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2021 Vol. 41, No. 4
Published: 2021-08-25
1
Evaluation of Consistency of Roche Electrochemiluminescence Method and Chemiluminescence Microparticle Immunoassay in Detecting Tumor Serum CA153,CA125 and CA199
Zhang, Fengqi
Objective
To verify the performance ofcombined detection of three tumor markers of CA125,CA153 and CA199 by Roche Cobase602 electrochemiluminescence method in breast cancer and liver cancer patients,and to evaluate the consistency of results of electrochemiluminescence method and chemiluminescence microparticle immunoassay for detecting CA125,CA153 and CA199 in tumor diagnosis.
Methods
The above two chemiluminescence methods were used to detect the CA199,CA125,and CA153 of the120 tumor serum samples submitted for examination in our hospital,and the consistency of the final test results obtained by these two methods was evaluated.
Results
For the serum levels of CA125,CA153 and CA199 at low concentrations (0.0-35.0 U/ml),there were statistically significant differences in the results of the two methods.There were no significant differences in the detection results of the two detection methods under the condition of CA125,CA153 and CA199 at middle concentration and high concentration (35.1-500.0 U/ml,>500.0 U/ml),
P>
0.05.
Conclusion
Roche Cobase602 electrochemiluminescence method and chemiluminescencemicroparticle immunoassay have good consistency in the high-value parts of ndicators such as CA125,CA153 and CA199.Although there is no universality,it can be seen that the data among the CA125,CA153 and CA199 detection systems at low concentration are not consistent,and are consistent at middle and high concentrations.
2021 Vol. 41 (4): 1-2 [
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140
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3
Case Report Analysis of Hepatitis C Virus in Heilongjiang Province From 2011-2020
Yu Lan, Hui Shan, Tong Xue, Ma Jing
Objective
To analyze the reported hepatitis C cases in Heilongjiang province from 2011 to 2020,thus providing evidence to policy making.
Methods
The data of hepatitis C cases were collected from the disease prevention andcontrol information system and its epidemic characteristics and data quality were analyzed.
Results
49386 cases of hepatitis Cwere reported during 2011-2020 in Heilongjiang.The number of reported cases decreased from 5604 in 2011 to 2837 in 2020,withan average annual decline of 7.28%,and the cases reported in all the 13 cities of the province.The number of reported cases in the top threecities (Harbin,Qiqihar,Suihua),reported the incidence rate of the top three cities (Heihe,Qigihar and Shuangyashan).There were no obvious seasonal characteristics,the disease occurs in all four seasons.In each year,the number of men was more than that of women.80.16% of the patients were 50 years old and above.Farmers accounted for the largest proportion of the patients(45.25%).
Conclusion
The incidence of hepatitis C reported in Heilongjiang during 2011-2020 showed a downward trend,and the differences seem in different areas.Middle-aged and elderly people and farmers are the key groups of hepatitis C infection.We should attach importance to the hepatitis C epidemic in key areas and key groups,improve the public's awareness of hepatitis C and disease prevention ability,and find and treat hepatitis C infected people to the maximum extent.
2021 Vol. 41 (4): 3-5 [
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143
)
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6
Efficacy of Fasudil Hydrochloride Combined With Aspirin in the Treatment of Acute Myocardial Infarction and Its Influence on Oxidative Stress and Inflammatory Indexes
Cao Xianglong
Objective
To analyze the clinical efficacy of fasudil hydrochloride combined with aspirin in the treatment of acute myocardial infarction and its influence on oxidative stress and inflammatory indexes.
Methods
Totally 120 patients with acute myocardial infarction admitted to our hospital were divided into two groups,namely 60 cases in the observation group and 60 cases in the control group.The efficacy,oxidative stress indicators and inflammatory indexes were compared.
Results
The efficacy of the observation group was better than that of the control group.After treatment,the levels of SOD and NO of theobservation group were higher than those of the control group while the levels of MDA and AGEs were lower than those of the control group(
P<
0.05).The inflammatory indexes such as interleukins and tumor necrosis factor were lower than those of the control group(
P<
0.05).
Conclusion
The combined application of fasudil hydrochloride and aspirin can improve the therapeutic effect of acute myocardial infarction,and reduce the inflammatory reactions and oxidative stress degree.
