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2021 Vol. 41, No. 6
Published: 2021-12-25
1
Effect of Alteplase Thrombolysis Combined With Butylphthalide on Acute Cerebral Infarction
Zhang Guotao, Li Dongli, Wu Jing
Objective
To investigate the therapeutic effect of alteplase thrombolysis combined with butylphthalide on acute cerebral infarction.
Methods
A total of 100 patients with acute cerebral infarction were selected and divided into an observation group（50 cases）and a control group（50 cases）according to the random number table method.Patients in the control group were treated with alteplase thrombolysis + conventional medications.On the basis of the control group，patients in the observation group were treated with butylphthalide for 14 days.Compare the levels of serum PTX-3，MMP-9，S100β，National Institutes of Health Stroke Scale（NIHSS）score，Montreal Cognitive Assessment Scale（MoCA）score before treatment and 14 days after treatment between the two groups.The incidence of adverse reactions during treatment was compared between the two groups.
Results
Compared with before treatment，the serum PTX-3，MMP-9，and S100β levels of the two groups were significantly reduced after 14 days of treatment，and the serum PTX-3，MMP-9，and S100β levels of the observation group were significantly reduced，and the difference was statistically significant（P<0.05）.Compared with before treatment，the NIHSS scores of the two groups were significantly reduced after 14 days of treatment，and the NIHSS score of the observation group decreased more significantly.Compared with before treatment，the MoCA scores of the two groups increased significantly after 14 days of treatment，and the MoCA score of the observation group increased more significantly，the difference was statistically significant（P<0.05）.There was no statistically significant difference in the incidence of adverse reactions between the two groups during treatment（P>0.05）.
Conclusion
On the basis of alteplase thrombolytic therapy，combined with butylphthalide in the treatment of acute cerebral infarction can effectively improve the patient's neurological and cognitive functions，the inflammatory response is reduced，and does not cause serious drug reactions，clinical treatment is safe and effective.
2021 Vol. 41 (6): 1-3 [
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139
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4
Analysis of Relationship Between Heart rate Variability and Severity of Coronary Artery Disease in Patients With Coronary Heart Disease
Ma Ning
Objective
To explore the correlation between severity of coronary artery disease and heart rate variability in the diagnosis and evaluation of patients with coronary heart disease.
Methods
70 patients who came to this hospital for treatment were selected and were diagnosed with coronary heart disease by coronary angiography.The severity of coronary artery disease was judged by Gensini score,and then the patients were grouped into mild group（n=25）,moderate group（n=23）and severe group（n=22）.The heart rate variability indexes levels were monitored among the three groups by 24h routine dynamic electrocardiogram,including percentage of heart beats>50ms during the adjacent normal RR period in the total number of 24h RR intervals（PNN50）,root mean square of the difference between adjacent normal RR intervals（rMSSD）,mean RR intervals per 5 min in 24 h（SDANN）and standard deviation of 24h normal RR intervals（SDNN）,and comparative analysis was performed.
Results
There were statistically significant differences in the heart rate variability indexes of PNN50,rMSSD,SDANN and SDNN among mild group,moderate group and severe group,and lower levels of heart rate variability indexes were associated with higher severity of coronary artery disease（
P<
0.05）.After multivariate Logistic regression analysis,heart rate variability is an independent risk factor for the progression of severity of coronary artery disease.According to Pearson correlation analysis,PNN50,rMSSD,SDANN and SDNN were negatively correlated with Gensini score.
Conclusion
Heart rate variability indexes in patients with coronary heart disease can more accurately assess coronary artery disease and have certain application value.
2021 Vol. 41 (6): 4-5 [
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149
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6
Clinical Effect of Invasive-Noninvasive Sequential Mechanical Ventilation on Patients With Severe Chronic Obstructive Pulmonary Disease and Respiratory Failure
Zhao Shuai
Objective
To investigate the clinical effect of invasive-noninvasive sequential mechanical ventilation in the treatment of severe chronic obstructive pulmonary disease patients with respiratory failure.
Methods
A total of 86 patients with severe chronic obstructive pulmonary disease and respiratory failure were selected and divided into experimental group（n=43）and control group（n=43）according to the random number table.The control group received continuous invasive mechanical ventilation,and the experimental group received invasive-noninvasive sequential mechanical ventilation.The mechanical ventilation time,hospitalization time,blood gas indexes（PaO
2
,PaCO
2
）,lung function（PEF,FEV1）and the incidence of ventilator-associated pneumonia（VAP）before and after treatment were compared between the two groups.
