18 cases were not pregnant.Univariate analysis showed that the natural pregnancy of patients with ovarian EMT was not related to BMI and lesion location（P>0.05）,but might be related to age,cyst diameter,R-AFS stage and EFI score（P<0.05）.Logistic regression analysis showed that older age,cyst diameter≥3cm,R-AFS stage ≥ stage III,EFI score<7 were risk factors for non pregnancy in patients with ovarian EMT（or>1,P<0.05）.GnRH-a treatment was a protective factor for spontaneous pregnancy in patients with ovarian EMT（or>1,P<0.05）. Conclusion The natural pregnancy rate of patients with ovarian EMT is affected by many factors.The risk factors of non pregnancy are old age,cyst diameter ≥ 3cm,R-AFS stage≥stage III,EFI score<7.GnRH-a treatment is the protective factor of spontaneous pregnancy. 2021 Vol. 41 (5): 29-30 [Abstract] ( 166 ) HTML (1 KB)  PDF (600 KB)  ( 161 ) 31 Analysis of Clinical Features and Prognosis of 46 Children Patients With Chronic Renal Failure Guo Nan Objective To investigate the clinical features and prognosis of 46 children patients with chronic renal failure（CRF）. Methods A retrospective analysis was performed on 46 children patients with CRF admitted to this hospital between May 2017 and April 2020.According to whether the prognosis was good,they were divided into the experimental group（23 cases,poor prognosis）and the control group（23 cases,good prognosis）.The clinical features and related influencing factors of prognosis were compared between the two groups of children patients with CRF. Results Among 46 children patients with CRF,there were 5 cases（10.87%）of unknown etiology and 41 cases（89.13%）of definite etiology.22 cases received symptomatic treatment（47.83%）,10 cases received renal transplantation（21.74%）and 14 cases received dialysis treatment（30.43%）.Common symptoms included 15 cases of vomiting（32.61%）,23 cases of edema（50.00%）,31 cases of anorexia（67.39%）and 30 cases of asthenia（65.22%）.The incidence rates of oliguria,edema,hyperkalemia,hyperchloremia,hyperphosphatemia,massive proteinuria and water-sodium retention of children patients with CRF in the experimental group were higher than those in the control group（P<0.05）.The application rate of renal transplantation was lower than that in the control group（P<0.05）.The dependent variable was whether the prognosis was good among children patients with CRF.Multivariate analysis found that hyperkalemia,hyperphosphatemia,massive proteinuria,water-sodium retention and renal transplantation were correlated with prognosis of children patients with CRF（P<0.05）. Conclusion Children patients with CRF will have a variety of clinical symptoms after the onset of the disease.The influencing factors of prognosis are hyperkalemia,hyperphosphatemia,massive proteinuria,water-sodium retention and renal transplantation.It is necessary to focus on the above factors to do symptomatic prevention and treatment in clinical practice. 2021 Vol. 41 (5): 31-33 [Abstract] ( 132 ) HTML (1 KB)  PDF (643 KB)  ( 183 ) 34 Observation on Effects of Cross-Matching Test With Low Ion Polybrene Zhao Xinyan Objective To explore the effects of cross-matching test with lowion polybrene in patients undergoing blood transfusion therapy. Methods The clinical data of 140 patients with blood transfusion therapy were analyzed.All patients used lowion polybrene to perform cross-matching test and lowion polybrene technology test.The positive detection rate,accuracy,sensitivity and detection time of the two detection methods were compared. Results In the lowion polybrene method,20positive cases were detected by the lowion polybrene technology test,with a positive rate of 20.00%.In the brine method,13 positivecases were detected by the brine method,with a positive rate of 9.26%.The positive rate of lowion polybrenemethod was higher than that of thebrinemethod（P<0.05）.The sensitivity,stability and accuracy of the lowion polybrene method were 94.00%,91.00% and 90.00% respectively,which were all higher than those of the brine method with 78.00%,76.00% and 74.00%（P<0.05）.The average time consumption of the lowion polybrene method was longer than that of the brine method [（7.24±1.75）vs.（4.17±0.56）min]（P<0.05）. Conclusion Cross-matching test with low ion polybrene can effectively prevent hemolytic transfusion reaction and ensure the safety of blood transfusion. 