2021 Vol. 41 (4): 6-7 [
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137
)
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8
Effect of Trimetazidine Combined With Perindopril on LVEDd and LVESD in Patients With Heart Failure
Cai Qinhong, Wu Haolong
Objective
To investigate the efficacy of trimetazidine combined with perindopril in the treatment of patients with heart failure and its effect on LVEDd and LVESD.
Methods
150 patients with heart failure in our hospital from March 2017 to March 2020 were randomly divided into study group and control group,75 cases in each group.The control group was treated with perindopril,and the study group was treated with trimetazidine combined with perindopril.
Results
The curative effect of the study group was better than that of the control group (
P<
0.05);the improvement of LVESD,LVEDd,LVEF and other indicators of the study group was better than that of the control group (
P<
0.05);the improvement of cardiac function classification of the study group was significantly better than that of the control group (
P<
0.05).
Conclusion
Trimetazidine combined with perindopril in the treatment of patients with heart failure can effectively enhance the therapeutic effect and promote the improvement of cardiac function,which can be widely used.
2021 Vol. 41 (4): 8-9 [
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181
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10
Effects of Imipenem Combined With Ambroxol on the Levels of WBC,PCT and CRP in Patients With Severe Pneumonia
Yang Mingjie, Dai Dunlin, Yu Jun
Objective
To explore the effects of imipenem combined with ambroxol on the levels of WBC,PCT and CRP in patients with severe pneumonia.
Methods
The clinical data of 80 patients with severe pneumonia admitted in our hospital from November 2018 to March 2020 were retrospectively analyzed and grouped according to different treatment plans.The patients treated with ambroxol were included in the control group(40 cases),and the patients treated with imipenem combined with ambroxol were included in the observation group(41 cases).Compare the symptoms improvement and mechanical ventilation time of the two groups.The WBC,PCT,CRP,arterial oxygen partial pressure(PaO
2
),and arterial carbon dioxide partial pressure(PaCO
2
) were compared between the two groups before treatment and after 14 days of treatment.
Results
The time for body temperature recovery and mechanical ventilation in the observation group was shorter than that in the control group,and the rate of lesion absorption was higher than that in the control group.The difference was statistically significant(
P<
0.05).Before treatment,there was no significant difference in WBC,PCT,CRP,PaO
2
,PaCO
2
between the two groups(
P>
0.05).After 14 days of treatment,WBC,PCT,CRP,and PaCO
2
in both groups were decreased,and PaO
2
was increased,and the change in the observation group was greater,the difference was statistically significant(
P<
0.05).
Conclusion
The treatment of severe pneumonia patients with imipenem combined with ambroxol can accelerate the absorption of the lesions,reduce the inflammatory response,increase the blood oxygen content,and promote the patients' early recovery of health.
2021 Vol. 41 (4): 10-11 [
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] (
140
)
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12
Observation on the Effect of Air Wave Pressure Circulation Therapy Device for Preventing Deep Vein Thrombosis in Cesarean Section
Zhu Tao
Objective
To study the effect of pulsed air wave pressure therapy on the prevention of postoperative deep venous thrombosis in women undergoing cesarean section.
Methods
98 cases of the study sample were selected from the cesarean section women admitted to our hospital from October 2019 to September 2020.The included cases were divided into analysis group (n=49) and normal group (n=49) by randomized grouping method.Carry out routine postoperative intervention for the parturients in the normal group,and carry out the pulse air wave pressure therapy instrument + routine postoperative intervention for the parturients in the analysis group.Comparative analysis of the coagulation function,swelling and pain of the lower extremities,deep vein thrombosis of the lower extremities,and swelling of the lower extremities were compared and analyzed.
Results
The plasma levels of Fib,TT,APTT and D dimer in the analysis group were lower than those in the normal group,and the PT level was higher than that in the normal group (
P<
0.05);there was no deep venous thrombosis of the lower limbs in the two groups,but the normal group The incidence of lower extremity swelling and pain (22.45%) was significantly higher than that of the analysis group (4.08%) (
P<
0.05);the reduction of swelling of the lower extremities after treatment in the analysis group was better than that of the normal group (
P<
0.05).