Results
The invasive mechanical ventilation time,total mechanical ventilation time,and hospital stay in the experimental group were shorter than those of the control group（
P<
0.05）,after treatment,the experimental group had higher PaO
2
and lower PaCO
2
than the control group（
P<
0.05）.After treatment,PEF and FEV1 in the experimental group were higher than those in the control group（
P<
0.05）.The incidence of VAP of the experimental group and the control group were 2.33%（1/43）and 11.63%（5/43）,there was no significant difference in comparison（
P>
0.05）.
Conclusion
Invasive-noninvasive sequential mechanical ventilation for severe chronic obstructive pulmonary disease patients with respiratory failure can improve blood gas indicators,improve patients’ pulmonary function,shorten the time of mechanical ventilation,prevent VAP,speed up the patient’s recovery process,and shorten the hospital stay.
2021 Vol. 41 (6): 6-8 [
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141
)
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8
The Effect of Parecoxib Combined With DEX Preemptive Analgesia on Serum IL-1β and TNF-α Levels in Elderly Patients Undergoing Total Hip Replacement Surgery
Dai Haixin, Wang Qiang, Huang Jidong
Objective
To study the effect of parecoxib combined with dexmedetomidine（DEX）preemptive analgesia on serum interleukin-1β（IL-1β）and tumor necrosis factor-α（TNF-α）in elderly patients undergoing total hip replacement surgery.
Methods
A total of 106 elderly patients undergoing total hip arthroplasty were selected and divided into observation group and control group according to a random number table method,53 cases in each group.The control group was treated with DEX for preemptive analgesia,and the observation group was treated with parecoxib at the same time.The postoperative pain score changes,inflammation-related factors levels and adverse drug reactions were observed in the two groups.
Results
After preemptive analgesia,the pain scores at 6h,12h,and 24h after surgery in the two groups were lower than those before surgery.The pain scores at 6h,12h,and 24h after surgery in the observation group were lower than those in the control group（
P<
0.05）.The levels of IL-1β and TNF-α in the observation group were lower than those in the control group（
P<
0.05）.There was no significant difference in the incidence of adverse reactions between the two groups（
P>
0.05）.
Conclusion
The preemptive analgesia of parecoxib combined with DEX can significantly alleviate patients' pain,help control the level of postoperative inflammation,and will not cause serious adverse reactions.
2021 Vol. 41 (6): 8-10 [
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] (
169
)
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11
Effect of Salvia Polyphenolic Injection on Angina Pectoris Attack and Cardiac Function Indexes in Patients With Stable Angina Pectoris
Wang Hewang
Objective
To investigate the effect of salvianolate on cardiac function and safety in patients with stable angina pectoris.
Methods
88 patients with stable angina pectoris were selected,and they were divided into two groups according to the random number table method,44 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with salvianolate.Angina pectoris attack,cardiac function,vascular endothelial function and adverse reactions were compared between the two groups.
Results
After treatment,the frequency of angina pectoris attack in the observation group was（1.06±0.21）times / week,which was less than that of the control group,and the attack time was（2.01±0.41）min,which was shorter than that of the control group（
P<
0.05）;after treatment,the left ventricular ejection fraction（LVEF）,cardiac output（CO）,E peak/A peak（E/A）of ventricular diastolic index in the observation group were（54.69±5.18）%,（5.08±0.89）L/min,（1.18±0.05）,which was higher than that of the control group（
P<
0.05）;After treatment,the nitric oxide（NO）of the observation group was（7.16±1.03）μmol/L,which was higher than that of the control group,and the endothelin-1（ET-1）was（53.62±5.24）ng/L,which was lower than that of the control group（
P<
0.05）;there was no serious adverse reaction in both groups.
Conclusion
Salvianolate can reduce the frequency of angina pectoris in patients with stable angina pectoris,shorten the duration,improve vascular endothelial function,and promote the recovery of cardiac function,which is safe and reliable.
2021 Vol. 41 (6): 11-13 [
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] (
137
)
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13
To Observe the Clinical Efficacy of Trimebutine Maleate Combined With Clostridium Butyricum Tablets in the Treatment of Irritable Bowel Syndrome
Chen Yu
Objective
To observe the irritable patients with a combination of trimebutine maleate with Clostridium butyricum tablets the clinical effect of treatment of irritable bowel syndrome.