2021 Vol. 41 (5): 34-35 [Abstract] ( 114 ) HTML (1 KB)  PDF (627 KB)  ( 205 ) 36 Analysis of Clinical Value of Ultrasound Soft index in Screening Fetal Chromosomal Abnormalities in Early Pregnancy Liu Qianqian Objective To explore the clinical value of ultrasound soft index in screening fetal chromosomal abnormalities in early pregnancy. Methods 1945 pregnant women in the first trimester of pregnancy who underwent routine prenatal screening in our hospital were selected.All of them underwent ultrasound soft indicators[（fetal nasal bone（NB））,neck translucency thickness（NT）] and maternal serological examination.Amniocentesis chromosome karyotype analysis or postpartum follow-up of low-risk pregnant women were used as gold standard to analyze the value of each method. Results A total of 40 cases of fetal chromosomal abnormalities（2.06%）were detected in 1945 pregnant women in the first trimester,including 7 cases of 18 trisomy syndrome（0.36%）,19 cases of 21 trisomy syndrome（0.98%）,4 cases of 45x（0.21%）,5 cases of 13 trisomy syndrome（0.26%）,2 cases of chromosome segment abnormality（0.10%）,3 cases of triploidy（0.15%）;126 cases of NT abnormalities（6.48%）,1819 cases of normal NT（93.52%）;12 cases of NB deletion（0.62%）,1932 cases of normal NB（99.33%）,amniocentesis showed 28 cases（1.44%）of fetal chromosomal abnormalities;111 cases（5.71%）of high-risk pregnant women were screened by serology,Amniocentesis showed 31 cases（1.59%）of fetal chromosomal abnormalities;the detection rate of fetal chromosomal abnormalities by ultrasound soft index combined with serological examination was higher than that by ultrasound soft index and serological single examination,the difference was statistically significant（P<0.05）;There was no significant difference in the detection rate of fetal chromosomal abnormalities between ultrasound soft index and serology（P>0.05）. Conclusion Ultrasound soft index can effectively detect fetal chromosomal abnormalities in early pregnancy,which combined with serological examination can improve the detection rate of fetal chromosomal abnormalities and improve the quality of the birth population. 2021 Vol. 41 (5): 36-37 [Abstract] ( 110 ) HTML (1 KB)  PDF (651 KB)  ( 200 ) 38 The Significance of Ultrasonic Aspect Ratio in Papillary Rhyroid Carcinoma With Different Maximum Diameters Jiang Dongya Objective To study the detection of ultrasonic aspect ratio in papillary rhyroid carcinoma with different maximum diametersand its clinical significance. Methods The clinical data of 105 patients with papillary thyroid carcinoma were retrospectively analyzed.According to the maximum diameter（d）,they were divided into group A（37 cases,d≤1cm）,group B（35 cases,1cm<d<2cm）and group C（33 cases,d≥2cm）.The differences in aspect ratios under ultrasound were compared between the groups of patients,and analyze the metastasis or recurrence of cancer during the 2 years of follow-up,and analyze the prognostic value of aspect ratio papillary thyroid cancer patients. Results There was no significant difference in age,BMI index and gender among the three groups of patients（P>0.05）,the aspect ratio of group A>group B>group C,the difference was statistically significant（P<0.05）.The aspect ratio was not significantly correlated with pathological characteristics such as patient age and gender（P>0.05）,but was significantly correlated with disease stage,HER-2 expression,capsule invasion,and aspect ratio stage I<stage II<stage III,the difference is statistically significant（P<0.05）.Logistic multivariate regression analysis showed that HER-2 positive,disease stage III,capsule invasion,aspect ratio ≥1 were independent risk factors for recurrence or metastasis of papillary thyroid carcinoma after treatment（P<0.05）. Conclusion The aspect ratio detection under ultrasound can effectively assist the clinical diagnosis of papillary thyroid carcinoma.Its value decreases with the increase of the maximum diameter of the lesion,and the aspect ratio ≥1 is an independent risk factor for the recurrence or metastasis of the disease after treatment,and clinical attention should be paid. 2021 Vol. 41 (5): 38-40 [Abstract] ( 213 ) HTML (1 KB)  PDF (668 KB)  ( 157 ) 41 Analysis of CT Signs and Pathological Features in Patients With Ground-Glass Nodules and Lung Adenocarcinoma Cui Zhiyong Objective To investigate the CT signs and pathological features in patients with ground-glass nodules and lung adenocarcinoma. Methods Using a retrospective research method,clinical data were collected among patients who underwent CT examinationand were diagnosed as ground-glass nodules and lung adenocarcinoma by pathological examination,including imaging data and pathological data.A total of 72 cases of data that met the criteria were included.According to the case classification,the patients were divided into three groups：preinvasive lesions（group A）,minimally invasive adenocarcinoma（group B）and invasive adenocarcinoma（group C）.The CT features were analyzed and compared among patients with different pathological types,including quantitative indicators（average CT value,lesion volume,maximum diameter）and qualitative indicators（image manifestations）. Results The CT signs of group C were mainly less even and uneven,with unclear borders and burr-like edges.The above signs were significantly different from those of sign distribution of groups A and B（P<0.05）.CT signs of patients in group C were 1.232 times,3.774 times and 17.857 times of the non-C type（A type and B type）in terms of uniform density,clear tumor lung boundary and burr edge risk respectively.The average CT value of group C was significantly higher than that of group A and group B [（-318.45±150.62）HU vs.