Conclusion
The intervention of pulsed air wave pressure therapy in cesarean section women can effectively improve the patient's blood coagulation function,reduce the risk of lower extremity swelling and pain,and lower extremity deep vein thrombosis,which has high promotion and application value.
2021 Vol. 41 (4): 12-14 [
Abstract
] (
152
)
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15
Effect of Posterior Intermuscular Space Approach Internal Fixation on VAS Score and Lmaging Indexes of Thoracolumbar Fracture and Dislocation
Zhao Yongming, Guo Xinjun, Yang Weiqiang, Tian Zhizhong
Objective
To investigate the effect of posterior intermuscular space approach internal fixation on pain (VAS) score and imaging indexes in patients with thoracolumbar fracture and dislocation.
Methods
Eighty-four patients with thoracolumbar fracture and dislocation were selected and divided into observation group (42 cases) and control group (42 cases) by lottery method.The control group was treated with the traditional open approach,while the observation group was treated with the posterior approach through the intramuscular space approach.After surgery,VAS score,spinal canal patency rate of the injured vertebra,percentage of the height of the anterior column of the responsible segment,and Cobb Angle were compared between the two groups.
Results
Five months after surgery,VAS score in the observation group was lower than that in the control group,and the difference was statistically significant (
P<
0.05).Five months after the operation,the injured vertebral canal patency rate,the percentage of the height of the front column of the responsible segment,and the level of Cobb Angle were all better than those before the operation,and the differences were statistically significant (
P<
0.05).
Conclusion
Compared with traditional open approach,posterior intermuscular approach internal fixation can effectively reduce postoperative pain in patients with thoracolumbar fracture and dislocation,improve the rate of spinal canal patency,percentage of responsible segment height of anterior column,and Cobb Angle,which is beneficial to the prognosis of patients.
2021 Vol. 41 (4): 15-16 [
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119
)
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17
Curative Effect of Compound Glycyrrhizin Injection in Adjuvant Treatment of Children With Henoch-Schonlein Purpura Nephritis and the Influence on Cytokines
Zhang Dan, Zhang Xiaofei
Objective
To investigate the therapeutic effect of compound glycyrrhizin injection in adjuvant treatment of children with Henoch-Schonlein purpura nephritis(HSPN) and the influence on cytokines.
Methods
A total of 60 children with HSPN were randomized into two groupA and group B,30 cases in each group.Group A was given conventional treatment,and group B was treated with compound glycyrrhizin injection on the basis of conventional treatment.After 4 weeks of treatment,clinical effects were observed.Changes in urine protein quantification,urine erythrocyte,serum creatinine,urine microalbumin (MAlb) and cytokines [interleukin-4 (IL-4),γ-interferon (IFN-γ)] were compared between groups.
Results
After 4 weeks of treatment,the total response rate of group B (90.00%) was significantly higher than that of group A(66.67%)(
P<
0.05).After treatment,urinary protein quantification,urine erythrocyteand serum creatinine of both groups were significantly decreased,and urine microalbumin (MAlb) significantly increased (
P<
0.05).Besides,the above indexes in group B were better than group A(
P<
0.05).IL-4 levels in both groups significantly decreased,andIFN-γ levels significantly increased (
P<
0.05),which were better in group B than group A(
P<
0.05).
Conclusion
Compound glycyrrhizin injection is effective in adjuvant treatment of children with HSPN,which can enhance renal function and regulate cytokine levels.
2021 Vol. 41 (4): 17-18 [
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109
)
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19
A Comparative Study of Effects of Standard Triple Therapy and Sequential Triple Therapy on the Levels of Serum Inflammatory Factors in Children Patients With Hp Infection
Cai Lixia
Objective
To observe the effects of standard triple therapy and sequential triple therapy on the levels of serum inflammatory factors in children patients with Hp infection.
Methods
The clinical data of 171 children patients with Hp infection were reviewed.According to different drug regimens,they were divided into the control group (84 cases,treated with standard triple therapy drugs) and the experimental group (87 cases,treated with sequential triple therapy drugs).The serum tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6),interleukin-8(IL-8) and total effective rate,Hp eradication rate and occurrence of adverse reactions were compared between the two groups before and after treatment.