Methods
in 182 cases as the research object,randomly divided into observation group（n=92）and control group（n=90）,were treated with basic treatment in all the patients after admission,the control group treated with trimebutine treatment in the observation group,the control group on the basis of Clostridium butyricum and treatment,the incidence of clinical efficacy and adverse reactions of two groups were observed in patients with clinical symptoms.
Results
After treatment,the recovery time of diarrhea,abdominal pain and recovery time of stool were significantly earlier than the control group（
P<
0.01）.The total effective rate of the observation group（90.22%）was significantly higher than that of the control group（76.67%）（
P<
0.05）.There was no significant difference in the incidence of adverse reactions（5.43%）between the observation group and the adverse reactions（7.77%）in the control group（
P>
0.05）.
Conclusion
The combination of trimebutine maleate and Clostridium butyricum in the treatment of irritable bowel syndrome can effectively alleviate the symptoms of diarrhea and abdominal pain,improve stool characteristics,have significant clinical effects,and has high drug safety.It can be used as a clinical treatment.One of the common treatment options for irritable bowel syndrome.
2021 Vol. 41 (6): 13-15 [
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] (
227
)
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16
Effect of Trastuzumab Combined With Sox Chemotherapy on HER-2 Positive Advanced Gastric Cancer and Progression Free Survival
Jiao Yang
Objective
To investigate the efficacy of trastuzumab combined with Sox chemotherapy in the treatment of advanced gastric cancer with positive human epidermal growth factor receptor-2（HER-2）and its effect on progression free survival（PFS）.
Methods
116 patients with HER-2 positive advanced gastric cancer were randomly divided into two groups,58 cases in each group.The control group was given Sox chemotherapy,and the observation group was given trastuzumab combined with Sox chemotherapy.The clinical efficacy,adverse reactions（leucopenia,neutropenia,thrombocytopenia,anemia,nausea,vomiting,mucositis）and PFS were compared between the two groups.
Results
After treatment,the
Objective
remission rate（RR）and disease control rate（DCR）of the observation group were 67.24% and 89.66%,respectively,which were higher than 48.28% and 72.41% of the control group,the difference was statistically significant（
P<
0.05）;during the treatment,there was no significant difference in the incidence of adverse reactions between the two groups（
P>
0.05）;the PFS time in the observation group was longer than that in the control group,the difference was statistically significant（
P<
0.05）.
Conclusion
Trastuzumab combined with Sox chemotherapy regimen can effectively improve the clinical efficacy of the treatment of HER-2 positive advanced gastric cancer,prolong the PFS time of patients,and do not significantly increase the toxicity and side effects,which is worthy of clinical promotion.
2021 Vol. 41 (6): 16-18 [
Abstract
] (
156
)
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18
Effect of Intervertebral Disc Nucleus Pulposus Excision Under Lateral Posterior Foraminal Endoscopy on Postoperative Pain Degreeand Lumbar Function in Patients With Lumbar Disc Herniation
Yang Defu, Tian Yuan, Li Jinjie, Song Junwei, Shi Xuefei
Objective
To investigate the effect of intervertebral disc nucleus pulposus excision under lateral posterior foraminal endoscopy（PTED）on postoperative pain（VAS）and lumbar function（ODI）in patients with lumbar disc herniation.
Methods
82 patients with lumbar disc herniation in our hospital were selected and divided into a study group（n=41）and a control group（n=41）according to the random number table method.The control group was treated withposterior interlaminar fenestration of the nucleus pulposus（FD）surgery,and the study group was treated with PTED.The operation condition,VAS and ODI scores before and after operation,serum soluble tumor necrosis factor type I receptor（sTNF-RI）,prostaglandin E2（PGE2）levels,and complications were counted.
Results
The operation time of the study group was longer than that of the control group,but the incision length was shorter than that of the control group,The blood loss during operation was less than that of the control group,the length of postoperative bed stay and postoperative hospital stay in the study group were shorter than those in the control group（
P<
0.05）;The VAS and ODI scores of the study group after operation were lower than those of the control group（
P<
0.05）;The serum sTNF-RI level of the study group was higher than that of the control group,and the PGE2 level was lower than that of the control group 1 day after operation（
P<
0.05）;The complication rate of the study group（4.88%）was lower than that of the control group（19.51%）（
P<
0.05）.