（-553.06±128.37）HU vs.（-568.94±135.41）HU]（P<0.05）.The lesion volume and maximum diameter in group C were higher than those in group A and group B（P<0.05）. Conclusion CT signs of patients with ground-glass nodules and lung cancer have a certain relationship with the pathological types of lung adenocarcinoma.The clear tumor lung boundary,burr shape and CT quantitative parameters can be used as predictors. 2021 Vol. 41 (5): 41-42 [Abstract] ( 203 ) HTML (1 KB)  PDF (649 KB)  ( 179 ) 43 Value of Transcranial Dopplerultrasonography in the Diagnosis of Vascular Headache and Observation on Changes of Cerebral Blood Flow Liu Ying Objective To analyze and explore the diagnostic value of transcranial Doppler ultrasonography on vascular headache,and to observe the changes of cerebral blood flow by means of transcranial Doppler examination for patients with vascular headache. Methods 162 patients with vascular headache admitted to were selected as the observation group,and another 60 healthy people during the same period were selected as the control group.A 2MHz probe was used to probe the vascular conditions and blood flow changes of anterior cerebral artery,middle cerebral artery,posterior cerebral artery,basilar artery and vertebral artery of patients. Results The average blood flow velocities of anterior cerebral artery,middle cerebral artery,posterior cerebral artery,basilar artery and vertebral artery of the observation group were significantly higher than those of the control group（P<0.001）.The abnormal rate of vascular vertebral artery in patients with vascular headache was the highest,reaching 97.53%.The abnormal rate of basilar artery was the lowest,accounting for 51.23%.The type of vascular abnormality was mainly the acceleration of blood flow,and the occurrence of vascular murmur was the least. Conclusion The average blood flow velocities of cerebral blood vessels of patients with vascular headache are significantly higher than those of healthy people.Transcranial Doppler ultrasonography can accurately detect the changes of cerebral blood flow of patients with vascular headache,and has a higher diagnostic value in the diagnosis of vascular headache. 2021 Vol. 41 (5): 43-44 [Abstract] ( 166 ) HTML (1 KB)  PDF (716 KB)  ( 132 ) 45 Diagnostic Value of Low-Dose CT Thin-Slice Technology on Small Pulmonary Nodules and Its Guiding Significance on Lymph Node Dissection Han Baoli, Cui Zhiyong, Jiang Weiqiang Objective To investigate the diagnostic value of low-dose CT thin-slice technology on small pulmonary nodules and its guiding significance on lymph node dissection. Methods A retrospective analysis was performed on 82 patients with small pulmonary nodules admitted to.All patients underwent low-dose and conventional-dose CT thin-slice technology.According to the different doses,they were divided into the experimental group（low-dose CT scanning technology）and the control group（conventional-dose CT scanning technology）.The qualitative diagnosis status,morphological characteristics,dose-length product and weighted CT dose index were compared between the two groups of patients with small pulmonary nodules. Results There were no significant differences in the the proportions of lung cancer,lung metastases,inflammatory nodules,granulomatous lesions,tuberculosis proliferation,difficulty of diagnosis,burrs,air bronchogram,calcification,cavities,lobulation and uneven density in the experimental group compared with those in the control group（P>0.05）.The dose-length product and weighted CT dose index of the experimental group were lower than those of the control group（P<0.05）. Conclusion In the diagnosis process of patients with small pulmonary nodules,low-dose and conventional-dose CT scanning technology both have relatively consistent detection effects in terms of qualitative diagnosis and morphological characteristics,and both can provide guidance for lymph node dissection,but the former one has relatively lower radiation dose and higher safety. 