Results
After treatment,the levels of serum TNF-α,IL-6,and IL-8 of the two groups of patients were decreased,and the levels in the experimental group were significantly lower than those in the control group (
P<
0.05).The total effective rate in the experimental group was higher than that in the control group (91.95% vs.79.76%) (
P<
0.05),and the eradication rate was higher than that in the control group (90.80% vs.66.67%)(
P<
0.05).The incidence rate of adverse reactions was 9.20% in the experimental group and was 14.29% in the control group(
P>
0.05).
Conclusion
Sequential triple therapy has better treatment effects than standard triple therapy for children patients with Hp infection,and it can significantly reduce the levels of serum inflammatory factors,and it is safe and effective and is worthy of clinical promotion.
2021 Vol. 41 (4): 19-20 [
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143
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21
Effect of Vitamin AD on Children With Recurrent Respiratory Tract Infection
Liang Menglin, Huang Xiangmin, Tan Xiong
Objective
To study the clinical effect of vitamin AD in the adjuvant treatment of children with recurrent respiratory tract infection.
Methods
60 children with recurrent respiratory tract infection 2019 were divided into control group and observation group,30 cases in each group.The control group was given basic treatment,and the observation group was treated with vitamin AD.The improvement time of main clinical symptoms,respiratory tract infection times,immune indexes and clinical efficacy of the two groups were compared.
Results
Compared with the observation group,the time of fever,wheezing,cough and lung rales in the control group were significantly longer than those in the observation group,there was statistical significance(
P<
0.05).After treatment,the number of respiratory tract infections in the control group was significantly higher than that in the observation group,and the data difference between the two groups was statistically significant(
P<
0.05);The levels of 25 hydroxyvitamin D3,immunoglobulin G,immunoglobulin M and immunoglobulin A in the control group were significantly lower than those in the observation group,there was statistical significance(
P<
0.05).The total effective rate of the observation group was 93.33%,significantly better than 73.33% of the control group,there was statistical significance(
P<
0.05).
Conclusion
Vitamin AD adjuvant treatment of children with recurrent respiratory tract infection has exact clinical effect,not only can significantly alleviate the clinical symptoms of children with fever,cough and wheezing,reduce the number of respiratory tract infections,but also significantly improve the immune function of children,which is worthy of promotion and application in pediatric clinical treatment.
2021 Vol. 41 (4): 21-23 [
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284
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24
Comparison of Effects of Four Different Concentrations of Hypertonic Saline Aerosol Treatment on Improving the Clinical Symptoms of Infant Bronchiolitis
Zhai Jingmei
Objective
To compare the effects of four different concentrations of hypertonic saline aerosol treatment on improving the clinical symptoms of infant bronchiolitis.
Methods
200 infants with bronchiolitis admitted to our hospital were selected as the study subjects and divided into four groups (group A,group B,group C,and group D) according to the random number table method,with 50 cases in each group.Group A,group B,group C and group D were treated with 3%,5%,6% and 7% hypertonic salineaerosol treatment respectively.The disappearance timesof clinical symptoms and signs,Wang severity score (CS) and adverse reactions were compared.
Results
There was no significant difference in the efficacy among the four groups (
P>
0.05).There was no significant difference in the CS score among the four groups after treatment(
P>
0.05).There were no significant differences in the disappearance times of clinical symptoms and signs among the four groups(
P>
0.05).The incidence rates of adverse reactions in groups A,B,C,and D were 0.00%,6.00%,12.00%,and 14.00% respectively.The incidence rate of adverse reactions in groups C and D was higher than that in group A(
P<
0.05).
Conclusion
Four different concentrations (3%,5%,6%,7%) of hypertonic saline aerosol treatment can effectively improve the clinical symptoms of infantbronchiolitis,but 3% hypertonic saline aerosol treatment has better safety.
2021 Vol. 41 (4): 24-25 [
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165
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26
Results of Coagulation Function Monitoring in Premature Infants of Different Gestational Ages and Their Correlation With Hemorrhagic Disease
Li Lina
Objective
To explore the results of coagulation function monitoring in premature infants of different gestational ages and their correlation with hemorrhagic disease.