Conclusion
The treatment of lumbar disc herniation with PTED has significant effect and safety,which is beneficial to improve the lumbar function of patients.
2021 Vol. 41 (6): 18-20 [
Abstract
] (
169
)
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21
Analysis on Spiritual Health Status and Influencing Factors of Patients With Gastric Cancer After Laparoscopic D2 Radical Gastrectomy
Zhang Qingwen
Objective
To observe the spiritual health status of patients with gastric cancer after laparoscopic D2 radical gastrectomy,and to analyze its influencing factors.
Methods
93 patients with gastric cancer who underwent laparoscopic D2 radical gastrectomy in the hospital from January 2018 to August 2020 were selected. The spiritual health status of patients was evaluated 3 months after operation and divided them into good group and poor group,designed a general data questionnaire to collect and record the general data of patients and compared them;the influencing factors of poor spiritual health were found out regression analysis.
Results
49 cases of 93 patients with gastric cancer after operation had poor spiritual health,accounting for 52.69%;compared the marital status and pathological stages of patients in poor group and good group（
P
<0.05）;the results of Logistic regression analysis showed that unmarried/divorced/widowed and high pathological stage were the influencing factors of the spiritual health of patients with gastric cancer after laparoscopic D2 radical gastrectomy（OR>1,
P
<0.05）.
Conclusion
Onmarried/divorced/widowed and high pathological stage may be the influencing factors of poor spiritual health of patients with gastric cancer after laparoscopic D25 radical gastrectomy.
2021 Vol. 41 (6): 21-22 [
Abstract
] (
173
)
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23
Effect of Buspirone in the Treatment of Schizophrenia and Its Influence on Cognitive Function and Quality of Life
Fan Lina
Objective
To investigate the therapeutic effect of buspirone on schizophrenia and its influence on cognitive function and quality of life.
Methods
146 schizophrenic patients in our hospital were selected and randomly divided into two groups-the observation group and the control group,with 73 patients in each group.The observation group was treated with buspirone combined with risperidone,while the control group was treated with routine treatment.After 3 months of treatment,the efficacy,cognitive function,quality of life and adverse reactions of the two groups were observed and compared.
Results
After 3 months of treatment,the overall effective rate of the observation group was 94.52%,which was higher than 83.56% of the control group（
P<
0.05）;the cognitive function score（CASI）and quality of life scale score（SF-36）of the observation group were higher than those of the observation group（
P<
0.05）;the adverse reactions of the observation group were not significantly different from those of the control group（
P
=0.677>0.05）.
Conclusion
Buspirone can significantly improve the cognitive function and quality of life of patients with schizophrenia,reduce the incidence of adverse reactions,the treatment effect is better than conventional treatment,worthy of clinical promotion.
2021 Vol. 41 (6): 23-24 [
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336
)
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25
Effects of Sequential Therapy of Budesonide Combined With Azithromycin on Levels of Serum IFN-γ and MCP-4 in Children Patients With MPP
Li Huan, Meng Gang
Objective
To explore the effects of sequential therapy of budesonide combined with azithromycin on levels of serum IFN-γ and MCP-4 in MMP children patients.
Methods
A clinically controlled study was used to collect 132 MMP children patients,and they were randomly divided into the observation group and the control group with 66 cases in each group.The children patients were all given symptomatic treatments such as regular cough relief and asthma relief,and the control group was given azithromycin sequential therapy,and the observation group was given sequential therapy of azithromycin combined with budesonide.The efficacy of the two treatment method was compared,and the changes of serum IFN-γ and MCP-4 levels were detected before and after treatment.
Results
The normal temperature recovery time,cough disappearance time and normal chest radiograph time were（4.1±0.8）d,（6.7±2.2）d and（8.8±3.4）d in the observation group,which were significantly lower than those in the control group with（4.5±1.3）d,（7.8±2.7）d and（10.5±3.6）d（
P<
0.05）.The levels of IFN-γ and MCP-4 after treatment were（14.3±2.8）ng/L and（26.3±5.4）pg/mL in the observation group,which were significantly lower than those in the control group with（17.5±4.7）ng/L and（32.7±7.2）pg/mL（
P<
0.05）.
Conclusion
Sequential therapy of budesonide combined with azithromycin can significantly reduce the levels of serum IFN-γ and MCP-4,and promote the health recovery of children patients with MMP.