2021 Vol. 41 (5): 45-46 [Abstract] ( 177 ) HTML (1 KB)  PDF (717 KB)  ( 183 ) 47 Effect of Hysteroscopic Electrotomy and Electrocoagulation on Postoperative Pregnancy of Endometrial Polyps La Hui, Quan Lili Objective To investigate the effect of hysteroscopic electrotomy and electrocoagulation on postoperative pregnancy of endometrial polyps. Methods Eighty cases of endometrial polyp patients admitted to our hospital were selected as study subjects,and divided into the control group and the observation group according to odd-even numbering method.The control group was treated with electrocoagulation excision,while the observation group was treated with hysteroscopic electrotomy.The clinical indicators,VEGF level and pregnancy status of the two groups were compared. Results There was no significant difference in intraoperative blood loss,length of hospital stay and operative time between the two groups（P>0.05）.Before treatment,there was no significant difference in VEGF level between the two groups（P>0.05）.After treatment,VEGF level in both groups was reduced,but the decrease in VEGF level in the observation group was more significant（P<0.05）.The pregnancy rate of the observation group was significantly higher than that of the control group,and the ectopic pregnancy rate and abortion rate were significantly lower than that of the control group,with statistically significant differences（P<0.05）. Conclusion Hysteroscopic electrotomy for the treatment of endometrial polyps is superior to electrocoagulation excision.The level of VEGF in the patient's body is improved,the fertility is good,and the curative effect is definite. 2021 Vol. 41 (5): 47-48 [Abstract] ( 144 ) HTML (1 KB)  PDF (718 KB)  ( 184 ) 49 Effects of Different Aspirin Regimens on Gamma Globulin Dosage and Liver Function of Children Patients With Kawasaki Disease Zhao Jiayan Objective To observe the effects of different aspirin regimens on gamma globulin dosage and liver function of children patients with Kawasaki disease（KD）. Methods 86 children patients with KD who were admitted to our hospital for treatment were selected and randomly divided into control group and observation group,with 43 cases in each group.Both groups were treated with gamma globulin combined with aspirin,and the children patients in observation group gradually reduced the aspirin dose after fever subsided,and the children patients in control group directly reduced the aspirin dose after fever subsided.The efficacy after 6 weeks of treatment,relief times of various clinical symptoms,average dose of gamma globulin and adverse drug reactions were compared between the two groups.The liver function indexes[aspartate minotransferase（AST）,alanine aminotransferase（ALT）,glutamyltransferase（GGT）] were compared between the two groups before treatment and after 6 weeks of treatment. Results After 6 weeks of treatment,the total effective rate of treatment in observation group was significantly higher than that in control group（P<0.05）.The relief times of symptoms such as cervical lymph node swelling and diffuse mucosal hyperemia in observation group were significantly shorter than those in control group,and the re-injection rate of gammaglobulin was significantly lower than that in control group（P<0.05）.The levels ofAST,ALTand GGT in the two groups were significantly lower than those before treatment,and the levels in observation group were significantly lower than those in control group during the same period（P<0.05）.There were no significant differences in the adverse drug reactions between the two groups（P>0.05）. Conclusion Aspirin combined with gamma globulin in the treatment of Kawasaki disease can speed up the disappearance of clinical symptoms and improve the efficacy,with high clinical promotion value. 2021 Vol. 41 (5): 49-51 [Abstract] ( 155 ) HTML (1 KB)  PDF (764 KB)  ( 144 ) 52 Application Value of Prenatal Four-Dimensional Ultrasound in the Diagnosis of Fetal Malformations Wang Aobo, Chen Zhen, Wang Wenhui Objective To explore the application value of prenatal four-dimensional ultrasound in the diagnosis of fetal malformations. Methods A total of 910 pregnant women who underwent antenatal check-ups in our hospital were included as research subjects.Compare the detection results of facial,central nervous system,digestive system,cardiac system,urinary system,limb skeletal system,skin,chest and abdominal cavity deformities by two-dimensional ultrasound and four-dimensional ultrasound.With the follow-up results as the standard,the accuracy of the two groups in diagnosing fetal abnormalities was compared. Results Among 910 pregnant women,902 had single pregnancy and 8 had twin pregnancy.A total of 58 malformed fetuses were detected,of which 48 had terminated their pregnancy,and 10 continued their pregnancy.The follow-up confirmed 64 malformations,39 fetal malformations were detected by two-dimensional ultrasound,the detection rate was 60.94%,and 55 fetal malformations were detected by four-dimensional ultrasound,the detection rate was 85.94%,and the detection rate of four-dimensional ultrasound was significantly higher than that Two-dimensional ultrasound（P<0.05）. Conclusion Compared with two-dimensional ultrasound,prenatal four-dimensional ultrasound can improve the efficiency and accuracy of screening for fetal malformations and is worthy of clinical promotion. 