Methods
A total of 120 premature infants were included in the study.According to the difference in gestational age,they were divided into small-gestational-age premature infant group(≤34 weeks,n=51) and large-gestational-age premature infant group (>34 weeks and <37 weeks,n=69).The fibrin degradation products (FDP),fibrinogen (FIB),prothrombin time (PT),activated partial thromboplastin time (APTT),D-dimer (DD) and other coagulation function indicators were monitored and analyzed at 2h after delivery,and the correlation between different gestational ages and hemorrhagic disease was analyzed.
Results
There were no significant differences in gender and delivery methods between small-gestational-age premature infant group and large-gestational-age premature infant group(
P>
0.05).The gestational age and body mass in small-gestational-age premature infant group was lower than those in large-gestational-age premature infant group (
P<
0.05).The levels of FDP,PT,APTT and DD in small-gestational-age premature infant group were higher than those in large-gestational-age premature infant group(
P<
0.05).The FIB level in small-gestational-age premature infant group was lower than that in large-gestational-age premature infant group(
P<
0.05).The total incidence rate of bleeding in small-gestational-age premature infant group was higher than that in large-gestational-age premature infant group (15.69% vs.2.89%) (
P<
0.05).
Conclusion
The results of coagulation function monitoring are different among premature infants of different gestational ages,and premature infants of small gestational ages are prone to hemorrhagic disease.Thus it is necessary to strengthen the coagulation function monitoring and strictly pay attention to patients of small gestational ages,so as to effectively prevent the occurrence of hemorrhagic disease.
2021 Vol. 41 (4): 26-27 [
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107
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28
Detection Value of Morphological Indexes of Sesamoid Axial Position Under X-ray In Patients With Halux Valgus
Li Yan
Objective
To explore the detection value of morphological indexes of sesamoid axial position under X-ray in patients with halux valgus.
Methods
A total of 69 patients with halux valgus were enrolled.All underwent halux valgus orthopedics.Before and after surgery,X-ray photography of sesamoid axial position was conducted.The position and rotation angle of sesamoids before and after surgery were measured.The foot deformity degree in patients with halux valgus was evaluated.The correlation between morphological indexes of sesamoid axial position and the diagnosis of patients with halux valgus was analyzed by Pearson correlation analysis.
Results
After surgery,axial position and rotation angle of sesamoids,and the position of tibial sesamoid were significantly decreased (
P<
0.05).The sesamoid position of sesamoid axial position,rotation angle of sesamoid and position of tibial sesamoid in sesamoid reduction group were significantly lower than those in sesamoid non-reduction group (
P<
0.05).Pearson correlation coefficient analysis showed that sesamoid position of sesamoid axial position was weakly correlated with position of tibial sesamoid (
P<
0.05),while strongly correlated with rotation angle of sesamoid (
P<
0.05).The position of tibial sesamoid is moderately correlated with rotation angle of sesamoid (
P<
0.05).
Conclusion
As morphological indexes of sesamoid axial position under X-ray,sesamoid position of sesamoid axial position and rotation angle of sesamoid can supplement the defects of weightbearing tangential radiograph,reflec severity of foot deformity and postoperative sesamoid reduction in patients with halux valgus.
2021 Vol. 41 (4): 28-29 [
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121
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30
Observation on the Clinical Effect of Combined Dental Pulp and Orthodontic Treatment on Permanent Upper Anterior Gingival Fracture
Liu xiao, Mao Junmu
Objective
To analyze the clinical effect of combined dental pulp and orthodontic treatment in patients with permanent upper anterior gingival fracture.
Methods
60 patients with permanent upper anterior gingival fracture were selected as the research objects.They were divided into control group(conventional restorative treatment) and observation group (tooth Endodontic and orthodontic combined restoration treatment),30 patients in each group.Compare the clinical efficacy after treatment.
Results
After treatment,the total effective rates of the observation group and the control group were (96.67%) and (66.67%) respectively,and the difference was statistically significant (
P<
0.05);the observation group and the control group had respectively (6.67%),(33.33%),the difference is statistically significant(
P<
0.05);the observation group and the control group have treatment satisfaction (96.67%),(66.67%),the difference is statistically significant(
P<
0.05).