2021 Vol. 41 (6): 25-27 [
Abstract
] (
137
)
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27
Clinical Diagnostic Value of Combined Detection of Tumor Markers AFP,AFP-L3 and DCP on Primary Hepatic Carcinoma
Liu Yuxi
Objective
To analyze the clinical value of combined detection of AFP,AFP-L3 and DCP in the diagnosis of primary hepatic carcinoma.
Methods
50 patients with primary hepatic carcinoma admitted to our hospital were included in the observation group,and 50 patients with hepatitis B cirrhosis were set as the control group.All patients underwent laboratory examination,and the levels of AFP,DCP and AFP-L3 were compared,and the diagnostic efficiency was calculated,and the ROC curve area was observed.
Results
The AFP of the observation group was higher than that of the control group [（834.21±100.35）ug/L vs.（100.04±10.42）ug/L]（
t
=51.481,
P<
0.001）.The AFP-L3 was（14.61±6.11）% in the observation groups and was（7.00±1.21）% in the control group（
t
=172.078,
P<
0.001）. There was a statistically significant difference in the DCP between the observation group and the control group [（3016.33±122.02）mAU/ml vs.（36.73±10.11）mAU/ml]（
t
=8.639,
P<
0.001）.The sensitivity and accuracy of combined detection in diagnosing primary hepatic carcinoma were the highest at 92.00% and 86.00% respectively.And the Kappa value of disease diagnosis was 0.72,showing good diagnostic consistency.The area under the curve of combined detection was 0.930,and the areas under the curves of AFP,DCP and AFP-L3 were 0.745,0.731 and 0.709 respectively,and the area under the curve of combined detection was the largest.
Conclusion
In the clinical diagnosis of primary hepatic carcinoma,the single AFP,AFP-L3 and DCP diagnosis all have high sensitivity,but the combined detection of the three can improve the ability of disease identification and reduce missed diagnosis and misdiagnosis.
2021 Vol. 41 (6): 27-29 [
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] (
187
)
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30
Clinical Observation of Emergency Escharectomy and Skin Grafting Combined with rh-bFGF in Treatment of Middle and Small Area Deep Burn
Han Beibei, Li Zhichao, Hu Dongtao
Objective
To study the effectS of emergency escharectomy and skin grafting combined with recombinant human basic fibroblast growth factor（rh-bFGF）on middle and small area deep burn wounds.
Methods
142 cases of patients with middle and small area deep burn treated in our hospital were selected for the study and divided into the escharectomy and skin grafting group（n=71）and the combined group（escharectomy and skin grafting combined with rh-bFGF,n=71）according to the different treatment method.The operation condition,skin graft survival rate,inflammatory reactions,allergic reactions,wound tissue fibroblast（FB）and capillary count were compared between the two groups.
Results
The mean operative area in the combined group was not significantly different from that in the control group [（17.81±4.92）% vs（17.39±4.86）% ]（
P>
0.05）.The skin survival rate of the combined group was significantly higher than that of the control group（100% vs 91.55%）（
P<
0.05）.The healing rate of the combined group at 15d and 20d was significantly higher than that of the control group（
P<
0.05）,and the average healing time was significantly shorter than that of the control group（
P<
0.05）.The positive rate of inflammatory reactions in the control group was higher than that in the combined group（
P<
0.05）,and there was no significant difference in the positive rate of allergic reactions between the two groups（
P>
0.05）.The number of FB and capillaries in the wound showed an upward trend（
P<
0.05）,and the number of FB and capillaries in the wound tissues at 14d and 21d after operation in the combined group was significantly higher than that in the control group（
P<
0.05）.
Conclusion
Emergency escharectomy and skin grafting combined with rh-bFGF can reduce the wounds inflammatory reaction,and promote the FB proliferation and angiogenesis and accelerate the healing of wounds in the patients with middle and small area deep burn.
2021 Vol. 41 (6): 30-32 [
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121
)
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33
Study on the Clinical Efficacy of Cefaclor and Bromhexine Hydrochloride Tablets in the Treatment of Infantile Bronchiolitis
Xu Xianjun, Dong Xudan, Li Xiaofang
Objective
To analyze the clinical efficacy of cefaclor and bromhexine hydrochloride tablets in the treatment of infantile bronchiolitis.