2021 Vol. 41 (5): 52-53 [Abstract] ( 138 ) HTML (1 KB)  PDF (764 KB)  ( 226 ) 54 Analysis of Advantages of Antibody Detection and Nucleic Acid Detection in the Clinical Diagnosis of AIDS Shi Lingling, Dong Lin Objective To analyze the advantages of antibody detection and nucleic acid detection in the diagnosis of AIDS patients. Methods A total of 100 AIDS patients diagnosed from January 2017 to February 2020 were used as observation subjects,including 72 early-infected patients and 28 middle-to-advanced patients.The clinical data were retrospectively analyzed,and the diagnosis accuracies of two detection methods on human immunodeficiency virus infectionin different periods were compared,and the diagnostic efficacy wascalculated. Results The accuracy of nucleic acid detectionand the accuracy of antibody detectionforvirus infection in patients with early AIDS were97.22% and 86.11% respectively,and the accuracy of nucleic acid detection was significantly higher than that of antibody detection（P<0.05）.The diagnostic accuracy of nucleic acid detectionand the diagnostic accuracy of antibody detectionforvirus infection in patients with middle-to-advanced AIDS were 82.14% and 92.86% respectively,and there was no statistically significant difference between the two detection methods（P>0.05）.The area under the curve of nucleic acid detection was higher than that of antibody detection（P<0.05）. Conclusion Nucleic acid detection and antibody detection are both effective methods for laboratory diagnosis of HIV infection.Relatively speaking,the accuracy of nucleic acid detectionis higher in early AIDS,and the accuracy of antibody detection is higher in middle-to-advanced AIDS.The diagnostic accuracy of the two detection methods varies at different periods,and overall nucleic acid detectionhas slightly better efficacy. 2021 Vol. 41 (5): 54-56 [Abstract] ( 147 ) HTML (1 KB)  PDF (787 KB)  ( 219 ) 57 Diagnostic Value and Prognostic Evaluation Ability of Real-Time Elastography and FibroScan in Evaluation of Liver Fibrosis About Non-Alcoholic Fatty Liver Disease Patients Lei Lisha, Xi Yunzhu, Yan Canqun, Luo Jing, Tan Wei Objective Observe the effect of diagnosis and evaluation of the effect after treatment of real-time elastography and FibroScan in evaluation of liver fibrosis about Non-alcoholic fatty liver disease patients. Methods Selected 241 NAFLD patients admitted as the research objects.Among them,136 patients with liver fibrosis were in the observation group,and 105 patients without liver fibrosis were in the control group.Both groups were given FS and RTE examinations,and the differences in general information and examination results of the two groups were compared.Observe and compare the results of FS and RTE examinations of the two groups of patients,and judge the diagnostic efficacy of the two detection methods and their combined use.Patients in the observation group were treated with anti-hepatic fibrosis drugs for 6 months to observe the treatment effect and the changes in laboratory indicators,FS and RTE examination results before and after treatment,and judge its effectiveness in prognostic evaluation. Results The ALT,AST,TC,and TG of the observation group of laboratory indicators were all higher than those of the control group（P<0.05）,and the differences were statistically significant.The LFI value of the observation group before treatment was 3.82±1.42 on average,which was higher than the control group 2.78±0.83 The difference was statistically significant（t=39.652,P<0.05）.The average LSM value of the observation group was 19.52±2.98,which was higher than that of the control group by 5.51±1.11.The difference was statistically significant（t=59.672,P<0.05）.The LFI value,LSM value and the ROC curve parameter area of the combined diagnosis are all higher than 0.700,indicating that the two indicators have higher diagnostic efficiency,but the sensitivity and specificity of the combination of the two are higher than the diagnosis result of a single indicator（P<0.05）.After the observation group was treated with anti-liver fibrosis drugs for 6 consecutive months,the laboratory indexes,LFI and LSM values all decreased significantly（P<0.05）. Conclusion Both FS and RTE are of high value in the diagnosis of liver fibrosis in patients with NAFLD.They can accurately determine the degree of liver fibrosis,simple operation,high accuracy,and strong repeatability.They can be used as anti-fibrosis treatments for patients As a non-invasive detection method for prognostic evaluation,it is recommended that the two be combined to further improve the accuracy of diagnosis. 