Conclusion
The clinical efficacy and safety of combined dental pulp orthodontic treatment for patients with permanent upper anterior and subgingival fractures are better,and the patients are more satisfied with the treatment and have higher clinical application value.
2021 Vol. 41 (4): 30-32 [
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132
)
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99
Analysis of the Effect of Pre-Hospital First Aid Training For Aged Care Workers and Survey of Their Employment Needs
Qi Li, Qu Yi, Zhang Yan, Li Min, Li Guiling, Song Tian, Fan Dan
Objective
To analyze the effect of pre-hospital first aid training for aged care workers and survey of their employment needs,and provide strategic measures for standardizing the team of elderly care workers in order to respond to aging actively.
Methods
113 nursing staff were trained in pre hospital first aid skills for five days,and then the effect was analyzed.
Results
Aged care workers who participated in the training were more satisfied with the teaching plan(97.3%) and the teaching content(96.5%),while the satisfaction with the training duration(45.1%) was low,the difference was statistically significant(
P<
0.05).The demand rate of higher wages,more training,less working hours and lower intensity was higher in people over 45 years old than in that under 45 years old (61.4% VS 38.5%,66.6% VS 33.3%,58.1% VS 30.8%,64.3% VS 35.7%),and the demand rate of qualification recognition was lower than that of people under 45 years old (82.5% VS 17.5%),the difference was statistically significant(
P<
0.05).The demand rate of people with elementary school and below education level for training is higher than that of aged care workers with junior high school education and above(52.4% VS 47.6%),and the demand for qualification certification is lower than that of aged care workers with junior high school education and above(82.5% VS 17.5%),the difference was statistically significant(
P<
0.05).
Conclusion
It is a good strategy to deal with the aging actively by building the aged care workers,improving the training system and standardizing the nursing profession.
2021 Vol. 41 (4): 99-101 [
Abstract
] (
125
)
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108
Application and Exploration of ‘Intelligent Medical Assistant' In Primary Medical Service-Taking Shouxian County As An Example
Chen Zhaozhen
Objective
To build a new mode of diagnosis and treatment service for grassroots doctor,improve the service ability of grassroots medical institutions,and effectively improve the level and application effectiveness of grassroots medical informatization with the platform of "intelligent doctor assistant".
Methods
Through the "intelligent doctor assistant" auxiliary diagnosis subsystem,chronic disease intelligent management subsystem,remote consultation system and PAD mobile terminal,the online and offline medical service resources were effectively integrated to improve the level of grassroots medical care.
Conclusion
through the application of "intelligent medical assistant" in the grass-roots level,the level of grass-roots medical service is promoted,and the people's medical experience is well.
2021 Vol. 41 (4): 108-109 [
Abstract
] (
152
)
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175
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126
Effect of Yiqi Tongmai Decoction on Cardiac Function and Inflammatory Response in Patients With Coronary Heart Disease and Heart Failure
Li Jingjing
Objective
To analyze the effect of Yiqi Tongmai Decoction on cardiac function and inflammatory response in patients with coronary heart disease and heart failure(HF).
Methods
186 patients with HF were selected and randomly divided into traditional Chinese medicine group(n=93)and Western medicine group(n=93).The western medicine group was given conventional western medicine treatment,on the basis of the western medicine group,the Chinese medicine group was given Yiqi Tongmai Decoction.The efficacy and cardiac function(LVEF,LVEDD)and serum inflammatory factor levels(IL-6,TNF-α)before and after treatment were compared between the two groups.The efficacy and cardiac function(LVEF,LVEDD)and serum inflammatory factor levels(IL-6,TNF-α)before and after treatment were compared between the two groups.
Results
The total effective rate of TCM group was 94.62%(88/93)higher than that of Western medicine group(75.57% (70/93)(
P<
0.05);after treatment,LVEF level in TCM group was higher than that in western medicine group,LVEDd level was lower(
P<
0.05);after treatment,serum IL-6 and TNF - α levels in TCM group were lower than those in western medicine group(
P<
0.05).
Conclusion
On the basis of western medicine treatment of HF patients with coronary heart disease,Yiqi Tongmai Decoction has a significant effect,which can reduce inflammation and improve heart function.
2021 Vol. 41 (4): 126-127 [
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150
)
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