Methods
116 children with moderate to severe bronchiolitis were divided into the control group（n=61）and the observation group（n=55）according to the random number table method.The control group was given compound ipratropium bromide and budesonide suspension,the observation group was combined with cefaclor and bromhexine hydrochloride tablets on the basis of the control group.The clinical efficacy,pulmonary function,inflammation and adverse reactions were compared between the two groups.
Results
The total effective rate of the observation group was higher than that of the control group（
P<
0.05）.After treatment,the RR of the two groups decreased,and VT,TPTEF/TE,and VPEF/VE increased.The RR of the observation group was lower than that of the control group,while VT,TPTEF/TE and TPEF/VE were higher than the control group（
P<
0.05）.After treatment,TGF-β1 and IL-10 increased in the two groups compared with before treatment.TGF-β1 and IL-10 in the observation group were higher than those in the control group（
P<
0.05）.There were no obvious adverse reactions during the treatment period in the other two groups.
Conclusion
The triple combination of cefaclor and bromhexine hydrochloride tablets,compound ipratropium bromide and budesonide suspension is effective in the treatment of bronchiolitis in children,and can coordinately improve lung function and reduce inflammation.
2021 Vol. 41 (6): 33-35 [
Abstract
] (
173
)
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35
Application Value of Carprost Tromethamine in the Prevention of Hemorrhage After Cesarean Section
Yang Ying, Xia Jinzhi, Lu Yongya
Objective
To observe the application value of carboprost tromethamine in preventing post-cesarean section hemorrhage（PPH）.
Methods
A total of 96 parturients who required cesarean section were selected and divided into control group and observation group according to random numbering,with 48 cases in each group.The control group was treated with pituitary gland+misoprostol+oxytocin for prevention,and the observation group was treated with carprost tromethamine+oxytocin for prevention.After administration,observe and compare the time of the third stage of labor（T1）,hemostasis time（T2）,postoperative 2 h bleeding（V1）,postoperative 24 h bleeding（V2）,hemoglobin concentration（Hb）,anemia incidence（R1）,PPH incidence（R2）,adverse reaction incidence（R3）and prothrombin time（T3）of the two groups.
Results
T1,T2,T3 of the observation group were shorter than those of the control group（
P<
0.05）,V1,V2,R1,R2,and R3 were all lower than the control group（
P<
0.05）,and Hb was higher than the control group（
P<
0.05）.
Conclusion
Carprost tromethamine can effectively prevent the occurrence of PPH in cesarean section,improve blood coagulation function and reduce the occurrence of adverse reactions,and has clinical application value.
2021 Vol. 41 (6): 35-37 [
Abstract
] (
135
)
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161
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38
Analysis of the Clinical Effect of Pituitrin Combined With Carprost Tromethamine in Preventing and Treating Postpartum Hemorrhage
Zhang Yanping, Wang Jing
Objective
To explore the clinical effect of pituitrin combined with carprost tromethamine in the prevention and treatment of postpartum hemorrhage.
Methods
A total of 102 women with high risk of postpartum hemorrhage were selected as subjects,and they were divided into study group and control group with 51 cases each according to the random number table method.The control group was treated with carboprost tromethamine,and the study group was treated with pituitrin on the basis of the control group.Observe the changes in the coagulation function（PT,APTT,PLT,Fbg）of the two groups immediately after delivery and 24h after delivery,and analyze and compare the differences in the amount of bleeding,the time to complete hemostasis,and the occurrence of adverse drug reactions within 24h after delivery.
Results
At 24h postpartum,the levels of PLT and Fbg of the two groups of parturients were significantly higher than those immediately after delivery,and the study group was significantly higher than the control group（
P<
0.05）.Maternal PT and APTT levels in the two groups were significantly lower than those immediately after delivery,and the study group was significantly lower than the control group（
P<
0.05）.The 30min,2h and 24h postpartum blood loss in the study group were significantly lower than those in the control group（
P<
0.05）.The time taken by the mothers in the study group to completely stop bleeding was significantly lower than that in the control group（
P<
0.05）.Within 24 hours after delivery,there was no significant difference in the incidence of nausea/vomiting,dizziness,and diarrhea between the two groups（
P>
0.05）.
Conclusion
Pituitrin combined with carboprost tromethamine can effectively treat postpartum hemorrhage,improve the coagulation function of the parturient,and has good safety.