2021 Vol. 41 (5): 57-59 [Abstract] ( 167 ) HTML (1 KB)  PDF (799 KB)  ( 191 ) 60 Correlation Between Serum Lp（a）,APN Levels and Renal Injury in Patients With Diabetic Nephropathy Wang Li Objective To investigate the correlation between serum lipoprotein（a）,LP（a）,adiponectin（APN）levels and renal injury in patients with diabetic nephropathy（DN）. Methods The clinical data of 60 patients with DN admitted were collected and included in group A,and the clinical data of 60 patients with simple type 2 diabetes mellitus（T2DM）admitted to the hospital during the same period were collected and included in group B.The general data of patients and laboratory indexes [Lp（a）,APN] were collected,and the correlation between Lp（a）,APN levels and renal injury in patients with DN was analyzed. Results In group A,there were 0 cases in stage I,0 cases in stage II,52 cases in stage III,8 cases in stage IV and 0 cases in stage v.The level of serum Lp（a）in patients with stage IV was higher than that in patients with stage III and group B,and the level of serum APN in patients with stage III was lower than that in patients with stage III and group B,and the difference was statistically significant（P<0.05）;Pearson linear correlation analysis showed that serum Lp（a）was positively correlated with renal injury index（UAER）in patients with DN（r>0,P<0.001）;APN was negatively correlated with UAER（r<0,P<0.001）. Conclusion Serum Lp（a）and APN levels are associated with renal injury in patients with DN.The occurrence and development of renal injury in patients with DN can be evaluated by monitoring serum Lp（a）and APN levels. 2021 Vol. 41 (5): 60-61 [Abstract] ( 122 ) HTML (1 KB)  PDF (785 KB)  ( 146 ) 103 Application of Interactive Group Management in in Vitro Fertilization-Embryo Transfer Patients Hao Ruinan Objective To explore the application effect of in vitro fertilization-embryo transfer（IVF-ET）patients through interactive group management,so as to provide a basis for the formulation of nursing intervention programs for IVF-ET patients. Methods A total of 85 IVF-ET patients in our hospital from January 2019 to January 2020 were selected and randomly divided into observation group（n=42,interactive group management）and control group（n=43,routine care）,All intervened for 3 months.The quality of life（SF-36）,negative emotions（SDS,SAS）and self-efficacy（GSES）of the two groups before and 3 months after the intervention were compared. Results After 3 months of intervention,the observation group had lower SDS and SAS scores,while SF-36 and GSES scores were higher（P<0.05）. Conclusion Compared with conventional nursing intervention,interactive group management intervention for IVF-ET patients is more conducive to reducing the negative emotions of patients,and the quality of life of patients is significantly improved.At the same time,the self-efficacy level of patients can be improved,and the clinical application value is high. 2021 Vol. 41 (5): 103-104 [Abstract] ( 110 ) HTML (1 KB)  PDF (911 KB)  ( 209 ) 129 Effect of Yangyin Yifei Decoction on Serum NO,VEGF Levels and KPS Scores in Patients With Non-Small Cell Lung Cancer Shen Qixin, Zhou Dongdong, Liu Jie Objective To investigate the effect of Yangyin Yifei Decoction on serum nitric oxide（NO）,vascular endothelial growth factor（VEGF）levels and KPS in patients with non-small cell lung cancer. Methods The clinical data of 60 patients with non-small cell carcinoma treated were retrospectively analyzed.31 patients treated with GP chemotherapy combined with Yangyin Yifei Decoction were included in the observation group.29 patients treated with GP chemotherapy were included in the control group.3 weeks was a course of treatment,and both groups were treated continuously for 2 courses.The KPS score,serum NO and VEGF levels,and the recurrence rate within 1 year were compared between the two groups. Results After 6 weeks of treatment,the KPS score and NO level of the observation group were higher than that of the control group,the VEGF level was lower than that of the control group,and the recurrence rate of the observation group within 1 year was lower than that of the control group.The difference was statistically significant（P<0.05）. Conclusion Yangyin Yifei Decoction can improve serum NO level and reduce blood VEGF concentration in patients with non-small cell lung cancer,and it has a significant effect in promoting patient recovery and improving prognosis. 2021 Vol. 41 (5): 129-130 [Abstract] ( 138 ) HTML (1 KB)  PDF (1002 KB)  ( 170 )

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