2021 Vol. 41 (6): 38-40 [
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131
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40
Construction of Home Nursing Model of Elderly Type 2 Diabetic Patients Based on Family Doctor service
Zheng Lianhua, He Xuwen, Liu Guolian, Niu Meng, Qiu Yanmin, Mai Juanjuan, Bai Yaru
Objective
To construct a scientific and practical home nursing model based on Family Doctor service for Elderly Type 2 diabetes patients in Community.
Methods
Based on literature review,investigation,semi-structured interview and expert meeting,the framework and specific content of home nursing model of elderly type 2 diabetic patients based on family doctor service were constructed.
Results
The expert judgment coefficient was 0.910,the degree of expert familiarity was 0.820,and the degree of expert authority was 0.865.The home nursing model contained Objective and purposes,service team,and service processes and content.
Conclusion
The home nursing model is logical,reliable and comprehensive,which can be used as reference for development of home care for elderly patients with type 2 diabetes in community.
2021 Vol. 41 (6): 40-42 [
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] (
135
)
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123
Observation Oneffects Ofintracranial Xiaoyudecoction Combined With Acupunctureand Moxibustion on Cerebral Blood Perfusion and Activities of Daily Living of Patients With Acute Cerebral Infarction Hemiplegia
Zhang Xiaolei
Objective
To observe the effects of intracranialXiaoyudecoction combined with acupuncture and moxibustion on cerebral blood perfusion and activities of daily living of patients with acute cerebral infarction（ACI）hemiplegia.
Methods
A total of 108 patients with ACI hemiplegia were selected as the research subjects,and they were divided into the study group（n=54）and the control group（n=54）according to the random number table method.The control group was given acupuncture and moxibustion,whereas the study group was combined with intracranialXiaoyu Decoction on the basis of the control group.After 1 month of treatment,the cerebral blood perfusion status[average blood flow velocity（Vm）of anterior cerebral artery（ACA）,middlecerebral artery（MCA）and posterior cerebralartery（PCA）],activities of daily living（Barthei index）,motor function score（FMA）and stroke specific quality of life score（SS-QOL）were observed and compared between the two groups before and after treatment.
Results
After 1 month of treatment,the Vm values of ACA,MCA,and PCA of the two groupswere lower than those before treatment（
P<
0.05）,and the values in the study group were significantly lower than those in the control group（
P<
0.05）.The scores of BI,FMA and SS-QOL in the two groups were higher than those before treatment（
P<
0.05）,and the scores in study group were significantly higher than those in control group（
P<
0.05）.
Conclusion
IntracranialXiaoyudecoction combined with acupuncture and moxibustion in the treatment of ACI hemiplegia can effectively improve the cerebral blood perfusion and activities of daily living,and can improve the motor functionof affected limb and quality of life.Therefore,it is worthy of further clinical promotion.
2021 Vol. 41 (6): 123-125 [
Abstract
] (
147
)
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(518 KB) (
119
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140
To Explore the Curative Effect of Qishao Shuwei Jiangan Decoction Combined With Western Medicine on Peptic Ulcer
Wang Pusi, Gao Quanyi
Objective
To explore the curative effect of Qishao Shuwei Jiangan Decoction combined with western medicine on peptic ulcer.
Methods
80 patients admitted to our hospital that met the PU inclusion criteria were selected as the research object,and were randomly divided into a traditional Chinese medicine group and a conventional group according to the random number table method,40 cases in each group.The conventional group was treated with Western medicine alone.The Chinese medicine group added Qishao Shuwei Jiangan Decoction on the basis of the conventional group for two consecutive months.The clinical efficacy and gastroscopy efficacy of the two groups were evaluated,and the changes of serum indexes of the two groups were compared.
Results
The total clinical effective rate of the Chinese medicine group was 92.50%,which was significantly higher than that of the conventional group of 90.00%.The total effective rate of gastroscopy in the traditional Chinese medicine group was 82.50%,which was significantly higher than that in the conventional group（60.00%）（
P<
0.05）.Compared with before treatment,the serum motilin（MTL）,somatostatin（SS）and gastrin（GAS）of the two groups of patients were improved after treatment,and the Chinese medicine group was more obvious,the differences were statistically significant（
P<
0.05）.
Conclusion
Qishao Shuwei Jiangan Decoction combined with western medicine has significant effect on the treatment of PU,which can effectively improve the level of gastrointestinal hormones in patients.
2021 Vol. 41 (6): 140-142 [
Abstract
] (
128
)
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(569 KB) (
144
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